2025
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NEW RENAISSANCE
INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE
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ISSUE 9
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ACUTE KIDNEY INJURY IN PATIENTS WITH SEVERE BURNS: PATHOGENESIS,
DIAGNOSIS, AND TREATMENT
Babajanova Sh.D.
Republican Perinatal Center, Tashkent, Uzbekistan
Ibragimova F.A.
Tashkent State Medical University, Tashkent, Uzbekistan
https://doi.org/10.5281/zenodo.17167311
Abstract.
Acute kidney injury in patients with severe burns is one of the most serious
complications in clinical practice. Its development is caused by fluid loss, circulatory disorders,
tissue breakdown, and inflammatory reactions that damage the kidneys. Early recognition with
laboratory and instrumental methods is very important for timely treatment. Management is based
on restoring fluid balance, supporting kidney function, preventing toxins from accumulating, and
in severe cases using blood purification methods. Preventive measures and comprehensive
therapy increase the chances of survival and help to preserve kidney function in burn patients.
Keywords:
severe burns, acute kidney injury, pathogenesis, diagnosis, treatment,
prevention, prognosis.
Introduction
Complicated ovarian tumors and tumor-like formations in girls remain a serious challenge
in pediatric and adolescent gynecology. Such conditions may present with torsion, rupture, or
bleeding, leading to acute abdominal pain and threatening reproductive health. In the past, radical
surgery often resulted in unnecessary loss of ovarian function. Today, the focus has shifted toward
organ-preserving approaches supported by modern minimally invasive techniques, especially
laparoscopy. These methods allow accurate diagnosis, minimal surgical trauma, and preservation
of ovarian tissue, which is essential for maintaining future fertility. The relevance of this problem
lies in ensuring timely diagnosis and applying treatment strategies that combine effectiveness with
preservation of reproductive potential in young patients.
Main part
Ovarian tumors and tumor-like formations in children and adolescents represent a
relatively rare but clinically significant condition in gynecology. Most of these masses are benign,
yet complications such as torsion, rupture, or hemorrhage can occur, leading to acute surgical
emergencies. The incidence of ovarian masses in girls is lower compared to adults, but their
clinical importance is higher due to the risk of delayed diagnosis and the impact on future
reproductive health. Epidemiological studies indicate that tumor-like lesions, such as functional
cysts, dermoid cysts, or benign epithelial tumors, make up the majority of cases, while malignant
neoplasms are less common but require careful consideration. The clinical presentation often
mimics other abdominal pathologies, which complicates diagnosis. Therefore, awareness of this
problem among pediatricians and gynecologists is crucial for timely management. Understanding
the epidemiology and clinical relevance forms the foundation for developing effective treatment
strategies.
2025
SENTABR
NEW RENAISSANCE
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VOLUME 2
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The diagnosis of complicated ovarian tumors in girls remains a challenge due to the
nonspecific clinical presentation. Symptoms such as acute abdominal pain, nausea, vomiting, or
signs of peritonitis may resemble appendicitis or intestinal obstruction. Traditional physical
examination alone is not sufficient for accurate diagnosis. Modern imaging technologies,
especially ultrasound with Doppler evaluation, are essential for identifying ovarian masses and
assessing blood flow disturbances during torsion. Magnetic resonance imaging (MRI) can provide
additional detail in unclear cases, offering precise differentiation between benign and malignant
lesions. Laboratory markers, including tumor markers, may support the diagnostic process, though
their specificity in children is limited. Despite advances, definitive diagnosis often requires
intraoperative evaluation. Early and accurate imaging is therefore critical not only for confirming
the diagnosis but also for guiding the choice of treatment strategy, reducing unnecessary radical
procedures, and ensuring organ preservation.
The modern principles of surgical treatment emphasize organ preservation as the primary
goal, especially in pediatric and adolescent patients. In the past, oophorectomy was commonly
performed, but research has shown that ovarian function can often recover after detorsion, even
when ischemia appears severe. Laparoscopic surgery is now the gold standard because it combines
diagnostic accuracy, minimal invasiveness, and therapeutic effectiveness. This approach allows
surgeons to perform detorsion, excise only the pathological mass, and preserve healthy ovarian
tissue. Benefits include reduced postoperative pain, faster recovery, minimal scarring, and a lower
risk of psychological trauma. Importantly, organ-preserving surgery helps maintain future
reproductive and hormonal function, which is vital for young patients. The choice of conservative
management over radical removal reflects the modern understanding of ovarian resilience and the
priority of safeguarding long-term reproductive potential.
Future perspectives in managing complicated ovarian tumors and tumor-like formations in
girls focus on refining diagnostic accuracy and expanding organ-preserving surgical options.
Advances in laparoscopic and robotic-assisted techniques hold promise for safer, more precise
interventions with better preservation of ovarian tissue. Intraoperative monitoring of ovarian
perfusion and innovative imaging methods may help assess tissue viability more accurately,
reducing unnecessary oophorectomies. Additionally, the development of standardized treatment
protocols and training programs for pediatric surgeons will improve clinical outcomes worldwide.
Emphasis is also being placed on long-term follow-up studies to evaluate the reproductive and
endocrine outcomes of organ-preserving surgeries. The integration of minimally invasive surgery
into routine pediatric gynecology represents a significant step forward, ensuring that treatment is
not only effective but also protective of the future health and quality of life of young patients.
These evolving principles highlight a shift from radical to conservative approaches in modern
medicine.
Conclusion
Complicated ovarian tumors and tumor-like formations in girls remain a challenging
problem in pediatric and adolescent gynecology. Their clinical significance lies not only in the
acute risks caused by torsion, rupture, or hemorrhage but also in the potential long-term
consequences for reproductive and hormonal health. The diagnostic process is often complicated
by nonspecific symptoms and overlapping features with other abdominal emergencies, which
2025
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underlines the importance of modern imaging and timely surgical evaluation. Contemporary
treatment principles emphasize organ preservation as the cornerstone of management.
Laparoscopic surgery has emerged as the gold standard, providing accurate diagnosis, minimal
invasiveness, and the opportunity to preserve functional ovarian tissue. Evidence suggests that
ovarian recovery is possible even after severe ischemia, which supports conservative surgical
approaches over radical oophorectomy. Future perspectives focus on improving diagnostic
technologies, intraoperative monitoring of ovarian viability, and expanding minimally invasive
surgical methods, including robotic-assisted techniques. By prioritizing organ preservation,
modern medicine ensures not only immediate recovery but also long-term reproductive and
psychological well-being for young patients.
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