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STUDY OF RISK FACTORS FOR ADVERSE PERINATAL OUTCOMES
IN WOMEN WITH PREECLAMPSIA.
Shamsiyeva Z.I.
Center for the Development of Professional Qualifications of Medical Workers,
Department of Obstetrics, Gynecology and Perinatal Medicine, Tashkent
https://doi.org/10.5281/zenodo.16024467
Key words:
moderate and severe preeclampsia, perinatal outcomes,
stillbirth,
Introduction.
Hypertensive disorders during pregnancy are one of the most common
causes of perinatal mortality. These disorders are closely related to many
factors, which makes them difficult to predict and prevent. Early diagnosis and
proper treatment play a crucial role in the well-being and life of a woman and
her child [
Preeclampsia is a serious complication of pregnancy that develops after the
20th week of pregnancy. Preeclampsia occurs in 2-8% of pregnancies, is one of
the most important causes of maternal and perinatal morbidity and mortality,
and has no downward trend. Maternal mortality is 12 times higher when
developing preeclampsia before 28 weeks of pregnancy. [
Preeclampsia has long-term consequences for both mother and her child.
The danger of this complication is that it does not heal completely after the end
of pregnancy [
The purpose of the study
– to identify associations between preeclampsia
management tactics and perinatal outcomes.
Materials and methods.
The independent variables were socio-demographic factors such as the age
and place of residence of the patients; factors related to obstetrics; the duration
of pregnancy (at the time of admission and delivery); prenatal monitoring of the
current pregnancy; current medical history (concomitant diseases); condition at
the time of admission, such as blood pressure measurement, proteinuria level,
and also, signs and symptoms of target organ damage; treatment methods,
including antihypertensive and anticonvulsant drugs, method of delivery; as
well as other perinatal factors, such as fetal heartbeat during childbirth, Apgar
score, and birth weight. The gestational age was considered reliable if it was
calculated based on the last normal menstrual cycle or using obstetric
ultrasound. The relationships were checked using Pearson's Х2-criterion and
binary logistic regression, with a p-value < 0.05 considered significant.
Results and Discussion.
CURRENT APPROACHES AND NEW RESEARCH IN
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In this study, almost 20 out of 100 newborns whose mothers suffered from
preeclampsia died. This indicator was higher (76.59% versus 23.4%) among
newborns whose mothers suffered from severe preeclampsia, compared with
newborns whose mothers suffered from mild preeclampsia (p = 0.01). More
than two thirds of the patients (69.3%) received magnesium sulfate to prevent
seizures. Perinatal mortality among women with diastolic blood pressure above
110 mmHg at admission was almost 3 times higher (adjusted odds ratio (AOR) =
2.824; 95% confidence interval (CI) (1,154–6,038)) compared with women with
diastolic blood pressure below 110 mmHg.
Conclusion.
Over the past 5 years, the perinatal mortality rate among women with
preeclampsia who were in hospital treatment was extremely high, with the
number of stillbirths exceeding the number of cases of early neonatal mortality
before discharge. The use of magnesium sulfate has become more common over
the years. Maternal diastolic blood pressure at admission to the hospital was
significantly associated with perinatal mortality.
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MODERN SCIENCES
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