DEVELOPMENT AND INNOVATIONS IN SCIENCE
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STUDY OF FUNCTIONAL INDICATORS IN LABORATORY ANIMALS
WITH INDUCED HYPERTIRHOSIS
Togaeva G.S.
Samarkand State Medical University, Uzbekistan
Oripov F.S.
Scientific supervisor: Doctor of Medical Sciences, Professor
https://doi.org/10.5281/zenodo.16741620
Annotation
. Issues of experimental modeling of thyroid pathology in
laboratory animals (hypothyroidism, hyperthyroidism, etc.) were considered,
and an analysis of research works was conducted to study functional disorders
from various div systems that occur under these experimental conditions.
Today, among the most reliable and easily reproducible experimental models of
thyroid pathologies, chemical models have found wide application. It has been
shown that thyroid diseases alter the functional state of the div's immune,
cardiovascular, nervous, and other systems.
Keywords:
endocrine system, thyroid gland, experimental animals,
hyperthyroidism.
Relevance.
Studying functional indicators in laboratory animals with
induced hyperthyroidism involves assessing various aspects related to excessive
thyroid hormone production. This may include analysis of metabolism,
cardiovascular, nervous systems, and other organs and systems.
Work objective
- To study the functional changes observed in the pancreas
as a result of experimental hyperthyroidism.
Material and methods.
To achieve our goal, 27 white non-breed
laboratory rats were obtained. 12 experimental animals constituted the control
group, and 15 - the main group. The experiment was conducted on 12-week-old
laboratory rats of female and male reproductive age, weighing 200-220 grams.
In the rats included in the experimental group, a model of experimental
hyperthyroidism was induced. From the experimental animals, 3 ml of blood
was taken directly from the heart cavity under anesthesia for laboratory testing.
The levels of thyroid hormones, pancreatic enzymes, and biochemical blood
parameters were determined, and a complete blood count was conducted.
Research results.
To determine the reactive changes in the functional
state of the thyroid gland in experimental animals and the level of its influence
on the secretory activity of the pancreas, a comparison of thyroid hormone
levels in the blood of experimental animals in the control group and in animals
with experimental thyrotoxicosis was conducted.
DEVELOPMENT AND INNOVATIONS IN SCIENCE
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Comparative values of thyroid hormones in the blood serum of the
control and experimental groups of rats.
Control group
TTG
T4
T3
sv T4
cvT3
TG
Men
0.28
IU/ML
182.
Nmol/L
2.27
NG/ML
22.74
Pmol/L
6.87
Pmol/L
56.2
ng/ml
Women
0.23
IU/ML
183.3
Nmol/L
2.54
NG/ML
23.1
Pmol/L
6.93
Pmol/L
57.7
ng/ml
Experimental
hyperthyroidism
TTG
T4
T3
free
T4.
free
T3
TG
Men
0.08
IU/ML
191.5
Nmol/L
2.76
NG/ML
26.
Pmol/L
7.75
Pmol/L
64
NG/ML
Women
0.087
IU/ML
197.1
Nmol/L
3.23
NG/ML
29.4
Pmol/L
8.43
Pmol/L
69
NG/ML
Conclusion:
Determining the reactive changes in the functional state of the
thyroid gland in experimental animals and a comparative analysis of the amount
of thyroid hormones in the blood of experimental animals showed a significant
decrease in the amount of TSH to 3.5 times compared to the control group. The
total amount of T4, T3, and free T4, T3, and TG hormones, on the contrary, was
significantly elevated in the experimental group (induced thyrotoxicosis)
compared to the control group. This indicates an increase in thyroid function in
animals with induced hyperthyroidism.
References:
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pp.
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https://applied-
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DEVELOPMENT AND INNOVATIONS IN SCIENCE
International scientific-online conference
119
5. Miroshnikov S. V., Notova S. V., Timasheva A. B., Kvan O. V. The effect of
experimental thyrotoxicosis and hypothyroidism on the elemental status of
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