Evaluation of markers of endothelial dysfunction (endothelin-1 and nitric oxide) and elemental status (zinc, iron, magnesium) of chronic kidney disease (CKD). The study includes 104 patients with different stages of CKD: 63 patients with I stage of CKD, and 26 patients with CKD stage III and 15 patients with CKD V stage. Results: in patients with CKD, endothelin-1 increased with simultaneous decrease in production of nitric oxide in the progression of CKD from I to V stage. The increase of the content of endothelin-1 by 2.5 times determined in patients with stage V CKD, which was accompanied by a decline of the ratio of the concentrations of NO/ET-1 by 5.5 times. In patients with CKD, elemental status impairments were detected, manifested by a decrease in the content of zinc, iron, and magnesium in the serum of blood at the first stage, with the maximum implementation in stage III CKD. Hypertension was detected in 68.3% of patients with CKD. Direct correlations were found between the content of serum iron and magnesium with the level of arterial pressure in patients with stage I CKD. In III and V stage CKD, a direct correlation of serum magnesium with blood pressure level and nitric oxide concentration was established. Conclusion: children with CKD have endothelial dysfunction and elemental status disorders, beginning with the first stage of CKD development, which can be considered as factors determining the progression of the pathological process in the kidneys.
Ivanova I.E. Chronic kidney disease in children and adolescents. Zdravoohranenie CHuvashii 2013; 2: 38–45. (in Russ)
Komarova O.V., Smirnov I.E., Kucherenko A.G., Tsygin A.N., Kostyushina I.S. Endothelial dysfunction in children with chronic kidney disease. Ros pediatr zhurn 2012; 5: 23–26. (in Russ)
Mel’nikova Yu.S., Makarova T.P. Endothelial dysfunction as the key link of chronic diseases pathogenesis. Kazanskij medicinskij zhurnal 2015; 96(4): 659–665. (in Russ)
Watson R.R., Preedy V.R., Zibadi S. Magnesium in human health and disease. New York: Humana Press, 2013; 309.
Kanbay M., Yilmaz M.I., Apetrii M., Saglam M., Yaman H., Unal H.U. et al. Relationship between serum magnesium levels and cardiovascular events in chronic kidney disease patients. Am J Nephrol 2012; 36(3): 228–237. DOI: 10.1159/000341868
Habibrahmanova Z.R., Makarova T.P., Sadykova D.I. Metabolism of quantity elements and essential trace elements in patients with essential arterial hypertension in different ecological settings. Kazanskij medicinskij zhurnal 2013; 94(6): 798–803. (in Russ)
Maret W. Zinc biochemistry: from a single zinc enzyme to a key element of life. Adv Nutr 2013; 4(1): 82–91. DOI: 10.3945/an.112.003038
Lobo J.C., Stockler-Pinto M.B., Farage N.E., Faulin Tdo E., Abdalla D.S., Torres J.P. et al. Reduced plasma zinc levels, lipid peroxidation, and inflammation biomarkers levels in hemodialysis patients: implications to cardiovascular mortality. Renal Failure 2013; 35(5): 680–685. DOI: 10.3109/0886022X.2013.789960
Petuhov V. S., Zan’ko S.N. Iron deficiency and endothelial dysfunction as risk factors and diagnostic markers of placental insufficiency. Vestnik VGMU 2011; 10(3): 55–64. (in Russ)
Smirnov I. E., Kucherenko A.G., Komarova O.V. Biomarkers of the formation of nephrosclerosis in chronic kidney disease in children. Ros pediatr zhurn 2014; 17(6): 10–15. (in Russ)