79
PHARMACEUTICAL TABLET MANUFACTURING PROCESS VIA WET
GRANULATION FOR IRON DEFICIENCY ANEMIA TREATMENT ERITIM
Shukhrat Makhmadaliyevich Turaboev
Institute of Bioorganic Chemistry AS RUz
Alfraganus University
https://doi.org/10.5281/zenodo.14915745
Annotation.
The most prevalent form of nutritional deficiency resulting in anemia is iron
deficiency, primarily caused by insufficient consumption of dietary iron. World Health
Organizations’ information indicate that, 40% of all children aged 6–59 months, 37% of
pregnant women and 30% of women 15–49 years of age are suffer from anaemia. Anemia is
most commonly found in children under the age of 5, especially infants and those under 2 years
old. These young children are particularly vulnerable to developing anemia [1].
According to research findings, the regions with the highest prevalence of anemia were
Western sub-Saharan Africa with a rate of 47.4%, followed by South Asia and Central sub-
Saharan Africa, both exhibiting a prevalence of 35.7%. These findings highlight the significant
burden of anemia in these specific geographic areas[1-3].
Iron deficiency anemia in pregnant women lead to damage of childbirth. People with Iron
deficiency anemia suffer from fatigue and weakness, Shortness of breath, rapid, irregular
heartbeat, poor concentration and cognitive difficulties.
Key words:
solution, iron deficiency anemia, tablet, technology.
Introduction.
Tablets are preferred by patients over other medicines due to their convenience, accurate
dosage, shelf stability, easy administration, taste masking, dose modification capability, wide
availability, and overall patient acceptability. Oral tablets are widely recognized as the
predominant drug delivery systems utilized in contemporary patient treatments.
Consequently, the pharmaceutical tablet manufacturing process (PTMP) occupies a crucial and
pivotal role in the pharmaceutical industry. The preparation of wet granulation as the primary
method for tablet manufacturing is widely acknowledged in pharmaceutical industry. This
process involves a series of sequential steps, including mixing, wet granulation, drying of the
granules, milling (if required), and tabletting.
Our research is focused on making tablets based on previous foundation by scientists of
the Institute of Bioorganic Chemistry, have obtained a “Eritim” drug based on the polypeptides
of the mammary gland, which is an erythropoiesis stimulator (an agent against anemia). Eritim
stimulates erythropoiesis, increases the amount of hemoglobin in peripheral blood, number of
erythrocytes and reticulocytes. Induces number of erythroblastic islets in the bone marrow and
their degree of maturation, as a result, stimulates the erythroid tumor of bone marrow. The
renal hormone erythropoietin plays an important role in stimulating functional activity of
hematopoietic cells of the bone marrow in mechanism of biological action of thymus factor.
The medicine of solution for oral administration by drops (10 ml solution contains 100 μg -
0.001% Eritim) in form of a solutionhas been used in medical practice since 2015.
Process Description. During research experiments Eritim and D-mannitol in a ratio of
1:1*105 prepared by drying in a lyophilic dryer, series 010321, expiration date 03.2023, have
been used.
80
A sample of 100 grams of powder was initially mixed with 5 milliliters of distilled water
and processed using wet granulation. The resulting mixture was left overnight in a dryer set at
37 degrees Celsius. The following day, materials was sieved through a 200-mm mesh. The result
showed that granules are made successfully and ready to next steps.
Subsequently, tablets were produced using granules in press machine. This systematic
procedure is a vital part of pharmaceutical manufacturing, ensuring the consistency and quality
of final tablet products. Tablets are have been produced as expected without any difficulties
while running machine.
In order to check tablets’ quality sample are given to pre-clinical research and results
were proved, tablet was the best formulation for Eritim, original medicine additionally, wet
granulation increased tablets quality.
Foydalanilgan adabiyotlar/Используемая литература/References:
1.
WHO/Анемия/Основные факты. Женева, 2023. [Электронный ресурс]. Режим
доступа: https://www.who.int/ru/news-room/fact-sheets/detail/anaemia (дата обращения
20.08.2024г).
2.
Pharmaceutical-thechnological properties of D-mannit and “Eritim” mixture. Conference
of scienific society of students materials. - Tashkent. -2021. -P. 218.
3.
Turaboev Sh.M., Ziyaev Ch.L., Sagdullaev B.T. Development of the technology of capsule
form Gosalidone // Journal of pharmaceuticals. - Tashkent, 2018. - №3. - P. 65-71.
