The One Health paradigm, emphasizes the interconnectedness of human, animal, and environmental health. Recognizing that disruptions in one domain affect others, the study underscores the importance of collaborative efforts across disciplines to address complex health issues. Herein we have highligted the challenges posed by diseases such as Bovine TB, Brucellosis, Q fever, Leptospirosis, rabies, Crimean-Congo Hemorrhagic Fever, and others. The narrative extends to global warming, environmental impacts, and the intricate relationships between climate change, agriculture, and health in low-income countries. 60% of infectious diseases are zoonotic, emphasizing the need for a One Health strategy. One Health initiative in various countries, including the Netherlands, the U.S., Kenya, Thailand, Australia, Norway, and Canada has remained successful. The study delves into the challenges faced by low-income countries, in implementing the One Health approach amidst climate-induced events, floods, and disease outbreaks. Furthermore, it highlights the significance of health education, surveillance, and prevention strategies for mitigating the impact of zoonotic diseases on public health, animal health, and the environment in low-income nations. The complex interplay of environmental changes, agricultural dynamics, and socio-economic factors underscores the need for a comprehensive and transdisciplinary approach to address zoonotic challenges effectively.
