Clinical, Immunological And Molecular-Genetic Characteristic Of Aggressive Pituitary Adenomas

Pituitary adenomas (PA) are monoclonal tumors arising from the cells of the adenohypophysis and represent approximately 10-15% of all intracranial tumors and 90% of the tumors of the sellaturcica. Pituitary adenomas occur in almost 20% of the general population. The estimated annual morbidity of pituitary adenoma is approximately 20 cases per 100,000of population, making it the third most common primary intracranial tumor after gliomas and meningiomas [9].