Том 5 № 10(MPHAPP) (2025): THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE “MODERN PHARMACEUTICS: ACTUAL PROBLEMS AND PROSPECTS”
Том 5 № 10(MPHAPP) (2025): THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE “MODERN PHARMACEUTICS: ACTUAL PROBLEMS AND PROSPECTS”
Опубликован:
29-10-2025
Статьи
5-7
39
13
USE OF INNOVATIVE METHODS IN TEACHING PHILOSOPHY IN HIGHER EDUCATION
Our country education in the system last in years done increasing wide comprehensive of reforms at the bottom supreme education system content update, information
globalized one in the period this education in the system pedagogical activity of the professors and teachers who are conducting education process organization to reach modernization, this to the process innovative technologies implementation to do, this regarding abroad from their experiences effective use such as important tasks cover received.
globalized one in the period this education in the system pedagogical activity of the professors and teachers who are conducting education process organization to reach modernization, this to the process innovative technologies implementation to do, this regarding abroad from their experiences effective use such as important tasks cover received.
8-9
29
10
ANALYSIS OF THE IMPACT OF THE CREDIT-MODULE SYSTEM ON THE QUALITY OF EDUCATION AND THE FORMATION OF INDEPENDENT LEARNING SKILLS IN STUDENTS
The Resolution of the President of the Republic of Uzbekistan No. PD-4884 dated November 6, 2020, established the introduction of a credit-module system in higher education and its gradual implementation in practice.
10
25
24
THE IMPORTANCE OF USING E-TRANSLATORS IN STUDYING A FOREIGN LANGUAGE
In today’s globalized world, foreign language knowledge is no longer a privilege but a necessity.
11
23
16
ENHANCING INDEPENDENT ENGLISH LEARNING THROUGH EDTECH AMONG PHARMACY STUDENTS IN MULTILINGUAL SETTINGS
To determine the effectiveness of EdTech tools in fostering independent English learning among pharmacy students in multilingual settings
12
29
14
“THE DEVELOPMENT OF MILITARY ART DURING THE TIME OF AMIR TEMUR AND THE TIMURIDS AND ITS SIGNIFICANCE TODAY”
The great statesman Sohibkiron Amir Temur, who left his name in the annals of history of our homeland, took a worthy place in world history with his sharp intellect, unique leadership skills and military skill.
13
19
12
MODERNIZATION OF PHARMACEUTICAL EDUCATION IN KAZAKHSTAN: CHALLENGES, STRATEGIES, AND PROSPECTS
In his Address, President of the Republic of Kazakhstan Kassym-Jomart Tokayev outlined the goal of developing the pharmaceutical industry and expanding domestic drug production by 30%.
14-15
20
9
LINGUODIDACTIC POTENTIAL OF THE DISCURSIVE APPROACH TO TEACHING FOREIGN LANGUAGES
In light of new qualitative changes in the system of continuous foreign language education, it is necessary to rethink approaches and methods of teaching, the object and units of learning.
16
27
4
REFORMS, ACHIEVEMENTS, PROBLEMS AND FUTURE PLANS IN THE FIELD OF PHARMACEUTICAL EDUCATION
Today, the pharmaceutical sector is an integral part of the rapidly developing field of medicine
17
16
14
FORMALIZATION OF NON-QUANTITATIVE MEDICAL DATA
Since different recognition algorithms perform differently on the same training sample, medical of information A synthetic decision rule that flexibly uses the strengths of algorithms is relevant from issues is considered.
18-19
24
12
MATHEMATICAL MODELING OF THE SPREAD OF THE EPIDEMIC
Studying the spread limit of the epidemic through the Kermak-McKendrick model and studying the mathematical expression of the breeding trend.
20
17
11
URGENT ISSUES IN INDUSTRIAL PHARMACY
To identify the main problems in the pharmaceutical industry, analyze their causes and consequences, and develop scientifically based proposals for reforms in the sector.
21
20
19
IMPROVEMENT OF PHARMACEUTICAL SERVICES IN PHARMACIES
Pharmaceutical services in pharmacies represent a crucial component of the healthcare system, ensuring the rational use of medicines, optimizing pharmacotherapy, and improving the overall quality of patient care.
22
24
4
METHODS FOR ANALYZING MEDICAL AND PHARMACEUTICAL DATA PROVIDED IN NON-QUANTITATIVE FORM
The heuristic approach is based on the researcher's knowledge and intuition, which are difficult to formalize.
23
20
17
METHODS OF USING MODERN PEDAGOGICAL TECHNOLOGIES IN THE DEVELOPMENT OF THINKING IN STUDENTS
This article discusses the fact that the process of developing students' creative abilities consists of theoretically developed didactic approaches, the tasks performed in this process, the principles that are important to follow in increasing efficiency, and the stages of their implementation.
24
16
9
CONDITIONS FOR IMPROVING INNOVATIVE TECHNOLOGIES IN THE FIELD OF PHARMACEUTICAL EDUCATION
A distinctive feature of modernized education is the improvement of innovative technologies, bringing the process of independent learning to a new qualitative level. For this, it is important to study the richest pedagogical experiences in this area, to organize the conditions for applying these experiences.
25-26
26
6
THE ROLE OF PUBLIC ASSOCIATIONS AND FAMILY COOPERATION IN SHAPING THE SPIRITUALITY OF YOUTH
In today’s rapidly changing era of globalization, Uzbekistan considers its future and prospects to be directly connected with the development and preservation of the family. This is clearly reflected in the fact that building a modern, exemplary and prosperous family, while enriching our traditional values, has become one of the priority directions of state policy.
27-28
32
9
THE ROLE OF LATIN LANGUAGE AND MEDICAL TERMS
The Latin language and medical terminology are important in the field of medicine, and their study and use are necessary for the effective and accurate transmission of medical knowledge.
29
28
5
APPLICATION OF SPECTROPHOTOMETRIC METHODS IN PHARMACY
The study of the interaction between camel thorn and medicinal products using the spectrophotometric method in the field of pharmacy
30-31
36
12
ИННОВАЦИОННОЕ РАЗВИТИЕ ФАРМАЦЕВТИЧЕСКОГО ОБРАЗОВАНИЯ
Развитие национального фармацевтического сектора имеет стратегическое, социальное и экономическое значение, в том числе и фармацевтического образованиия.
32-33
84
10
SHIFOKOR VA BEMOR MUNOSABATLARINING ASOSIY MEZONLARI
T.Parsons shifokor va bemor uchun ideal rol turlarini ishlab chiqdi. Garchi shifokor va bemor, uning fikriga ko'ra, umumiy maqsad - ikkinchisining sog'lig'ini tiklash bilan bog'liq bo'lsa-da, ularning vazifalari va imtiyozlari keskin farqlanadi.
34-35
26
19
USING INTERACTIVE METHODS IN TEACHING STUDENTS
The modern methods of the educational process aimed at the comprehensive computerization and visualization of teaching subjects are focused on enhancing the quality of professional skills development in students.
36
25
9
EFFECTIVENESS OF USING EXTERNAL SOURCES IN LANGUAGE TEACHING
The current process requires the use of the most modern sources. However, no matter how up-to-date the textbooks are, they cannot fully satisfy the growing demands and demands for innovations.
37
29
9
THE ROLE OF FORMATIVE ASSESSMENT IN WRITING CLASSES
Writing is often seen as one of the hardest skills to master in language learning. It requires more than just correct grammar or vocabulary — students need to organize ideas, create logical arguments,
and express themselves clearly.
and express themselves clearly.
38-39
27
14
LOYALTY PROGRAM "HEALTH CLUB" FOR SYRIAN PHARMACIES
Pharmacies in Syria face chronic supply disruptions, price volatility, and reduced consumer purchasing power.
40
32
12
HUMAN RESOURCES SUPPORT FOR THE PHARMACEUTICAL INDUSTRY: CHALLENGES IN TRAINING SPECIALISTS
Human resources support for the pharmaceutical industry is one of the key factors in its sustainable development and in improving the quality of healthcare services for the population.
41
26
5
GLOBAL TRENDS AND NATIONAL APPROACHES TO THE TRAINING OF CLINICAL PHARMACISTS
Clinical pharmacy plays a key role in ensuring the rational use of medications and reducing the incidence of drug-related complications, which, according to the WHO, account for up to 10% of hospitalizations worldwide.
42-43
20
18
TRANSFORMING PHARMACEUTICAL EDUCATION FOR THE FUTURE: A GLOBAL ASSESSMENT OF SUCCESSES, CHALLENGES, AND EMERGING OPPORTUNITIES
Pharmaceutical education plays a crucial role in preparing the next generation of professionals who will shape global healthcare delivery.
44-47
22
11
ОПЫТ И ПЕРСПЕКТИВЫ ПОДГОТОВКИ ИНОСТРАННЫХ СТУДЕНТОВ В САНКТ-ПЕТЕРБУРГСКОМ ГОСУДАРСТВЕННОМ ХИМИКО ФАРМАЦЕВТИЧЕСКОМ УНИВЕРСИТЕТЕ
Международная деятельность Федерального государственного образовательного учреждения высшего образования «Санкт-Петербургский государственный химико-фармацевтический университет» Министерства здравоохранения Российской Федерации (СПХФУ Минздрава России) одним из его конкурентных преимуществ на современном рынке образовательных услуг.
48-49
23
4
FARMATSEVTIKA SOHADIGI ISLOHOTLARDA KADRLAR MASALASI
Ta’lim tizimida zamon talabiga mos ravishda kadrlarni tayyorlashda yuqori o’rin tutadi. U butun jamiyatning barcha sohalarida, xususan, ijtimoiy, siyosiy, huquqiy, iqtisodiy, fan, texnika va madaniyati bilan bevosita va bilvosita bog‘liqdir.
50-51
22
6
FARMATSEVTIK TA’LIMDA ANTROPOLOGIYA-FALSAFIY FAN SIFATIDA O’QITISHNING ISTIQBOLLARI
Ta’lim tizimida zamon talabiga mos ravishda kadrlarni tayyorlashda yuqori o’rin tutadi.
52
20
10
РОЛЬ ФИЛОСОФСКОГО МИРОВОЗЗРЕНИЯ В ФОРМИРОВАНИИ ФАРМАЦЕВТИЧЕСКОГО ОБРАЗОВАНИЯ
Современное фармацевтическое образование сталкивается с необходимостью подготовки специалистов, которые не только владеют узкопрофессиональными знаниями, но и способны принимать ответственные решения в условиях неопределенности.
53
38
20
ANTIK DAVRDA O‘RTA OSIYO KO‘CHMANCHI XALQLARINING IJTIMOIY IQTISODIY VA SIYOSIY HAYOTI
Antik davrda O‘rta Osiyo hududida yashagan ko‘chmanchi xalqlarning (saklar, massagetlar, daxlilar, yuechjilar va boshqalar) ijtimoiy tuzilishi, iqtisodiy faoliyati va siyosiy tizimi tahlil qilish.
54
17
19
PHARMACEUTICAL COMPANIES IN THE DIGITAL AGE: TOP MANAGEMENT'S ATTITUDE TO CORPORATE COMMUNICATIONS
The authors of the article consider the problem of improving internal and external communications in the context of digital transformation. This fact requires the top management of pharmaceutical companies to rethink their approaches and move to more effective corporate communication models.
55
23
12
THE ROLE OF BIOLOGICALLY ACTIVE FOOD SUPPLEMENTS IN HUMAN VITALITY
Dietary supplements (DS) are substances that activate the body's self-regulation processes, restoring its natural dynamic balance and paving the way for healing. In the US, 80% of the population uses them, and in Europe, over 50%. Dietary supplements are natural or similar biologically active substances intended for direct oral administration in the form of powder, tablets, capsules, syrups, extracts, tinctures, concentrates, etc
57
17
10
EVALUATION OF LACTIC ACID PRODUCTION ACTIVITY OF PROBIOTIC LACTOBACILLI
Today, lactic acid is considered one of the most demanded bioproducts worldwide. This acid is widely used in the food industry, pharmaceuticals, cosmetology, and many other sectors.
58
13
2
BIOPHARMACEUTICAL STUDY OF AN ANTIOXIDANT DRUG FORMULATION BASED ON ST. JOHN’S WORT (HYPERICUM PERFORATUM)
Oxidative stress plays a key role in the development of many disorders associated with the cardiovascular and nervous systems as well as chronic inflammation.
59-60
25
16
INFLUENCE OF PACKAGING MATERIALS ON THE STABILITY OF “AFEROL” TABLETS DURING LONG-TERM STORAGE
The medicinal product “Aferol” coated tablets, containing ferrous fumarate as the active pharmaceutical ingredient (API), are widely used for the treatment and prevention of iron deficiency anemia (IDA). The stability of such preparations is critically important, as ferrous fumarate is highly sensitive to environmental factors, including moisture, oxygen, light, and temperature.
61-62
20
9
DETERMINATION OF A MATHEMATICAL MODEL OF THE EXTRACTION PROCESS USING FILTRATION AND MASS EXCHANGE EQUATIONS
As in scientific and technical, industrial, social and other spheres, the study of processes through mathematical modeling based on digital technologies, which allows predicting their results, is becoming increasingly important in pharmaceutical production.
63-64
23
15
DEVELOPMENT OF A MEDICINAL PHYTOPARD PRESERVATIVE DENTAL POLYMER WITH A MODERATE COMPOSITION OF MOTHER OF PEARL (MATRICARIA, CHAMOMILLA) DRY EXTRACT
An analysis of the literature on the chemical composition, medicinal properties and use of the chamomile plant in medicine, in particular in dentistry, was carried out.
65
25
7
OPTIMIZATION OF EXTRACT PRODUCTION FROM CURCUMA LONGA
Phytotherapy based on medicinal plants is one of the oldest therapeutic practices in human history and still holds an important place in modern medicine.
66-67
20
9
STORAGE CONDITIONS AND SHELF LIFE DETERMINATION OF THE HEPATOPROTECTIVE HERBAL TEA “HEPASILIMARIN”
Herbal teas derived from medicinal plants have been traditionally and extensively utilized for centuries in folk medicine as well as in modern pharmaceutical practice
68
22
16
STUDY ON THE SELECTION OF TECHNOLOGY FOR “VINAMIR” TABLETS
Import substitution is one of the priority tasks of the pharmaceutical industry in the Republic of Uzbekistan.
69-70
27
6
DEVELOPMENT OF A METHOD FOR OBTAINING A DRUG USED IN UROLITHIASIS
According to the World Health Organization (WHO), herbal medicines account for a significant portion of the pharmaceutical industry.
71-72
24
5
DETERMINATION OF TECHNOLOGICAL PROPERTIES OF MADDER EXTRACT
Urolithiasis (urolithiasis) is a polyetiologic, polypathognomonic metabolic disorder characterized by the formation of kidney stones.
73
24
11
DEVELOPMENT OF OBTAINING A DRY EXTRACT FROM THE HERB OF EQUISETUM ARVENSE
The importance of marketing research on the diuretic pharmaceutical market is determined by their key role in modern therapeutic practice.
74-75
19
5
DEVELOPMENT OF A TECHNOLOGY FOR OBTAINING DRY EXTRACT AND ESSENTIAL OIL FROM WORMWOOD HERB
Wormwood (Artemisia (spp.) is widespread in the flora of Kazakhstan and has long been used in folk medicine as a medicinal plant for gastrointestinal diseases, as an anti-inflammatory, antimicrobial, and restorative
76-77
19
9
DEVELOPMENT OF A TECHNOLOGY FOR OBTAINING LIQUID EXTRACT FROM THE PLANT ANTHEMIS TINCTORIA L.
In recent years, the extraction of biologically active substances from medicinal plants and their use in the production of pharmaceuticals has been one of the most pressing areas of research.
78-79
30
10
DETERMINATION OF PHYSICAL, CHEMICAL AND TECHNOLOGICAL PROPERTIES OF THE SUBSTANCE CLOTRIMAZOLE A
Mycoses of the skin are a common global problem, affecting 20-30% of the world's population and ranking second among all skin diseases.
80-81
24
6
OPTIMIZATION OF THE TECHNOLOGY FOR HEPATOPROTECTIVE HERBAL TEA
In recent years, the prevalence of liver and biliary tract diseases in the Republic has steadily increased: approximately 15–17% of the adult population suffers from various hepatic pathologies. The etiology and pathophysiology of these diseases are complex, and their treatment requires polyvalent agents capable of acting through several mechanisms (antioxidant, antiinflammatory, cytoprotective,regenerative).
82
27
14
TECHNOLOGICAL DESIGN AND PRODUCTION FEATURES OF THE DOSAGE FORM IN THE FORM OF CAPSULES OF ANTI-DIABETIC PHARMACOLOGICAL AGENTS
Diabetes mellitus is one of the most common chronic, non-communicable diseases of our time, affecting millions of people worldwide.
83-84
21
18
IMMUNOSUPPRESSIVE DRUGS: SCIENTIFIC PRINCIPLES OF DEVELOPING COMBINATION DOSAGE FORMS
Immunosuppressant drugs are among the key therapeutic groups in modern transplantology and the treatment of autoimmune diseases.
84-85
17
6
CHARACTERISTICS AND TECHNOLOGY OF OBTAINING DRY EXTRACT OF COMMON RASPBERRY (RUBUS IDAEUS), GROWING IN SOUTHERN KAZAKHSTAN
Common raspberry (Rubus Raspberry (idaeus) is the most common berry bush, possessing high nutritional and biologically active properties.
86-87
17
7
SELECTION OF OPTIMAL CONDITIONS FOR VACUUM EVAPORATION AND DRYING TO OBTAIN A DRY EXTRACT
In recent years, there has been a growing interest in biologically active food supplements with sedative effects.
88
18
4
STUDY OF THE CRYSTALLOGRAPHIC PARAMETERS OF THE ESCIN SUBSTANCE
Escin is a natural mixture of triterpene saponins consisting of α- and β-isoforms. These isoforms differ in melting point, angle of rotation of the polarization plane, solubility, hemolytic index, and other physical properties.
89
21
4
EVALUATION OF PHYSICAL AND MECHANICAL PROPERTIES OF ALBENDAZOLE TABLETS USED IN VETERINARY PRACTICE
This abstract describes the results of evaluating the physicomechanical properties of Albendazole tablets obtained from supramolecular complexes of albendazole with glycyrrhizic
acid, its monoammonium and monopotassium salts
acid, its monoammonium and monopotassium salts
90-91
14
4
MODERN METHODS OF MICROENCAPSULATING ACTIVE PHARMACEUTICAL SUBSTANCES
Microencapsulation is one of the most promising methods for improving the stability, bioavailability, and controlled release of drugs.
92
21
5
INVESTIGATION OF THE KINETIC REGULARITY OF THE FORMATION OF INTERPOLYMER COMPLEXES OF SODIUM CARBOXYMETHYLCELLULOSE WITH CARBOPOL AS THE BASIS FOR SOFT DRUGS
In recent years, Interpolymer complexes (IPCs) based on sodium carboxymethylcellulose polysaccharide (Na-CMC) with various polycations have aroused considerable interest due to their universal application. Cellulose-derived IPCs have great potential in drug particle delivery systems in medicinal products
93
28
10
PHARMACEUTICAL INTERPOLYMER COMPLEXES BASED ON SODIUM CARBOXYMETHYLCELLULOSE POLYSACCHARIDE AND POLYACRYLAMIDE
An analysis of international literature data shows that polyelectrolyte complexes (PEC) are very promising, occupy an important place in materials technology, engineering, medicine, and other areas of the national economy, as they reveal a number of unique and most valuable properties.
94-95
26
14
REPRODUCTION OF THE PLANT INULA HELENIUM L. AND SEPARATION OF EXTRACTIVES OF THE PLANT INULA HELENIUM L.
Inula helenium L., commonly known as elecampane, is a perennial herbaceous plant belonging to the Asteraceae family, notable for its striking yellow flowers and distinctive large leaves.
96
26
7
PREPARATION OF CREAM BASED ON CARTHAMUS TINCTORIUS L. FLOWER EXTRACT AND EVALUATION OF ITS QUANTITATIVE INDICATORS
In recent years, the prevalence of dermatological diseases has been increasing, leading to a significantly greater demand for effective and safe skin care products.
97
45
12
DISPERSIBLE TABLETS — PROSPECTS FOR THE DEVELOPMENT OF A NEW DOSAGE FORM: CASE STUDY OF NYSTATIN DISPERSIBLE TABLET FORMULATION
Dispersible tablets are one of the most promising solid dosage forms, offering ease of use, especially for patients with swallowing difficulties such as children, the elderly, and patients with dysphagia
98-99
29
6
PHARMACEUTICAL AND TECHNOLOGICAL FEATURES OF THE DEVELOPMENT OF ADHESIVE FILMS WITH ASIAN MINT EXTRACT (MENTHA ASIATICA BORISS.)
Modern dentistry requires dosage forms that provide prolonged and localized release of active substances.
100-101
25
12
«НОВЫЕ ПОДХОДЫ К СОЗДАНИЮ КОМПОЗИЦИОННЫХ МАТЕРИАЛОВ НА ОСНОВЕ ТОПИНАМБУРА»
Oсобое внимание уделяется разработке и изучению технологии получения нескольких марок эфиров целлюлозы из высокочистых марок целлюлозы, передаваемых из местного сырья - топинамбура, волокнистых отходов хлопкоочистительных предприятий, стеблей сафлоры.
102-103
27
7
SELECTION OF THE PRESCRIPTION OF A MEDICAL AND COSMETIC CREAM WITH ANTI-INFLAMMATORY EFFECT
Currently, the Uzbek market is dominated by imported medical and cosmetic products, which outweigh domestic medicines.
104-105
21
5
STUDY OF THE DYNAMICS OF ALCOHOL EXTRACTION OF PHYSALIS ANGULATA
Physalis angulata (angular physalis) is an erect annual herbaceo us plant of the Solanaceae family.
106
26
11
VALSARTAN, ASKORBIN KISLOTASI VA KOENZIM 10 in-academy.uz SUBSTANSIYALARNING TEXNOLOGIK KO’RSATKICHLARINI O’RGANISH
Kombinirlangan dori vositalarining asosiy ahamiyati – davolash samaradorligini oshirish, qabul qilish tartibini yengillashtirish orqali bemorning holatini yaxshilash va tarkibidagi har bir necha xil komponentlarning kichik dozalari hisobiga nojo‘ya ta’sirlar xavfini kamaytirishdir.
107-108
815
50
“ETIKOKS” YALLIG’LANISHGA QARSHI TABLETKANING TARKIBINI TANLASHDA ASOSIY ME’ZONLAR
Farmakoterapiyada yallig‘lanish jarayonini davolash uchun nosteroid yallig‘lanishga qarshi vositalar (NYaQV) hisoblanadi.
109-110
34
4
KLARITROMITSIN SUBSTANSIYASI ASOSIDA TABLETKA TARKIBINI ISHLAB CHIQISH
Yuqoridagilarni inobatga olib taqdiqotmiz obyekti bo’lgan klaritromitsin antibiotikigini mahalliy ishlab chiqarilishini kengaytirish maqsadida klaritromitsin asosida tarkib ishlab chqildi.
111
25
13
ASSESSMENT OF THE QUALITY INDICATORS OF THE BIOLOGICALLY ACTIVE ADDITIVE BASED ON GERANIUM SANGUINEUM
According to statistical analyses, most agents used today for the treatment of infectious throat diseases are obtained through chemical synthesis, while preparations derived from natural raw materials are relatively rare
112
31
19
OBTAINING AROMATIC WATER BY STEAM DISTILLATION FROM THYME HERB (THYMUS SERPYLLUM) NATIVE TO THE KYRGYZ REPUBLIC
Aromatic waters are widely used in pharmacy and phytocosmetology due to their natural origin and mild effect on the skin.
113
22
5
EXTEMPORAL CHEWABLE PASTILLES: FROM THE CONCEPT OF THE DOSAGE FORM TO QUALITY CONTROL
chewable pastilles combine taste masking, ease of use and the ability to select
individual doses, which is especially valuable in pediatrics, geriatrics and for patients with dysphagia.
individual doses, which is especially valuable in pediatrics, geriatrics and for patients with dysphagia.
114
32
5
OPTIMIZATION OF THE PACKAGING PROCESS ON THE “IBUPROFEN 400 mg” TABLET PRODUCTION LINE
Modern requirements for the quality of medicinal products imply high precision in packaging labeling, especially in mass production.
115-116
22
9
STUDY OF THE INFLUENCE OF GRANULATION ON THE QUALITY INDICATORS OF THE «NIFIKOR» TABLETS
Chronic heart failure (CHF) is one of the most unfavorable pathological conditions that significantly reduces the duration and quality of life for patients.
