American Journal Of Biomedical Science & Pharmaceutical Innovation
15
https://theusajournals.com/index.php/ajbspi
VOLUME
Vol.05 Issue06 2025
PAGE NO.
15-18
10.37547/ajbspi/Volume05Issue06-04
Analysis Of Medicinal Plants Against Diabetes And
Collections Based On Them, As Well As Bioactive
Additions
Jalilov Utkirbek Mamarakhimovich
Tashkent Pharmaceutical Institute, Department of Drug Technology, UZ senior lecturer, Uzbekistan
Kasimov Saidali Doniyorbek ugli
Tashkent Pharmaceutical Institute, Master's student in the specialty "Technology of Medicines and Preparations", Uzbekistan
Received:
14 April 2025;
Accepted:
10 May 2025;
Published:
17 June 2025
Abstract:
This article provides information about medicinal plants used in medicine against diabetes, as well as in
its prevention, and remedies, compositions, substances obtained on their basis, and their technologies. During
the research, the results of studying dozens of representatives of local medicinal plants and their individual
properties, as well as the properties of their collections, indications for use, in the treatment of diabetes mellitus,
the beneficial properties of medicinal plants and collections, and their technological properties are presented.
Keywords:
Diabetes, sugar content, glucose, insulin, cumulative, diet, metabolism, extract, phytotea, bioactive
supplement, technology, medicinal plants.
Introduction:
Diabetes mellitus is a metabolic disorder
characterized by a decrease in insulin levels in the
blood and an increase in glucose levels. In the
treatment of diabetes, antidiabetic drugs are of great
importance. One of the important directions in
medicine is the use of herbal preparations with mild
effects, low side effects, and high effectiveness. For the
prevention and treatment of diabetes, medicinal plants
containing a number of biologically active substances
are used.
In developed modern medicine, herbal remedies used
in the treatment of diabetes mellitus are of great
importance due to their relative harmlessness, healing
properties, including normalizing blood glucose levels,
anti-obesity, and other properties. Plant preparations
and formulations with an antidiabetic effect are used
to stimulate insulin production processes and facilitate
digestion[1].
In the field of endocrinology, various blood sugar-
lowering agents are recommended as an antidote to
diabetes and concomitant diseases caused by a
decrease in insulin levels.
Depending on the technology of obtaining medicinal
plant preparations and complexes against diabetes
mellitus, various extracts can be obtained from ground
plant materials. These extracts contain several
medicinal substances isolated using various separators,
and also in the crushed plant material during the
preparation of the compositions, biologically active
substances are fully present.
Purpose of the research: development, analysis,
generalization of drugs, biologically active substances,
and kits with antidiabetic effects and their
technologies.
METHODS
When obtaining extracts from medicinal plants, the
selection of the extractant is carried out depending on
the type of plant, the part of the raw material, and the
groups of biologically active substances contained in it.
Usually, various potent ethyl alcohol, water, essential
oils, or other separators are used in work processes.
Extraction processes utilize maceration, percolation,
and ultrasonic extraction methods [2].
One of the promising methods is obtaining extracts
using ultrasonic extraction. In ultrasonic extraction, the
plant is soaked in a separator and subjected to
American Journal of Applied Science and Technology
16
https://theusajournals.com/index.php/ajast
American Journal of Applied Science and Technology (ISSN: 2771-2745)
ultrasonic exposure, in which the plant tissues are
subjected to high-speed vibrations under high pressure
and vacuum due to the phenomenon of cavitation. As
a result, organic substances in tissues, including
substances that can be released into the excretory
medium, are released into the excretory medium, i.e.,
the extraction process occurs. With this method, it is
possible to carry out extraction processes both in the
laboratory and on an industrial scale.
Below, taking into account the demand and interest in
medicines based on medicinal plants, including
antidiabetic preparations and kits, information is
provided on the main antidiabetic drugs and medicinal
plant-based kits, their mechanisms of action,
indications for use and features of use, technologies for
obtaining them, and the use of products obtained from
various medicinal plants in medical practice.
