68
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
STUDY ON THE SELECTION OF TECHNOLOGY FOR “VINAMIR” TABLETS
Khakimova K.U.¹
Yunusova Kh.M.²
Ilhamova N.B.²
¹State Institution “Center for Pharmaceutical Product Safety”, Tashkent city, Republic of
Uzbekistan
²Tashkent
Pharmaceutical Institute, Tashkent city, Republic of Uzbekistan
e-mail: kamolauygunovna@gmail.com
https://doi.org/10.5281/zenodo.17318485
Relevance:
Import substitution is one of the priority tasks of the pharmaceutical industry in the
Republic of Uzbekistan. Particular attention is given to the production of high-tech medicinal
products that meet modern quality and safety requirements. This area is especially important in the
context of the rational use of national production potential and reducing dependence on foreign
supplies. In psychiatry and neurology, the introduction of modern antidepressant medicines is a key
aspect of import substitution. The development of combined preparations offers additional
opportunities to improve the effectiveness of depression therapy and to expand the range of
domestically produced dosage forms.
Objective of the study.
The purpose of this work was to create combined antidepressant tablets
that are convenient to use, possess high bioavailability, and remain stable during storage. The active
ingredients included mirtazapine, venlafaxine hydrochloride, as well as dry extracts of lemon balm
(
Melissa officinalis
) and peppermint (
Mentha piperita
).
Materials and methods.
In the development of the “Vinamir” tablet technology, active
pharmaceutical ingredients (APIs) and excipients were used in compliance with the requirements of
the State Pharmacopoeia of the Republic of Uzbekistan (SP RUz), as well as relevant regulatory and
technical documentation (GOST, OST, TU). The tablets were produced using direct compression
without a granulation stage, which shortens the process and reduces costs but imposes high
requirements on the quality of the initial substances. The technological properties of substances and
excipients were analyzed using Erweka equipment (Germany). Particle size was determined by
microscopy with the VideoTest program. Selection of excipients considered their solubility, stability,
compressibility, ability to ensure rapid and complete release of active substances, and the formation
of mechanically strong tablets. Various combinations of excipients were tested to optimize the
formulation. The study involved calcium carbonate, methylcellulose, polyvinylpyrrolidone (PVP),
glucose, lactose, sucrose, potato and corn starch, microcrystalline cellulose, carboxymethylcellulose,
magnesium stearate, calcium stearate, stearic acid, and other substances. In total, more than twenty
formulations were examined. The quality of the obtained samples was assessed in accordance with
current regulatory documentation.
Results.
Experimental samples of combined tablets were obtained by direct compression.
However, their properties proved unsatisfactory: the mass adhered to the compression tooling, and
the samples did not meet the requirements for disintegration and friability. Despite testing more than
twenty excipient combinations, satisfactory results were not achieved.
Conclusions.
Tablets produced by direct compression did not comply with the requirements of
the State Pharmacopoeia of the Republic of Uzbekistan for solid dosage forms. To achieve the
necessary quality parameters, further studies are required using alternative technologies (such as wet
or dry granulation), which would allow obtaining optimal pharmaceutical and technological
characteristics of the “Vinamir” preparation.