117
30
6
IN VITRO STUDY OF THE BIOEFFECTIVENESS OF A TABLET WITH A SEDATIVE EFFECT
One of the current problems in the pharmaceutical industry is the creation of innovative, highly bioeffective, affordable, and low-toxic drugs based on local medicinal plant raw materials, as well as the localization of the production of recommended drugs.
118
28
25
МОДЕЛИРОВАНИЕ ПРОЦЕССА ДЕСОРБЦИИ ДЕЗЛОРАТАДИНА ИЗ СПЛАВОВ С ПОЛИВИНИЛПИРРОЛИДОНОМ МЕТОДОМ МОЛЕКУЛЯРНОЙ ДИНАМИКИ
Дезлоратадин, лекарственный препарат с доказанной антигистаминной активностью, в настоящее время на фармацевтическом рынке представлен в лекарственных формах: таблетки, раствор и сироп.
119-120
19
9
DETERMINATION OF QUALITY INDICATORS OF MINCED MEAT PREPARED ON THE BASIS OF ANTI-ANEMIA COLLECTION
Anemia is characterized by diseases that are widespread in the Republic of Uzbekistan. According to prominent scholars who have researched the field, the disorder has now been reported in 2 out of every 4 individuals and in some districts in 65% of the population.
121-122
22
13
DEVELOPMENT OF COMPOSITION AND TECHNOLOGY OF FACE CREAM
This work presents a developed natural face cream based on coconut oil and talc, which has moisturizing, softening, and mating properties
123-124
16
8
EVALUATION OF THE QUALITY AND BIOAVAILABILITY OF MEDICINAL FILMS BASED ON ALOE EXTRACT AND METILURACIL
The effective treatment of many dermatological diseases is associated with the use, along with traditional dosage forms (ointments, gels, solutions), of modern dosage forms such as
polymeric medicinal films.
polymeric medicinal films.
125-126
31
13
РАЗРАБОТКА ТЕХНОЛОГИИ БИОЛОГИЧЕСКОЙ АКТИВНОЙ ДОБАВКИ «ДЕПРЕСФАН» УСПОКОИТЕЛЬНОГО ДЕЙСТВИЯ
Биологически активные добавки (БАД), являются наиболее эффективным способом устранения дефицита витаминов и минералов, но при условии содержания биологических веществ в дозах, соответствующих физиологическим потребностям человека.
127
13
6
MEDICINES FOR CHILDREN
The limited range of pediatric medications and the forms in which they are produced prompted the First International Expert Conference on Essential Medicines for Children to
be held in Geneva in 2006.
be held in Geneva in 2006.
128-129
32
16
DETERMINATION OF THE QUALITY INDICATORS OF ANTI-ALLERGIC LIQUID EXTRACT OBTAINED FROM THE COLLECTION OF THE LITTLE TREES
Today, problems related to climate change and environmental pollution are leading to a further aggravation of the situation, and factors such as environmental degradation, increased
consumption of food products enriched with chemical additives and preservatives, excessive use of medications, lack of exercise, stress, etc.
consumption of food products enriched with chemical additives and preservatives, excessive use of medications, lack of exercise, stress, etc.
130-131
29
9
DETERMINATION OF QUALITY PARAMETERS OF A LIQUID EXTRACT BASED ON LOCAL MEDICINAL PLANTS USED IN INFLAMMATORY DISEASES OF THE GASTROINTESTINAL TRACT
Peptic ulcer disease of the stomach and duodenum is a chronic, recurrent disorder characterized by mucosal defects and ulcer formation in the stomach and duodenal walls.
132-133
51
8
SHAMCHA DORI SHAKLINING RIVOJLANISH ISTIQBOLLARI
Zamonaviy farmatsevtika sanoatida dori vositalarining yangi shakllarini ishlab chiqish va amaliyotga joriy etish soha rivojining ustuvor yo‘nalishlaridan biridir
134
18
3
RESEARCH ON THE DEVELOPMENT OF A STOMATOLOGICAL PHYTOTOOTHPASTE BASED ON LOCAL RAW MATERIALS
Phytotherapy is a rich and inexhaustible source of nature, which provides the possibility of individual use of medicinal plants, taking into account the classification of diseases, leading symptoms and syndromes, as well as their etiopathogenesis.
135
38
12
“ALLERGIYA VA YALLIG’LANISHDA QO’LLASH UCHUN QURUQ EKSTRAKT OLISHDA O’SIMLIKLARNI TANLASH”
Hozirgi davrda allergik kasalliklar va yallig‘lanish bilan kechuvchi holatlar dunyo bo‘yicha eng keng tarqalgan muammolardan biri bo‘lib qolmoqda.
136
32
24
"KVERTEKS" PREPARATI SAMARALI TISH VOSITASIDIR
Karies, gingivit va periodontit kabi og'iz kasalliklari dunyodagi eng keng tarqalgan kasalliklardan biridir. JSST ma'lumotlariga ko'ra, dunyo bo'ylab 3,5 milliardga yaqin odam og'iz bo’shlig’i kasalliklaridan aziyat chekmoqda
137-138
24
7
DEVELOPMENT OF TECHNOLOGY AND QUALITY ASSESSMENT OF DENTAL GEL
Parrot and oral cavity diseases are multifactorial in nature and, as established by modern research, are caused by microbial aggression.
139
24
14
STUDY OF TECHNOLOGICAL PROPERTIES OF TABLET MASS “PODAGRIN”
The basis of the development of gout is hyperuricemia, which is a constant excess of uric acid in the blood.
140-141
15
15
ИЗУЧЕНИЕ ВЛАГОУСТОЙЧИВОСТИ ТАБЛЕТОК “АСРУТАС”
исследование и разработка шипучих таблеток является актуальной задачей фармацевтической науки, т.к. удобство пользования быстрорастворимыми газообразующими препаратами создает им широкие возможности применения и обеспечивает высокий терапевтический эффект лекарственных веществ.
142
15
6
IMMUNITETNI TIKLOVCHI BIOLOGIK FAOL QO‘SHIMCHA YARATISH BORASIDA TADQIQOTLAR
Barcha dori preparatlariga asosan quyidagi talablar qo‘yiladi: biofaollik, sifat, mikrobiologik tozalik va turg‘unlik.
143
16
32
TO THE QUESTION OF CHOOSING THE RESEARCH OBJECT ON THE TOPIC OF NOOTROPIC DRUGS
Nootropic drugs occupy a key place in modern neurological and psychiatric practice, as they help improve cognitive functions, memory recovery, concentration, and neuroplasticity.
144-145
24
5
DEVELOPMENT OF CITRATE DRY RABBIT PLASMA SEPARATION TECHNOLOGY
Blood plasma is a valuable biological fluid that contains many proteins, immunoglobulins, coagulation factors, and biologically active substances.
146
23
14
RHUS CORIARIA L. ASOSIDA OLINGAN QURUQ EKSTRAKTNING TEXNOLOGIK XOSSALARI
Statistika agentligining rasmiy ma’lumotlariga ko’ra hozirgi kunga kelib respublikamizda aholini birinchi marta tashxis bilan qayd qilingan kasalliklarga chalinish turlari boʻyicha eng yuqori koʻrsatkich nafas organlari kasalliklari hissasiga toʻgʻri kelib, har 100 ming aholidan 13 ming nafarida ushbu kasallanish kuzatilmoqda.
147-148
22
20
ПЕРСПЕКТИВЫ РАЗРАБОТКИ ЛЕКАРСТВЕННОГО ПРЕПАРАТА РАНОЗАЖИВЛЯЮЩЕГО ДЕЙСТВИЯ НА ОСНОВЕ МИКРОНИЗИРОВАННОГО КАОЛИНИТА И ЭФИРНОГО МАСЛА РАСТЕНИЙ КАЗАХСТАНА
Проблема инфицированных ран остается одной из ключевых в клинической практике
149
16
6
FITSLIM — A HERBAL-BASED WEIGHT LOSS PRODUCT
In recent years, obesity has become a serious medical and social problem worldwide.
150
13
8
TECHNOLOGY OF OBTAINING A COMBINED TINCTURE OF LINGONBERRY AND BEARBERRY LEAVES
Lingonberry and bearberry leaves should be considered valuable medicinal plant raw materials for the production of medicinal products.
151-152
33
4
PROSPECTS FOR THE DEVELOPMENT OF A WOUND-HEALING DRUG BASED ON MICRONIZED KAOLINITE AND ESSENTIAL OILS OF KAZAKHSTAN PLANTS
The problem of infected wounds remains one of the key challenges in clinical practice.
153
15
10
COMPARATIVE STUDY OF THE SWELLING BEHAVIOR OF POLYMER PATCHES BASED ON GELLAN GUM AND AGAR-AGAR
In recent years, natural polysaccharides have been extensively studied as promising components for the development of dosage forms with controlled release.
154
28
6
MODERN TECHNOLOGIES FOR THE PRODUCTION AND STANDARDIZATION OF HERBAL PHARMACEUTICAL SUBSTANCES
The development of phytopharmaceuticals requires the introduction of innovative methods for obtaining substances from medicinal plant raw materials.
155
16
6
SELECTION OF THE OPTIMAL TYPE OF EXTRACTANT FOR OBTAINING EXTRACT FROM COMMON CORN (ZEA MAYS L.) RAW MATERIAL
Corn silk (Zea mays L.) is a source of biologically active substances (BAS), among which flavonoids are of particular importance.
156
18
6
DEVELOPMENT OF A TRANSDERMAL MEDICINE FOR WOUND HEALING
the relevance is due to the high prevalence of wound pathology and the lack of complex and effective means for its treatment in the domestic pharmaceutical market.
157
12
7
RESEARCH ON THE DEVELOPMENT OF A STOMATOLOGICAL PHYTOTOOTHPASTE BASED ON LOCAL RAW MATERIALS
Phytotherapy is a rich and inexhaustible source of nature, which provides the possibility of individual use of medicinal plants, taking into account the classification of diseases, leading symptoms and syndromes, as well as their etiopathogenesis.
158
31
3
TECHNOLOGY OF OBTAINING DRY LYOPHILIC EXTRACT OF DESERT SAGE (SALVIA DESERTA SHANGIN.)
Medicinal plant raw materials are an important source of biologically active substances, which is why dry forms are preferred for the creation of phytopharmaceuticals due to
their stability, ease of dosing, and storage.
their stability, ease of dosing, and storage.
159
21
22
MAKING A TINCTURE FROM WILD WATERMELON ROOT AND ITS USE FOR STROKES
Cardiovascular diseases, particularly stroke, are widespread among the population, independently of age
160-161
22
15
THE USE OF ULTRAFILTRATION IN THE EXTRACTION OF TRITERPENE SAPONINS CONTAINED IN HERNIARIA GLABRA PLANT
Today, the purification and standardization of biologically active substances extracted from medicinal plants is a pressing issue.
162-163
12
8
EVALUATION OF THE QUALITY AND BIOAVAILABILITY OF MEDICINAL FILMS BASED ON ALOE EXTRACT AND METILURACIL
The effective treatment of many dermatological diseases is associated with the use, along with traditional dosage forms (ointments, gels, solutions), of modern dosage forms such as polymeric medicinal films.
164-165
17
6
DEVELOPMENT OF TECHNOLOGY FOR THE BIOLOGICAL ACTIVE ADDITIVE "DEPRESSFAN" WITH A CALMING EFFECT
Biologically active supplements (BAS) are the most effective way to eliminate vitamin and mineral deficiencies, provided that the supplements contain biological substances in doses that meet the physiological needs of the human body.
166
21
10
STUDY OF RHEOLOGICAL PROPERTIES OF HYDROGELS BASED ON OXIDIZED NANOCELLULOSE DERIVATIVES
Nowadays, nanocellulose (NC) derivatives are used in various high-quality functional applications.
167
19
7
FORMULATION AND EVALUATION OF NOVEL DOSAGE FORMS OF GLYCYRRHIZIC ACID
Glycyrrhizinic acid, a triterpene saponin, is a biologically active compound known for its pronounced antioxidant and anti-inflammatory properties.
168
16
8
SUT KISLOTASI ASOSIDA OLINGAN POLIMERNING FIZIK KIMYOVIY XOSSALARI
Akrilamid (AA) va boshqa to‘yinmagan amidlar asosida polimerlarni sintez qilishning asosiy usuli radikal polimerizatsiya bo‘lib, u barcha ma’lum usullar bilan amalga
oshirilishi mumkin
oshirilishi mumkin
169-170
13
8
STUDY OF THE RHEOLOGY OF THE PASTE “UROKONIT-MR”
Kidney and urinary system diseases of various etiologies occupy an important place in the general structure of the population's morbidity
172
18
23
STANDARD OPERATIONAL PROCESSES IN PHARMACIES
Creating a quality system requires the development of standard operational procedures for the sale of medicinal products and pharmacy assortment goods, as well as for all types
of work that influence the quality of activities
of work that influence the quality of activities
173-174
17
5
COMPARATIVE ANALYSIS OF THE IMPACT OF TRADITIONAL AND MODERN MEDICINES IN GASTRITIS
Gastritis is an inflammation of the gastric mucosa, which can occur in acute or chronic forms. Its causes include Helicobacter pylori infection, acid hyper secretion, and other contributing factors.
175-176
25
7
UROLITHIASIS UROLITHIAS CLASSIFICATION – TYPES AND COMPOSITION OF STONES IN UROLITHIAS DISEASE
Urolithiasis are common type of urological disease, accounting for approximately
12% of the population. The increasing incidence of the disease is associated with risks such as chronic
kidney disease and end-stage renal failure.
12% of the population. The increasing incidence of the disease is associated with risks such as chronic
kidney disease and end-stage renal failure.
177-178
14
16
CONTENT ANALYSIS OF THE RANGE OF ANTIALLERGIC DRUGS IN THE REPUBLIC OF UZBEKISTAN FOR 2021-2025
Currently, the prevalence of allergic diseases is constantly increasing. Allergic diseases and their complications lead to a decrease in the quality of life and an increase in the need
for anti-allergic drugs.
for anti-allergic drugs.
179-181
23
49
COMPARATIVE ANALYSIS OF GLUCOCORTICOID PRICES IN THE TREATMENT OF RHEUMATOID ARTHRITIS
rheumatoid arthritis is a chronic autoimmune disease of connective tissue,
characterized by progressive joint damage and deformity, as well as the development of disability.
Contemporary pharmacotherapy includes disease-modifying ant rheumatic drugs, biological agents,
and symptomatic treatment.
characterized by progressive joint damage and deformity, as well as the development of disability.
Contemporary pharmacotherapy includes disease-modifying ant rheumatic drugs, biological agents,
and symptomatic treatment.
182-183
48
12
NEW PROCEDURAL RULES FOR THE CIRCULATION OF MEDICINES AND MEDICAL DEVICES
Conclusions: with this decreeAmendments and additions are made to the Law of the Republic of Uzbekistan "On Medicinal Products and Pharmaceutical Activities" and the national standard of
the Republic of Uzbekistan, harmonized with the international standard "ISO:13485", is approved.
the Republic of Uzbekistan, harmonized with the international standard "ISO:13485", is approved.
184
15
13
INNOVATIVE MANAGEMENT IN PHARMACY: STRATEGY FOR MARKET ENTRY OF NEW DRUGS BASED ON LOCAL MEDICINAL PLANTS
In recent years, the pharmaceutical market of Uzbekistan has been actively developing towards localization of production and reducing import dependency.
185
20
15
ASSORTMENT ANALYSIS OF HORMONAL DRUGS REGISTERED IN THE REPUBLIC OF UZBEKISTAN
hormones are important for a person to lead an active life. Hormones regulate all the processes that go in the body, support its stability, respond to external and internal changes, while
controlling reproductive health and growth.
controlling reproductive health and growth.
186-187
26
9
RETROSPECTIVE ANALYSIS OF THE VARIATIVITY OF SUPPLY OF THE MOST DEMANDED ANTIBIOTICS IN THE TERRITORY OF THE REPUBLIC OF UZBEKISTAN
Analysis of supply stability assesses the reliability and predictability of logistical processes by measuring indicators such as failure frequency, delivery times, and service quality to ensure timely delivery of goods and minimize risks.
188-189
26
6
ASSORTMENT ANALYSIS OF LOCAL SYSTEMIC ANTIVIRAL MEDICINES IN THE REPUBLIC OF UZBEKISTAN BY PRESCRIPTION AND OVER-THE COUNTRY STATUS
This study analyzed the market for systemic antiviral drugs and presented the results
using the content analysis method.
using the content analysis method.
190
27
12
IMPROVING DRUG LOGISTICS MANAGEMENT AS A FACTOR FOR ENSURING NATIONAL DRUG SECURITY
Drug safety is a key element of the national healthcare system, ensuring public access to quality medications.
191-192
23
6
RISK ANALYSIS IN THE PRODUCTION OF EFFERVESCENT TABLETS WITH HERBAL EXTRACTS: A CASE STUDY OF MORUS ALBA L
In modern conditions, there is a growing interest in drugs and biologically active additives containing plant extracts.
193
37
19
ANALYSIS OF THE ASSORTMENT OF BIOLOGICALLY ACTIVE ADDITIVES REGISTERED IN THE REPUBLIC OF UZBEKISTAN
Biologically active additives - the same as natural or the same as natural, will be intended for consumption or inclusion in the composition at the same time as biological food.
194
18
8
PHARMACOECONOMIC APPROACHES TO OPTIMIZING MEDICINE SUPPLY IN THE REPUBLIC OF KAZAKHSTAN
Medicine supply for the population is a key element of the healthcare system of the Republic of Kazakhstan.
195
44
15
COOPERATION IN THE FIELD OF PHARMACEUTICS: EXPERIENCE AND PROSPECTS
International cooperation in pharmaceutics is manifested through the registration of foreign medicines, which contributes to expanding public access to innovative therapies and
improving quality standards.
improving quality standards.
196
31
9
SYSTEMATIC REVIEW AND META-ANALYSIS OF THE EFFICACY AND SAFETY OF TARGETED AND IMMUNOTARGETED AGENTS IN THE TREATMENT OF NON-SMALL CELL LUNG CANCER
Non-small cell lung cancer (NSCLC) remains one of the leading causes of cancer
related morbidity and mortality worldwide
related morbidity and mortality worldwide
197
38
11
HIGH-COST ANTICANCER DRUGS: CLINICAL BENEFIT OR FINANCIAL BURDEN FOR THE HEALTHCARE SYSTEM?
The growing number of innovative but expensive anticancer drugs imposes a significant burden on healthcare systems
198
17
4
MINIMIZATION OF COSTS ON MEDICINES USED IN THE TREATMENT OF STOMACH CANCER
Oncological diseases rank second after cardiovascular diseases in terms of mortality. Stomach cancer is one of the most common oncological diseases
199-200
34
17
CURRENT TRENDS IN THE DEVELOPMENT OF THE PHARMACEUTICAL INDUSTRY: GLOBAL AND NATIONAL EXPERIENCE
the pharmaceutical market remains one of the key sectors of the global economy: rising healthcare expenditures, demographic changes, and technological innovations are shaping new
requirements for quality, marketing, and production localization.
requirements for quality, marketing, and production localization.
201-202
17
5
STRATEGIES FOR REDUCING SIDE EFFECTS OF DRUGS IN ONCOGEMATOLOGICAL DISEASES
Oncogematological diseases, especially in children, can cause serious negative effects and long-term health problems.
203-204
35
12
ANALYSIS OF FACTORS INFLUENCING THE MARKET OF ANTI OSTEOPOROTIC DRUGS
osteoporosis is a systemic disorder characterized by reduced bone mass, strength, and microarchitecture, leading to increased bone fragility.
205-206
26
12
COMPARATIVE ANALYSIS OF EXISTING QUALITY MANAGEMENT SYSTEMS AT PHARMACEUTICAL ENTERPRISES OF THE ALMATY REGION
The development of the pharmaceutical industry in the Almaty region requires the introduction of effective quality management systems based on international GMP standards. This is due to the need to ensure the safety and effectiveness of medicines, as well as Kazakhstan's integration into the regulatory space of the EAEU.
207
36
9
COMPETENCE MODEL OF A PHARMACEUTICAL MANAGER
The modern pharmaceutical industry is undergoing profound transformation. The digitalization of production and management processes, the introduction of artificial intelligence, increased competition in the global market, and the development of biotechnology and personalized medicine require specialists to possess not only professional pharmaceutical knowledge but also a comprehensive set of managerial, strategic, analytical, and communication skills.
208
20
11
DEMAND AND PREFERENCES FOR THE USE OF CARDIOVASCULAR DRUGS
Cardiovascular diseases (CVD) are the leading cause of death worldwide, including in the former Soviet Union.
209
18
6
OVARIAN CANCER INCIDENCE RATE IN THE REPUBLIC OF UZBEKISTAN
According to the 2022 statistics of the Republican Specialized Scientific and Practical Medical Center for Oncology and Radiology , ovarian cancer ranks 7th in the structure of total cancer in the Republic of Uzbekistan, and the incidence of ovarian cancer is 2.9 per 100,000 population. Among the female population of the country, ovarian cancer ranks 3rd after breast cancer and cervical cancer, and is 5.8 per 100,000 female population. In 2022, 1,033 patients with ovarian cancer were diagnosed for the first time.
210
17
10
ECONOMIC ASPECTS OF DEVELOPING A PHYTOGEL BASED ON PURSLANE
Herbal preparations are in high demand due to their safety and biological activity. Purslane (Portulaca oleracea) is a promising source of anti-inflammatory and antioxidant compounds,
making it an attractive candidate for phytogel development.
making it an attractive candidate for phytogel development.
211-212
14
5
CONTENT ANALYSIS OF THE ASSORTMENT OF NON-STEROIDAL ANTI INFLAMMATORY DRUGS
Inflammatory processes represent one of the primary pathogenetic factors in the development of numerous diseases
213-214
19
8
THE MODERN MARKET OF TRANSDERMAL DRUG DELIVERY SYSTEMS: ANALYSIS OF REGISTRIES OF THE REPUBLIC OF KAZAKHSTAN AND THE EAEU
Transdermal therapeutic systems (TTS) represent one of the most promising directions in the development of dosage forms, as they enable controlled delivery of active substances
while bypassing the gastrointestinal tract and reducing the risk of adverse effects.
while bypassing the gastrointestinal tract and reducing the risk of adverse effects.
215-216
21
7
GOVERNMENT SUPPORT MEASURES FOR API MANUFACTURERS IN RUSSIA AND ABROAD
the strategic importance of the development of the active pharmaceutical
substances (API) market for the sustainability of Russian healthcare and reducing import dependence
in the context of global economic and geopolitical challenges
substances (API) market for the sustainability of Russian healthcare and reducing import dependence
in the context of global economic and geopolitical challenges
217
63
8
OVERVIEW OF THE KAZAKHSTAN MARKET FOR PERFUMERY AND COSMETIC PRODUCTS
In the context of globalisation and the tightening of technical regulations of the Eurasian Economic Union TR 009/2011, it is important to analyse the market structure, consumer
preferences and the potential for localising the production of cosmetic products.
preferences and the potential for localising the production of cosmetic products.
218-219
36
10
MODERN PROBLEMS OF PROVIDING THE POPULATION WITH AFFORDABLE AND HIGH-QUALITY MEDICINES
The sustainable development of the pharmaceutical sector plays a decisive role in ensuring public health.
220
11
5
PHARMACOECONOMIC ANALYSIS OF MEDICINES USED IN THE TREATMENT OF PNEUMONIA AND THEIR PRIC ING MECHANISMS
community-acquired pneumonia (VP) retains a leading position in the structure of infectious morbidity, with an annual incidence of 5-20 cases per 1,000 population.
221-222
29
10
MARKETING ANALYSIS OF DRUGS USED IN OBSTETRICS AND GYNECOLOGY
At present, the prevalence of obstetric and gynecological diseases is increasing worldwide, which makes this issue one of the most urgent problems in the global healthcare system.
223
27
13
HUMAN RESOURCES SUPPORT FOR THE PHARMACEUTICAL INDUSTRY: CHALLENGES IN TRAINING SPECIALISTS
human resources support for the pharmaceutical industry is one of the key factors
in its sustainable development and in improving the quality of healthcare services for the population
in its sustainable development and in improving the quality of healthcare services for the population
224-225
39
11
ENSURING THE POPULATION’S ACCESS TO AFFORDABLE AND HIGH QUALITY MEDICINES: CONTEMPORARY CHALLENGES
The sustainable development of the pharmaceutical sector plays a crucial role in
ensuring public health.
ensuring public health.