RESULTS
Below are several plants, assortments, and biologically
active supplements used in the treatment of diabetes
mellitu
Beans (Galega officinalis) - a rhizomatous perennial
herbaceous plant of the legume family, the aerial part
of which is used in folk medicine for the treatment of
snake bites, infections, edema, as well as for milk loss
in breastfeeding women. In modern medicine,
biologically active additives with antidiabetic, diuretic,
diaphoretic, lactogenic, and anthelmintic effects are
produced from it.
Properties of medicinal peas: helps reduce blood sugar
levels, normalizes metabolism, restores kidney
function, gently removes excess fluid from the div,
stimulates milk production in nursing mothers,
eliminates inflammation, and fights infections. Beans
are also included in antidiabetic formulations[5].
Bean peel (Phaseolus) is a typical genus of annual
plants of the legume family, with about 97 species
found in warmer regions of the world. In addition to
proper hypoglycemic properties, it has anti-
inflammatory and anti-rheumatic, as well as diuretic
and antibiotic effects. They dissolve stones in the
bladder and kidneys, lowering blood pressure. Due to
the high content of valuable substances in bean pods,
they are widely used for medicinal purposes. Medicinal
and beneficial properties of bean peel: reducing blood
sugar levels, fighting excess weight, eliminating
hypersensitivity and hypertension, anti-rheumatic
effect, diuretic, removal of kidney stones, elimination
of skin diseases, treatment of chronic pancreatitis and
cardiovascular pathologies. In medicine, decoctions
and infusions are made from bean peel, and it is also
included in antidiabetic formulations.
Use in diabetes mellitus (when sugar levels increase), at
home. The peels are ground into powder using a coffee
grinder and 400 ml of boiling water is poured over 50 g
of raw material. After 12 hours of infusion, take 120 ml
before meals.
Safflower (Salvia) or sage is a large genus of perennial
herbaceous plants and shrubs belonging to the
Lamiaceae family. Preparations made from the aerial
parts (leaves and flowers) of medicinal sage have a
sugar-lowering,
anti-inflammatory,
astringent,
antiseptic, hemostatic, softening, and diuretic effect,
reducing sweating. Mavrak is also used in the form of a
decoction or infusion for stomatitis, bleeding gums, as
a astringent and antiseptic for rinsing the mouth in
tonsillitis, and in the form of sprinklers for
gynecological diseases. The medicinal sage plant
inhibits lactation in nursing mothers and has a positive
effect on gastritis, colitis, stomach ulcers, meteorism,
and gallbladder inflammation.
It has been established that sage extract helps reduce
blood glucose levels in rats with type 1 diabetes by
activating a specific receptor. When these receptors
are activated, they can cleanse the blood of excess free
fatty acids. This improves insulin sensitivity. Another
study on mice with type 2 diabetes showed that sage
tea has the same effect as metformin, which regulates
blood sugar levels in people with the same disease[4].
Dandelion (Taraxacum) is the most popular species of
the dandelion genus of the Dandelion family. It is a
perennial herbaceous plant, reaching a height of 10-40
cm. Its distribution range extends throughout the CIS,
except for the far north. The flowers, leaves, and roots
of dandelion are used in medicine as a healing remedy.
The presence of bitter glycosides, taraxerolic
compounds, and other substances in the composition
of dandelion root has been established. Its roots are
also a sugar-lowering, choleretic, appetite-stimulating,
and
gastric-inducing
compound
tea.
Antihyperglycemic, antioxidant, and anti-inflammatory
properties of dandelion helped in the treatment of
patients with type II diabetes mellitus. The roots of the
plant contain soluble fiber (inulin). Moving throughout
the div in an undigested form, it helps slow down the
absorption of sugar into the bloodstream by improving
long-term control of blood sugar levels [3].
