129
INDIVIDUALIZED LASER-PHOTODYNAMIC THERAPY IN THE TREATMENT
OF POST-BURN SCARS
Umarkhodjaev A.M.
Gulyamov S.S.
Sadykov R.R.
Tashkent Pediatric Medical Institute, Tashkent, Uzbekistan
Tashkent Medical Academy, Tashkent, Uzbekistan
https://doi.org/10.5281/zenodo.15350243
Relevance
Post-burn scars remain one of the most difficult challenges in reconstructive and
aesthetic dermatology. They often lead to physical discomfort, psychological distress, and
social adaptation difficulties, especially when localized on visible parts of the div. Standard
treatment methods may not always be effective due to the individual characteristics of scar
tissue formation, healing dynamics, and skin type. An individualized approach using combined
laser and photodynamic therapy (PDT) presents a promising alternative. This dual-modality
strategy enhances treatment efficiency through synergistic effects of laser ablation and
cellular-level photochemical reactions induced by photosensitizers. Such an approach aims to
optimize treatment outcomes and minimize side effects.
Objective:
To evaluate the clinical efficacy and safety of individualized laser-
photodynamic therapy in the management of post-burn scars.
Materials and Methods:
The clinical study included 28 patients aged 7 to 45 years with
post-burn scars located on the face, neck, and upper limbs. Patients were individually
assessed using ultrasonography and scar classification scales to determine the treatment
protocol. Laser therapy was performed using fractional CO2 and pulsed dye lasers.
Photodynamic therapy was administered with second-generation photosensitizers and 635
nm light source. Each patient underwent 3–5 treatment sessions with a 2-week interval. The
efficacy was evaluated based on the Vancouver Scar Scale, patient satisfaction surveys, and
photographic documentation.
Results:
Clinical results showed significant improvements in scar texture, color, and
flexibility in 85% of cases. On the Vancouver Scar Scale, average scores improved from 10.4 to
5.1. Patients reported a reduction in itching and tightness and improved cosmetic appearance.
No serious adverse effects were observed, and mild erythema resolved within 48 hours. The
individualized approach allowed for the customization of laser parameters and PDT dosing,
improving therapeutic precision.
Conclusion:
Individualized laser-photodynamic therapy is an effective and safe method
for treating post-burn scars. The personalized approach allows for optimized treatment
protocols tailored to the patient's scar characteristics, resulting in improved clinical outcomes
and higher patient satisfaction. This technique should be considered a valuable addition to
modern scar management practices.
References:
Используемая литература:
Foydalanilgan adabiyotlar:
1.
Ahima R.S., Flier J.S. Adipose tissue as an endocrine organ.
Trends in Endocrinology &
130
Metabolism.
2000;11(8):327–332.
2.
Kershaw E.E., Flier J.S. Adipose tissue as an endocrine organ.
Journal of Clinical
Endocrinology & Metabolism.
2004;89(6):2548–2556.
3.
Ouchi N., Parker J.L., Lugus J.J., Walsh K. Adipokines in inflammation and metabolic
disease.
Nature Reviews Immunology.
2011;11(2):85–97.
4.
Tilg H., Moschen A.R. Adipocytokines: mediators linking adipose tissue, inflammation
and immunity.
Nature Reviews Immunology.
2006;6(10):772–783.
5.
Steppan C.M., Lazar M.A. The current biology of resistin.
Journal of Internal Medicine.
2004;255(4):439–447.
6.
Fasshauer M., Blüher M. Adipokines in health and disease.
Trends in Pharmacological
Sciences.
2015;36(7):461–470.
7.
Turer A.T., Scherer P.E. Adiponectin: mechanistic insights and clinical implications.
Diabetologia.
2012;55(9):2319–2326.
