102
CHANGES IN PERIPHERAL VESSELS DEPENDING ON THE LEVEL OF
ARTERIAL HYPERTENSION IN PATIENTS WITH ISCHEMIC HEART DISEASE
AND ARTERIAL HYPERTENSION
Odiljonov H.X.
Alimov D.A.
Maksudova M.X.
Saydaliyev R.S.
Tashkent medical academy, Tashkent , Uzbekistan.
https://doi.org/10.5281/zenodo.14791982
Abstract.
Arterial stiffness as a marker of subclinical target organ damage in patients
with arterial hypertension (AH) is an important and independent predictor of mortality and
cardiovascular morbidity. The review examines factors that contribute to increased vascular
wall stiffness with a focus on smoking, mechanisms of increased arterial stiffness with aging,
and the effect of arterial stiffness on increased systolic and pulse blood pressure (BP).
Particular attention is paid to the effect of pulse blood pressure on the risk of cardiovascular
complications, primarily on the incidence of stroke and cognitive impairment.
Key words:
arterial hypertension, pulse blood pressure, stroke.
The purpose
. During the study pronounced structural and functional changes in
peripheral arteries were revealed with a decrease in their elasticity, increased elasticity of the
vascular wall, early atherosclerotic changes in the CCA, both in patients with obesity and
insulin resistance (IR) compared with patients with hypertension.
Materials and methods
. 30 patients with hypertension were examined, of which 5
patients with stage II hypertension and 25 with obesity. To assess structural and functional
changes peripheral arteries, duplex scanning was performed arterial imaging using linear
ultrasound sensor 3-12 MNz on a Philips Envizor device with assessment IMT of the common
carotid artery, common femoral artery, main renal artery in B-mode according to general
accepted methodology.
Results.
When assessing structural changes in the vessel wall, a significant decrease in
the elasticity of the CCA was revealed. In patients with hypertension, AC decreased by 15.9%,
and in patients with obesity - by 45.2% (p <0.01) and by 57.8% with combination with IR
(p<0.01) without significant differences among themselves. More pronounced wall disorders
OSA in obese patients revealed a highly significant increase in Ep by 82.5% (p<0.01) and YEM
– by 93.8% (p<0.01), and when combined with IR - by 91.9% and 2.2 times respectively. At
the same time, the elasticity index increased Si as an indicator independent of blood pressure
level. In a group in HD patients it was 2.21±0.3 (p<0.05), increased by 28.7%, with obesity -
2.85±0.22 (p<0.01) and increased by 42.8%, with combination with IR - 4.03±0.24 (with
control 27.5±0.27).
Conclusions:
The definite connection obtained between metabolic disorders and
increased elasticity of large arteries by thickening their walls in conditions of obesity, insulin
inactivation, lipid metabolism disorders suggests that the vascular effect of hypertension
leads to to a change in the wall in the form of its elasticity with a decrease elasticity.
References:
1.
Gapon L.I. Hypertension and arterial wall stiffness in clinical practice: literature review.
103
Russian Journal of Cardiology. 2024;29(5):5924. (In Russ.)
https://doi.org/10.15829/1560-
. EDN: VPKVJT
2.
РЕМОДЕЛИРОВАНИЕ
ПЕРИФЕРИЧЕСКИХ
АРТЕРИЙ
КАК
ПРЕДИКТОР
ЭНДОТЕЛИАЛЬНОЙ
ДИСФУНКЦИИ
ПРИ
АРТЕРИАЛЬНОЙ
ГИПЕРТОНИИ
И
АБДОМИНАЛЬНОМ ОЖИРЕНИИ Молчанова Н.Н., Загретдинов И.А., Терегулова А.М.,
Мингазитдинова Л.Н. *, Муталова Э.Г., Новикова Л.Б