Stevia (Stevia) is a genus of perennial plants belonging
to the Asteraceae family, comprising approximately
260 herbaceous and shrub species that grow mainly in
the Americas. Crushed leaves of honey stevia have long
been used as a natural sweetener, and now as a sugar
substitute due to the growing need for low-
carbohydrate and low-sugar diets. Plant leaves, their
aqueous extract, and isolated glycosides (stevioside
American Journal of Applied Science and Technology
17
https://theusajournals.com/index.php/ajast
American Journal of Applied Science and Technology (ISSN: 2771-2745)
and rebaudioside) are typically used as sweeteners.
Stevia leaves are 30 times sweeter than sucrose, and
the isolated steviazides are 250-300 times sweeter.
Unlike artificial sweeteners (such as cyclamate and
saccharin), stevia is not only not carcinogenic but, on
the contrary, very beneficial. Stevia is low in calories,
does not contain glucose, and therefore is absorbed
without the help of insulin, which is very important for
diabetics [6].
Ginko biloba (Ginko biloba) is currently the only
representative of the gymnosperm family of the ginkgo
family. The tree reaches a height of up to 40 m and a
diameter of up to 1 m; young seedlings resemble some
coniferous trees. It grows wild only in some parts of
China. It is cultivated in southern Crimea and on the
Black Sea coast of the Caucasus. Extract obtained from
the leaves of Ginco biloba is used in medicine to
improve the function of small blood vessels. It is also
widely used for improving brain function, diabetes, and
other purposes [7-8].
Cichorium intybus is a perennial herb with a thick root,
belonging to the Asteraceae family. It is used as a
medicinal plant and among the people as a spice, as
well as a substitute for coffee. The famous Abu Ali ibn
Sina used sachratqi to treat diseases of the
gastrointestinal tract and eyes, eye inflammation, and
gout. In modern medicine, sachratqi has found a wide
variety of applications due to its beneficial medicinal
properties (calming, sugar-lowering, astringent,
choleretic, diuretic, anti-inflammatory, antipyretic,
anthelmintic properties). The anti-diabetic and anti-
obesity effect of chicory is valuable due to the high
content of the high-molecular-weight polysaccharide
inulin in its roots. It is inulin that helps reduce blood
sugar levels, improve metabolism and digestion,
therefore, all its properties are considered important in
the complex prevention and treatment of diabetes.
Phytodiabetol syrup 250ml. Produced in Russia
(Bioinventika LLC). Use: in diabetes, as a source of
vitamins. Composition: blueberry branches, common
bean peel, medicinal gallega herb, bird cherry herb,
great ash root, water extract of cinnamon rosehip fruit,
vitamin E420, E440, vitamin 9-14 premix (vitamin C,
vitamin B1, vitamin B6, vitamin B3, vitamin B5, vitamin
B9, vitamin H, vitamin B12), E202. Take 15 ml 3 times a
day [10].
Diabefit tea. Supports pancreatic function, improves
metabolism and mood. Composition: dandelion root,
mint leaf, chamomile flower, cherry grass, valerian
root, thyme root, oat straw, flaxseed, bean pods.
Method of use: 1 filter bag of 2 g is placed in a beaker
(200 ml), hot water is poured over it, and it is steeped
for one night. The infusion is taken 200 ml 3 times a day
after meals. The duration of admission is from 15 to 30
days[11].
STOP Diabetic Elixir, 300 mg 180 Oil Capsule. Plant
extracts of chamomile, beans, bean pods based on
unrefined flaxseed oil, omega-3 and gelatin mass [12].
FITOCHOY GLYUNORM. Filter-package 25 pieces per 1
gram. Manufactured by Zamona Rano company.