227-228
41
10
O‘ZBEKISTON FLORASIDA O‘SUVCHI TRIPLEUROSPERMUM DISCIFORME O‘SIMLIGINING FITOKIMYOVIY TARKIBI
Tripleurospermum Sch. Bip. - Uchkarraurug‘ turkumiga mansub oʻsimlik turlari sharq tabobatida keng qoʻllaniladi va tarkibi biologik faol moddalarga boyligi bilan ajralib turadi. Mazkur turkum Asteraceae oilasiga mansub va yer yuzida taxminan 40 ga yaqin turi tarqalgan
229-230
26
5
LIPIDS OF SENNA ANGUSTIFOLIA LEAVES
Senna angustifolia Vahl. (syn. Cassia angustifolia Vahl), from the Fabaceae family, is a valuable medicinal plant that grows in the desert regions of Sudan, Saudi Arabia, and Somalia
231-232
24
5
QUANTITATIVE ANALYSIS OF ASCORBIC ACID IN THE AERIAL PARTS OF BIDENS FRONDOSA L
Medicinal plants contain a complex of chemical compounds that have a diverse and multifaceted effect on the human body.
233-234
25
15
DETERMINATION OF WATER-SOLUBLE VITAMINS IN THE ABOVE-GROUND PART OF THE CREEPING CLOVER
it is well known that vitamins play a role in energy metabolism, the biosynthesis of amino acids and fatty acids, photorepression processes, blood coagulation, calcium absorption, and
more.
more.
235-236
23
18
DEVELOPMENT OF A METHODOLOGY FOR THE ANALYSIS OF SOME PSYCHOTROPIC SUBSTANCES BY THE TLC METHOD
The study of medicinal products containing psychotropic substances should be carried out using a simple, accessible, and rapid method - thin-layer chromatography.
237
35
7
SURUNKALI VENOZ ETISHMOVCHILIGINI DAVOLASHDA QO’LLANILADIGAN DORI VOSITALARINING MARKETING TAHLILI
Venoz etishmovchiligi — qon tomir tizimining eng keng tarqalgan kasalliklaridan biridir.
238
20
10
PROBLEMS AND OPPORTUNITIES OF AUTOMATING QUALITY CONTROL IN A MEDICINE LABORATORY
Automation of quality control in laboratories is becoming an integral part of the production process. On the one hand, it increases the efficiency, accuracy, and speed of laboratory analysis. On the other hand, the implementation of automated systems faces a number of challenges that require a professional approach.
239-240
19
12
STATE OF METROLOGICAL SUPPORT FOR VISCOSITY MEASUREMENT
Today, viscosity measuring instruments are widely used in the oil industry, fuel industry, medicine, cosmetology, and other important industries for assessing product quality and
safety indicators and controlling technological processes in production conditions.
safety indicators and controlling technological processes in production conditions.
241-242
20
4
ETERMINATION OF MINERAL ELEMENTS IN THE ABOVE GROUND PART OF NONEA PULLA L.
Nonea pulla L. is one of the promising medicinal plants, containing tannins, coumarins, organic acids, anthocyanins, vitamin A, ascorbic acid, amino acids, polysaccharides, flavonoids, alkaloids, and microelements, but this plant has not been sufficiently studied.
243-244
28
11
LOPHANTHUS ANISATUS (BENTH) ANALYSIS OF QUERCETIN CONTENT IN THE AERIAL PARTS
According to the data reported in the literature, the raw material of lophanthus anisatus (Benth.) exhibits immunomodulatory activity and contributes to faster recovery from complications of pneumonia, bronchitis, and bronchial asthma.
245-246
24
11
ANALYSIS OF FREE AMINO ACIDS OF FRUITS OF LUFFA ECHINATA ROXB
The Decree of the President of the Republic of Uzbekistan dated January 29, 2025 No. PF-13 “On additional measures for the accelerated development of the pharmaceutical industry” sets out priority tasks such as the development of the biologically active additives industry in order to rapidly develop the pharmaceutical industry, provide the population with medicines of guaranteed
quality, safety and effectiveness, localize production, organize medicinal plant plantations to form raw material bases for industry enterprises, and launch projects for the processing of medicinal plants grown on these plantations by the end of 2026.
quality, safety and effectiveness, localize production, organize medicinal plant plantations to form raw material bases for industry enterprises, and launch projects for the processing of medicinal plants grown on these plantations by the end of 2026.
247-248
19
8
UFFA ECHINATA ROXB. MEVALARINING ERKIN AMINOKISLOTALARI TAXLILI
O‘zbekiston Respublikasi Prezidentining 29 yanvar 2025 yildagi «Farmasevtika tarmog‘ini jadal rivojlantirishga oid qo‘shimcha chora-tadbirlar to‘g‘risida» gi PF-13-son Farmonida
farmasevtika tarmog‘ini jadal rivojlantirish, aholini sifatli, xavfsizligi va samaradorligi kafolatlangan dori vositalari bilan ta'minlash maqsadida biologik faol qo‘shimchalar sanoatini rivojlantirish, ishlab chiqarishni mahalliylashtirish, soha korxonalariga xom ashyo bazalarini shakllantirishda dorivor o‘simliklar plantasiyalarini tashkil etish va 2026 yil yakuniga qadar ushbu plantasiyalarda yetishtirilgan dorivor o‘simliklarni qayta ishlash loyihalari ishga tushirilishi kabi ustuvor vazifalar belgilab berilgan.
farmasevtika tarmog‘ini jadal rivojlantirish, aholini sifatli, xavfsizligi va samaradorligi kafolatlangan dori vositalari bilan ta'minlash maqsadida biologik faol qo‘shimchalar sanoatini rivojlantirish, ishlab chiqarishni mahalliylashtirish, soha korxonalariga xom ashyo bazalarini shakllantirishda dorivor o‘simliklar plantasiyalarini tashkil etish va 2026 yil yakuniga qadar ushbu plantasiyalarda yetishtirilgan dorivor o‘simliklarni qayta ishlash loyihalari ishga tushirilishi kabi ustuvor vazifalar belgilab berilgan.
249-250
11
5
ON THE STUDY OF THE FLAVONOIDS OF LADIGINIA BUCHARICA LIPSKIYI
Within the flora of Uzbekistan, many wild-growing plants remain insufficiently and unevenly studied
251-252
22
13
DETERMINATION OF THE AUTHENTICITY OF THE GLABRUS DRY EXTRACT
For the test solution, 1.0 g of the powdered sample was dissolved in 10 ml of a methanol–water (70:30) mixture and filtered. Depending on the active components of the plant, different mobile-phase
compositions were selected to separate various active substances.
compositions were selected to separate various active substances.
253-254
15
6
PHYTOCHEMICAL STUDY OF COUMARINS IN THE AERIAL PARTS OF PRANGOS FEDTSCHENKOI (REGEL ET SCHMALH.) KOROV
Coumarin compounds are derivatives of cis-ortho-hydroxycinnamic acids. They are known for their biological activities, particularly their anticoagulant effects, while furocoumarins act as photosensitizers, i.e., they increase skin sensitivity to UV radiation (applied in the treatment of vitiligo). From this perspective, the search for coumarin-containing plants, isolation of their bioactive compounds, identification of their chemical structures, and study of their pharmacological activity are highly relevant.
255
29
10
MEDICINAL PLANTS GROWING IN UZBEKISTAN
The traditional use of herbal medicines dates back to long-established historical traditions. Official medicine, based on the experience of folk medicine, confirmed, substantiated, selected, and systematized the most valuable and theoretically understandable information in practice and modern science.
256
20
10
QUANTITATIVE DETERMINATION OF POLYHEXAMETHYLENE GUANIDINE HYDROCHLORIDE IN A COMBINED PHARMACEUTICAL FORMULATION
The development of novel antibacterial agents represents a promising direction in modern medicine. The demand for such drugs is continuously increasing due to the growing
bacterial resistance to existing antimicrobial agents.
bacterial resistance to existing antimicrobial agents.
257-258
23
6
DETERMINATION OF THE MONOSACCHARIDE COMPOSITION BY PAPER CHROMATOGRAPHY METHOD FROM ACORUS CALAMUS L., HELICHRYSI MARACANDICUM POP EX KIRP. AND AERVA LANATA L.
Plant polysaccharides are multifunctional biopolymers with a wide range of pharmacological activities.
259-260
16
5
DETERMINATION OF THE QUANTITY OF COBALT-30 IN THE CAPSULE "KOASK-30" BY THE MASS SPECTROMETRIC METHOD
An analysis of the pricing and assortment policy in the market of antianemic drugs has shown that it is necessary to take measures to develop and introduce into production domestic substances and dosage forms,as well as diversification of regional local production through the development of product varieties and the introduction of import-substituting products.
261-262
19
13
PHYTOCHEMICAL ANALYSIS OF DRIED EXTRACT OBTAINED FROM PLANTS USED IN BILIARY TRACT AND LIVER DISEASES
Currently, liver and gallbladder diseases are widespread among the population, often resulting from irregular eating habits, excessive consumption of fatty products, physical inactivity, and the stagnation of bile
263
20
11
PHYTOCHEMICAL STUDY OF COMMON BASIL LEAVES
this work is aimed at studying the main active ingredients of basil leaves, which have anti-inflammatory, choleretic, antiseptic effects.
264
21
6
ANALYSIS OF THE TRACE ELEMENT COMPOSITION OF TOOTHPASTES
The aim of the study is to determine the micro- and macronutrient composition of toothpastes from various price categories using atomic emission spectral analysis to assess their safety and
effectiveness.
effectiveness.
265-266
19
4
APPLICATION OF THE IMMOBILISATION METHOD TO INCREASE THE STABILITY OF ENZYMES
It should be noted that enzymes have reciprocal and opposite processes, which disrupts the stability of substances in combination with the second component.
267-268
22
7
RAMAN SPECTROSCOPIC IDENTIFICATION OF SULFAMETHOXAZOLE IN PHARMACEUTICAL DOSAGE FORMS
Sulfonamides are a group of compounds with antibacterial activity that have been widely used in medicine since the early 20th century. These substances exert a bacteriostatic effect by inhibiting the growth and reproduction of microbial cells. The mechanism of action of sulfonamides is based on the disruption of the biosynthesis of essential metabolites in bacteria, such as folic acid and dihydrofolate.
269-270
30
15
POLAR LIPIDS OF ACHILLEA MILLEFOLIUM L. LEAVES
Achillea millefolium L. is a perennial halotolerant species widely distributed across Central Asia, the European part of the Russian Federation and Siberia, the Caucasus, Western
Europe and other regions.
Europe and other regions.
271-272
30
10
NEUTRAL LIPIDS OF THE AERIAL PART OF ARTEMISIA JUNCEA
Artemisia juncea Kar. et Kir. (rush-like wormwood, family Asteraceae) is a perennial herbaceous halophytic plant growing on moderately saline soils and is one of the most widespread Artemisia species in the flora of Uzbekistan. A. juncea is widely used in folk and traditional medicine.
273
14
8
COMPARATIVE QUALITY CONTROL AND STANDARDIZATION OF DICLOFENAC-CONTAINING MEDICINAL PRODUCTS IN TABLET FORM
Diclofenac sodium and diclofenac potassium salts to inflammation against, pain leaver and antipyretic features because of medicine in practice wide applicable drugs to the point
They are arthritis, rheumatism, neuralgia, muscles and in the joints the pains in reduction primary from tools is considered.
They are arthritis, rheumatism, neuralgia, muscles and in the joints the pains in reduction primary from tools is considered.
274
26
4
PHYTOCHEMICAL ANALYSIS OF FLAVONOIDS IN HORSETAIL (EQUISETUM ARVENSE)
Flavonoids, being an important group of plant secondary metabolites, play a key role in the physiological functioning of plants and have a wide range of biological activities, including antioxidant, anti-inflammatory, antibacterial and cardioprotective effects. Horsetail (Equisetum arvense) is one of the plants traditionally used in folk medicine, known for its medicinal properties due, among other things, to the presence of flavonoids
275-276
41
9
STUDY OF THE BLACK SEA OLIVE (ELAEAGNUS ANGUSTIFOLIA)
Elaeagnus angustifolia, also known as jida, is a species of oleaster found in Uzbekistan. Its leaves, seeds, and flowers, along with its fruits, contain a complex of biologically active substances.
277
12
3
PHYSIOLOGICAL-BIOCHEMICAL AND MEDICINAL PROPERTIES OF LEMON
In this article, I will provide you with information about citrus fruits that we all love to eat, which are widely distributed worldwide and rich in vitamins beneficial for our body. To discuss the nutritional and therapeutic-prophylactic properties of lemons, a lot of information about its chemical composition has been collected in the literature.
278
17
9
SYNTHESIS OF IMATINIB ESSINATE AND ITS INCLUSION COMPLEXES INHIBITING CANCER CELL PROLIFERATION
Cancer is one of the fastest-growing diseases and ranks second worldwide after cardiovascular diseases in terms of mortality.
279-280
18
8
ASSESSMENT OF MICROBIOLOGICAL PURITY OF CLARY SAGE LEAVES (SALVIA SACLAREA L.)
Salvia L. (sage) is one of the largest genera of the Lamiaceae family. Plants of this genus have long been used in folk and traditional medicine in various countries to relieve pain, protect against oxidative stress, free radical damage, angiogenesis, inflammation, as well as bacterial and viral infections.
281-282
25
6
UZUM BARGIDAN QURUQ EKSTRAKTNI OLISH, TARKIBIDAGI TEMIR MIQDORINI ANIQLASH
So’nggi yillarda yosh bolalarda, ayniqsa xomilador ayollarda, organizmda temir moddasi yetishmasligi natijasida kamqonlik kasalligi ko’payib bormoqda. Bu kasalliklarda xozirgi kunda temir (II) tuzlari qo’shilgan xar xil nomlardagi dori vositalari mavjud bo’lib, bemorlar tomonidan qabul qilinib kelinmoqda.
283
19
7
STORAGE REQUIREMENTS AND SHELF LIFE OF THE DIURETIC HERBAL PREPARATION ‘ALERVA’
Herbal preparations are medicinal products based on plant components such as herbs, flowers, roots, and fruits. They possess various therapeutic and restorative properties and are
often used as preventive remedies.
often used as preventive remedies.
284-285
17
7
РАЗРАБОТКА МЕТОДА ВЭЖХ ПРИ АНАЛИЗЕ ПРЕПАРАТА «РЕГИДРЕЙД ЦИНК»
Создание высокоэффективных многокомпонентных лекарств является одной из основных практических задач современной фармации, поэтому важна проблема контроля, связанная с точной оценкой качественного и количественного состава препаратов.
286-287
22
8
STUDY OF THE VITAMIN COMPOSITION OF HIPPOPHAE RHAMNOIDES
Sea buckthorn (Hippophaë rhamnóides) is a valuable source of biologically active substances. While the fruit is well-studied, the leaves remain less well-researched, although they contain a complex of vitamins and antioxidants. Determination of their vitamin composition is important for use in the pharmaceutical and food industries, as well as for the prevention of hypovitaminosis.
288-289
18
11
ARSLONQUYRUQ O‘SIMLIK YER USTKI QISMI XOMASHYOSIDAN SUV YORDAMIDA QURUQ EKSTRAKT OLISH
Biofaol dorivor moddalarni o‘simliklardan ajratib olish , biofaol bo‘lgan moddalarni xar tomonlama kimyoviy , fizik-kimyoviy tahlil usullarini ishlab chiqish va dori vositasini yaratish , uni standartlash, sifatini belgilash davr talabi bo‘lib qoldi. Dori vositalarini tahlil qilib, samaradorligini fizik-kimyoviy usullar yordamida tadqiqot usullaridan foydalangan xolda sifatini belgilash talab etilmoqda.
290-291
21
6
YANTOQ O’SIMLIGIDAN QURUQ ESTRAKT OLISH VA UNING TAHLILI
Oʻzbekiston hududlarida keng tarqalib oʻsadigan yantoq
(верблюжья колючка) oʻsimligini hom ashyosidan suv yordamida quruq ekstrakt olish.
Tadqiqot maqsadi: Ishni maqsadi Toshkent viloyati, Bo‘stonliq rayonida o‘stirilgan yantoq
(Alhagi pseudalhagi - Верблюжья колючка) oʻsimligining er ustki qismidan suv yordamida quruq
ekstrakt olib yig’indini foiz miqdorini aniqlash
(верблюжья колючка) oʻsimligini hom ashyosidan suv yordamida quruq ekstrakt olish.
Tadqiqot maqsadi: Ishni maqsadi Toshkent viloyati, Bo‘stonliq rayonida o‘stirilgan yantoq
(Alhagi pseudalhagi - Верблюжья колючка) oʻsimligining er ustki qismidan suv yordamida quruq
ekstrakt olib yig’indini foiz miqdorini aniqlash
292-293
43
9
“САФРОБОЗ” ЙИҒМАСИ ТАРКИБИДАГИ ОКСИДОЛЧИН КИСЛОТАЛАР ЙИҒИНДИСИНИНГ МИҚДОРИНИ АНИҚЛАШ
Доривор ўсимликлар асосида олинган сафро хайдовчи воситаларга клиник
амалиётида талаб катта, негаки уларни таъсири синтетик дори воситаларга нисбатан
юмшоқроқ ва таъсири давомийлироқ. Ўсиликлардан олинадиган дори воситаларини сафро
хайдовчи хусусиятини ошириш ва ёндош касалликларни даволаш мақсадида ҳар–ҳил
ўсимликлардан турли йиғмалар фойдаланилади.
амалиётида талаб катта, негаки уларни таъсири синтетик дори воситаларга нисбатан
юмшоқроқ ва таъсири давомийлироқ. Ўсиликлардан олинадиган дори воситаларини сафро
хайдовчи хусусиятини ошириш ва ёндош касалликларни даволаш мақсадида ҳар–ҳил
ўсимликлардан турли йиғмалар фойдаланилади.
294-295
23
13
ОПРЕДЕЛЕНИЕ БИОЛОГИЧЕСКИ АКТИВНЫХ ВЕЩЕСТВ И МИКРОБИОЛОГИЧЕСКОЙ ЧИСТОТЫ В НОВОМ ЖЕЛЧЕГОННОМ СБОРЕ
Желчегонные средства, нормализуя отток желчи эффективно используются
при лечении патологии печени и желчного пузыря
при лечении патологии печени и желчного пузыря
296-297
21
13
TAGETES PATULA L. XOMASHYOSI TARKIBIDAGI ERUVCHAN VITAMINLARNI YUSSX USULIDA ANIQLASH
Xalq tabobatida Tagetes patula L. o‘simligining to‘pgullaridan olinadigan
damlamalar va qaynatmalardan keng foydalanadi. O‘simlik tarkibining biologik moddalar bilan
boyliligi unga yallig‘lanishga qarshi, antibakterial, antioksidant, peshob haydovchi, tinchlantiruvchi,
gastroprotektor xususiyatlar beradi. Tagetes patula L. o‘simligidan tayyorlangan preparatlarni
tibbiyot amaliyotiga joriy etish uchun ushbu o‘simlig xomashyosining kimyoviy tarkibini yanada
chuqurroq o‘rganish maqsadida eruvchan vitaminlar tadqiq etildi.
damlamalar va qaynatmalardan keng foydalanadi. O‘simlik tarkibining biologik moddalar bilan
boyliligi unga yallig‘lanishga qarshi, antibakterial, antioksidant, peshob haydovchi, tinchlantiruvchi,
gastroprotektor xususiyatlar beradi. Tagetes patula L. o‘simligidan tayyorlangan preparatlarni
tibbiyot amaliyotiga joriy etish uchun ushbu o‘simlig xomashyosining kimyoviy tarkibini yanada
chuqurroq o‘rganish maqsadida eruvchan vitaminlar tadqiq etildi.
298
18
6
QUANTITATIVE DETERMINATION OF L-ARGININE HYDROCHLORIDE IN THE DRUG "ESCILAR" BY THE TITRATION METHOD
High drug quality is one of the most important criteria for producing a highly
effective and safe medication. In modern medicine, medications containing amino acids are widely
used for the diagnosis, treatment, and prevention of many diseases. Compared to more complex
methods, titration offers a good price-performance ratio, being a more accessible method of
quantitative analysis. This method allows for the determination of substance content with high
accuracy, down to hundredths of a milligram. Compared to more complex methods, titration offers a
good price-performance ratio, being a more accessible method of quantitative analysis. Therefore, the
use of titration remains relevant and in demand today.
effective and safe medication. In modern medicine, medications containing amino acids are widely
used for the diagnosis, treatment, and prevention of many diseases. Compared to more complex
methods, titration offers a good price-performance ratio, being a more accessible method of
quantitative analysis. This method allows for the determination of substance content with high
accuracy, down to hundredths of a milligram. Compared to more complex methods, titration offers a
good price-performance ratio, being a more accessible method of quantitative analysis. Therefore, the
use of titration remains relevant and in demand today.
299-300
21
7
ФУРАДРАЗОЛ ДОРИ ВОСИТАСИНИ ЮССХ УСУЛИДА ТАҲЛИЛИ
Юқори самарали кўп компонентли дори воситаларини ишлаб
чиқиш замонавий фармациянинг асосий амалий вазифаларидан бирига кириб, уларнинг сифат
ва миқдорий таркибини аниқ учун муқобил таҳлил усулларини ишлаб чиқиш муҳим аҳамиятга
эга. Турли ҳил табиатдаги моддаларни ўз ичига олган кўп компонентли дори моддаларни
таҳлил қилиш одатда маълум қийинчиликлар билан боғлиқ
чиқиш замонавий фармациянинг асосий амалий вазифаларидан бирига кириб, уларнинг сифат
ва миқдорий таркибини аниқ учун муқобил таҳлил усулларини ишлаб чиқиш муҳим аҳамиятга
эга. Турли ҳил табиатдаги моддаларни ўз ичига олган кўп компонентли дори моддаларни
таҳлил қилиш одатда маълум қийинчиликлар билан боғлиқ
301-302
27
5
DETERMINATION OF THE CRYSTAL STRUCTURE OF THE SUBSTANCE "VIAREN"
In pharmaceutical technology, most substances used in the development of solid
dosage forms have a powdery nature. During the technological processing of such active substances,
their physicochemical and technological properties are taken into account. According to
biopharmaceutical theory, the quality indicators and bioavailability of finished dosage forms largely
depend on the physicochemical and technological parameters of the medicinal substances, primarily
on the crystalline modifications of the particles.
dosage forms have a powdery nature. During the technological processing of such active substances,
their physicochemical and technological properties are taken into account. According to
biopharmaceutical theory, the quality indicators and bioavailability of finished dosage forms largely
depend on the physicochemical and technological parameters of the medicinal substances, primarily
on the crystalline modifications of the particles.
303-304
9
16
BIOECOLOGICAL PROPERTIES OF AKMELLA OLERACEAE (L.) R.K.JANSEN UNDER INTRODUCTION CONDITIONS
For the treatment and timely prevention of diseases, medicinal plants containing
bioactive substances are used to obtain pure preparations. Akmella oleraceae is one of the medicinal
plants containing bioactive substances. Akmella oleraceae (L.) R.K.Jansen is an annual herb
belonging to the Asteraceae family.
bioactive substances are used to obtain pure preparations. Akmella oleraceae is one of the medicinal
plants containing bioactive substances. Akmella oleraceae (L.) R.K.Jansen is an annual herb
belonging to the Asteraceae family.
305
23
8
QUALITY CONTROL AND STANDARDIZATION OF BIOACTIVE COMPOUNDS IN THE DRY EXTRACT 'EXTRADENT'
Herbal preparations remain an important direction in pharmaceutical science due
to their wide pharmacological effects and relatively low toxicity. 'Extradent' is a dry extract consisting
of Calendula officinalis, Urtica dioica, Capsella bursa-pastoris, and Polygonum hydropiper. These
plants are known to contain flavonoids, carotenoids, tannins, amino acids, and mineral elements that
contribute to the therapeutic properties of the preparation.
to their wide pharmacological effects and relatively low toxicity. 'Extradent' is a dry extract consisting
of Calendula officinalis, Urtica dioica, Capsella bursa-pastoris, and Polygonum hydropiper. These
plants are known to contain flavonoids, carotenoids, tannins, amino acids, and mineral elements that
contribute to the therapeutic properties of the preparation.
306-307
16
6
DETERMINATION OF STABILITY OF THE COMBINED HEPATOPROTECTIVE DRUG “HEPATON”
Stability is one of the key criteria of the quality of medicinal products,
determining their effectiveness, safety, and shelf life. It is especially critical to take this parameter
into account in the development and production of infusion solutions, since they are administered
directly into the systemic bloodstream, bypassing the protective barriers of the body. This means that
any changes in the composition or properties of such solutions can immediately affect the patient’s
condition. In this regard, infusion preparations must have a high degree of physicochemical stability
and strictly comply with a number of parameters close to physiological ones: osmolarity, pH level,
transparency, viscosity, and sterility.
determining their effectiveness, safety, and shelf life. It is especially critical to take this parameter
into account in the development and production of infusion solutions, since they are administered
directly into the systemic bloodstream, bypassing the protective barriers of the body. This means that
any changes in the composition or properties of such solutions can immediately affect the patient’s
condition. In this regard, infusion preparations must have a high degree of physicochemical stability
and strictly comply with a number of parameters close to physiological ones: osmolarity, pH level,
transparency, viscosity, and sterility.
