Volume 04 Issue 02-2022
5
The American Journal of Engineering and Technology
(ISSN
–
2689-0984)
VOLUME
04
I
SSUE
02
Pages:
5-8
SJIF
I
MPACT
FACTOR
(2020:
5.
32
)
(2021:
5.
705
)
OCLC
–
1121105677
METADATA
IF
–
7.856
Publisher:
The USA Journals
ABSTRACT
The most convenient way to assess the quality of a drug substance is to determine the melting rate of the drug. The
solubility of a solid drug is defined as the percentage of the drug that passes into the solution over a period of time. It
is convenient to evaluate the solubility of drugs to compare different forms of the drug and to control the quality
during the production process. Many methods and devices have been developed to determine the rate of melting.
KEYWORDS
Relatively little, and in most cases, pharmacological and technological parameters.
INTRODUCTION
Bioavailability (BS) is the amount of a drug that enters
the bloodstream when administered orally, by
injection, inhalation, or otherwise. We know that when
administered
intravenously,
BS
enters
the
bloodstream 100%, in other ways (oral, rectal,
intramuscular, etc.), relatively little, and in most cases
less than 100%. The biological effectiveness of drugs
(DP) depends on their breakdown, dissolution and
separation of drugs (DV) from the drug, so it is
necessary to evaluate the above pharmacological and
Research Article
DETERMINATION OF BIOLOGICALLY ACTIVE SUBSTANCES BY
MODERN METHODS
Submission Date:
January 20, 2022,
Accepted Date:
February 08, 2022,
Published Date:
February 23, 2022 |
Crossref doi:
https://doi.org/10.37547/tajet/Volume04Issue02-02
Yodgorova M.O.
Assistant, Bukhara MTI, Uzbekistan
Journal
Website:
https://theamericanjou
rnals.com/index.php/ta
jet
Copyright:
Original
content from this work
may be used under the
terms of the creative
commons
attributes
4.0 licence.
Volume 04 Issue 02-2022
6
The American Journal of Engineering and Technology
(ISSN
–
2689-0984)
VOLUME
04
I
SSUE
02
Pages:
5-8
SJIF
I
MPACT
FACTOR
(2020:
5.
32
)
(2021:
5.
705
)
OCLC
–
1121105677
METADATA
IF
–
7.856
Publisher:
The USA Journals
technological parameters in the development of drugs.
Also, in assessing their quality in industrial production,
it is necessary to assess whether these indicators meet
the requirements. Determining the breakdown of solid
dosage forms does not allow a complete conclusion to
be drawn about the release of the drug from them, so
it is not appropriate to assess their bioavailability.
The most convenient way to assess the quality of a
drug substance is to determine the melting rate of the
drug. The solubility of a solid drug is defined as the
percentage of the drug that passes into the solution
over a period of time. It is convenient to evaluate the
solubility of drugs to compare different forms of the
drug and to control the quality during the production
process. Many methods and devices have been
developed to determine the rate of melting.
Devices and methods must meet the following
conditions:
Know the exact dimensions of the appearance of
each part of the device;
The device is relatively simple, easy to use, and
experimental
It must be appropriate when circumstances change,
and it must produce the same results;
The melting process in the device is adapted to the
absorption process in vivo;
The device must be controllable, be able to change
speed, provide a smooth non-turbulent mixing;
The samples can be immersed in the solvent even
during the operation of the device.
During the melting process, the sample should not be
affected by any mechanical particles;
The melting vessel must be closed and visible to
monitor the melting process. Standard of solvent
must be;
Disk method
This method is necessary to determine the true rate of
melting. The shape of this method has changed several
times, depending on the speed of rotation, the setting
of the sample, and the appearance of the handle to
control the movement of the solvent.
In this method, the tablet is attached to the acrylic
holder (disc) using paraffin, and only the top of the
tablet touches the solvent. The sample holder is
circulated in a 200 ml solvent container at 37 ° C. The
number of revolutions is 300 or 400.
