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ASSOCIATION OF BRONCHIAL ASTHMA AND CONNECTIVE TISSUE
DYSPLASIA IN CHILDREN: PREVALENCE AND CLINICAL
SIGNIFICANCE
Ilmuratova M.A.
Abdullayeva D.T.
Tashkent Medical Academy, Tashkent,Uzbekistan
e-mail: boshmanova93@bk.ru
https://doi.org/10.5281/zenodo.15411170
Relevance of the Problem
: One of the most common chronic lung diseases,
representing a significant social problem, is bronchial asthma. According to
epidemiological studies, the total number of people suffering from bronchial
asthma approaches 7 million. Limited studies on the clinical course of bronchial
asthma in children with connective tissue dysplasia (CTD) have confirmed one
of the key principles of the classification concept of CTD. This principle
considers CTD as a structural and functional background that determines the
characteristics of associated pathology.
Purpose of the Study
: To assess the impact of connective tissue dysplasia
(CTD) on the clinical course of bronchial asthma in children and to identify the
disease's features against the background of CTD.
Research Methods
: The study included 32 pediatric patients aged 5 to 14
years who were hospitalized in the pediatric allergology department of the 2nd
clinic of the Tashkent Medical Academy (TMA). The patients were divided into
two groups:
The first group consisted of 23 children with bronchial asthma without
CTD.
The second group included 11 children with bronchial asthma on the
background of CTD.
All patients underwent laboratory, instrumental, and functional studies of
the respiratory system. A specialized scoring system was used to identify
connective tissue dysplasia.
Study Results
: Based on the scoring system, various phenotypic markers
and minor developmental anomalies (MDA) were identified in the patients. The
scores allowed for the classification of the severity of CTD. The selection was
conducted as follows: if a patient had no more than six phenotypic signs and 2–3
MDA signs, it was considered normal. The most frequently observed phenotypic
and MDA signs among our patients were: Craniofacial anomalies
(dolichocephaly, nasal septum deviation, nosebleeds, skull deformity) in 5
patients. Oral cavity changes (high-arched palate, dental anomalies,
ACADEMIC RESEARCH IN MODERN SCIENCE
International scientific-online conference
142
underdevelopment of the upper jaw) in 1 patient. Skin changes (visible venous
network) in 3 patients. Chest deformities (shoemaker's chest, scoliosis,
kyphosis, increased bone fragility, funnel chest) in 5 patients. Joint
abnormalities (manifesting as hypermobility, arthralgia, arthritis) in 4 patients
Conclusion
: Thus, in children with bronchial asthma against the
background of connective tissue dysplasia, the disease is characterized by a
more severe course and reduced quality of life. Early medical monitoring of such
patients may contribute to the successful implementation of pathogenetic
therapy and the prevention of severe complications, including bronchial
asthma.Recent studies emphasize the genetic and molecular background of
connective tissue dysplasia (CTD), which leads to structural disorders in
collagen and elastin fibers. These abnormalities affect the integrity of bronchial
walls, reducing their elasticity and resilience, thereby aggravating bronchial
asthma symptoms. CTD may also contribute to altered immune responses, which
intensify airway inflammation in asthmatic patients. It has been found that
children with CTD more frequently experience chest deformities, scoliosis, and
increased frequency of upper respiratory tract infections. A comprehensive and
multidisciplinary management approach is essential for such patients, including
genetic counseling, physiotherapy, and allergological monitoring.
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