308-309
56
23
O’ZBEKISTONDA YETISHTIRILGAN DORIXONA UKROPI (FOENICULUM VULGARE MILL.) MEVASI BIOLOGIK FAOL MODDALARI TAHLILI
Dorixona ukropi (Foeniculum vulgare Mill.) soyabonguldoshlar oilasiga mansub
o’simlik bo’lib, O’zbekiston Respublikasi ko’pgina viloyatlarida yetishtiriladi. Mevasi efir moyiga
boy bo’lib, farmatsevtikada keng qo’llaniladi. Adabiyotlar manbaalarini o’rganish natijasi shuni
ko’rsatdiki, ushbu o’simlik mevasi biologik faol moddalari O’zbekistonda kam o’rganilgan.
o’simlik bo’lib, O’zbekiston Respublikasi ko’pgina viloyatlarida yetishtiriladi. Mevasi efir moyiga
boy bo’lib, farmatsevtikada keng qo’llaniladi. Adabiyotlar manbaalarini o’rganish natijasi shuni
ko’rsatdiki, ushbu o’simlik mevasi biologik faol moddalari O’zbekistonda kam o’rganilgan.
310-311
93
9
STUDYING THE ELEMENT COMPOSITION OF DRY EXTRACT FROM TRIBULUS TERRESTRIS L.
Microelements are essential for living organisms, and numerous studies have
shown that minerals play a major role in human life. This is because without them, vital processes
cannot proceed properly. They also ensure the formation of the chemical structure of all human
tissues, including muscle tissue. It is known that plant macro- and microelements are better absorbed
by the human body. Unlike organic compounds in the human body, they are not synthesized, but are
obtained only through food. Therefore, a systematic study of the mineral composition of medicinal
plants and preparations obtained from them is of great importance in pharmacy. Tribulus terrestris is
a promising plant with sufficient reserves and is widely distributed in Uzbekistan. It is being studied
for the purpose of obtaining medicines and biologically active additives. In the process of analysis, it
is important to study the elemental composition of the dry extract obtained for the purpose of
developing a medicine.
shown that minerals play a major role in human life. This is because without them, vital processes
cannot proceed properly. They also ensure the formation of the chemical structure of all human
tissues, including muscle tissue. It is known that plant macro- and microelements are better absorbed
by the human body. Unlike organic compounds in the human body, they are not synthesized, but are
obtained only through food. Therefore, a systematic study of the mineral composition of medicinal
plants and preparations obtained from them is of great importance in pharmacy. Tribulus terrestris is
a promising plant with sufficient reserves and is widely distributed in Uzbekistan. It is being studied
for the purpose of obtaining medicines and biologically active additives. In the process of analysis, it
is important to study the elemental composition of the dry extract obtained for the purpose of
developing a medicine.
312-313
14
4
SPECTROSCOPIC ANALYSIS OF 2-METHYLTHIOBENZOXAZOLE AND THEIR COMPLEX COMPOUNDS WITH 3D-METALS
Derivatives of oxazole and 2-aminothiobenzoxazole are recognized as substances of medical
importance. It is known that oxazole derivatives are substances with various pharmacological effects.
For example, it is used as a remedy against cancer, microbes, inflammation, herbicide, antibacterial,
antiviral, antihistamine, antioxidant, estrogen receptor inhibitor, and hepatitis C virus. Compounds of
2-aminothiobenzoxazole also have luminescent properties.
importance. It is known that oxazole derivatives are substances with various pharmacological effects.
For example, it is used as a remedy against cancer, microbes, inflammation, herbicide, antibacterial,
antiviral, antihistamine, antioxidant, estrogen receptor inhibitor, and hepatitis C virus. Compounds of
2-aminothiobenzoxazole also have luminescent properties.
314-315
23
12
LOCAL UNDER THE CIRCUMSTANCES CULTIVATED SPANISH LAVENDER (LAVANDULA STOIC L.) OF PHARMACOGNOSTIC FEATURES AND STANDARDIZATION CRITERIA
Last in years Uzbekistan In the Republic medicinal plants cultivation, reproduction
work and them pharmaceutical to practice current to grow issues state on a scale current direction as
confession Our Republic Presidential Decree No. PQ-4901 of November 26, 2020 “On measures to
expand the scope of scientific research on the cultivation and processing of medicinal plants, and the
development of their seed production” in the decision new, promising medicinal plants scientific
basically study, their raw material standardization and pharmacopoeia requirements suitable quality
standards working exit task This is fixed. plant our country in the flora natural accordingly wide not
distributed and pharmacognostic features enough unexplored because of it scientific in terms of
research to do, morphological, anatomical and physicochemical indicators determination and
medicinal raw material as standardization criteria working exit pharmaceutical working release, local
medicinal drugs assortment in expansion current importance profession will reach.
work and them pharmaceutical to practice current to grow issues state on a scale current direction as
confession Our Republic Presidential Decree No. PQ-4901 of November 26, 2020 “On measures to
expand the scope of scientific research on the cultivation and processing of medicinal plants, and the
development of their seed production” in the decision new, promising medicinal plants scientific
basically study, their raw material standardization and pharmacopoeia requirements suitable quality
standards working exit task This is fixed. plant our country in the flora natural accordingly wide not
distributed and pharmacognostic features enough unexplored because of it scientific in terms of
research to do, morphological, anatomical and physicochemical indicators determination and
medicinal raw material as standardization criteria working exit pharmaceutical working release, local
medicinal drugs assortment in expansion current importance profession will reach.
316
15
11
DEVELOPMENT AND STANDARDIZATION OF SYNBIOTICS WITH LACTOBACTERIUM PLANTARUM SUBSTANCE AND OLIGOSACCHARIDES
According to the definition by the World Health Organization (WHO), probiotics
are viable microorganisms that, when administered in adequate amounts, confer a health benefit on
the host. In 2013, the International Scientific Association for Probiotics and Prebiotics refined this
definition, stating that the term «probiotic» may only be applied to preparations that meet the
following requirements: accurate information on the microorganisms present, including their strains,
is provided; a sufficient number of viable bacteria is maintained until the end of the shelf life; and
studies confirming the safety and efficacy of the introduced strains are available. Thus, fermented
food products and fecal transplants that do not specify species and strain composition are not
considered probiotics. Experimental studies and numerous clinical observations have shown that
different probiotic strains are necessary for the correction of intestinal symptoms.
are viable microorganisms that, when administered in adequate amounts, confer a health benefit on
the host. In 2013, the International Scientific Association for Probiotics and Prebiotics refined this
definition, stating that the term «probiotic» may only be applied to preparations that meet the
following requirements: accurate information on the microorganisms present, including their strains,
is provided; a sufficient number of viable bacteria is maintained until the end of the shelf life; and
studies confirming the safety and efficacy of the introduced strains are available. Thus, fermented
food products and fecal transplants that do not specify species and strain composition are not
considered probiotics. Experimental studies and numerous clinical observations have shown that
different probiotic strains are necessary for the correction of intestinal symptoms.
317
22
20
MACROSCOPIC EXAMINATION OF THE COMMON SELF-HEAL (PRUNELLA VULGARIS L.)
Common self-heal (Prunella vulgaris L.) is a promising medicinal plant used in
folk medicine as an anti-inflammatory, antihistamine, antibacterial, and antifungal agent. In light of
the growing interest in herbal preparations, the study of morphological characteristics of the above
ground parts of this species growing in the Republic of Uzbekistan is of particular importance.
folk medicine as an anti-inflammatory, antihistamine, antibacterial, and antifungal agent. In light of
the growing interest in herbal preparations, the study of morphological characteristics of the above
ground parts of this species growing in the Republic of Uzbekistan is of particular importance.
318
17
6
DETERMINATION OF COMMODITY INDICATORS (FINENESS AND IMPURITIES) OF NEPETA DENSIFLORA HERB
The primary source for the search of new medicinal plants
is the arsenal of traditional medicine. Various species of the genus Nepeta (family Lamiaceae) are
used in folk medicine to strengthen and stabilize the immune system, enhance the overall tone of the
body, and reduce the impact of adverse environmental factors on human health.
is the arsenal of traditional medicine. Various species of the genus Nepeta (family Lamiaceae) are
used in folk medicine to strengthen and stabilize the immune system, enhance the overall tone of the
body, and reduce the impact of adverse environmental factors on human health.
319
28
20
REACTION OF 4,6-DIAMINO-2-MERCAPTOPYRIMIDINE WITH ALKYL HALIDE
Pyrimidine derivatives are among the most important compounds in medicinal chemistry and
pharmaceutics [1], possessing a wide range of biological activities, including antidiabetic [2], anti
inflammatory [3], anticancer [4], antibacterial [5], antihypertensive, as well as antifungal and
antitubercular properties
pharmaceutics [1], possessing a wide range of biological activities, including antidiabetic [2], anti
inflammatory [3], anticancer [4], antibacterial [5], antihypertensive, as well as antifungal and
antitubercular properties
320-321
32
13
SPECTROPHOTOMETRIC DETERMINATION OF TRACE AMOUNTS OF SILVER(I) IONS USING H-RESORCINOL
A new organic reagent, H-resorcinol, was employed as a highly sensitive, selective,
and rapid-acting reagent for the determination of silver (I) ions. The interaction of silver (I) with H
resorcinol occurs through the formation of a stable coordination bond. At pH = 10, an ammonia buffer
solution was used as a background electrolyte, resulting in the formation of a 1:1 (silver:H-resorcinol)
molar ratio complex. This approach is of particular importance, as the reliable and selective
determination of trace silver ions holds significant analytical value in environmental monitoring,
pharmaceutical analysis, and industrial quality control, where the accurate detection of even very low
concentrations of silver is essential.
and rapid-acting reagent for the determination of silver (I) ions. The interaction of silver (I) with H
resorcinol occurs through the formation of a stable coordination bond. At pH = 10, an ammonia buffer
solution was used as a background electrolyte, resulting in the formation of a 1:1 (silver:H-resorcinol)
molar ratio complex. This approach is of particular importance, as the reliable and selective
determination of trace silver ions holds significant analytical value in environmental monitoring,
pharmaceutical analysis, and industrial quality control, where the accurate detection of even very low
concentrations of silver is essential.
322-323
21
2
HIRSHFELD SURFACE ANALYSIS OF THE CRYSTAL STRUCTURE OF THE COMPLEX COMPOUND OF Cu (II) NITRATE BASED ON THE 2,5-DI (METHYLTHIO) -1,3,4-THIADIAZOLE LIGAND
Currently, the Hirshfeld surface analysis method is widely used to identify
intermolecular interactions in the crystal structure of compounds and to study their impact on the
stability of the crystal lattice. The theoretical data obtained through this method are yielding good
results in studying the practical properties of crystals. Therefore, investigating the structure of this
complex using this method is one of the urgent scientific issues of the research.
intermolecular interactions in the crystal structure of compounds and to study their impact on the
stability of the crystal lattice. The theoretical data obtained through this method are yielding good
results in studying the practical properties of crystals. Therefore, investigating the structure of this
complex using this method is one of the urgent scientific issues of the research.
324
24
19
IN VITRO CULTIVATION OF RED-SOIL ASTRAGALUS (ASTRAGALUS TERRAE RUBRAE BUTKOV)
The flora of Uzbekistan is rich and diverse, containing numerous rare and endemic
plant species. Among them, Red-soil Astragalus (Astragalus terrae rubrae Butkov) is a unique
endemic species listed in the “Red Book of Uzbekistan.” This plant is distinguished by its high content
of bioactive compounds such as flavonoids, saponins, polysaccharides, and organic acids. These
components exhibit cardioprotective, immunostimulatory, and anti-inflammatory activities, making
the species a valuable resource for pharmaceutical applications. However, the progressive reduction
of its natural populations highlights the necessity of employing in vitro biotechnological approaches
for its conservation and large-scale propagation
plant species. Among them, Red-soil Astragalus (Astragalus terrae rubrae Butkov) is a unique
endemic species listed in the “Red Book of Uzbekistan.” This plant is distinguished by its high content
of bioactive compounds such as flavonoids, saponins, polysaccharides, and organic acids. These
components exhibit cardioprotective, immunostimulatory, and anti-inflammatory activities, making
the species a valuable resource for pharmaceutical applications. However, the progressive reduction
of its natural populations highlights the necessity of employing in vitro biotechnological approaches
for its conservation and large-scale propagation
325-326
28
13
HIRSHFELD SURFACE ANALYSIS OF THE COMPLEX FORMED BY Cu (II) NITRATE WITH 1-ETHYL-2- (ETHYLTHIO) -1H-BENZO[d]IMIDAZOLE
Hirschfeld surface analysis is a method that enables a more
analytical study of intermolecular interactions. This analytical technique allows for the investigation
and visualization of the size, shape, quality, and quantity of intermolecular contact surfaces in
molecular crystals.
analytical study of intermolecular interactions. This analytical technique allows for the investigation
and visualization of the size, shape, quality, and quantity of intermolecular contact surfaces in
molecular crystals.
327
62
20
LICORICE ROOT (GLYCYRRHIZA GLABRA L.) AS A MEDICINAL PLANT FROM SOUTHERN KAZAKHSTAN
Licorice (Glycyrrhiza spp.) is a genus of perennial legumes whose roots are widely
used in traditional medicine as an expectorant, anti-inflammatory, and antiviral agent. In Kazakhstan,
licorice is found in the steppes and along moist river floodplains, especially in the southern regions
(Turkestan, Zhambyl, and Almaty regions). In recent years, there has been intensive harvesting of
wild-growing stocks, which puts the species at risk in some areas. Objective: To characterize the
phytochemical profile of licorice roots collected in the southern regions of Kazakhstan and to assess
the potential of licorice for the phytomelioration of saline soils.
used in traditional medicine as an expectorant, anti-inflammatory, and antiviral agent. In Kazakhstan,
licorice is found in the steppes and along moist river floodplains, especially in the southern regions
(Turkestan, Zhambyl, and Almaty regions). In recent years, there has been intensive harvesting of
wild-growing stocks, which puts the species at risk in some areas. Objective: To characterize the
phytochemical profile of licorice roots collected in the southern regions of Kazakhstan and to assess
the potential of licorice for the phytomelioration of saline soils.
328-329
15
14
SYNTHESIS OF MEDICINES BASED ON THE COORDINATION COMPOUND OF Zn(II) WITH GLUTARIC AND NICOTINIC ACIDS
Chronic deficiency of the trace element zinc is known to lead to immunodeficiency. Zinc is an
effective immunostimulant. Zinc is present in all internal organs, tissues, fluids, and almost 100% of
the body's enzymatic systems. Zinc acts as a "secondary mediator" of immune cells and significantly
shortens the duration of inflammation. When a person catches a cold, a large amount of zinc is
consumed in the first few hours, and the need for it increases 6-8 times. Zinc has anti-inflammatory,
antioxidant, and antibacterial properties. Zinc reduces susceptibility to acute lower respiratory tract
infections. Zinc ions stimulate the production of endogenous α- and γ-interferons, which also exert
antiviral activity, including against COVID-19.
effective immunostimulant. Zinc is present in all internal organs, tissues, fluids, and almost 100% of
the body's enzymatic systems. Zinc acts as a "secondary mediator" of immune cells and significantly
shortens the duration of inflammation. When a person catches a cold, a large amount of zinc is
consumed in the first few hours, and the need for it increases 6-8 times. Zinc has anti-inflammatory,
antioxidant, and antibacterial properties. Zinc reduces susceptibility to acute lower respiratory tract
infections. Zinc ions stimulate the production of endogenous α- and γ-interferons, which also exert
antiviral activity, including against COVID-19.
330-331
20
10
SYNTHESIS OF POLYMERIC NITROGEN DONATIONS BASED ON INULIN DERIVATIVES
Nitric oxide (NO) donors are widely used in the treatment of cardiovascular
diseases, pulmonary hypertension, and are also actively studied in the treatment of neurodegenerative
pathologies. Such drugs as Nitroglycerin, Molsidomine and Nicorandil are capable of releasing nitric
oxide. In the context of the growing number of chronic diseases and an aging population, there is a
growing need for effective and safe means regulating the bioavailability of NO. In addition, the
improvement of synthesis methods makes it possible to obtain nitrogen donors with a given structure
that ensures controlled release of NO under physiological conditions of the body. For these reasons,
the development of new methods for the synthesis of nitrogen donors with controlled release and high
biocompatibility is becoming a particularly interesting task.
diseases, pulmonary hypertension, and are also actively studied in the treatment of neurodegenerative
pathologies. Such drugs as Nitroglycerin, Molsidomine and Nicorandil are capable of releasing nitric
oxide. In the context of the growing number of chronic diseases and an aging population, there is a
growing need for effective and safe means regulating the bioavailability of NO. In addition, the
improvement of synthesis methods makes it possible to obtain nitrogen donors with a given structure
that ensures controlled release of NO under physiological conditions of the body. For these reasons,
the development of new methods for the synthesis of nitrogen donors with controlled release and high
biocompatibility is becoming a particularly interesting task.
332
18
14
OBTAINING A HERBAL COMPOSITION WITH HEPATOPROTECTIVE PROPERTIES AND DETERMINING THE QUALITY INDICATORS IN ITS COMPOSITION
The search for herbal remedies that increase the liver’s resistance to the harmful
effects of toxins and stimulate detoxification processes is relevant .
effects of toxins and stimulate detoxification processes is relevant .
333
19
16
SYNTHESIS OF POLYMER BASES BASED ON INULIN
In recent decades, researchers have paid special attention to natural polymers as a
basis for creating biocompatible materials that are widely used in medicine, pharmaceuticals, food
and cosmetics industries. One of these promising polysaccharides is inulin, a plant
heteropolysaccharide consisting mainly of fructose residues. Inulin has a number of valuable
properties: it is non-toxic, resistant to human digestive enzymes and can be chemically modified,
which makes it attractive for obtaining new functional materials. Due to its bioavailability and ability
to structural modification, inulin opens up wide opportunities for creating materials with adjustable
properties. For example, various polymer bases with specified physicochemical and biological
properties can be created on the basis of inulin. In turn, polymer bases can find application as drug
carriers, as well as as components of hydrogel systems and composite materials.
basis for creating biocompatible materials that are widely used in medicine, pharmaceuticals, food
and cosmetics industries. One of these promising polysaccharides is inulin, a plant
heteropolysaccharide consisting mainly of fructose residues. Inulin has a number of valuable
properties: it is non-toxic, resistant to human digestive enzymes and can be chemically modified,
which makes it attractive for obtaining new functional materials. Due to its bioavailability and ability
to structural modification, inulin opens up wide opportunities for creating materials with adjustable
properties. For example, various polymer bases with specified physicochemical and biological
properties can be created on the basis of inulin. In turn, polymer bases can find application as drug
carriers, as well as as components of hydrogel systems and composite materials.
334-335
33
3
FENUGREEK - A NEW PROMISING MEDICINAL PLANT OF UZBEKISTAN
In recent years, great attention has been paid to the development of medicinal plants
in the country at the state level. In this regard, a number of resolutions and decrees of the President
of the Republic of Uzbekistan, in particular, the Decree No. PF-139 dated May 20, 2022 "On
measures to create an added value chain through the effective use of the raw material base of
medicinal plants, support for processing", stipulates that all districts of the Republic should specialize
in the cultivation of anise, saffron, lovage, lavender, stevia, chamomile, marigold, lovage, yarrow,
yarrow, yarrow, yarrow, peppermint and other medicinal plants, and in this regard, from 2022 to
2026, new medicinal plant plantations will be established on an area of 36,000 hectares.In 2017, the
Decree of the President of the Republic of Uzbekistan PF-5032 "On the establishment of the free
economic zones "Nukus-Farm", "Zomin-Farm", "Kosonsoy-Farm", "Syrdaryo-Farm", "Boysun
Farm", "Bostonliq-Farm", "Parkent-Farm" also provided for the establishment of the cultivation of
medicinal plants in these territories. In order to ensure the implementation of this DecreeNova Pharm
JV has acquired the Boysun-farm land plot for the cultivation of various medicinal plants, in particular
turmeric and fenugreek plants imported from India, which are used as raw materials for Ayurvedic
medicines.
in the country at the state level. In this regard, a number of resolutions and decrees of the President
of the Republic of Uzbekistan, in particular, the Decree No. PF-139 dated May 20, 2022 "On
measures to create an added value chain through the effective use of the raw material base of
medicinal plants, support for processing", stipulates that all districts of the Republic should specialize
in the cultivation of anise, saffron, lovage, lavender, stevia, chamomile, marigold, lovage, yarrow,
yarrow, yarrow, yarrow, peppermint and other medicinal plants, and in this regard, from 2022 to
2026, new medicinal plant plantations will be established on an area of 36,000 hectares.In 2017, the
Decree of the President of the Republic of Uzbekistan PF-5032 "On the establishment of the free
economic zones "Nukus-Farm", "Zomin-Farm", "Kosonsoy-Farm", "Syrdaryo-Farm", "Boysun
Farm", "Bostonliq-Farm", "Parkent-Farm" also provided for the establishment of the cultivation of
medicinal plants in these territories. In order to ensure the implementation of this DecreeNova Pharm
JV has acquired the Boysun-farm land plot for the cultivation of various medicinal plants, in particular
turmeric and fenugreek plants imported from India, which are used as raw materials for Ayurvedic
medicines.
336-337
23
4
SYNTHESIS AND CHARACTERIZATION OF HYDROXYAPATITE NANOPARTICLES FOR BIOMEDICAL APPLICATIONS
In this study, the synthesis of hydroxyapatite (HA) is reported. Currently, in addition to the
traditional (oral and injection) methods of drug delivery to the body, delivery using some chemical
means (micelles, liposomes, etc.) is more preferred by researchers. When using these tools, the
advantages of such substances are that they can reduce the cytotoxicity of chemotherapeutic agents,
reduce the amount of administered drugs, target delivery, and other features. In our studies, the
nanopolymers used for drug delivery encountered some barriers in crossing the cornea of the skin.
When HA nanoparticles were used they provided mechanical strength due to their crystalline
structure. A hydrothermal synthesis method was used to synthesize HA nanoparticles.
traditional (oral and injection) methods of drug delivery to the body, delivery using some chemical
means (micelles, liposomes, etc.) is more preferred by researchers. When using these tools, the
advantages of such substances are that they can reduce the cytotoxicity of chemotherapeutic agents,
reduce the amount of administered drugs, target delivery, and other features. In our studies, the
nanopolymers used for drug delivery encountered some barriers in crossing the cornea of the skin.
When HA nanoparticles were used they provided mechanical strength due to their crystalline
structure. A hydrothermal synthesis method was used to synthesize HA nanoparticles.
338-339
35
11
MORPHOLOGICAL STRUCTURE OF THE TRIPOLIUM PLANT GROWING WILD IN OUR REPUBLIC
The Tripolium plant (especially species such as Tripolium vulgare and Tripolium
pannonicum) grows wild in Uzbekistan, but their morphological and chemical characteristics have
not been sufficiently studied. For the Pharmacopoeia of the Republic of Uzbekistan, the scientific
study of new medicinal plants and the development of quality standards serve as an important source
for the production of medicinal preparations.
pannonicum) grows wild in Uzbekistan, but their morphological and chemical characteristics have
not been sufficiently studied. For the Pharmacopoeia of the Republic of Uzbekistan, the scientific
study of new medicinal plants and the development of quality standards serve as an important source
for the production of medicinal preparations.
340-341
28
12
ISOLATION OF THE METABOLITES FROM ASTRAGALUS ALOPECIAS AND DETERMINATION OF THEIR CHEMICAL STRUCTURE
Currently, the drugs used in medicine are mainly synthetic drugs, their therapeutic
effect is effective and fast, but they have some harmful effects. Therefore, a lot of work is being done
in the world to create drugs from relatively harmless plant raw materials. In Uzbekistan, providing
our people with harmless, high-quality, affordable drugs remains one of the important tasks of our
state policy.
effect is effective and fast, but they have some harmful effects. Therefore, a lot of work is being done
in the world to create drugs from relatively harmless plant raw materials. In Uzbekistan, providing
our people with harmless, high-quality, affordable drugs remains one of the important tasks of our
state policy.
342-343
22
13
SYNTHESIS OF SUPERCHARGED CHITOSAN DERIVATIVES
Modern polymer chemistry is actively evolving toward the development of
functionalized biopolymers with tailored physicochemical and biomedical properties. Chitosan, a
derivative of chitin, is a polymer containing reactive amino groups, which makes it a promising raw
material for the design of novel biologically active macromolecular systems. One of the key
requirements for chitosan derivatives is their solubility under neutral or mildly alkaline conditions.
