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TO EVALUATE THE HEMOSTATIC ACTIVITY OF NEW LOCAL
SPONGE APPLICATION HEMOSTATIC IMPLANTS
Ganjiev F.Kh.
Bukhara branch of the Republican Scientific
Center for Emergency Medical Care
https://doi.org/10.5281/zenodo.16023919
Relevance:
On today day popular groups are " mucoadhesive agents" (
chitosan , amylopectin) and " factor concentrators" coagulation " ( zeolites ,
kaolin ). Also, a group of " aggregation and adhesion stimulators " ( collagen ,
cellulose ) is distinguished. At the same time, representatives of the above
groups have common characteristics – very high porosity and hydration
capacity. More one group unites substances that “promote protein denaturation”
(inorganic salts metals , as well as salts of acrylic acid and its derivatives).
Polyacrylates Also are the basis of adhesives with hemostatic activity. However ,
most modern MGS are complex and it is this group that is the most promising .
Bleeding due to trauma or surgery is a serious health problem, and uncontrolled
bleeding can lead to death. Therefore, the development of safe, effective and
convenient hemostatic materials is important. Active hemostatic agents
currently used for hemostasis research are divided into four broad categories:
natural polymers, synthetic polymers, inorganic materials and metal-containing
materials. Hemostatic materials are prepared in various forms for wound care
based on the active ingredients used. These materials include nanofibers , gels,
sponges and nanoparticles . Hemostatic materials find their application in the
field of wound care and are also used for hemostasis in cancer surgery. Timely
and effective hemostasis can reduce the possibility of tumor cell dissemination
with blood. This review discusses the results of current research conducted in
this area and the challenges that exist in the field of hemostatic materials
development. The review also provides a platform for further development of
hemostatic materials. Bleeding caused by trauma or surgery is a serious health
problem, and uncontrolled bleeding can lead to death. Therefore, the
development of safe, effective and convenient hemostatic materials is important.
Stopping bleeding from small wounds is achieved through a number of
measures, such as vasoconstriction, platelet thrombosis and blood coagulation.
The aim of the study was
to evaluate the hemostatic activity of new local
spongy application hemostatic agents. implants based on sodium
carboxymethylcellulose in an experiment in vitro .
Rationale for conducting the study
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The implementation of this research work will be carried out according to
the plan of research work of the Bukhara State Medical Institute named after
Abu Ali ibn Sino " Application of a hemostatic sponge" Blood stop » in liver
injuries In an experimental model in rabbits
(2023).
Type and design of the study
Type of study: open, controlled. Experimental studies will be conducted in 2
stages:
The first stage - experimental studies will be carried out on mongrel rabbits
.
The second stage involves slaughtering animals and conducting histological
studies, recording the results in journals, statistically processing the results and
describing them in the form of a report on the studies conducted.
There is an urgent need to develop safe, effective and stable hemostatic
materials.
Some hemostatic materials can activate hemostatic pathways in the human
div in various ways. For example, chitosan sponges can promote hemostasis by
activating and aggregating platelets using the negative charges on the chitosan
surface . At the same time, the absorbent properties of the sponge help increase
the local concentration of platelets and coagulation factors in the wound. This
leads to the activation of the coagulation cascade. Some hemostatic materials
can also be loaded with hemostatic drugs. It was observed that thrombin-loaded
gelatin sponges, which were used to study a pig liver bleeding model, can be
used to achieve superior hemostasis.
Currently, most commercially available hemostatic materials are designed
to treat large flat wounds, so it is necessary to develop materials for the
treatment of deep, irregular wounds. For the treatment of wounds near joints, it
is necessary to develop flexible hemostatic materials that adhere tightly to the
surrounding tissues to prevent displacement of the dressing. Excessive bleeding
prevents adhesion. Hemostatic materials prepared as hydrogels and sponges
adhere well to tissues. It is necessary to study methods for safe removal or
destruction of materials after their use.
Thus , at present the most effective directions for improving hemostatics
are: the synthesis of preparations based on chitosan or kaolin derivatives , the
creation of new forms (powder or granules poured into the bleeding area,
pastes, woven materials of specific weaving; carriers for hemostatics - powder
applicators that can be used to stop bleeding in deep wounds with a narrow
entrance and cavities; Z- fold bandages (bandage soaked in a hemostatic agent
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and folded like an accordion); meshes holding kaolin; return to the historically
first and undeservedly forgotten: cotton bandages), synthesis of new polymers,
such as " Blood stop » , synthesis of artificial platelets and other coagulation
factors
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