Effects Of F-18 On KCL And Phenylephrine - Induced Contractions Of Rat Aorta

The mechanism of action of the alkaloid 1-(2´-bromine-4´,5´-dimethoxyphenyl) - 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (F-18) on the functional activity of smooth muscle cells of the rat aorta was studied. Isometric contraction activity was recorded using a Grass FT – 03 (Grass Instrument, USA) mechanotron. The relaxant effect of the F-18 alkaloid was found to be associated with blockade of Ca^{2 +} (IP₃R) channels in the SR, along with voltage- dependent and receptor-operated Ca²⁺channels in the aorta smooth muscle cell plasmalemma.