DEVELOPMENT AND INNOVATIONS IN SCIENCE
International scientific-online conference
50
COMPARATIVE CHARACTERISTICS OF THE PREVALENCE OF
CHOLELITHIASIS AMONG FEMALE AND MALE POPULATION OF
GERONTOLOGICAL AGE IN THE FERGANA VALLEY DEPENDING ON
AGE CATEGORIES
Mamasaliev N.S.
Salakhiddinov S.Z.
Mamasaliev Z.N.
Usmonov B.U.
Qalandarov D.M.
Andijan State Medical Institute, Uzbekistan
https://doi.org/10.5281/zenodo.15131065
Relevance.
According to the WHO, in the modern treatment and diagnostic
process of cholelithiasis (CSD) it is important, especially in individuals of the
gerontological group (75-90 years and above), not only to provide scientific
information on a certain type of treatment (surgical or conservative) and clinical
and fundamental recommendations, but also to acquire modern innovative
technologies acceptable for preventive surgery and the ability to use them. For
the advanced development of CSD surgery in the 21st century, it is important to
identify the most susceptible individuals with high or very high risk for this
pathology and their special prevention to ensure the process of early detection,
effective
and
safe
treatment
(with
proper
pharmacovigilance,
pharmacoepidemiological screening) and the prevention of not only CSD itself,
but also formidable complications of cholecystectomy, cholecystostomy,
choledochotomy,
choledochomyotomy
and
transduodenal
sphincteropapillotomy.
The aim of the study
is to study the prevalence, pharmacoepidemiology of
cholelithiasis and its main risk factors among the male and female unorganized
population of the gerontological group of the Fergana Valley to enable
scientifically based planning and optimization of early diagnosis, prevention and
treatment of this disease.
The object of the study
was a contingent of 4,500 individuals of the
gerontological age population, formed using random number tables based on the
nominal electoral lists of men and women in three regions of the Fergana Valley;
as well as 779 patients with cholelithiasis who were undergoing inpatient
treatment in the regional multidisciplinary hospitals of Andijan, Namangan and
Fergana (for VEN analysis).
The subject of the study:
were the results of general clinical and
biochemical
blood
tests,
survey,
physical,
instrumental
and
DEVELOPMENT AND INNOVATIONS IN SCIENCE
International scientific-online conference
51
pharmacoepidemiological monitoring; as well as the method of "daily nutrition
reproduction" adapted to the peculiarities of Uzbek cuisine.
Research methods.
To solve the set tasks, epidemiological, clinical,
laboratory, biochemical, instrumental, pharmacoepidemiological and statistical
research methods were used, as well as the “daily nutrition reproduction”
method.
Results of the study.
We analyzed the results of an epidemiological study
on the prevalence of cholelithiasis among the female and male population of
gerontological age in the Fergana Valley, depending on age categories.
The prevalence of cholelithiasis in the population of the gerontological
group ≥60 - 90 years old, estimated by epidemiological criteria, was 42.5%
among men and 57.5% among women (X2 ⁼ 0.222; P˃0.05; RR⁼95% CI ⁼ 0.907 -
1.174).
In the analysis, the closest associations of cholelithiasis with age were
found. Relatively high rates of prevalence of cholelithiasis, both in men and
women, were established in the group of men and women 60-74 and 75-89
years old; among the same groups ≥90 years old, reliably low rates of prevalence
of cholelithiasis were noted. The prevalence of cholelithiasis in the age group of
those examined was 35.3%, among the male population - 19.5% and among the
female population - 15.8% (Х2 ⁼4.091; Р˂0.05; RR⁼1.497; 95% CI ⁼ 1.010 -
1.504). Among those examined aged 75 - 89 years, cholelithiasis was found with
a prevalence rate of 45.2%, in men 19.0% and in women 26.2% [
ꭓ
2 ⁼0.007;
Р˃0.05; RR⁼1.008; 95% CI ⁼ 0.830 - 1.224]. Among those examined aged ≥90
years, the incidence of cholelithiasis was 2.69%, and among the male and female
populations in this age category, it was established with a prevalence rate of
1.15% and 1.54%, respectively (X2 ⁼0.735; P˃0.05; RR⁼1.404; 95% CI ⁼0.049 –
3.038)
Literatures:
1.
Буеверов А.О. Клинико – патологические параллели неалкогольной
жировой болезни печени и желчно каменной болезни//Росс журн
гастроэнтерол гепатом колопрохтол. – 2019; 29 (1). – С. 17 – 21.
2.
Драпкина О.М. Неалкогольная жировая болезнь лечени: не закрытие
терапевтические нельзя//В кн:VII Международный интернет конгресс
специалистов по внутренние болезням. – Москва. – VI DOX. – 2018. – С. 13 –
14.
3.
Ермолов А.С., Дасаев М.А. Юргенко С.В. Диагностика и лечение
холангиолитиаза после холецистэктомии//Хирургия – 2002 - №4. – С. 6 – 9.
DEVELOPMENT AND INNOVATIONS IN SCIENCE
International scientific-online conference
52
4.
Иваткин В.Т., Маев И.В. и др. Рекомендации Российской
гастроэнтеролической
ассосации
по
диагностике
и
лечению
желчнокаменной болезни//РЖГГК, 2016. - №3. – С. 64 – 80.
5.
Королев М.П., Федотов Л.Е., Аванесян Р.Г., и др. Холедохолитиаз,
имитирующий
первичный
склерозирующий
холангит//”Вестник
хирургии”. – 2017. - № 4. С – 93.
6.
Онещенко С.В., Дарвин В.В. Профилактика послеоперационных
осложнений в хирургии описторхнозногопоражения желчевыводящих
путей. //Анналы хирургической гепатологии. – 2017. – ТОМ 22 - №4 – С. 66.
7.
Павлов И.А. Оптимизация лечебной тактики при остром холецистите
у больных пожилого и старческого возраста//ДИС…канд.мед.наук. – М - .
2002. – С. 170.
8.
Рыбачков В.В. Механическая желтуха//Ярославль – Изд.дом. ЯГТУ. –
2015 – С. 196 – 198.
9.
Aymerich R.R., Prakaash C. et al. Sphincter of oddi manometry: is it
necessary to measure both biliary and pancreatic sphincter pressures?//
Gastrointest Endosc – 2000: 52 (2): 184 – 185.
10.
Festi D, Dormi A. et al. Incidence of gallstone disease in Italy: results from a
multicenter, population – based Italian study (the MICOL project)//World J
Gastroenterol. – 2008: 14(34): 5283 – 5286.
11.
Hughes B.B. et al. Projections of global health out comes from 2005 to
2060 using the International Futures integ. Fore casting model. Bull worid. Helth
Organ. 2011;89:479 – 484.
12.
https://www.un.org/en/sections.
13.
Jaunoo SS. et al. Post cholecystectomy syndrome (PCS).//Int S Surg. 2010:
8(1):16.