However, the limited solubility of native chitosan significantly restricts its practical applications.
Therefore, the development of highly charged chitosan derivatives remains a relevant and promising
research direction. In this context, the introduction of cationic groups into the chitosan backbone can
enhance not only its solubility at neutral or slightly alkaline pH values but also its inherent biological
activity.
functionalized biopolymers with tailored physicochemical and biomedical properties. Chitosan, a
derivative of chitin, is a polymer containing reactive amino groups, which makes it a promising raw
material for the design of novel biologically active macromolecular systems. One of the key
requirements for chitosan derivatives is their solubility under neutral or mildly alkaline conditions.
However, the limited solubility of native chitosan significantly restricts its practical applications.
Therefore, the development of highly charged chitosan derivatives remains a relevant and promising
research direction. In this context, the introduction of cationic groups into the chitosan backbone can
enhance not only its solubility at neutral or slightly alkaline pH values but also its inherent biological
activity.
344-345
16
5
HANDELIA TRICHOPHYLLA POLYSACCHARIDES
Handelia trichophylla is a perennial herbaceous plant of the Asteraceae family,
widespread in Central Asia. The plant contains a rich complex of biologically active substances:
essential oils, sesquiterpene lactones, flavonoids, polysaccharides, tannins, amino acids, choline,
carotenoids, ascorbic acid, organic acids, and sugars. Studying the carbohydrate complex of this
species is of interest for the search for new sources of natural polysaccharides with potential
biological activity.
widespread in Central Asia. The plant contains a rich complex of biologically active substances:
essential oils, sesquiterpene lactones, flavonoids, polysaccharides, tannins, amino acids, choline,
carotenoids, ascorbic acid, organic acids, and sugars. Studying the carbohydrate complex of this
species is of interest for the search for new sources of natural polysaccharides with potential
biological activity.
346-347
19
7
DETERMINATION OF THE COMPOSITION OF SOLUBLE VITAMINS IN RAW MATERIALS OF TAGETES PATULA L. USING THE HPLC METHOD
In folk medicine, infusions and decoctions obtained from the inflorescences of
Tagetes patula L. are widely used. The richness of the plant's composition with biological substances
gives it anti-inflammatory, antibacterial, antioxidant, diuretic, sedative, and gastroprotective
properties. Soluble vitamins were studied for a deeper study of the chemical composition of the raw
material of the plant Tagetes patula L. for the introduction of preparations made from it into medical
practice.
Tagetes patula L. are widely used. The richness of the plant's composition with biological substances
gives it anti-inflammatory, antibacterial, antioxidant, diuretic, sedative, and gastroprotective
properties. Soluble vitamins were studied for a deeper study of the chemical composition of the raw
material of the plant Tagetes patula L. for the introduction of preparations made from it into medical
practice.
348-349
94
19
PHYTOCHEMICAL STUDY OF PEROVSKIA SCROPHULARIIFOLIA
A decoction of the above-ground part of Perovskia scrophulariifolia Bunge (family
Lamiacaeae) is used in folk medicine for scabies in humans and animals, as well as for healing
sunburn and skin diseases. Dried flowers of the plant are brewed and consumed as tea to relieve
gastrointestinal diseases and abdominal pain. In some countries of the Asian region, P.
scrophulariifоlia is used to remove intestinal parasites from the body. The above-ground part of P.
scrophulariifolia
contains
essential
oil,
abietane
diterpenoids,
flavonoid diosmetin,
phenylpropanoids, anthocyanins, nitrogenous compounds, eugenol glycosides, benzyl alcohol,
salidroside and terpenoids. The chemical composition of the roots of P.scrophulariifolia has not been
studied.
Lamiacaeae) is used in folk medicine for scabies in humans and animals, as well as for healing
sunburn and skin diseases. Dried flowers of the plant are brewed and consumed as tea to relieve
gastrointestinal diseases and abdominal pain. In some countries of the Asian region, P.
scrophulariifоlia is used to remove intestinal parasites from the body. The above-ground part of P.
scrophulariifolia
contains
essential
oil,
abietane
diterpenoids,
flavonoid diosmetin,
phenylpropanoids, anthocyanins, nitrogenous compounds, eugenol glycosides, benzyl alcohol,
salidroside and terpenoids. The chemical composition of the roots of P.scrophulariifolia has not been
studied.
350-351
28
15
SYNTHESIS OF GALACTOMANNAN DIALDEHYDE DERIVATIVES AND INVESTIGATION OF THEIR PHYSICAL AND CHEMICAL PROPERTIES
Galactomannan is a polysaccharide mainly composed of D-mannose and D-galactose, linked
by α-1,4 and -1,6 glycosidic bonds. These connections define the structure of the polysaccharide
and influence its physicochemical properties. The structure can vary, with different branching from
galactose residues affecting its overall characteristics. Dialdehyde derivatives of galactomannan are
novel compounds formed through oxidation or chemical modification. These derivatives enhance the
polymer's rigidity, solubility, and mechanical strength. They can also react with primary amino
groups, forming imino (azomethine) bonds and Schiff bases, which are significant in various
applications. This study explores the production of low molecular weight galactomannan dialdehyde
derivatives, their reaction conditions, and their physicochemical properties.
by α-1,4 and -1,6 glycosidic bonds. These connections define the structure of the polysaccharide
and influence its physicochemical properties. The structure can vary, with different branching from
galactose residues affecting its overall characteristics. Dialdehyde derivatives of galactomannan are
novel compounds formed through oxidation or chemical modification. These derivatives enhance the
polymer's rigidity, solubility, and mechanical strength. They can also react with primary amino
groups, forming imino (azomethine) bonds and Schiff bases, which are significant in various
applications. This study explores the production of low molecular weight galactomannan dialdehyde
derivatives, their reaction conditions, and their physicochemical properties.
352
18
5
PHYTOCHEMICAL STUDY OF QUINCE FRUITS
Quince (Cydonia oblonga) is a valuable source of vitamins, micro- and macroelements, as well
as phenolic compounds and flavonoids. The biologically active substances of quince exhibit
antioxidant, anti-inflammatory, and tonic effects, making it a promising object of phytochemical
research. Studying the chemical composition of quince fruits is relevant for substantiating their
application in medicine, dietology, and the food industry.
as phenolic compounds and flavonoids. The biologically active substances of quince exhibit
antioxidant, anti-inflammatory, and tonic effects, making it a promising object of phytochemical
research. Studying the chemical composition of quince fruits is relevant for substantiating their
application in medicine, dietology, and the food industry.
353
30
8
ANALYSIS OF FLAVONOID COMPOSITION OF ALLIUM MOTOR BY HPLC
In recent years, the isolation of bioactive compounds from natural sources and the
evaluation of their pharmaceutical potential have become important directions of scientific research.
In particular, plants of the genus Allium have long been used in traditional medicine. Their chemical
composition has been shown to include flavonoids, phenolic acids, vitamins, and other biologically
active compounds. In this context, a comprehensive chemical analysis of Allium motor and the
assessment of its pharmaceutical and bioactive properties represent a relevant task.
evaluation of their pharmaceutical potential have become important directions of scientific research.
In particular, plants of the genus Allium have long been used in traditional medicine. Their chemical
composition has been shown to include flavonoids, phenolic acids, vitamins, and other biologically
active compounds. In this context, a comprehensive chemical analysis of Allium motor and the
assessment of its pharmaceutical and bioactive properties represent a relevant task.
354
19
16
COMPARATIVE ANALYSIS OF EXTRACTION METHODS FOR STANDARDIZING GREEN WORMWOOD HERB
Green wormwood herb (Artemisia viridis Willd.) is of considerable interest in
pharmaceutical practice due to its pronounced biological properties: anti-inflammatory, antiseptic,
and choleretic. One of the key stages of standardization is the selection of the optimal extraction
method that ensures a high yield of biologically active substances while maintaining their stability.
In this regard, the study and comparative evaluation of various extraction methods is a relevant task.
This study provides a comparative assessment of the effectiveness of various methods for extracting
flavonoids from green wormwood herb collected in the highlands of Kyrgyzstan. The study included
ultrasonic extraction and Sokslet extraction. Quantitative determination of the total flavonoid content
in green wormwood herb was performed on a Shimadzu spectrophotometer at a wavelength of 410
nm. Using quercetin as a standard, in accordance with the methodology recommended by GF RF XV.
pharmaceutical practice due to its pronounced biological properties: anti-inflammatory, antiseptic,
and choleretic. One of the key stages of standardization is the selection of the optimal extraction
method that ensures a high yield of biologically active substances while maintaining their stability.
In this regard, the study and comparative evaluation of various extraction methods is a relevant task.
This study provides a comparative assessment of the effectiveness of various methods for extracting
flavonoids from green wormwood herb collected in the highlands of Kyrgyzstan. The study included
ultrasonic extraction and Sokslet extraction. Quantitative determination of the total flavonoid content
in green wormwood herb was performed on a Shimadzu spectrophotometer at a wavelength of 410
nm. Using quercetin as a standard, in accordance with the methodology recommended by GF RF XV.
355
19
16
THE STUDY OF NUMERICAL PARAMETERS OF WALNUT LEAVES (JUGLANS REGIA L.), GROWING IN THE NUT AND FRUIT FORESTS OF KYRGYZSTAN
In the official medicine of the CIS countries, a large amount of medicinal plant raw
materials is widely used, which is regulated by regulatory documentation on quality. The flora of
Kyrgyzstan includes 4,100 species of higher plants, of which more than 200 species are medicinal
plants. Walnut (Juglans regia L.), which grows in the unique natural conditions of the Arslanbob
forest area of Kyrgyzstan, is a promising source of medicinal plant raw materials. Walnut leaves are
widely used in folk medicine due to their antiseptic, anti-inflammatory and restorative properties. The
relevance of studying walnut as a medicinal plant raw material is due to its wide application in folk
medicine and its high potential for use in official pharmacotherapy. The unique natural growing
conditions, rich chemical composition and pronounced medicinal properties make walnut leaves a
promising object for scientific research. However, there is no pharmacopoeia article for this raw
material. In this regard, an important area is the study of numerical indicators of raw materials, which
will become the basis for the development of regulatory documentation.
materials is widely used, which is regulated by regulatory documentation on quality. The flora of
Kyrgyzstan includes 4,100 species of higher plants, of which more than 200 species are medicinal
plants. Walnut (Juglans regia L.), which grows in the unique natural conditions of the Arslanbob
forest area of Kyrgyzstan, is a promising source of medicinal plant raw materials. Walnut leaves are
widely used in folk medicine due to their antiseptic, anti-inflammatory and restorative properties. The
relevance of studying walnut as a medicinal plant raw material is due to its wide application in folk
medicine and its high potential for use in official pharmacotherapy. The unique natural growing
conditions, rich chemical composition and pronounced medicinal properties make walnut leaves a
promising object for scientific research. However, there is no pharmacopoeia article for this raw
material. In this regard, an important area is the study of numerical indicators of raw materials, which
will become the basis for the development of regulatory documentation.
356-357
24
8
PHARMACOGNOSTIC STUDY OF DENTAL COLLECTION OF MEDICINAL PLANTS
monophytopreparations, consisting of a single medicinal plant, demonstrate lower
efficacy compared to herbal mixtures that combine several components. This treatment approach,
with its broader spectrum of action, allows physicians to offer patients a more comprehensive
therapeutic effect.
efficacy compared to herbal mixtures that combine several components. This treatment approach,
with its broader spectrum of action, allows physicians to offer patients a more comprehensive
therapeutic effect.
358-359
24
17
РАЗРАБОТКА МЕТОДИКИ АНАЛИЗА НЕКОТОРЫХ ПСИХОТРОПНЫХ ВЕЩЕСТВ МЕТОДОМ ТСХ
Исследование лекарственных препаратов, содержащих психотропные
вещества, целесообразно проводить с помощью простого, доступного и экспрессного метода - тонкослойной хроматографии (ТСХ). Преимущества метода - быстрота разделения, высокая
разрешающая способность, чувствительность и простота подготовки сорбента, являются
основными причинами широкого использования его при экспертном исследовании многих
лекарственных препаратов и сложных лекарственных смесей. Метод ТСХ имеет значительные
преимущества перед химическими методами, особенно при анализе многокомпонентных
лекарственных смесей он позволяет разделять и идентифицировать отдельные составные
части, а также близкие по химической структуре и свойствам вещества.
вещества, целесообразно проводить с помощью простого, доступного и экспрессного метода - тонкослойной хроматографии (ТСХ). Преимущества метода - быстрота разделения, высокая
разрешающая способность, чувствительность и простота подготовки сорбента, являются
основными причинами широкого использования его при экспертном исследовании многих
лекарственных препаратов и сложных лекарственных смесей. Метод ТСХ имеет значительные
преимущества перед химическими методами, особенно при анализе многокомпонентных
лекарственных смесей он позволяет разделять и идентифицировать отдельные составные
части, а также близкие по химической структуре и свойствам вещества.
360-361
54
10
РОЛЬ БИОЛОГИЧЕСКИ АКТИВНЫХ ДОБАВОК К ПИЩЕ В ЖИЗНЕДНЯТЕЛЬНОСТИ ЧЕЛОВЕКА
Биологически активные добавки (БАД) – это вещества, активирующие
реакции саморегуляции организма, восстанавливающие естественный динамический баланс и
открывающие путь к исцелению. В США их употребляет 80% населения, а в Европе - более
50%. БАД – это натуральные или аналогичные биологически активные вещества,
предназначенные для непосредственного приема внутрь в форме порошка, таблеток, капсул,
сиропов, экстрактов, настоек, концентратов и т.п.
реакции саморегуляции организма, восстанавливающие естественный динамический баланс и
открывающие путь к исцелению. В США их употребляет 80% населения, а в Европе - более
50%. БАД – это натуральные или аналогичные биологически активные вещества,
предназначенные для непосредственного приема внутрь в форме порошка, таблеток, капсул,
сиропов, экстрактов, настоек, концентратов и т.п.
362
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8
B GURUH VITAMINLARI SAQLAGAN DORI VOSITALARI TAHLILINING MUQOBIL USULLARINI ISHLAB CHIQISH VA VALIDATSIYALASH
So‘nggi yillarda biologik faol qo‘shimchalar va vitamin-mineral komplekslarga
bo‘lgan talab ortib bormoqda. Aholining turmush tarzi, ekologik omillar hamda ovqatlanishdagi
nomutanosibliklar organizmda vitaminlar, xususan, B guruhi vitaminlari yetishmovchiligi xavfini
oshirmoqda. Vitamin B2 (riboflavin), B3 (nikotinamid) va B6 (piridoksin) moddalar almashinuvi,
asab tizimi faoliyati va immun tizimni mustahkamlashda muhim ahamiyatga ega. Shu bois,
“Компливит актив” kabi biologik faol moddalar saqlagan kompleks preparatlardagi vitaminlar
miqdorini aniq belgilash ularning sifatini nazorat qilish, xavfsizligi va samaradorligini ta’minlashda
dolzarbdir. Farmakopeya talablari va xalqaro standartlarga muvofiq holda miqdoriy tahlil metodlarini
ishlab chiqish va amalda qo‘llash zamonaviy farmatsevtik tahlilning muhim vazifalaridan biri
hisoblanadi.
bo‘lgan talab ortib bormoqda. Aholining turmush tarzi, ekologik omillar hamda ovqatlanishdagi
nomutanosibliklar organizmda vitaminlar, xususan, B guruhi vitaminlari yetishmovchiligi xavfini
oshirmoqda. Vitamin B2 (riboflavin), B3 (nikotinamid) va B6 (piridoksin) moddalar almashinuvi,
asab tizimi faoliyati va immun tizimni mustahkamlashda muhim ahamiyatga ega. Shu bois,
“Компливит актив” kabi biologik faol moddalar saqlagan kompleks preparatlardagi vitaminlar
miqdorini aniq belgilash ularning sifatini nazorat qilish, xavfsizligi va samaradorligini ta’minlashda
dolzarbdir. Farmakopeya talablari va xalqaro standartlarga muvofiq holda miqdoriy tahlil metodlarini
ishlab chiqish va amalda qo‘llash zamonaviy farmatsevtik tahlilning muhim vazifalaridan biri
hisoblanadi.
363
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12
STUDY OF THE BIOLOGICAL ACTIVITY OF THE COMPLEX COMPOUND [Cu (Tsk)2](Glu)2 USING THE PASS ONLINE PROGRAM
A powerful set of methods for predicting the biological activity of chemical compounds on a
computer is methods based on Bayesian probability. The Pass software package is a program capable
of predicting the biological activity spectra of chemical compounds known to date. The Pass program
(online) is based on the study of the biological activity of substances depending on their structure.
This program contains known Pa and Pi values for the substance, these values represent the theoretical
probability. That is, Pa is pharmacologically active, Pi is pharmacologically inactive. If Pa >0.71,
such a molecule is considered active. The online pass program works on the principle of structural
biological activity. In this case, the value of Pa determines the pharmacological activity of the
substance against a certain disease, and the value of Pi determines the low pharmacological activity
against this disease.
computer is methods based on Bayesian probability. The Pass software package is a program capable
of predicting the biological activity spectra of chemical compounds known to date. The Pass program
(online) is based on the study of the biological activity of substances depending on their structure.
This program contains known Pa and Pi values for the substance, these values represent the theoretical
probability. That is, Pa is pharmacologically active, Pi is pharmacologically inactive. If Pa >0.71,
such a molecule is considered active. The online pass program works on the principle of structural
biological activity. In this case, the value of Pa determines the pharmacological activity of the
substance against a certain disease, and the value of Pi determines the low pharmacological activity
against this disease.
364
27
22
VALERIANA OFFICINALIS L. – MAIN RAW MATERIAL FOR PRODUCING DRUGS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES
The use of valerian has a long history in folk medicine. It was mentioned in written
sources as early as the 2nd century as a sleep aid and sedative. Valerian preparations were
recommended by Galen for insomnia, and in the 16th century, they were used to treat nervousness,
palpitations, and headaches. Beginning in the mid-20th century, valerian tincture began to be used
for stressful situations.
sources as early as the 2nd century as a sleep aid and sedative. Valerian preparations were
recommended by Galen for insomnia, and in the 16th century, they were used to treat nervousness,
palpitations, and headaches. Beginning in the mid-20th century, valerian tincture began to be used
for stressful situations.
365-366
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7
PROSPECTS FOR THE USE OF ESSENTIAL OIL FROM FILIPENDULOUS YARROW RAW MATERIALS
Filipendulous yarrow (Achillea filipendulina Lam.) is a perennial herbaceous plant
widely distributed in Central and Southwest Asia. Plants of the Achillea genus have traditionally been
used in folk and modern medicine due to their high content of biologically active compounds. Of
particular interest is the essential oil of A. filipendulina, which exhibits antibacterial, antimicrobial,
antioxidant, and anti-inflammatory effects. Despite the widespread use of the Achillea genus, the
essential oil of A. filipendulina remains insufficiently studied, which determines the relevance of its
investigation.
widely distributed in Central and Southwest Asia. Plants of the Achillea genus have traditionally been
used in folk and modern medicine due to their high content of biologically active compounds. Of
particular interest is the essential oil of A. filipendulina, which exhibits antibacterial, antimicrobial,
antioxidant, and anti-inflammatory effects. Despite the widespread use of the Achillea genus, the
essential oil of A. filipendulina remains insufficiently studied, which determines the relevance of its
investigation.
367
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8
DEVELOPMENT OF BIODEGRADABLE BANDAGES FROM PINUS SYLVESTRIS BARK: PHYTOCHEMICAL ANALYSIS AND BIOLOGICAL ACTIVITY
Modern medicine has an urgent need for environmentally friendly, biocompatible,
and effective wound dressing materials. The bark of Scots pine (Pinus sylvestris) is a promising
renewable source of biologically active compounds with proven antimicrobial and wound-healing
properties, which determines the relevance of its study.
and effective wound dressing materials. The bark of Scots pine (Pinus sylvestris) is a promising
renewable source of biologically active compounds with proven antimicrobial and wound-healing
properties, which determines the relevance of its study.
368-369
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6
ОПРЕДЕЛЕНИЕ КОЛИЧЕСТВО ОБЩЕГО БЕЛКА В БАДЕ « »
Преимущество биологически активных добавок на основе
фитопрепаратов заключается в том, что они зачастую имеют комплексный состав и действуют
сразу в нескольких фармакологически активных направлениях: гепатопротекторном,
антиоксидантном, желчегонном, противовоспалительном и иммуномодулирующем. Среди
них следует отметить биологически активную добавку «…» которые состоит из экстрактов
лекарственных растений и, благодаря их синергетическому эффекту, обладает высокой
эффективностью в улучшении функции печени.
фитопрепаратов заключается в том, что они зачастую имеют комплексный состав и действуют
сразу в нескольких фармакологически активных направлениях: гепатопротекторном,
антиоксидантном, желчегонном, противовоспалительном и иммуномодулирующем. Среди
них следует отметить биологически активную добавку «…» которые состоит из экстрактов
лекарственных растений и, благодаря их синергетическому эффекту, обладает высокой
эффективностью в улучшении функции печени.
370-371
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10
“GEPA-LAYK” QURUQ EKSTRAKTI TARKIBIDAGI FLAVONOIDLAR MIQDORINI ANIQLASH
Bugungi kunda jigar kasalliklari dunyo miqyosida eng keng tarqalgan surunkali
kasalliklardan biri hisoblanadi. O‘tkir va surunkali gepatitlar, toksik gepatozlar, alkogolli jigar
zararlanishlari, steatoz va sirroz kabi holatlar nafaqat rivojlanayotgan, balki rivojlangan davlatlar
sog‘liqni saqlash tizimi oldida turgan dolzarb muammolardan biri bo‘lib qolmoqda. Mahalliy xom
ashyo asosida jigar kasalliklariga qarshi dori vositasini olish uchun izlanishlar olib borildi.
kasalliklardan biri hisoblanadi. O‘tkir va surunkali gepatitlar, toksik gepatozlar, alkogolli jigar
zararlanishlari, steatoz va sirroz kabi holatlar nafaqat rivojlanayotgan, balki rivojlangan davlatlar
sog‘liqni saqlash tizimi oldida turgan dolzarb muammolardan biri bo‘lib qolmoqda. Mahalliy xom
ashyo asosida jigar kasalliklariga qarshi dori vositasini olish uchun izlanishlar olib borildi.
372-373
15
4
DETERMINATION OF ANTIOXIDANT PROPERTIES OF FACTORY-GROWN CHICKEN EGGSHELLS
Today, bone diseases are increasing due to calcium deficiency, and to
prevent and eliminate this condition, eggshells are a natural source rich in calcium. They are not only
a source of calcium, but also play an important role in the absorption of D3, which is obtained with
solar energy, into the body.
prevent and eliminate this condition, eggshells are a natural source rich in calcium. They are not only
a source of calcium, but also play an important role in the absorption of D3, which is obtained with
solar energy, into the body.
374-375
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2
PHYTOCHEMICAL ANALYSIS AND BIOLOGICAL ACTIVITY OF TAMARIX RAMOSISSIMA: A REVIEW
Tamarix ramosissima is a shrub plant widely distributed in arid regions. In recent
years, its chemical composition and pharmacological properties have been investigated, which opens
prospects for the development of new phytopreparations. Phytochemical analysis confirms the
presence of flavonoids, phenolic compounds, terpenoids, alkaloids and saponins in the plant, which
determines its biological activity.
years, its chemical composition and pharmacological properties have been investigated, which opens
prospects for the development of new phytopreparations. Phytochemical analysis confirms the
presence of flavonoids, phenolic compounds, terpenoids, alkaloids and saponins in the plant, which
determines its biological activity.
376
68
11
ʼPEROVSKIA KUDRJASCHEVII – A PROMISING SOURCE OF BIOLOGICALLY ACTIVE TERPENOIDS
Perovskia kudrjaschevii Gorschk. & Pjataeva (family Lamiacaeae) is a medicinal,
essential oil, dye and honey plant. It is found in Uzbekistan, Tajikistan and Kyrgyzstan. The chemical
composition of the components of Perovskia kudrjaschevii has not been previously studied.
essential oil, dye and honey plant. It is found in Uzbekistan, Tajikistan and Kyrgyzstan. The chemical
composition of the components of Perovskia kudrjaschevii has not been previously studied.
377
12
6
CREATION OF NEW MEDICINAL PRODUCTS
In recent years, the development of new, more effective drugs has become a
pressing issue due to the increasing level of drug resistance. According to the World Health
Organization, more than 700,000 patients die each year from antibiotic-resistant infections.
