YOSH OLIMLAR
ILMIY-AMALIY KONFERENSIYASI
in-academy.uz/index.php/yo
50
THE EFFECT OF OMEPRAZOLE ACE INHIBITORS, SITOTEK AND THEIR
COMBINATIONS ON THE INDICATORS OF OXIDATIVE STRESS AND NO
FORMATION IN THE GASTRIC MUCOSA
Yakubov A. В.
Pulatova D. B.
Musayeva L. J.
Ilkhomova Z. E.
Tashkent Medical AcademyTashkent Medical Academy
https://doi.org/10.5281/zenodo.13960421
Annotation.
The study of the safety of the use of medicines is not only a clinical, but also
an important socio-economic task, the solution of which can ensure the success of
pharmacotherapy. The aim of the study was to identify and analyze drug adverse adverse
reactions (NPR) caused by drugs of the angiotensin converting enzyme (ACE) inhibitor group
with the possibility of preventing their development and timely treatment. The most common
among NPR are dry cough, bronchospasm, and allergic reactions. Other NSAIDs - hypotension,
hyperkalemia, proteinuria, reversible acute renal failure - are less common. Special
complications of drug therapy include angioedema and agranulocytosis. The method of
spontaneous messages revealed an increase in blood pressure after taking enalapril.
Keywords:
angiotensin converting enzyme inhibitors; ACE inhibitors; adverse side
reactions; NPR; pharmacotherapy.
The purpose of the study:
to study the results of studying the effects of ACE, omeprazole
and sitotek on the parameters of sex in the gastric mucosa
Materials and methods of research
. Experimental studies were carried out on 78 male
rats of a mixed population weighing 160-200 g, which were on a regular vivarium diet. The
animals were divided into 13 groups of 6 individuals each.
Results of the study:
Angiotensin converting enzyme (ACE) plays an important role in
the regulation of blood pressure and water-salt metabolism, but its effect on the stomach and
digestive system also deserves attention. Regulation of blood supply: ACE is involved in the
process of vasoconstriction, which can affect the blood supply to the stomach. This, in turn, can
have an effect on gastric juice secretion and digestive processes. Effects on secretion: Studies
show that ACE and its inhibitors can affect the secretion of gastrin, a hormone that stimulates
the production of gastric juice. Changes in gastrin levels can lead to various digestive disorders.
Pathological conditions: In some diseases, such as gastritis or peptic ulcer disease, there may
be a change in ACE activity, which affects inflammatory processes and tissue healing. Effects on
the microbiota: ACE can have an indirect effect on the intestinal microbiota, which is also
important for the health of the stomach and the entire digestive tract. In general, ACE plays a
multifaceted role in the functioning of the stomach and digestive system
Conclusions:
Thus, the choice of a drug for the treatment of nonsteroidal anti-
inflammatory drugs (NSAIDs)-induced gastropathies in patients with rheumatological diseases
presents significant difficulties, primarily due to the need for anti-ulcer treatment against the
background of continued NSAID therapy. In many patients admitted to a rheumatology hospital
due to an exacerbation of the underlying disease, when ulcers or erosions of the upper
gastrointestinal tract are detected, NSAIDs cannot be canceled even temporarily, since this can
lead to a significant deterioration and an increase in joint syndrome.
YOSH OLIMLAR
ILMIY-AMALIY KONFERENSIYASI
in-academy.uz/index.php/yo
51
References:
1.
Gastropathy caused by NSAIDs: from understanding the mechanisms of development to
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A.N.Sudakova, E.I. Rosenblit//Ter.arch.-2007.–No.2.–pp.81-85.
2.
Drozdov V.P. Gastropathies caused by nonsteroidal anti-inflammatory drugs:
pathogenesis, prevention and treatment. // Consiliummedicum. -2005. –Appendix 1.–pp.3-7.
3.
Minushkin O.N., Maslovsky L.V., Leonov V.M. Prevention of NSAID gastropathies in
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