DONOR FACTORS ASSOCIATED WITH THE FUNCTIONING OF KIDNEY TRANSPLANT IN THE LIVING RELATED KIDNEY TRANSPLANTATION

Abstract

Research aim: to establish modifiable and unmodifiable risk factors for an unfavorable outcome of kidney transplantation. Materials and methods. The material of the study was 365 related kidney donors, who were observed from 2010 to 2021 in the department of vascular surgery and kidney transplantation of the Republican Specialized Scientific and Practical Medical Center of Surgery named after academician V.Vakhidov. All donors met the criteria of the regulation "About approval of the temporary regulation on the procedure for conducting for transplantation of kidney and (or) liver lobe, as well as hematopoietic stem cells of bone marrow" Resolution of the Cabinet of Ministers of the Republic of Uzbekistan, dated 23.10.2017 No. 859 and "On amendments and additions to the Resolution of the Cabinet of Ministers of the Republic of Uzbekistan dated October 23, 2017 No. 859 "About approval of the temporary regulation on the procedure for conducting for transplantation of kidney and (or) liver lobe" Resolution of the Cabinet of Ministers of the Republic of Uzbekistan, dated 06.21.2021 No. 387, as there is own standard not available yet in the Republic of Uzbekistan. All donors were divided into groups: men, women, including women who did not give birth, women who gave birth, donorsmothers. Conclusions: 1. Optimal donors of related kidney transplantation in some cases had an increased proinflammatory background, a high level of medium molucar peptides (MMP), which did not affect the level of their filtration abilities of the kidney and had no clinical manifestations. 2. The increase in IL-6, CRP in donors correlated with both age and BMI. The age of the donor exerted influence the level of NTproBNP, systolic blood pressure (SBP), diastolic blood pressure (DBP), IL-6, CRP. TNF-alpha had no correlation with proinflammatory factors, age, BMI, subthreshold endotoxemia level. 3. Maternal donors had statistically significantly elevated levels of medium molucar peptides- 2 (SMP2) and TNF-alpha. 4. Installed significant impact of the age of the donor over 39 years, donor IL-6 more than 5.06 pg/ml and TNF-alpha more than 0.9 pg/ml on the risk of delayed renal graft function in the recipient. 5. On the quality of the graft was influenced by maternal donors, as this group of donors had an inverse correlation between decrease in creatinine and TNF-alpha levels at r=-0.31, p<0.05, and a correlation with SMP2 and TNF-alpha was also found in these donors at r=0.42, p=0.03. These data confirm, that maternal donation is an unfavorable factor for the outcome of renal graft