Therefore, the creation of new chemical classes of drugs with a broad spectrum of action and low
toxicity is one of the main priorities of the pharmaceutical industry.
pressing issue due to the increasing level of drug resistance. According to the World Health
Organization, more than 700,000 patients die each year from antibiotic-resistant infections.
Therefore, the creation of new chemical classes of drugs with a broad spectrum of action and low
toxicity is one of the main priorities of the pharmaceutical industry.
378-379
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19
PHENOLIC COMPOUNDS OF PLANTS BELONGING TO THE GENUS ATRAPHAХIS
At present, the isolation of biologically active substances from plants, the comprehensive study
of their chemical structure and properties, as well as the investigation of their biological and
pharmacological characteristics, is one of the urgent tasks. Phenolic compounds, which are
widespread in the plant kingdom, represent a large class of natural compounds. Phenolic compounds
participate in various processes occurring in the human body and exhibit antioxidant properties;
moreover, as antiradical agents, they slow down radical mechanism-based reactions that take place
in the organism under the influence of external physico-chemical factors.
of their chemical structure and properties, as well as the investigation of their biological and
pharmacological characteristics, is one of the urgent tasks. Phenolic compounds, which are
widespread in the plant kingdom, represent a large class of natural compounds. Phenolic compounds
participate in various processes occurring in the human body and exhibit antioxidant properties;
moreover, as antiradical agents, they slow down radical mechanism-based reactions that take place
in the organism under the influence of external physico-chemical factors.
380
19
9
ANALYSIS OF MOLECULAR INTERACTIONS OF THE ENERGY STRUCTURE OF LIPOIC ACID
Lipoic acid (LA) is a sulfur-containing organic compound with powerful
antioxidant properties, neutralizing free radicals and reducing oxidative stress. This helps prevent
diseases such as skin aging, neurodegenerative disorders, cancer, and cardiovascular diseases. Lipoic
acid also activates liver enzymes, which helps in detoxification, removal of toxins and heavy metals,
and maintaining liver health. Due to the improvement of the body's metabolism, LA is used in
medicine as a drug for the treatment of diabetes and cancer. Its antioxidant activity also helps protect
cells from damage caused by oxidative stress, slowing down the aging process, improving tissue
regeneration, and maintaining cellular health at the molecular level. Lipoic acid, therefore, becomes
not only an important element in the therapeutic approach, but also a promising means for the
prevention of many diseases associated with metabolic disorders and aging of the body
antioxidant properties, neutralizing free radicals and reducing oxidative stress. This helps prevent
diseases such as skin aging, neurodegenerative disorders, cancer, and cardiovascular diseases. Lipoic
acid also activates liver enzymes, which helps in detoxification, removal of toxins and heavy metals,
and maintaining liver health. Due to the improvement of the body's metabolism, LA is used in
medicine as a drug for the treatment of diabetes and cancer. Its antioxidant activity also helps protect
cells from damage caused by oxidative stress, slowing down the aging process, improving tissue
regeneration, and maintaining cellular health at the molecular level. Lipoic acid, therefore, becomes
not only an important element in the therapeutic approach, but also a promising means for the
prevention of many diseases associated with metabolic disorders and aging of the body
381-382
17
6
SYNTHESIS OF ENTEROADSORBENT-INTRODUCING Fe AND Al POLYHYDROXYCATION BETWEEN MONTMORILLONITE LAYERS
Efficiency: enterosorbents are substances with a high specific surface area, capable of adsorbing
molecules, ions and various particles. They are used in medicine for various purposes, they have
antimicrobial and detoxifying properties, for example, the ability to bind to heavy metals and toxins,
and they are used in the performance of some complex tasks, such as poisoning models (food
poisoning, diarrhea, allergies). Therefore, the synthesis of adsorbents and catalyst carriers, which are
absolutely harmless to human health and economically inexpensive, with high adsorption properties,
is considered urgent today.
molecules, ions and various particles. They are used in medicine for various purposes, they have
antimicrobial and detoxifying properties, for example, the ability to bind to heavy metals and toxins,
and they are used in the performance of some complex tasks, such as poisoning models (food
poisoning, diarrhea, allergies). Therefore, the synthesis of adsorbents and catalyst carriers, which are
absolutely harmless to human health and economically inexpensive, with high adsorption properties,
is considered urgent today.
383-384
15
8
SYNTHESIS, STRUCTURE, AND INVESTIGATION OF A COMPLEX COMPOUND BASED ON THE BENZIMIDAZOLE DERIVATIVE OF Co (II)
Currently, benzimidazole and its derivatives are the main raw materials for the
development of important therapeutic agents in medicine and pharmaceuticals. For example,
benzimidazole and its derivatives exhibit pharmacological activities such as antimicrobial, antiviral,
anticancer, anti-inflammatory, and neurotropic, psychoactive, and analgesic properties. The synthesis
of drugs with high pharmaceutical properties and the creation of new generations of drugs using new
benzimidazole derivatives is currently one of the most important areas of the modern pharmaceutical
industry.
development of important therapeutic agents in medicine and pharmaceuticals. For example,
benzimidazole and its derivatives exhibit pharmacological activities such as antimicrobial, antiviral,
anticancer, anti-inflammatory, and neurotropic, psychoactive, and analgesic properties. The synthesis
of drugs with high pharmaceutical properties and the creation of new generations of drugs using new
benzimidazole derivatives is currently one of the most important areas of the modern pharmaceutical
industry.
385
19
9
PROPAGATION OF THE TIEN SHAN SPRUCE BY SEEDS
In the context of climate change and urbanization, the introduction and cultivation
of ornamental and ecologically significant tree species is of particular importance. The Tien Shan
spruce is a valuable species of coniferous plants that is highly decorative and resistant. The study of
its seed propagation in the Turkestan region is of practical and scientific significance
of ornamental and ecologically significant tree species is of particular importance. The Tien Shan
spruce is a valuable species of coniferous plants that is highly decorative and resistant. The study of
its seed propagation in the Turkestan region is of practical and scientific significance
386
46
10
STUDY OF BIOLOGICALLY ACTIVE COMPONENTS OF PEROVSKIA BOTSCHANTZEVII
The growing need for medicinal products prepared on the basis of plant raw
materials is explained by their high content of biologically active compounds, good efficiency, safety,
and a wide range of therapeutic action. Perovskia botschantzevii Kovalevsk. & Koczk (family
Lamiacaeae) is a medicinal, essential oil, dye and honey plant growing on rocky slopes, pebbles, in
the river valleys of Kyrgyzstan, Uzbekistan, Tajikistan, and Afghanistan.
materials is explained by their high content of biologically active compounds, good efficiency, safety,
and a wide range of therapeutic action. Perovskia botschantzevii Kovalevsk. & Koczk (family
Lamiacaeae) is a medicinal, essential oil, dye and honey plant growing on rocky slopes, pebbles, in
the river valleys of Kyrgyzstan, Uzbekistan, Tajikistan, and Afghanistan.
387-388
22
17
MULTISCALE THEORETICAL INVESTIGATION OF HEAVY METAL AND ORGANIC POLLUTANT SORPTION ON FUNCTIONALIZED CELLULOSE DERIVATIVES
Water contamination by heavy metals (Pb²⁺, Cd²⁺, Ni²⁺), metalloid ions (As(III),
As(V), Cr(VI)), and persistent organic pollutants (phenolic derivatives, pharmaceutical residues,
dyes) remains a major environmental concern worldwide. Conventional water treatment methods are
often insufficient to achieve both high efficiency and selectivity. In this context, biopolymeric
sorbents based on modified cellulose offer significant advantages due to their biocompatibility,
availability, and ease of functionalization. Dialdehyde cellulose grafted with thiosemicarbazide
(DAC@TCH) and its thiol-functionalized derivative (DAC@TCH–SH) are particularly promising
candidates for the selective binding of toxic metal ions and organic pollutants.
As(V), Cr(VI)), and persistent organic pollutants (phenolic derivatives, pharmaceutical residues,
dyes) remains a major environmental concern worldwide. Conventional water treatment methods are
often insufficient to achieve both high efficiency and selectivity. In this context, biopolymeric
sorbents based on modified cellulose offer significant advantages due to their biocompatibility,
availability, and ease of functionalization. Dialdehyde cellulose grafted with thiosemicarbazide
(DAC@TCH) and its thiol-functionalized derivative (DAC@TCH–SH) are particularly promising
candidates for the selective binding of toxic metal ions and organic pollutants.
389
16
6
DEVELOPMENT OF NEW PHARMACEUTICAL PRODUCTS BASED ON THE PLANT OBJECT ELAEAGNUS ANGUSTIFOLIA L.
The increase in chronic diseases, multi-organ pathology, and complications from
long-term use of synthetic drugs necessitates the search for alternative sources of medicines with
minimal side effects. In this context, interest in herbal medicines with comprehensive effects and
good tolerability is growing. Elaeagnus angustifolia (narrow-leaved oleaster) has traditionally been
used in folk medicine as an analgesic and anti-inflammatory agent. Modern studies confirm the
presence of bioactive compounds (BACs) in this plant, which can serve as the basis for the
development of effective and safe pharmaceutical products, exhibiting antioxidant, analgesic, and
antibacterial activities.
long-term use of synthetic drugs necessitates the search for alternative sources of medicines with
minimal side effects. In this context, interest in herbal medicines with comprehensive effects and
good tolerability is growing. Elaeagnus angustifolia (narrow-leaved oleaster) has traditionally been
used in folk medicine as an analgesic and anti-inflammatory agent. Modern studies confirm the
presence of bioactive compounds (BACs) in this plant, which can serve as the basis for the
development of effective and safe pharmaceutical products, exhibiting antioxidant, analgesic, and
antibacterial activities.
390
22
7
MAIN GROUPS OF BIOLOGICALLY ACTIVE SUBSTANCES OF CHICKWEED (STELLARIA MEDIA L.) AND THEIR PHARMACOLOGICAL SIGNIFICANCE
Chickweed (Stellaria media L.) is a widespread annual plant in the
Caryophyllaceae family, possessing a rich chemical composition. Interest in this species stems from
the presence of various biologically active substances, which determine its pharmacological activity
and potential for use in herbal medicine. However, despite this, there are no medications based on
chickweed (Stellaria media L.). Studying its properties would expand the pharmaceutical market.
Caryophyllaceae family, possessing a rich chemical composition. Interest in this species stems from
the presence of various biologically active substances, which determine its pharmacological activity
and potential for use in herbal medicine. However, despite this, there are no medications based on
chickweed (Stellaria media L.). Studying its properties would expand the pharmaceutical market.
391-392
17
5
ALKYNYLATION REACTIONS OF SOME HETEROATOMIC ALDEHYDES IN THE PARTICIPATION OF PHENYLACETYLENE
In our country, the synthesis of new types of chemicals that have found their place
in the world market, the creation of methods for obtaining import-substituting compounds intended
for export, and their use in the pharmaceutical, chemical, energy, and construction sectors are urgent
tasks, and scientific research is being conducted in this area and certain results are being achieved.
in the world market, the creation of methods for obtaining import-substituting compounds intended
for export, and their use in the pharmaceutical, chemical, energy, and construction sectors are urgent
tasks, and scientific research is being conducted in this area and certain results are being achieved.
393
15
10
DETERMINATION OF OPTICAL PROPERTIES OF COLORANTS IN SOME CONFECTIONERY PRODUCTS
The aim of the experiment was a qualitative and quantitative analysis of the dyes contained in
selected colored confectionery products. The resulting confectionery products consisted of red,
yellow, blue, and black dyes, as well as natural beetroot dye. Each product was dry-weighed on a
precision analytical balance and ground into powder. The optical properties of the powder were
preliminarily analyzed using an X.Rite.eye one pro instrument. The results are presented in the table.
selected colored confectionery products. The resulting confectionery products consisted of red,
yellow, blue, and black dyes, as well as natural beetroot dye. Each product was dry-weighed on a
precision analytical balance and ground into powder. The optical properties of the powder were
preliminarily analyzed using an X.Rite.eye one pro instrument. The results are presented in the table.
394-395
34
13
MACRO- AND MICROELEMENTS IN THE AERIAL PARTS OF ATRAPHAXIS PYRIFOLIA
In our research, the main objective was defined as the study of the chemical components of
Atraphaxis pyrifolia, a plant belonging to the Polygonaceae family.
In June 2025, we initiated the qualitative and quantitative analysis of macro- and microelements
in the aerial parts of Atraphaxis pyrifolia, collected in the mountainous areas of Parkent District,
Tashkent Region, as part of the study of its chemical components.
The analysis of the chemical composition of the studied plant provides an opportunity to draw
more precise conclusions about this species.
Atraphaxis pyrifolia, a plant belonging to the Polygonaceae family.
In June 2025, we initiated the qualitative and quantitative analysis of macro- and microelements
in the aerial parts of Atraphaxis pyrifolia, collected in the mountainous areas of Parkent District,
Tashkent Region, as part of the study of its chemical components.
The analysis of the chemical composition of the studied plant provides an opportunity to draw
more precise conclusions about this species.
396-397
26
5
PRODUCTION OF DRY POWDER COMPOSITES BASED ON SODIUM AND CALCIUM STEARATE
One of the main tasks of the world industry is to provide the construction industry
with new, high-quality products. The processing of metals, which perform an important function in
the construction industry, is of great importance, that is, their production in various sizes. Therefore,
it is necessary to process metals and prepare wires of various sizes from them, to study in more detail
the composition of these wires and various physical and mechanical processes occurring on their
surfaces, to search for opportunities for the widespread use of dry welding components used in the
drawing and processing of metals. Therefore, it is important to develop effective methods for
obtaining dry welding components and welding electrodes used in the drawing of metal wires based
on local raw materials.
with new, high-quality products. The processing of metals, which perform an important function in
the construction industry, is of great importance, that is, their production in various sizes. Therefore,
it is necessary to process metals and prepare wires of various sizes from them, to study in more detail
the composition of these wires and various physical and mechanical processes occurring on their
surfaces, to search for opportunities for the widespread use of dry welding components used in the
drawing and processing of metals. Therefore, it is important to develop effective methods for
obtaining dry welding components and welding electrodes used in the drawing of metal wires based
on local raw materials.
398
28
22
STUDYING ESSENTIAL OIL TECHNOLOGY BASED ON LOCAL PLANT RAW MATERIALS
Rose oil, ointments, creams, and sprays based on it are currently widely used in
cosmetology and dermatology. Ibn Sina noted that the Damask rose (nasrin) is useful for cooling
nerves, helping with ringing and noise in the ears, and toothache. And in Bulgaria, a medicinal product
called rozanol has been developed; its active ingredient is rose oil, which has antispasmodic,
choleretic, and bactericidal properties.
cosmetology and dermatology. Ibn Sina noted that the Damask rose (nasrin) is useful for cooling
nerves, helping with ringing and noise in the ears, and toothache. And in Bulgaria, a medicinal product
called rozanol has been developed; its active ingredient is rose oil, which has antispasmodic,
choleretic, and bactericidal properties.
399-400
31
5
DETERMINATION OF BIOACTIVE SUBSTANCES IN OIL EXTRACT
Vitamin E is a group of important natural compounds, the basis of which is
tocopherols and tocotrienols. Tocopherols are used as antioxidants, the most powerful antioxidant is
δ-tocopherols. They have a strong neuroprotective, antioxidant effect, and also reduce the risk of
cancer. In addition, they have an antihypoxant effect, reducing the need for oxygen in cells.
It protects cells from damage by free radicals, thereby slowing down the aging process. All
compounds in this group are fat-soluble.
tocopherols and tocotrienols. Tocopherols are used as antioxidants, the most powerful antioxidant is
δ-tocopherols. They have a strong neuroprotective, antioxidant effect, and also reduce the risk of
cancer. In addition, they have an antihypoxant effect, reducing the need for oxygen in cells.
It protects cells from damage by free radicals, thereby slowing down the aging process. All
compounds in this group are fat-soluble.
401-402
39
3
MIXED-LIGAND COMPLEX OF COBALT WITH GLUTARIC ACID AND NICOTINAMIDE (CoGANA) MOLECULAR DOCKING ANALYSIS
Glutaric acid (pentanedioic acid) is an aliphatic organic compound used as a raw
material in the synthesis of anticancer drugs and antibiotics, pharmaceutical and chemical products,
as well as a model compound for understanding metabolic disorders and hereditary enzyme
deficiencies. Cobalt, being a component of vitamin B12, forms complexes, and its deficiency leads
to anemia. Therefore, the synthesis of a complex compound involving glutaric acid, nicotinamide,
and cobalt, followed by an analysis of its physicochemical and pharmacokinetic properties, is an
important research task.
material in the synthesis of anticancer drugs and antibiotics, pharmaceutical and chemical products,
as well as a model compound for understanding metabolic disorders and hereditary enzyme
deficiencies. Cobalt, being a component of vitamin B12, forms complexes, and its deficiency leads
to anemia. Therefore, the synthesis of a complex compound involving glutaric acid, nicotinamide,
and cobalt, followed by an analysis of its physicochemical and pharmacokinetic properties, is an
important research task.
403-404
26
7
THE ROLE OF SAFFRON EXTRACT IN THE REGULATION OF THIOL STATUS INULIN OBTAINED FROM SEVERAL PLANTS ENDEMIC TO KAZAKHSTAN
Inulin is a polysaccharide extracted from the vegetative mass and roots of plants (chicory,
elecampane, dandelion, etc.) and used as a dietary supplement, improving the nutritional properties
of foods, as a sweetener for patients with 2nd type diabetes, and as a valuable prebiotic for the human
microbiome. The polysaccharide is found in high concentrations in plant tubers and roots, where it
serves as a storage function. Research by several scientists has shown that inulin is also synthesized
in large quantities in the rhizomes of certain rubber-bearing plants.
elecampane, dandelion, etc.) and used as a dietary supplement, improving the nutritional properties
of foods, as a sweetener for patients with 2nd type diabetes, and as a valuable prebiotic for the human
microbiome. The polysaccharide is found in high concentrations in plant tubers and roots, where it
serves as a storage function. Research by several scientists has shown that inulin is also synthesized
in large quantities in the rhizomes of certain rubber-bearing plants.
405
25
26
BIOLOGICAL CHARACTERISTICS AND MORPHOLOGICAL FEATURES OF GREENHOUSE GRAPES
The development of viticulture in protected soil conditions requires the study of
the biological and morphological characteristics of various varieties. These studies make it possible
to evaluate the anatomical structure of the shoots and the morphological characteristics of the
varieties, which is important for the breeding, introduction and adaptation of grapes in Kazakhstan
the biological and morphological characteristics of various varieties. These studies make it possible
to evaluate the anatomical structure of the shoots and the morphological characteristics of the
varieties, which is important for the breeding, introduction and adaptation of grapes in Kazakhstan
406
20
8
MORPHOLOGICAL AND ANATOMICAL FEATURES OF AGRIMONIA ASIATICA JUZ. AND AGRIMONIA PILOSA LDB
Representatives of the genus Agrimonia L. are valuable medicinal plants widely
used in traditional medicine. However, the morphological and anatomical characteristics of its various
species have not been sufficiently studied, which complicates species diagnostics and the rational use
of raw materials.
used in traditional medicine. However, the morphological and anatomical characteristics of its various
species have not been sufficiently studied, which complicates species diagnostics and the rational use
of raw materials.
407-408
18
12
SYNTHESIS OF NEW BIOACTIVE COMPOUNDS BASED ON ORGANIC CHEMISTRY AND THEIR PROSPECTS FOR APPLICATION IN PHARMACEUTICALS
Introduction to Bioactive Compounds and Organic Chemistry The intersection of bioactive
compounds and organic chemistry serves as a cornerstone in the advancement of pharmaceutical
applications, offering a comprehensive understanding of how natural and synthetic substances can
interact within biological systems. Bioactive compounds, which are pivotal in developing therapeutic
agents, possess the ability to bring about significant biochemical changes. Organic chemistry, with
its focus on the structure, properties, and reactions of carbon-containing compounds, provides the
necessary framework for synthesizing new bioactive agents. Recent developments in natural products
chemistry, particularly techniques like high-resolution screening and miniaturization of assays, are
revolutionizing how these compounds are identified and tested for efficacy. These innovations
facilitate the discovery of novel drugs while improving the efficiency of bioassay-guided
fractionation processes, thereby enhancing productivity in pharmaceutical research. As the field
progresses, the synergy between organic chemistry and bioactive compounds will remain integral to
meeting healthcare challenges and fostering drug development.
compounds and organic chemistry serves as a cornerstone in the advancement of pharmaceutical
applications, offering a comprehensive understanding of how natural and synthetic substances can
interact within biological systems. Bioactive compounds, which are pivotal in developing therapeutic
agents, possess the ability to bring about significant biochemical changes. Organic chemistry, with
its focus on the structure, properties, and reactions of carbon-containing compounds, provides the
necessary framework for synthesizing new bioactive agents. Recent developments in natural products
chemistry, particularly techniques like high-resolution screening and miniaturization of assays, are
revolutionizing how these compounds are identified and tested for efficacy. These innovations
facilitate the discovery of novel drugs while improving the efficiency of bioassay-guided
fractionation processes, thereby enhancing productivity in pharmaceutical research. As the field
progresses, the synergy between organic chemistry and bioactive compounds will remain integral to
meeting healthcare challenges and fostering drug development.
409
22
8
STUDY OF THE ACTIVITY OF α-AMYLASE ENZYME IN WHEAT (TRITICUM) GRAINS GROWING IN UZBEKISTAN
Wheat (Triticum) is one of the oldest and most widely cultivated cereal crops in
the world. It was domesticated from wild grains and has played a major role in the history of human
agriculture. Wheat is mainly used in the production of bread, pasta, sweets, and other food products.
Wheat (Triticum aestivum), widely grown in Uzbekistan, is not only a major food source, but
also a natural storehouse of valuable biologically active substances. Enzymes contained in the grain,
in particular α-amylase, play a key role in the hydrolysis of starch and are one of the important factors
determining the nutritional value of wheat. Changes in the activity of this enzyme directly affect the
quality of flour products, baking technology, as well as the production of dietary and biologically
active additives. Therefore, the study of α-amylase activity in wheat grains grown in Uzbekistan, the
identification of its differences by variety, and its application in practice are of urgent scientific and
practical importance for the pharmaceutical, food, and biologically active additive production sectors.
the world. It was domesticated from wild grains and has played a major role in the history of human
agriculture. Wheat is mainly used in the production of bread, pasta, sweets, and other food products.
Wheat (Triticum aestivum), widely grown in Uzbekistan, is not only a major food source, but
also a natural storehouse of valuable biologically active substances. Enzymes contained in the grain,
in particular α-amylase, play a key role in the hydrolysis of starch and are one of the important factors
determining the nutritional value of wheat. Changes in the activity of this enzyme directly affect the
quality of flour products, baking technology, as well as the production of dietary and biologically
active additives. Therefore, the study of α-amylase activity in wheat grains grown in Uzbekistan, the
identification of its differences by variety, and its application in practice are of urgent scientific and
practical importance for the pharmaceutical, food, and biologically active additive production sectors.
410-411
23
6
ТЕРМОДИНАМИКА ВЗАИМОДЕЙСТВИЯ В СИСТЕМЕ НАТРИЙКАРБОКСИМЕТИЛЦЕЛЛЮЛОЗЫ-ПОВИДОН-ЙОДА
Карбоксиметилцеллюлоза натрия (NаКМЦ) занимает особое место
благодаря хорошей растворимости в воде, полиэлектролитным свойствам, способности
вступать в интерполимерные реакции, образовывать фазовые сетки с ионными и ионно
координационными связями. Представляет собой нетоксичное и инертное биологическое
вещество, что позволяет использовать его в медицине и фармацевтике. По химическому
составу
повидон-йод
поливинилпирролидоном.
представляет
Широко
собой
сложную комбинацию йода с
используемых
вспомогательных
веществ
в
фармацевтической промышленности. Повидон-йод дезинфицирует раны, помогает
заживлению ран и предотвращает развитие инфекций. Его также используют с целью
антисептической п
благодаря хорошей растворимости в воде, полиэлектролитным свойствам, способности
вступать в интерполимерные реакции, образовывать фазовые сетки с ионными и ионно
координационными связями. Представляет собой нетоксичное и инертное биологическое
вещество, что позволяет использовать его в медицине и фармацевтике. По химическому
составу
повидон-йод
поливинилпирролидоном.
