Quinazolinone is a heterocyclic compound that exhibits a wide range of pharmacological activities. This review article aims to explore the various pharmacological actions of quinazolinone and the underlying mechanisms of action. Quinazolinone has been found to possess a broad spectrum of biological activities, including anti-cancer, anti-inflammatory, antimicrobial, anti-tubercular, anti-diabetic, and anti-hypertensive activities, among others. This review provides an in-depth analysis of the various pharmacological properties of quinazolinone, its chemical structure, and the mechanisms of action involved in these activities. The quinazolinone nucleus has been recognized as an important pharmacophore that is present in a variety of biologically active compounds. Due to its versatile nature, quinazolinone-based compounds have been studied for their diverse pharmacological activities, such as anti-inflammatory, anti-cancer, anti-diabetic, anti-microbial, and anti-viral effects. This review provides an overview of the various quinazolinone derivatives, their chemical structure, and the wide range of pharmacological actions that they exhibit. The underlying mechanisms of these pharmacological actions are also discussed in detail, highlighting the potential therapeutic applications of quinazolinone derivatives. Overall, this review underscores the importance of quinazolinone derivatives as an interesting scaffold for the design and development of novel pharmacologically active compounds.
Abbas, S.E.; Barsoum, F.F.; Georgey, H.H.; Mohammed, Synthesis and antitumor activity of certain 2,3,6-trisubstituted quinazolin-4(3H)-one derivatives. Bull. Fac. Pharm. Cairo Univ., 2013, 51(2), 273-282. [http://dx.doi.org/10.1016/j.bfopcu.2013.08.003]
Banu, B.H.; Bharathi, K.; Prasad, K.V. Synthesis, characterization and evaluation of in vitro antioxidant and anti-inflammatory activity of 2-(4-oxo-2-phenylquinazolin-3(4H)-yl) substituted acetic acids. IOSR J. Pharm., 2012, 2(1), 97-104. [http://dx.doi.org/10.9790/3013-021097104]
Faraj, F.L.; Zahedifard, M.; Paydar, M.; Looi, C.Y.; Abdul Majid, N.; Ali, H.M.; Ahmad, N.; Gwaram, N.S.; Abdulla, M.A. Synthesis characterization, and anticancer activity of new quinazoline derivatives against MCF-7 cells. ScientificWorldJournal, 2014, 2014, 1-15. [http://dx.doi.org/10.1155/2014/212096] [PMID: 25548779]
Arora, R.; Kapoor, A.; Gill, N.S.; Rana, A.C. Quinazolinone: An overview. Int. Res. J. Pharm., 2011, 2, 21-28.
Saad, H.A.; Osman, N.A.; Moustafa, A.H. Synthesis and analgesic activity of some new pyrazoles and triazoles bearing a 6,8-dibromo-2- methylquinazoline moiety. Molecules, 2011, 16(12), 10187-10201. [http://dx.doi.org/10.3390/molecules161210187] [PMID: 22157581]
Priya, M.G.; Girija, K.; Ravichandran, N.In vitro study of anti-inflammatory and antioxidant activity of 4-(3H)-quinazolinone derivatives. Rasayan J. Chem.,2011, 4, 418-424.
Rakesh, K.P.; Manukumar, H.M.; Gowda, D.C. Schiff’s bases of quinazolinone derivatives: Synthesis and SAR studies of a novel series of potential anti-inflammatory and antioxidants. Bioorg. Med. Chem. Lett., 2015, 25(5), 1072-1077. [http://dx.doi.org/10.1016/j.bmcl.2015.01.010] [PMID: 25638040]
Patel, D.R.; Patel, K.C. Synthesis, characterization andin vitro antimicrobial screening of some new MCT reactive dyes bearing nitro quinazolinone moiety. J. Saudi Chem. Soc., 2015, 19(4), 347-359. [http://dx.doi.org/10.1016/j.jscs.2012.02.002]
Khodarahmi, G.; Jafari, E.; Hakimelahi, G.; Abedi, D.; Rahmani Khajouei, M.; Hassanzadeh, F. Synthesis of some new quinazolinone derivatives and evaluation of their antimicrobial activities.Iran. J. Pharm. Res., 2012, 11(3), 789-797. [PMID: 24250506]
Wang, D.; Gao, F. Quinazoline derivatives: Synthesis and bioactivities. Chem. Cent. J., 2013, 7(1), 95. [http://dx.doi.org/10.1186/1752-153X-7-95] [PMID: 23731671]
Kumar, D.; Mariappan, G.; Husain, A.; Monga, J.; Kumar, S. Design, synthesis and cytotoxic evaluation of novel imidazolone fused quinazolinone derivatives. Arab. J. Chem.,2017, 10(3), 344-350. [http://dx.doi.org/10.1016/j.arabjc.2014.07.001]
Keche, A.P.; Kamble, V.M. Synthesis and anti-inflammatory and antimicrobial activities of some novel 2-methylquinazolin-4(3H)-one derivatives bearing urea, thiourea and sulphonamide functionalities. Arab. J. Chem., 2019, 12(7), 1522-1531. [http://dx.doi.org/10.1016/j.arabjc.2014.10.025]
F Zayed, M.; H Hassan, M. Synthesis and biological evaluation studies of novel quinazolinone derivatives as antibacterial and anti- inflammatory agents. Saudi Pharm. J.,2014, 22(2), 157-162. [http://dx.doi.org/10.1016/j.jsps.2013.03.004] [PMID: 24648828]
Devi, K.; Kachroo, M. Synthesis and anti-tubercular activity of some new 2, 3-disubstituted quinazolinones.Pharma Chem., 2014, 6, 353-359.
Refaie, F.M.; Esmat, A.Y.; Gawad, S.M.A.; Ibrahim, A.M.; Mohamed, M.A. The antihyperlipidemic activities of 4(3H) quinazolinone and two halogenated derivatives in rats. Lipids Health Dis., 2005, 4(1), 22. [http://dx.doi.org/10.1186/1476-511X-4-22] [PMID: 16202158]
Gobinath, M.; Subramanian, N.; Alagarsamy, V. Design, synthesis and H1-antihistaminic activity of novel 1-substituted-4-(3-chlorophenyl)-[1,2,4] triazolo [4,3-a] quinazolin-5(4H)-ones. J. Saudi Chem. Soc., 2015, 19(3), 282-286. [http://dx.doi.org/10.1016/j.jscs.2012.02.006]
Gulick, R.M. New antiretroviral drugs. Clin. Microbiol. Infect., 2003, 9(3), 186-193. [http://dx.doi.org/10.1046/j.1469-0691.2003.00570.x] [PMID: 12667250