Properties of tea: to normalize carbohydrate
metabolism,
normalizes
metabolism,
especially
carbohydrate metabolism, to support pancreatic
function, to prevent the development of carbohydrate
metabolism
disorders
(diabetes
mellitus),
recommended as an additional source of biologically
active substances. Composition: leaves of nettle (Folia
urticae), young shoots of blueberry (Myrtilliherba), wild
geranium (Herba hyperici), wild buttercup (Herba
hypericiscabri, dagaldalachoyoti), field horsetail
(Herbaequisetiarvensis), nettle (Herba bidentis),
chamomile (Flores chamomillae), blueberry fruits
(Myrtilli fructus), rosehip fruit (Fructus Rósae), tall
andiz or (Rhizomata et radices Inulae, andiz root bark),
large andiz (Rhizomataetradices Inulaegrandis, andiz
yellow root). Preparation and dosage: 500 ml over 2 g
of herbal tea (2 packets for single brewing)
CONCLUSION
Medicinal plants, formulations, and biologically active
supplements are important in the treatment of
diabetes. They are lighter and harmless compared to
synthetic agents, do not harm the div, and allow their
use in patients in need of constant medications, such as
diabetes. In the treatment of diabetes, it is possible to
use a single plant product or several plant groups.
Plant-based phytopreparations recommended for the
treatment of diabetes have some drawbacks. Their
weak effect and limited effectiveness in acute cases
necessitate their combination with other treatment
methods when necessary. Phytotherapy is constantly
developing, increasing the scope and interest in its use
due to the accumulated experience and positive results
of treatment.
REFERENCES
https://med24.uz/ru/bolezn/saxarnyy-diabet
Hasanov.J.H., Usmanov.K.I., Avezov.T.A. Forecasting
the duration of the process by applying neural
networks to the high-critical extraction process //
Pharmaceutical Bulletin of Uzbekistan//-2017- No1-25-
31. Tashkent.
I.J.
Karomatov,
M.S.
Davlatova.
"Treatmental
properties of the medicinal plant dandelion." "Biology
and Integrative Medicine" No. 9 (26) October 2018, pp.
147-156.
Salvia officinalis (Sage) Leaf Extract as Add-on to Statin
American Journal of Applied Science and Technology
18
https://theusajournals.com/index.php/ajast
American Journal of Applied Science and Technology (ISSN: 2771-2745)
Therapy in Hypercholesterolemic Type 2 Diabetic
Patients: a Randomized Clinical Trial Saeed Kianbakht 1
✓
, Farzaneh Nabati 1, Behrooz Abasi 2 1. Medicinal
Plants Research Center, Institute of Medicinal Plants,
ACECR, Karaj, Iran. 2. Diabetes Clinic, Karaj, Iran I J M C
M Original Article Summary 20 16, Vol.5, No 3.
Antioxidants (Basel) 2021 Aug 26;10 (9):1362.
doi:10.3390/antiox10091362
Halyna Hachkova 1,*, Mariia Nagalievska 1, Zoriana
Soliljak 1, Olena Kanyuka 1, Alicja Zofia Kucharska 2,
Anna Sokół
-
Łętowska 2, Elena Belonovskaya 3,
Vyacheslav Buko 3, Nataliia Sybirna 1 Medicinal Plants
Galega officinalis L. and Yacon Leaves as Potential
Sources of Antidiabetic Drugs
Ajami M, Seyfi M, Abdollah pouri Hosseini F, Naseri P,
Velayati A, Mahmoudnia F, Zahedi M, Hajifaraji M.
Effects of stevia on glycemic and lipid profile of type 2
diabetic patients: A randomized controlled trial.
Avicenna J Phytomed, 2020; 10 (2): 118-127.
Journal of Clinical Pharmacology George B. Kudolo PhD
Effect of 3-month intake of Ginkgo biloba extract (EGb
761) on pancreatic b-cells in response to glucose load
in people with insulin-independent diabetes mellitus.
https://uz.wikipedia.org/wiki/Ginkgo
Annayeva G.B. Medicinal properties of chicory and its
role in the preparation of beverages. "Bulletin of
Science" No4 (61) T.4 April 2023.
https://www.asna.ru/car
https://tea-kavkaz.ru/1-gornye-chai-i-travyanye-
napitki/celebnye-travyanye-sbory/diabefit-20-filtr-
paketov
https://o-
zd.ru/catalog/popravit_zdorove/kapsuly_drazhzhe_ta
bletki/9760/
http://apteka999.uz/ru/catalog/2572-fitachay-
glyunorm-(zamona-rano)