представляет
Широко
собой
сложную комбинацию йода с
используемых
вспомогательных
веществ
в
фармацевтической промышленности. Повидон-йод дезинфицирует раны, помогает
заживлению ран и предотвращает развитие инфекций. Его также используют с целью
антисептической п
412-413
31
4
COORDINATION COMPOUND OF VO (II) WITH GLUTARIC ACID AND NICOTINAMIDE
To maintain the stability of the internal environment of living organisms, it is
extremely important to maintain physiological levels of trace elements. This fact can be explained by
the fact that some trace elements are contained in the body in the form of complex coordination
compounds with organic ligands, which are more biologically active and less toxic than compounds
of inorganic origin. Vanadium is present in the body in very small amounts, but it is known to be
involved in the regulation of carbohydrate and lipid metabolism, promotes better oxygenation of
haemoglobin, has an insulin-like effect, namely, it promotes the absorption of glucose by cells, and
is thought to have an antitumour effect. Nicotinamide participates in redox reactions, plays a role in
blood formation, and exhibits antioxidant properties. Glutaric acid participates in energy metabolism
and increases the intensity of enzymatic processes
extremely important to maintain physiological levels of trace elements. This fact can be explained by
the fact that some trace elements are contained in the body in the form of complex coordination
compounds with organic ligands, which are more biologically active and less toxic than compounds
of inorganic origin. Vanadium is present in the body in very small amounts, but it is known to be
involved in the regulation of carbohydrate and lipid metabolism, promotes better oxygenation of
haemoglobin, has an insulin-like effect, namely, it promotes the absorption of glucose by cells, and
is thought to have an antitumour effect. Nicotinamide participates in redox reactions, plays a role in
blood formation, and exhibits antioxidant properties. Glutaric acid participates in energy metabolism
and increases the intensity of enzymatic processes
414
13
5
CULTIVATION OF HYPERICUM PERFORATUM L. PLANT AND STUDY OF ITS BIOMORPHOLOGICAL PROPERTIES
The one of the promising medicinal plant that is widely used in folk medicine is
the St John’s wort (Hypericum perforatum L.). Unlike what is already in circulation, research on the
distribution of medicinal plants, their bioecological characteristics, growing technology, and their
reserve is promise for the pharmaceutical sector. The preparations which contain vitamins, essential
oils, caratinoids and alkaloids were recovered from the St John’s wort plant have a twisting, antiseptic
and wound tissue fast-graduating effect. In medicine, it is used in the treatment of gastrointestinal
(colitis, diarrhea), oral diseases (gingivitis and stomatitis) and Burns of II and III degrees, as well as
for rinsing the mouth. Taking into account the above information, the possibilities of planting and
caring for the St John’s wort were considered in the irrigated regions of the Republic
the St John’s wort (Hypericum perforatum L.). Unlike what is already in circulation, research on the
distribution of medicinal plants, their bioecological characteristics, growing technology, and their
reserve is promise for the pharmaceutical sector. The preparations which contain vitamins, essential
oils, caratinoids and alkaloids were recovered from the St John’s wort plant have a twisting, antiseptic
and wound tissue fast-graduating effect. In medicine, it is used in the treatment of gastrointestinal
(colitis, diarrhea), oral diseases (gingivitis and stomatitis) and Burns of II and III degrees, as well as
for rinsing the mouth. Taking into account the above information, the possibilities of planting and
caring for the St John’s wort were considered in the irrigated regions of the Republic
415-416
20
7
DETERMINATION OF BIOLOGICALLY ACTIVE SUBSTANCES AND MICROBIOLOGICAL PURITY IN THE NEW CHOLESTERIC COLLECTION
Philogenetic agents, normalizing bile flow, are effectively used in the treatment
of liver and gallbladder pathologies. For the treatment and elimination of bile stasis, along with
preparations of synthetic origin, medicinal plants with a pronounced choleretic effect are often used.
Immortelle flower phytopreparations enhance the liver's functional capacity, thereby increasing bile
secretion, leading to an increase in the amount of cholates in bile and a decrease in bile viscosity;
corn stalks are effective for gallbladder and urinary tract infections, as well as liver diseases and
jaundice.
of liver and gallbladder pathologies. For the treatment and elimination of bile stasis, along with
preparations of synthetic origin, medicinal plants with a pronounced choleretic effect are often used.
Immortelle flower phytopreparations enhance the liver's functional capacity, thereby increasing bile
secretion, leading to an increase in the amount of cholates in bile and a decrease in bile viscosity;
corn stalks are effective for gallbladder and urinary tract infections, as well as liver diseases and
jaundice.
417
12
4
DETERMINATION OF ALLAPININ CONTENT BY NON-AQUEOUS ACID-BASE TITRATION AND METHOD VALIDATION
Allapinin is an antiarrhythmic drug that blocks sodium channels in the heart due to
the presence of lappaconitine. As an antiarrhythmic drug belonging to the diterpene alkaloid group,
assessing the quality parameters of Allapinin, studying its properties, and comparatively evaluating
quality control methods are essential. Another important task is to assess the validation parameters of
the quantitative determination method of Allapinin
the presence of lappaconitine. As an antiarrhythmic drug belonging to the diterpene alkaloid group,
assessing the quality parameters of Allapinin, studying its properties, and comparatively evaluating
quality control methods are essential. Another important task is to assess the validation parameters of
the quantitative determination method of Allapinin
418-419
17
4
DETERMINATION OF THE AMOUNT OF OXIDOLIC ACIDS CONTAINED IN THE "SAFROBOS" COLLECTION
Cholear agents based on medicinal plants are in high demand in clinical practice,
as their effect is milder and longer-lasting compared to synthetic drugs. In order to increase the
choleretic properties of plant-derived medicines and treat concomitant diseases, various plant-based
preparations are used.
as their effect is milder and longer-lasting compared to synthetic drugs. In order to increase the
choleretic properties of plant-derived medicines and treat concomitant diseases, various plant-based
preparations are used.
420
15
8
INFLUENCE OF FACTORS ON THE ADSORPTION ACTIVITY OF SORBENTS
In case of drug poisoning, one of the first remedies is the introduction of
enterosorbents into the human body. Studies show that enterosorbents may have different ability to
bind toxins. Therefore, it was necessary to study the influence of factors such as the pH of the
medium, temperature and time on the adsorption activity.
enterosorbents into the human body. Studies show that enterosorbents may have different ability to
bind toxins. Therefore, it was necessary to study the influence of factors such as the pH of the
medium, temperature and time on the adsorption activity.
421-422
19
9
QUANTITATIVE DETERMINATION OF ASCORBIC ACID IN A DIETARY SUPPLEMENT VITAMINNI BY HPLC METHOD
Gummy dietary supplements in the form of jelly bears represent a modern and
convenient dosage form of vitamin-mineral complexes. One of the most demanded components of
such supplements is ascorbic acid (vitamin C), which possesses pronounced antioxidant properties
and is involved in numerous metabolic processes of the human body. To control the quality of such
dietary supplements, it is necessary to use highly accurate analytical methods, among which the most
sensitive is the high-performance liquid chromatography (HPLC) method.
convenient dosage form of vitamin-mineral complexes. One of the most demanded components of
such supplements is ascorbic acid (vitamin C), which possesses pronounced antioxidant properties
and is involved in numerous metabolic processes of the human body. To control the quality of such
dietary supplements, it is necessary to use highly accurate analytical methods, among which the most
sensitive is the high-performance liquid chromatography (HPLC) method.
423
19
5
PHYTOCHEMICAL POTENTIAL AND DIAGNOSTIC FEATURES OF ARTHROPHYTUM LONGIBRACTEATUM KOROVIN
Arthrophytum longibracteatum Korovin is a rare species of the family
Chenopodiaceae Less., growing in the arid ecosystems of Kazakhstan. This plant remains poorly
studied in terms of pharmacognostic aspects, which highlights the necessity of its comprehensive
investigation as a potential source of biologically active compounds
Chenopodiaceae Less., growing in the arid ecosystems of Kazakhstan. This plant remains poorly
studied in terms of pharmacognostic aspects, which highlights the necessity of its comprehensive
investigation as a potential source of biologically active compounds
424-425
29
7
LIPIDS OF THE AERIAL PARTS OF ARTEMISIA ANNUA L.
Lipids of medicinal plants are of interest as a source of biologically active
compounds. Artemisia annua L. (annual wormwood) is known for its antimalarial and anti
inflammatory properties, but the lipid composition of its aboveground parts has not been sufficiently
studied.
compounds. Artemisia annua L. (annual wormwood) is known for its antimalarial and anti
inflammatory properties, but the lipid composition of its aboveground parts has not been sufficiently
studied.
426
24
10
LIPID COMPOSITION OF THE AERIAL PARTS OF SAGE (SALVIA SP.)
Plants of the genus Salvia are rich in biologically active compounds. Studying the
lipid complex of the above-ground parts of sage is important for assessing its potential as a source of
functionally valuable polyunsaturated fatty acids and related components.
lipid complex of the above-ground parts of sage is important for assessing its potential as a source of
functionally valuable polyunsaturated fatty acids and related components.
427-428
23
15
MAHALLIY O’SIMLIK XOMASHYOLARI ASOSIDA OLINGAN O’T HAYDOVCHI YIG’MA TARKIBIDAGI SUVDA ERIYDIGAN VITAMINLARNI O’RGANISHGA DOIR
vitaminlar tanada yetarli bo‘lmasa, moddalar almashinuvi (metabolizm)
buzilishiga, jismoniy va aqliy faoliyatning susayishiga, hamda tez charchashga olib keladi.
Shuningdek, vitamin yetishmovchiligi immun tizimini zaiflashtirib, organizmni kasallik keltiruvchi
omillarga nisbatan himoyasiz holatga keltiradi. Natijada turli kasalliklarga, xususan, surunkali va
patologik holatlarga moyillik ortadi. Vitaminlar organizmdagi ko‘plab metabolik jarayonlarda
ishtirok etgani sababli, ularni kasalliklarning oldini olish va davolashda qo‘llash muhimdir. Ular
boshqa davo vositalarining samaradorligini oshirish, ularning ta’sirini kuchaytirish yoki to‘ldirishda
ham muhim rol o‘yna
buzilishiga, jismoniy va aqliy faoliyatning susayishiga, hamda tez charchashga olib keladi.
Shuningdek, vitamin yetishmovchiligi immun tizimini zaiflashtirib, organizmni kasallik keltiruvchi
omillarga nisbatan himoyasiz holatga keltiradi. Natijada turli kasalliklarga, xususan, surunkali va
patologik holatlarga moyillik ortadi. Vitaminlar organizmdagi ko‘plab metabolik jarayonlarda
ishtirok etgani sababli, ularni kasalliklarning oldini olish va davolashda qo‘llash muhimdir. Ular
boshqa davo vositalarining samaradorligini oshirish, ularning ta’sirini kuchaytirish yoki to‘ldirishda
ham muhim rol o‘yna
430
15
6
STUDY OF THE WOUND HEALING EFFECT OF NITRO-CONTAINING DERIVATIVES OF CARBOXYMETHYLINULIN
Wound healing is a complex process of physiological reactions aimed at restoring
the integrity of the skin and tissues. Disruptions in wound healing processes can lead to chronic
inflammation, infection, and the formation of difficult-to-treat defects. In this regard, special attention
is paid to the development of effective and biocompatible wound healing agents with minimal side
effects and promoting accelerated restoration of damaged tissues. It is known that some nitric oxide
donors promote accelerated wound healing by stimulating angiogenesis through dilation of blood
vessels. In addition, the use of nitric oxide donors also promotes activation of cell proliferation and
enhanced collagen synthesis, which plays a key role in restoring skin structure
the integrity of the skin and tissues. Disruptions in wound healing processes can lead to chronic
inflammation, infection, and the formation of difficult-to-treat defects. In this regard, special attention
is paid to the development of effective and biocompatible wound healing agents with minimal side
effects and promoting accelerated restoration of damaged tissues. It is known that some nitric oxide
donors promote accelerated wound healing by stimulating angiogenesis through dilation of blood
vessels. In addition, the use of nitric oxide donors also promotes activation of cell proliferation and
enhanced collagen synthesis, which plays a key role in restoring skin structure
431-432
31
5
STUDY OF ACUTE TOXICITY OF THE SAMPLE "SILICON POWER NANOSILICON" BASED ON SILICON NANOPARTICLES
In recent years, despite significant advances in the field of creating synthetic drugs,
many of which, unfortunately, are characterized by the presence of side effects and have
contraindications to application, substances of natural origin remain one of the promising sources for
obtaining new, highly effective drugs for the prevention and complex therapy of destructive lesions
of the stomach and intestines.
many of which, unfortunately, are characterized by the presence of side effects and have
contraindications to application, substances of natural origin remain one of the promising sources for
obtaining new, highly effective drugs for the prevention and complex therapy of destructive lesions
of the stomach and intestines.
433
45
11
“PROVIZORSKIY" GEPATOPROTEKTOR BALZAMINI O’TKIR ZAHARLILIGINI O`RGANISH
O`simlik tarkibli ko`p komponentli preparat bo`lib,turli davolash mexanizmiga ega
organizm uchun nojo`ya ta`sir ko`rsatmaydi.Shundan kelib ciqqan holda,”Provizorskiy”
gepatoprotektor balzamini farmakologik xususiyati ekspremental modellarda o`rganildi.
organizm uchun nojo`ya ta`sir ko`rsatmaydi.Shundan kelib ciqqan holda,”Provizorskiy”
gepatoprotektor balzamini farmakologik xususiyati ekspremental modellarda o`rganildi.
434
26
6
PHARMACOECONOMIC EVALUATION OF SCREENING AND DIAGNOSIS OF TYPE 2 DIABETES MELLITUS IN OUTPATIENT AND INPATIENT SETTINGS IN KAZAKHSTAN
In recent years, there has been a rapid increase in the global prevalence of
diabetes mellitus, which has reached the level of a non-communicable epidemic [1]. According to the
International Diabetes Federation (IDF), the number of people with diabetes increased from 151
million in 2000 to 425 million in 2017 [2]. According to the National Diabetes Registry of
Kazakhstan, as of January 1, 2017, 293,171 patients were registered, including 17,231 patients with
type 1 diabetes and 275,736 patients with type 2 diabetes. The annual increase in the number of
diabetic patients in Kazakhstan is 8–10%, along with a rising frequency of severe complications. All
these factors demonstrate the high relevance of the problem for the country’s healthcare system.
diabetes mellitus, which has reached the level of a non-communicable epidemic [1]. According to the
International Diabetes Federation (IDF), the number of people with diabetes increased from 151
million in 2000 to 425 million in 2017 [2]. According to the National Diabetes Registry of
Kazakhstan, as of January 1, 2017, 293,171 patients were registered, including 17,231 patients with
type 1 diabetes and 275,736 patients with type 2 diabetes. The annual increase in the number of
diabetic patients in Kazakhstan is 8–10%, along with a rising frequency of severe complications. All
these factors demonstrate the high relevance of the problem for the country’s healthcare system.
435
27
9
DETERMINATION OF FLAVONOIDS IN MEDICINAL PLANT EXTRACT (POLYGONUM AVICULARE L)
Polygonum aviculare L., also known as knotweed or bird's-foot buckwheat,
belongs to the buckwheat family (Polygonaceae). This widespread, seemingly inconspicuous plant
grows along roadsides, in yards, and in wastelands. The phytochemical composition of Polygonum
aviculare includes tannins, resins, traces of essential oil, vitamins C and K, and provitamin A. Its
leaves contain significant amounts of ascorbic acid in reduced form (405–450 mg%) and reversibly
oxidized form (253–300 mg%). In addition, the flavonol glycoside avicularin (C₂₀H₁₈O₁₁) has been
identified; upon hydrolysis, quercetin and arabinose are formed. Oxymethylanthraquinones have been
found in the plant's roots. The plant exhibits anti-inflammatory, hemostatic, diuretic, antioxidant, and
restorative properties. It is used for gastrointestinal and urinary tract disorders, bleeding, and in the
complex treatment and rehabilitation of cancer patients.
belongs to the buckwheat family (Polygonaceae). This widespread, seemingly inconspicuous plant
grows along roadsides, in yards, and in wastelands. The phytochemical composition of Polygonum
aviculare includes tannins, resins, traces of essential oil, vitamins C and K, and provitamin A. Its
leaves contain significant amounts of ascorbic acid in reduced form (405–450 mg%) and reversibly
oxidized form (253–300 mg%). In addition, the flavonol glycoside avicularin (C₂₀H₁₈O₁₁) has been
identified; upon hydrolysis, quercetin and arabinose are formed. Oxymethylanthraquinones have been
found in the plant's roots. The plant exhibits anti-inflammatory, hemostatic, diuretic, antioxidant, and
restorative properties. It is used for gastrointestinal and urinary tract disorders, bleeding, and in the
complex treatment and rehabilitation of cancer patients.
436-437
22
5
INHIBITORY EFFECT OF LUTEOLIN ON FSH-INDUCED 17β -ESTRADIOL BIOSYNTHESIS
In women of reproductive age, estrogen is a C18 steroid with diverse physiological
roles, primarily produced by the granulosa cells of the ovaries through endocrine signaling. Its
functions include promoting the development of secondary sexual traits, controlling gonadotropin
release to trigger ovulation, preparing tissues for progesterone activity, preserving bone density,
regulating lipoprotein metabolism, preventing urogenital atrophy, modulating insulin sensitivity, and
supporting cognitive health. In healthy premenopausal women, 17β-estradiol (E2) is the predominant
circulating estrogen, synthesized in the ovaries. This synthesis occurs through the aromatization of
androstenedione into estrone (E1), which is subsequently converted into 17β-estradiol. During normal
menstrual cycles, 17β-estradiol functions as a systemic hormone, exerting regulatory actions on
distant target tissues.
roles, primarily produced by the granulosa cells of the ovaries through endocrine signaling. Its
functions include promoting the development of secondary sexual traits, controlling gonadotropin
release to trigger ovulation, preparing tissues for progesterone activity, preserving bone density,
regulating lipoprotein metabolism, preventing urogenital atrophy, modulating insulin sensitivity, and
supporting cognitive health. In healthy premenopausal women, 17β-estradiol (E2) is the predominant
circulating estrogen, synthesized in the ovaries. This synthesis occurs through the aromatization of
androstenedione into estrone (E1), which is subsequently converted into 17β-estradiol. During normal
menstrual cycles, 17β-estradiol functions as a systemic hormone, exerting regulatory actions on
distant target tissues.
438-439
16
20
EFFECT OF LUTEOLIN ON OVARIAN MORPHOLOGY IN MICE WITH POLYCYSTIC OVARY SYNDROME (PCOS)
Polycystic ovary syndrome (PCOS) is a complex and multifactorial reproductive,
endocrine and metabolic disorder with diverse clinical manifestations, covering a wide spectrum of
symptoms from reproductive dysfunction to metabolic disturbances, which poses significant
challenges to patients’ quality of life and health. The etiology of PCOS remains unclear and involves
a complex interaction of genetics, environment and endocrine system. This makes prevention, early
diagnosis and effective treatment particularly challenging. Current treatment strategies for PCOS are
primarily aimed at symptomatic treatment rather than at curing the disease itself. Although existing
medications such as oral contraceptives and insulin sensitizers can alleviate symptoms to some extent,
their long-term use may be associated with a number of side effects such as lipid metabolism disorders
and increased insulin resistance, and some patients may have a suboptimal response to therapy.
Luteolin can regulate aromatase expression through the MKK3/6-p38 MAPK-CREB pathway. This
study reveals a potential role for TPL2 as a novel target in estrogen biosynthesis, providing new
insights for the treatment of PCOS.
endocrine and metabolic disorder with diverse clinical manifestations, covering a wide spectrum of
symptoms from reproductive dysfunction to metabolic disturbances, which poses significant
challenges to patients’ quality of life and health. The etiology of PCOS remains unclear and involves
a complex interaction of genetics, environment and endocrine system. This makes prevention, early
diagnosis and effective treatment particularly challenging. Current treatment strategies for PCOS are
primarily aimed at symptomatic treatment rather than at curing the disease itself. Although existing
medications such as oral contraceptives and insulin sensitizers can alleviate symptoms to some extent,
their long-term use may be associated with a number of side effects such as lipid metabolism disorders
and increased insulin resistance, and some patients may have a suboptimal response to therapy.
Luteolin can regulate aromatase expression through the MKK3/6-p38 MAPK-CREB pathway. This
study reveals a potential role for TPL2 as a novel target in estrogen biosynthesis, providing new
insights for the treatment of PCOS.
440-441
17
6
PROSPECTS FOR THE USE OF APIGENIN IN BREAST CANCER THERAPY
Breast cancer (BC) continues to represent one of the most pressing health
challenges of modern oncology, ranking as the leading cause of cancer-related morbidity and
mortality among women globally. According to recent international epidemiological projections, by
the year 2040 the overall incidence of BC is expected to rise by more than 40%, thereby placing an
even greater burden on healthcare systems and highlighting the urgent necessity for novel and more
effective therapeutic strategies.
challenges of modern oncology, ranking as the leading cause of cancer-related morbidity and
mortality among women globally. According to recent international epidemiological projections, by
the year 2040 the overall incidence of BC is expected to rise by more than 40%, thereby placing an
even greater burden on healthcare systems and highlighting the urgent necessity for novel and more
effective therapeutic strategies.
442
26
4
EFFECT OF THE M-10 DRUG ON ARTERIAL PRESSURE IN WHITE RATS
Today, cardiovascular diseases are one of the most pressing problems in
the global healthcare system and are one of the leading causes of death worldwide. According to the
World Health Organization, more than 17 million people die annually from cardiovascular diseases.
Therefore, the search for new biologically active substances and the assessment of their impact on
the cardiovascular system are of great scientific and practical importance.
the global healthcare system and are one of the leading causes of death worldwide. According to the
World Health Organization, more than 17 million people die annually from cardiovascular diseases.
Therefore, the search for new biologically active substances and the assessment of their impact on
the cardiovascular system are of great scientific and practical importance.
443-444
16
15
CAPPARIS SPINOSA L. ANTI-HYPOXIA ACTIVITY OF POLYSACCHARIDE ASSEMBLAGES FROM THE ROOT PART OF THE PLANT
Hypoxia is one of the leading factors in the pathogenesis of cardiovascular and neurological
diseases, ranking first among other pathological conditions in the body in terms of prevalence and
death. Most often, the state of hypoxia is observed together in various pathological conditions that
occur mainly in diseases of the cardiovascular system, respiratory system, as well as in some
infectious diseases and acute poisoning.ypoxia is one of the leading factors in the pathogenesis of
cardiovascular and neurological diseases, ranking first among other pathological conditions in the
body in terms of prevalence and death.
diseases, ranking first among other pathological conditions in the body in terms of prevalence and
death. Most often, the state of hypoxia is observed together in various pathological conditions that
occur mainly in diseases of the cardiovascular system, respiratory system, as well as in some
infectious diseases and acute poisoning.ypoxia is one of the leading factors in the pathogenesis of
cardiovascular and neurological diseases, ranking first among other pathological conditions in the
body in terms of prevalence and death.
445
41
7
THE EFFECT OF BACTERIAL ENDOTOXINS ON THE LEVEL OF ALANINE AMINOTRANSFERASE AND ASPARTATE AMINOTRANSFERASE IN THE BLOOD
Bacterial endotoxins, also known as polysaccharides (LPS), are known to be the main
component of the outer membrane of gram-negative bacteria. Bacterial endotoxins are present in the
bloodstream throughout life and participate in the regulation of immune system activity at all levels.
Lipopolysaccharides enable the adaptation of the immune and other vital body systems to constantly
changing external and internal environmental conditions. However, excessive bacterial endotoxins
entering the bloodstream can cause the development of endotoxin aggression and endotoxin shock,
or acute multiple organ failure syndrome. It has been shown that damage to liver parenchymal cells
begins with membrane disruption resulting from lipopolysaccharide activation of the arachidonic acid
cascade . It has also been shown that 3 hours after intravenous administration of bacterial endotoxins,
the number of lysosomes within parenchymal cells localized around the bile ducts increases
component of the outer membrane of gram-negative bacteria. Bacterial endotoxins are present in the
bloodstream throughout life and participate in the regulation of immune system activity at all levels.
Lipopolysaccharides enable the adaptation of the immune and other vital body systems to constantly
changing external and internal environmental conditions. However, excessive bacterial endotoxins
entering the bloodstream can cause the development of endotoxin aggression and endotoxin shock,
or acute multiple organ failure syndrome. It has been shown that damage to liver parenchymal cells
begins with membrane disruption resulting from lipopolysaccharide activation of the arachidonic acid
cascade . It has also been shown that 3 hours after intravenous administration of bacterial endotoxins,
the number of lysosomes within parenchymal cells localized around the bile ducts increases
446
13
5
STUDY OF THE SPECIFIC ACTIVITY OF A BIOACTIVE SUPPLEMENT FOR THE PREVENTION OF CONSTIPATION
According to the World Health Organization (WHO) and other medical research
data, 10–20% of the global population suffers from chronic constipation. This issue is especially
prevalent among women, the elderly, pregnant women, and individuals with sedentary lifestyles.
