ILM-FAN VA INNOVATSIYA
ILMIY-AMALIY KONFERENSIYASI
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10
THE IMPORTANCE OF COLCHICINE IN MANAGING SKIN CANCER CELLS
Allaev Otabek
International Sakharov Environmental University Minsk, Belarus
https://doi.org/10.5281/zenodo.13838352
Skin cancer is the most common type of cancer worldwide, affecting millions of people
annually. It is divided into two main categories: melanoma and non-melanoma skin cancers
(such as basal cell carcinoma and squamous cell carcinoma). The high incidence of skin cancer,
along with rising cases due to increased UV exposure, has prompted the need for more effective
treatments. At the core of colchicine's anticancer effect is its inhibition of microtubule
dynamics, leading to the disruption of mitosis in rapidly dividing cancer cells. Beyond
microtubule inhibition, colchicine has also been shown to induce apoptosis through several
pathways, including activation of caspases, inhibition of the anti-apoptotic Bcl-2 protein, and
regulation of p53. Additionally, colchicine disrupts the tumor vasculature by inhibiting
endothelial cell function, thus impairing tumor angiogenesis
Colchicine's cytotoxic properties can interact on a variety of cancer cell lines, including
breast, lung, and colorectal cancers. Studies have shown that colchicine inhibits the migration
and invasion of cancer cells in vitro. Furthermore, its efficacy is compared to standard
chemotherapeutic agents like paclitaxel and vinblastine, highlighting colchicine’s potential as a
potent alternative or complementary agent. Preclinical studies have demonstrated colchicine's
cytotoxic effects on melanoma cell lines and other non-melanoma skin cancer models.
Colchicine inhibits cell proliferation, induces apoptosis, and suppresses cancer cell migration
in vitro The clinical use of colchicine has been limited by its narrow therapeutic window and
associated toxicity. However, emerging strategies, such as nanoparticle delivery systems, aim
to overcome these limitations by improving colchicine’s bioavailability and targeting skin
cancer cells more effectively.
Colchicine presents a promising yet underutilized tool for the treatment of skin cancers,
particularly melanoma, due to its ability to target microtubule formation and disrupt key
cellular processes necessary for tumor growth. However, the major obstacle to its clinical use
remains its toxicity. Ongoing research into drug delivery systems, combination.