The method used in the laboratory glass. This method
uses 250ml of solvent heated to a temperature of 37 ±
0.5C °. Mixing is done with a propeller mixer in the
middle. The number of revolutions is 1min / 60. In this
method, the method of mixing the sample is critically
evaluated. It is recommended to prevent the rotation
of the sample from the bottom hemisphere round
container.
An improvement that solves this problem is to put the
sample in a basket or holder. The fixed position of the
basket on the iron base is achieved by means of a
magnet placed at the bottom of the basket. Fixation of
another type of these devices is done by means of
plates. The plate capsules are made of organic glass or
Teflon, which allows you to insert many capsules and
tablets. There is no difficulty in evaluating capsules
when using such a device. The solvent circulation in
front of the samples is also regular.
In the past, taking natural medicines has been done on
several approaches, including: in heart disease from
eye medications in cardiac eye diseases consumed, all
toxins in certain amounts used as a medicine.
Volume 04 Issue 02-2022
7
The American Journal of Engineering and Technology
(ISSN
–
2689-0984)
VOLUME
04
I
SSUE
02
Pages:
5-8
SJIF
I
MPACT
FACTOR
(2020:
5.
32
)
(2021:
5.
705
)
OCLC
–
1121105677
METADATA
IF
–
7.856
Publisher:
The USA Journals
Aspirin was released 330 years ago. It has been
poisonous for years has been showing a negative
rather than a positive effect throughout. So far,
scientists have been working to reduce the toxic
effects of aspirin are working on. Of course, poisons
are drugs in small quantities plays a role. Some
scientists believe that by consuming small amounts of
poison, they hardened their bodies. lion venom little by
little. The div hardens even when consumed. Do not
use some inhibitors as a medicine at this time measures
are being taken. Mercury is a very strong poison, but in
Karakalpak Stan it is used as a medicine. It is in a certain
dose kills microorganisms, but has a strong effect on
the div shows. Recent use of metabolites as drugs
established. Palavering and in lowering human blood
pressure uses drugs such as diazole. These drugs lower
blood pressure only for a certain period of time, but if
they are produced in associations, they can be
obtained by genetic engineering.
Work to get any medication or metabolite should start
with the selection of raw materials in the first place.
There are several types of raw materials to choose
from.
The right choice is very important. These are biological
raw materials are of great importance. Biological raw
materials are also available respectively divided into
three groups: animal, microorganism and plant. Human
and animal organs are very rich in raw materials.
For example, obtaining albumin, globulin and other
substances from them possible. It is different from the
glands present in animal raw materials different
hormones are obtained. These include the pancreas
and gonads can be an example. The adrenal glands are
a source of hormones. In microorganisms, the
adaptation process goes very well. Enhancing the
synthesis of ascorbic acid by growing the in a sorbent
possible. Penicillin, ampicillin and organic from
microorganisms acids are obtained. The field of
biotechnology is a new direction in science, technology
in the laboratory and in the enterprise environment to
the problem of drug deficiency, creating the possibility
of obtaining substances helps put a check.
Especially the drug in a biological way using nasal
engineering by transferring the offspring to a
microorganism or plant for preparation, certain
conditions are created for tissue development. The
hormones
interferon,
riboflavin,
insulin
and
somatotropin are obtained using engineering. Plants
like Jenshen are being propagated.
Fungi are propagated in this way, and from them are
home remedies (arachic acid, semi-saturated aromatic
fatty acids, etc.) Being taken. Obtained by
biotechnology in the late twentieth century total
pharmaceuticals with a product volume of $ 28.9 billion
8.5 mid. dollars. Amino acids in the Japanese world, is
the largest state in terms of obtaining antibiotics,
alcohols and stabilized enzymes.
CONCLUSION
Raw materials of medicinal plants and medicines
derived from them Drugs play an important role in
providing the population of the republic with
medicines. Contains all medicinal plants there are
different compounds.
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Volume 04 Issue 02-2022
8
The American Journal of Engineering and Technology
(ISSN
–
2689-0984)
VOLUME
04
I
SSUE
02
Pages:
5-8
SJIF
I
MPACT
FACTOR
(2020:
5.
32
)
(2021:
5.
705
)
OCLC
–
1121105677
METADATA
IF
–
7.856
Publisher:
The USA Journals
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