ACADEMIC RESEARCH IN MODERN SCIENCE
International scientific-online conference
161
AGE-RELATED ASPECTS OF OSTEOARTHRITIS IN WOMEN
Shodikulova Gulandom Zikriyayevna
Sadikova Shaxnoza Norkulovna
Samarkand State Medical University, Samarkand, Uzbekistan
Departament of Internal Medicine №3
https://doi.org/10.5281/zenodo.12771084
Annotation.
Osteoarthritis (OA) is becoming one of the most common
diseases of modern society, affecting more than 20% of the world's population
over the age of 50, and the number of patients with OA is constantly growing,
which is associated with an increase in life expectancy. Generally, etiology of OA
is multifactorial and includes both constitutional (old age, gender, obesity,
heredity, state of reproductive function) and mechanical factors. The results of
sample studies conducted in Uzbekistan suggest that currently at least 30% of
the working–age population of our country is overweight and 25% is obese. A
steady increase in obesity is observed in almost all countries of the world:
over the past 10 years, its prevalence in the world has increased by an
average of 75%. However, despite the high prevalence, the effect of
abdominal obesity on the course of OA in women has not been studied. The
disease is based on genetic, endocrine causes, irrational overloads, and
obesity. Late diagnosis and ineffective therapy lead to a decrease in the quality
of life of patients with OA, an increase in temporary disability and early
disability of people of working age.
The purpose of the research
was conducting an anthropometric and
somatometric examination and establishing div types in women with
osteoarthritis in the age aspect.
Materials and methods of research
. We examined 122 women with OA
of large and small joints. Patients were divided into two groups. Women of the
mature age (40-60 years ) 27% and elderly women (from 61 to 74 years) 73%.
The control group consisted of 40 women aged 45-65 years without OA. The
results of the research. All anthropometric indicators were processed by the
method of variational statistics using the interactive SOMA software package
and the Statistic 7.0 application software package. Calculations of the
average statistical value (M), the standard deviation from the average (δ),
the error of the average (m) were carried out. The reliability of the intergroup
differences of the studied features was assessed using the Student-Fisher t-
criterion and χ2.
The results.
The analysis of somatometric data showed that
women with OA were statistically significantly more likely to have lower
ACADEMIC RESEARCH IN MODERN SCIENCE
International scientific-online conference
162
height, greater div weight, BMI, more fat and bone mass against the
background of lower values of muscle mass compared to women of the same
age population. In women with OA , the decrease in the proportion of
muscle mass in the soma reached almost 10%. In addition, with abdominal
type of obesity, damage to a larger number of joints, more pronounced X-ray
changes and functional disorders were observed. Among the examined women,
a megalosomal constitution was detected in 83% of cases, a mesosomal
constitution was registered in 15% of cases and a leptosomal constitution
was practically not detected. The megalosomal constitution is characterized
by high height, increased div weight, strong development of
musculature and bone tissue, as well as pronounced development of adipose
tissue. These women are overweight and obese, which is an additional risk
factor in the development and progression of OA.
In conclusion
somatotyping allowed us to establish that the majority of
the studied women with OA had a megalosomal constitution and among
them there were practically no women with a leptosomal constitution. In the
age aspect, it was indicated that older women had statistically significantly
higher indicators of height, div weight and BMI compared with women of
mature age.
List of references:
1. Chevreau A., Drape J. L., Godefroy D., Dupont A. M., LeBleveque G., Mirat A.,
Moutounet L. Pain in the inner part of the knee joint // J. Radiology. Radiology. -
1999. - т.80 (6). - С. 640-651.
2. Folomeeva O. M., Amirjanova V. N., Yakusheva E. O. Disability of the Russian
population due to rheumatic diseases // Rossiia. rheumatol., 2004. - № 3. - С.70-
79
3. Hauchberg M. K., Lethbridge-Jacu M., Tobin J. D., Bone mineral density and
osteoarthritis: data from the Baltimore Longitudinal Study of Aging // Cartilage
Osteoarthritis, 2004; 12 Supplement A: P. 45-8.
4. Nasonov E. L. Osteoporosis and osteoarthritis: mutually exclusive or
complementary diseases?/ E.L. Nasonov// Medical Consilium. -2000. - Т. 2, № 6.
- С. 248-252.
5. Nasonov E. L. Osteoporosis in rheumatic diseases// Manual on Osteoporosis,
ed. Benevolensky L. I., 2003 - P. 346-359.
