DOI:
https://doi.org/10.37547/TAJMSPR/Volume02Issue12-19Keywords:
Chronic atrophic gastritis chronic non-atrophic gastritisAbstract
The association between HP infection and CAH development suggested by the Correa cascade is supported by several cohort studies. To diagnose and determine the severity of atrophy at the Center, patients underwent a serological analysis by ELISA method in the clinical and biochemical laboratory of the State Institution "RSNPMCT and MR". Analyzes were taken in 69 (58.5%) patients, including 35 (50.7%) with CAH, 34 (49.3%) with CNG. Analysis of the non-invasive indicator of the level of pepsinogens in patients with CAH determined that severe atrophy was detected in 20%, moderate atrophy - 42.9%, weak atrophy - 34.3%, and no atrophy was found in 2.9% of patients. The pepsinogen parameters in patients with CNG were also as follows: PG I was within 95.4 ± 7.2 μg / L, PG II 14.5 ± 1.3 and PGI / PGII 6.6 ± 0.2. Pepsinogen values were more pronounced in patients with CAH: with a pronounced degree of atrophy, PGI was 8.7 ± 0.1 μg / l and PGI / PGII was 1.1 ± 0.1; with moderate atrophy 16.6 ± 0.9 μg / l and 1.6 ± 0.1; with mild atrophy 27.2 ± 1.5 and 2.3 ± 0.2, respectively.
References
Abdullaeva U.K. Predicting the risk of atrophic transformation in chronic gastritis using serum pepsinogen // World journal of pharmaceutical research, Faculty of Pharmacy Medical University, Bulgaria, Vol. 8, Iss. 13, 2019, P. 219-228 DOI:10.20959/wjpr201913-16304
Abdullaeva U.K., Sobirova G.N., Karimov M.M., Aslonova I.J. The prevalence and possibilities of prevention of noncardial gastric cancer in the Bukhara region // American journal of medicine and medical sciences, 2020, 10(9), Р. 679-681. DOI:10.5923/j.ajmms.20201009.11
Belkovets A.V. et al. Experience of non-invasive diagnosis of atrophic gastritis in current clinical practice. // Bulletin of the SB RAMS, 2013. - No. 4.- P. 71-76. [in russian]
Bordin D.S. et al. Serological biopsy and screening for gastric cancer. // Malignant tumors, 2014. - No. 2 (9) .- P.30-36. [in russian]
Huang et al. Serum pepsinogen levels are correlated with age, sex and the level of helicobacter pylori infection in healthy individuals // The American journal of the medical sciences, 2016. - Vol. 35 (2). - P. 481-486.
Karimov M.M., Sobirova G.N., Abdullaeva U.K. Chronic gastritis and carcinogenesis issues // journal "Bulletin of the club of pancreatologists", Donetsk National Medical University, Ministry of Health of Ukraine, Kiev, Ukraine, No. 4, 2019, pp. 65-70. doi: 10.33149/vkp.2019.04.09 [in russian]
Kotachi T. et al.Serological evaluation of gastric cancer risk based on pepsinogen and Helicobacter pylori antibody: Relationship to endoscopic findings. // Digestion, 2017. – Vol. 95. – P. 314–8.
Kotelevets S.M., SA Chekh Serological Criteria for Mild, Moderate and Severe Atrophy in Atrophic Gastritis. // Biol Med., 2015. – Vol. 7. – P. 235.
Roman L.D. et al. Prevalence of H.pylori Infection and Atrophic Gastritis in a Populationbased Screening with Serum Biomarker Panel (GastroPanel®) in St. Petersburg. // Anticancer Res., 2016. – № 36 (8). – Р. 4129–38.
Sobirova G.N., Abdullaeva U.K. Immunopatogenesis of chronic gastritis and its role in carcinogenesis // Journal of biomedicine and practice, Tashkent, Uzbekistan. №4, 2018, стр. 20-27. http://dx.doi.org/10.26739/2181-9300-2018-4-4
Sobirova G.N., Abdullaeva U.K., Mirzaeva D.B., Ismitdinova N.S. Immunopatogenesis of chronic gastritis and its role in carcino genesis // ACADEMICIA An international multidisciplinary research journal, affliated to Kurukshetra university, Kurukshetra, India. Vol.8, Iss.12, 2018, P. 32-40. doi: 10.5958/2249-7137.2018.00072.1
Sobirova G.N., Abdullaeva U.K., Nosirova M.S., Aslonova I.J. Evaluation of the gastrointestinal mucosa by the OLGA system in chronic atrophic gastritis // Journal of critical reviews, Kuala Lumpur, Malaysia, Vol. 7, Iss. 2, 2020, P. 409- 413. DOI: dx.doi.org/10.31838/jcr.07.02.80
Syrjänen K. A Panel of Serum Biomarkers (GastroPanel®) in Non-invasive Diagnosis of Atrophic Gastritis. Systematic Review and Meta-analysis // Anticancer Res., 2016. – Vol. 36 (10). – P. 5133–5144.