Constipation not only causes discomfort but can also lead to hemorrhoids, anal fissures, intestinal
dysfunction, and chronic toxicosis.Long-term use of many synthetic laxatives can result in intestinal
habituation (tolerance), dysbiosis, and disruption of the water-electrolyte balance. Therefore, there is
a growing demand for natural, safe, and effective alternatives.The global laxative market exceeded
$10 billion USD in 2024, and continues to grow annually. In the bioactive supplements segment,
constipation-relief products stand out as a distinct and growing category
data, 10–20% of the global population suffers from chronic constipation. This issue is especially
prevalent among women, the elderly, pregnant women, and individuals with sedentary lifestyles.
Constipation not only causes discomfort but can also lead to hemorrhoids, anal fissures, intestinal
dysfunction, and chronic toxicosis.Long-term use of many synthetic laxatives can result in intestinal
habituation (tolerance), dysbiosis, and disruption of the water-electrolyte balance. Therefore, there is
a growing demand for natural, safe, and effective alternatives.The global laxative market exceeded
$10 billion USD in 2024, and continues to grow annually. In the bioactive supplements segment,
constipation-relief products stand out as a distinct and growing category
447-448
28
7
EVALUATION OF THE STATE OF THE CARDIOVASCULAR SYSTEM OF RABBITS UNDER INFLUENCE OF FREE AND BOUND FORM OF THE CYTOSTATIC AGENT DOXORUBICIN
Targeted drugs, which significantly reduce the toxic effects of cytostatic drugs, are
widely used in clinical practice for the treatment of cancer. The Institute of Bioorganic Chemistry of
the Academy of Sciences of the Republic of Uzbekistan has developed a polysaccharide-conjugated
form of doxorubicin (DOX), PGA-DOX, which has promising medical implications.
widely used in clinical practice for the treatment of cancer. The Institute of Bioorganic Chemistry of
the Academy of Sciences of the Republic of Uzbekistan has developed a polysaccharide-conjugated
form of doxorubicin (DOX), PGA-DOX, which has promising medical implications.
449
15
5
ANALYSIS OF GENE EXPRESSION PROFILE CHANGES FOLLOWING THERAPY WITH 4-[(3-ETHOXY-3-OXOPROPANOYL) AMINO] BENZOIC ACID IN EXPERIMENTAL CHRONIC HEART FAILURE
Topicality. Chronic heart failure (CHF) is associated with systemic oxidative stress and
significant impairment of cellular metabolism, contributing to damage to target organs, particularly
the kidneys. Current therapeutic approaches have limited efficacy in correcting these metabolic
disorders. Succinate dehydrogenase (SDH) inhibitors, such as 4-[(3-ethoxy-3-oxopropanoyl) amino]
benzoic acid (etmaben), are considered potential agents for metabolic therapy; however, their
molecular mechanisms of action in established CHF remain poorly understood.
significant impairment of cellular metabolism, contributing to damage to target organs, particularly
the kidneys. Current therapeutic approaches have limited efficacy in correcting these metabolic
disorders. Succinate dehydrogenase (SDH) inhibitors, such as 4-[(3-ethoxy-3-oxopropanoyl) amino]
benzoic acid (etmaben), are considered potential agents for metabolic therapy; however, their
molecular mechanisms of action in established CHF remain poorly understood.
450
21
14
STUDYING THE CAUSES OF FIBROADENOMA DISEASE IN YOUNG GIRLS IN UZBEKISTAN
In recent years, breast diseases, in particular various tumors, have had a significant
impact on women's health worldwide. Currently, fibroadenoma (breast cancer) is a benign tumor that
is common in young women and girls. Since the widespread prevalence of fibroadenoma in young
girls is associated with reproductive health, the psychological state of women, and future motherhood
opportunities, an in-depth study of the topic is one of the current issues. Based on the results of
epidemiological observations conducted in Uzbekistan, approximately 7-9% of young girls aged 18
25 have been diagnosed with fibroadenoma. Objectives of the study: To conduct a metrological
analysis of the causes of fibroadenoma in young girls, to identify hormonal and hereditary factors,
and to study the factors influencing it
impact on women's health worldwide. Currently, fibroadenoma (breast cancer) is a benign tumor that
is common in young women and girls. Since the widespread prevalence of fibroadenoma in young
girls is associated with reproductive health, the psychological state of women, and future motherhood
opportunities, an in-depth study of the topic is one of the current issues. Based on the results of
epidemiological observations conducted in Uzbekistan, approximately 7-9% of young girls aged 18
25 have been diagnosed with fibroadenoma. Objectives of the study: To conduct a metrological
analysis of the causes of fibroadenoma in young girls, to identify hormonal and hereditary factors,
and to study the factors influencing it
451-452
19
7
RESEARCH ON THE PHARMACOLOGICAL ACTIVITY OF ISATIS TINCTORIA SEED OIL
I. tinctoria seed oil contains a number of bioactive components, including alkaloids,
flavonoids, and phenolic compounds, which may have anti-inflammatory, antioxidant, antimicrobial,
and antiviral effects. Studies of the pharmacological activity of the oil may provide new data for its
use as a natural remedy for various diseases, such as respiratory tract infections, skin inflammations,
wounds and burns.
flavonoids, and phenolic compounds, which may have anti-inflammatory, antioxidant, antimicrobial,
and antiviral effects. Studies of the pharmacological activity of the oil may provide new data for its
use as a natural remedy for various diseases, such as respiratory tract infections, skin inflammations,
wounds and burns.
453-454
23
7
STUDY OF THE ANTIPYRETIC ACTION OF DRY EXTRACT RHEUM TATARICUM L.
Herbal preparations are multicomponent, have different mechanisms of action and
do not have side effects on the body. Based on this, we studied the pharmacological activity of the
dry extract of Rheum Tataricum L. on experimental models .
do not have side effects on the body. Based on this, we studied the pharmacological activity of the
dry extract of Rheum Tataricum L. on experimental models .
455-456
28
8
EXCRETION OF THE MICROLEMENT MANGANESE
Manganese (Mn) is an essential nutrient for cellular activity, acting as a cofactor
for enzymes such as arginase and glutamine synthetase. These metalloproteins enable manganese to
play a key role in various bodily functions, including development, digestion, reproduction,
antioxidant protection, energy production, immune response, and regulation of nerve activity.
for enzymes such as arginase and glutamine synthetase. These metalloproteins enable manganese to
play a key role in various bodily functions, including development, digestion, reproduction,
antioxidant protection, energy production, immune response, and regulation of nerve activity.
457-458
18
8
THE IMPORTANCE OF TREATING STOMACH AND DUODENAL ULCER DISEASE IN PHYTOTHERAPY AND ITS ANALYSIS THROUGH THE EXAMPLE OF MEDICINAL PLANTS
In modern medicine, one of the most pressing challenges is the increasing
prevalence of gastrointestinal disorders, particularly gastric and duodenal ulcers. The primary
etiological factor of these conditions is the bacterium Helicobacter pylori, which damages the
protective mucosal barrier of the gastrointestinal tract, disrupts gastric acidity, and initiates
inflammatory processes. Peptic ulcer disease is considered one of the most widespread internal
pathologies, requiring a comprehensive therapeutic approach. The main objectives of treatment are
pain relief, ulcer healing, prevention of complications, and reduction of recurrence, making this
condition a highly relevant issue in contemporary healthcare.
prevalence of gastrointestinal disorders, particularly gastric and duodenal ulcers. The primary
etiological factor of these conditions is the bacterium Helicobacter pylori, which damages the
protective mucosal barrier of the gastrointestinal tract, disrupts gastric acidity, and initiates
inflammatory processes. Peptic ulcer disease is considered one of the most widespread internal
pathologies, requiring a comprehensive therapeutic approach. The main objectives of treatment are
pain relief, ulcer healing, prevention of complications, and reduction of recurrence, making this
condition a highly relevant issue in contemporary healthcare.
459-460
23
6
THE THERAPEUTIC EFFECTIVENESS IN EXPERIMENTAL GASTRIC ULCERS ACID SODIUM SALT WITH SALLITSILAT INDUKSION GLITSERRIZIN ANALYSIS OF MONOAMMONIY
Current period, gastric and o‘n two fingers of the intestine wounds (peptic ulcer disease) health
storage system important clinical and social problems one as distinguished is. The world healthyliqni
storage organization data according, this pathology of the population, 10-20 % up to that part of the
cover will. Though modern in pharmacology wide ko‘lamli medicinal drugs available are, despite
them each always also of the patient's individual needs for a complete answer you give can't. For this
reason, natural source and less nojoiz‘ya effect have that substances, the therapeutic capabilities of a
deep study topical is.
storage system important clinical and social problems one as distinguished is. The world healthyliqni
storage organization data according, this pathology of the population, 10-20 % up to that part of the
cover will. Though modern in pharmacology wide ko‘lamli medicinal drugs available are, despite
them each always also of the patient's individual needs for a complete answer you give can't. For this
reason, natural source and less nojoiz‘ya effect have that substances, the therapeutic capabilities of a
deep study topical is.
461-462
13
6
4
EVALUATION OF HYPOLIPIDEMIC ACTIVITY OF FLAVONOIDS FROM CROCUS SATIVUS
It is currently established that lipid metabolism disorders are a leading risk factor
for the development of cardiovascular diseases -vascular diseases, mainly due to the significant
influence of cholesterol on the development of atherosclerosis, diabetes mellitus, obesity, and,
accordingly, the risk of developing ischemic stroke. Therefore, the search for new active agents
capable of exerting a pharmacocorrective effect on impaired lipid metabolism remains a highly
relevant task. As part of the ongoing search for new non-toxic and effective herbal remedies for the
treatment of cardiovascular disease and ischemic stroke, encouraging results were obtained when
considering a drug with the tentative name “Saflavin” (dry powder of the aqueous fraction of the
ethanol extract of secondary metabolites of Crocus sativus L. stamens).
for the development of cardiovascular diseases -vascular diseases, mainly due to the significant
influence of cholesterol on the development of atherosclerosis, diabetes mellitus, obesity, and,
accordingly, the risk of developing ischemic stroke. Therefore, the search for new active agents
capable of exerting a pharmacocorrective effect on impaired lipid metabolism remains a highly
relevant task. As part of the ongoing search for new non-toxic and effective herbal remedies for the
treatment of cardiovascular disease and ischemic stroke, encouraging results were obtained when
considering a drug with the tentative name “Saflavin” (dry powder of the aqueous fraction of the
ethanol extract of secondary metabolites of Crocus sativus L. stamens).
461-462
13
6
EVALUATION OF HYPOLIPIDEMIC ACTIVITY OF FLAVONOIDS FROM CROCUS SATIVUS
It is currently established that lipid metabolism disorders are a leading risk factor
for the development of cardiovascular diseases -vascular diseases, mainly due to the significant
influence of cholesterol on the development of atherosclerosis, diabetes mellitus, obesity, and,
accordingly, the risk of developing ischemic stroke. Therefore, the search for new active agents
capable of exerting a pharmacocorrective effect on impaired lipid metabolism remains a highly
relevant task. As part of the ongoing search for new non-toxic and effective herbal remedies for the
treatment of cardiovascular disease and ischemic stroke, encouraging results were obtained when
considering a drug with the tentative name “Saflavin” (dry powder of the aqueous fraction of the
ethanol extract of secondary metabolites of Crocus sativus L. stamens).
for the development of cardiovascular diseases -vascular diseases, mainly due to the significant
influence of cholesterol on the development of atherosclerosis, diabetes mellitus, obesity, and,
accordingly, the risk of developing ischemic stroke. Therefore, the search for new active agents
capable of exerting a pharmacocorrective effect on impaired lipid metabolism remains a highly
relevant task. As part of the ongoing search for new non-toxic and effective herbal remedies for the
treatment of cardiovascular disease and ischemic stroke, encouraging results were obtained when
considering a drug with the tentative name “Saflavin” (dry powder of the aqueous fraction of the
ethanol extract of secondary metabolites of Crocus sativus L. stamens).
463
16
4
STUDY OF THE ANTIPROLIFERATIVE ACTIVITY OF A DRY EXTRACT PREPARED FROM THE AERIAL PART OF THE LOCAL LOPHANTHUS ANISATUS BENTH
Inflammation is a complex complex reaction of the body as a whole, has a protective-adaptive
nature and is formed in the process of evolution, expressed mainly by local tissue changes - alteration,
exudation, caused by impaired local circulation, emigration and proliferation of leukocytes. In folk
medicine, anise lofant is used for inflammatory processes of the respiratory organs, bronchitis, to
improve the immune system, for gastritis, hepatitis, gastrointestinal disorders, as a strengthening and
anti-aging agent.
nature and is formed in the process of evolution, expressed mainly by local tissue changes - alteration,
exudation, caused by impaired local circulation, emigration and proliferation of leukocytes. In folk
medicine, anise lofant is used for inflammatory processes of the respiratory organs, bronchitis, to
improve the immune system, for gastritis, hepatitis, gastrointestinal disorders, as a strengthening and
anti-aging agent.
464
16
4
COMPARATIVE EVALUATION OF THE EFFECTIVENESS OF EMHPS AND ITS METABOLITE EMSP ON RESPIRATORY PARAMETERS, MOTOR ACTIVITY AND GENE EXPRESSION OF MITOCHONDRIAL COMPLEXES IN MICE UNDER CONDITIONS OF INTERMITTENT HYPOXIA
Intermittent hypoxia (IH) is a pathological factor that provokes oxidative stress,
which can initiate a cascade of pathological conditions, mitochondrial dysfunction, inflammation,
endothelial dysfunction and metabolic disorders. In this regard, the study of active antioxidants is
relevant. In this work, we studied the antihypoxic properties of the metabolite of
ethylmethylhydroxypyridine succinate (EMHPS) - ethylmethylsulfapyridine (EMSP) on the IH
model in mice. In previous studies, EMSP exhibited antihypoxic and antioxidant properties [1-3].
which can initiate a cascade of pathological conditions, mitochondrial dysfunction, inflammation,
endothelial dysfunction and metabolic disorders. In this regard, the study of active antioxidants is
relevant. In this work, we studied the antihypoxic properties of the metabolite of
ethylmethylhydroxypyridine succinate (EMHPS) - ethylmethylsulfapyridine (EMSP) on the IH
model in mice. In previous studies, EMSP exhibited antihypoxic and antioxidant properties [1-3].
465
27
7
METHOD FOR EXPERIMENTAL STUDY OF THE ACUTE TOXICITY OF PLANT COLLECTIONS
Currently, the problems of preserving and strengthening human health are
becoming increasingly urgent on a global scale. In particular, the side effects of synthetic chemical
drugs, allergic reactions, and negative consequences resulting from long-term use increase the need
for natural medicines. From this point of view, the importance of medicines prepared on the basis of
medicinal plants in our lives is increasing. Medicinal plants have been used in folk medicine since
ancient times and have natural, environmentally friendly properties that have a mild effect on the
human body. The modern pharmaceutical industry also pays great attention to the production of
effective medicines from the components of medicinal herbs. Therefore, conducting scientific
research on the study of medicinal plants, the possibilities of their proper collection, processing, and
use as a medicinal product is a pressing issue. The choice of this topic, on the one hand, contributes
to the formation of a healthy lifestyle, and on the other hand, serves the preservation and development
of our national traditional medicine
becoming increasingly urgent on a global scale. In particular, the side effects of synthetic chemical
drugs, allergic reactions, and negative consequences resulting from long-term use increase the need
for natural medicines. From this point of view, the importance of medicines prepared on the basis of
medicinal plants in our lives is increasing. Medicinal plants have been used in folk medicine since
ancient times and have natural, environmentally friendly properties that have a mild effect on the
human body. The modern pharmaceutical industry also pays great attention to the production of
effective medicines from the components of medicinal herbs. Therefore, conducting scientific
research on the study of medicinal plants, the possibilities of their proper collection, processing, and
use as a medicinal product is a pressing issue. The choice of this topic, on the one hand, contributes
to the formation of a healthy lifestyle, and on the other hand, serves the preservation and development
of our national traditional medicine
466-467
19
17
EXPERIMENTAL ANIMAL MODELS USED IN LIVER DISEASES
Liver diseases are among the leading causes of mortality worldwide. Animal
models play a crucial role in the preclinical stage for the development and evaluation of
hepatoprotective drugs. Liver disorders such as hepatitis, steatosis, fibrosis, and cirrhosis pose
significant social and economic challenges globally. According to the World Health
models play a crucial role in the preclinical stage for the development and evaluation of
hepatoprotective drugs. Liver disorders such as hepatitis, steatosis, fibrosis, and cirrhosis pose
significant social and economic challenges globally. According to the World Health
468-469
34
8
STUDY OF THE ALLERGIC AND CUMULATIVE EFFECTS OF A HERBAL TEA MADE FROM A CICHORIUM INTYBUS PLANT
One of the priority tasks in the field of pharmaceuticals is to provide the population
of our republic with effective and safe medicinal products and biologically active supplements (BAS)
derived from local plants.
of our republic with effective and safe medicinal products and biologically active supplements (BAS)
derived from local plants.
470-471
16
10
ИЗУЧЕНИЕ ЭФФЕКТА ИНТРАНАЗАЛЬНОГО ВВЕДЕНИЯ ИНСУЛИНА И ИНСУЛИНОПОДОБНОГО ПЕПТИДА НА КОГНИТИВНЫЕ ПАРАМЕТРЫ ЖИВОТНЫХ
нарушения обменных процессов инсулина и системы передачи сигналов
инсулина в центральной нервной системе могут способствовать развитию различных
заболеваний головного мозга, следствием большинства из которых являются когнитивные
расстройства. Своевременная диагностика и адекватная патогенетическая терапия
неврологических осложнений сахарного диабета имеют крайне важное значение
в комплексном ведении пациентов с данным заболеванием
инсулина в центральной нервной системе могут способствовать развитию различных
заболеваний головного мозга, следствием большинства из которых являются когнитивные
расстройства. Своевременная диагностика и адекватная патогенетическая терапия
неврологических осложнений сахарного диабета имеют крайне важное значение
в комплексном ведении пациентов с данным заболеванием
472-473
27
9
STUDYING THE ANTI-INFLAMMATORY PROPERTIES OF SALVIA OFFICINALIS
Inflammation is one of the body's defense mechanisms that develops as a response
to infection, injury, or other adverse effects. At the same time, chronic inflammatory processes are
considered an important pathogenetic factor in the development of atherosclerosis, diabetes mellitus,
arthritis, and even oncological diseases. In recent decades, scientific research has shown great interest
in natural bioactive substances, particularly extracts from medicinal plants, as potential sources of
anti-inflammatory agents.
to infection, injury, or other adverse effects. At the same time, chronic inflammatory processes are
considered an important pathogenetic factor in the development of atherosclerosis, diabetes mellitus,
arthritis, and even oncological diseases. In recent decades, scientific research has shown great interest
in natural bioactive substances, particularly extracts from medicinal plants, as potential sources of
anti-inflammatory agents.
474-475
18
8
DETERMINATION OF ANTIMICROBIAL ACTIVITY OF DRY RASPBERRY LEAVES
The medicinal properties of plants are determined by their active substances, based
on which or by synthesizing which the pharmaceutical industry produces effective medicinal herbal
preparations. Therefore, the search for alternative medicinal herbal preparations with a wide spectrum
of antimicrobial activity is very relevant.
on which or by synthesizing which the pharmaceutical industry produces effective medicinal herbal
preparations. Therefore, the search for alternative medicinal herbal preparations with a wide spectrum
of antimicrobial activity is very relevant.
476
29
6
HERBAL REMEDIES IN THE TREATMENT OF ANTI-ULCER DRUGS
Peptic ulcer disease (PUD) holds a special place among chronic diseases of the
gastrointestinal tract due to its prevalence and severity. We know that in most cases, synthetic drugs
are taken which have a pronounced pharmacotherapeutic effect. However, they also have side effects
on other functional organs. This limits their possible use in some cases (for children and pregnant
women) as well as for individual intolerance to synthetic drugs. In this regard, the use of medicinal
plants with anti-ulcer effects is relevant.
gastrointestinal tract due to its prevalence and severity. We know that in most cases, synthetic drugs
are taken which have a pronounced pharmacotherapeutic effect. However, they also have side effects
on other functional organs. This limits their possible use in some cases (for children and pregnant
women) as well as for individual intolerance to synthetic drugs. In this regard, the use of medicinal
plants with anti-ulcer effects is relevant.
477
21
4
CHANGES IN THE PHYSICAL ENDURANCE OF MICE BASED ON THE RESULTS OF A SWIMMING TEST BASED ON THE COMBINED USE OF ACTOPROTECTIVE AGENTS
Physical performance is a key indicator of the functional state of the body,
reflecting the ability to exercise and fatigue resistance. In sports physiology and pharmacology,
endurance assessment is important in developing training programs and testing various effects. Mice
are widely used as models due to their genetic uniformity and sensitivity. The swimming to
exhaustion test is a valid method of assessing endurance
reflecting the ability to exercise and fatigue resistance. In sports physiology and pharmacology,
endurance assessment is important in developing training programs and testing various effects. Mice
are widely used as models due to their genetic uniformity and sensitivity. The swimming to
exhaustion test is a valid method of assessing endurance
478-479
28
5
CARDIAC MARKERS IN THE BLOOD OF RATS EXPOSED TO FREE AND BOUND DOXORUBICIN
The anthracycline antibiotic doxorubicin (DOX) is widely used in clinical
practice for the treatment of cancer; however, its high cardiotoxicity limits its use. The development
of targeted delivery systems for the cytostatic agent to the tumor site has significantly reduced DOX
toxicity. Research in this area has also been conducted at the Institute of Bioorganic Chemistry of the
Academy of Sciences of the Republic of Uzbekistan, where various DOX derivatives have been
obtained. Comprehensive studies are currently underway on the promising polysaccharide
conjugated drug PGA-DOX. To assess the cardiotoxic effect of various drugs, levels of various
cardiac markers are determined.
practice for the treatment of cancer; however, its high cardiotoxicity limits its use. The development
of targeted delivery systems for the cytostatic agent to the tumor site has significantly reduced DOX
toxicity. Research in this area has also been conducted at the Institute of Bioorganic Chemistry of the
Academy of Sciences of the Republic of Uzbekistan, where various DOX derivatives have been
obtained. Comprehensive studies are currently underway on the promising polysaccharide
conjugated drug PGA-DOX. To assess the cardiotoxic effect of various drugs, levels of various
cardiac markers are determined.
480
26
12
INVESTIGATION OF THE SPECIFIC EFFECT OF A DENTAL GEL BASED ON THE HANDELIA PLANT
Due to the high prevalence of oral inflammatory diseases among the population of
our republic, the development of natural-based dental gels and the study of their activity is considered
relevant.
our republic, the development of natural-based dental gels and the study of their activity is considered
relevant.
481
10
3
THERAPEUTIC STRATEGIES FOR CEREBRAL ATHEROSCLEROSIS UNDER HIGH-ALTITUDE CONDITIONS: ADAPTIVE-METABOLIC CORRECTION
Cerebral atherosclerosis under high-altitude conditions has a more severe course
due to chronic hypobaric hypoxia, which enhances mitochondrial dysfunction, lipid peroxidation, and
energy deficit in brain cells. This leads to faster progression of cognitive impairments and increases
the risk of ischemic stroke. The search for therapeutic strategies focused not only on the vascular
component but also on adaptive-metabolic support is a pressing task.
due to chronic hypobaric hypoxia, which enhances mitochondrial dysfunction, lipid peroxidation, and
energy deficit in brain cells. This leads to faster progression of cognitive impairments and increases
the risk of ischemic stroke. The search for therapeutic strategies focused not only on the vascular
component but also on adaptive-metabolic support is a pressing task.
482-483
16
10
STUDYING THE ANTIANEMIC ACTIVITY OF THE PREPARATION FOLIC ACID
Anemia is a group of diseases characterized by a decrease in the number of
circulating red blood cells and (or) hemoglobin (Hb) in a unit of blood volume below the normal level
for a given age and gender. Today, the relevance of the anemia problem remains high: every fourth
person in the world suffers from anemia, and women and children are especially affected. Anemia is
a common symptom of a wide range of diseases, including malignant tumors, and requires attention
due to its severe consequences for health and quality of life, especially in Africa and Southeast Asia.
Prevention and treatment of iron deficiency is one of the most important health problems in many
countries around the world. In the treatment of anemia, folic acid plays a key role, ensuring the
process of formation of blood cells (erythrocytes) when there is a lack of iron in the body. Stimulates
erythropoiesis, participates in the synthesis of nucleic and amino acids, purine and pyrimidine bases,
in the metabolism of choline and histidine.
circulating red blood cells and (or) hemoglobin (Hb) in a unit of blood volume below the normal level
for a given age and gender. Today, the relevance of the anemia problem remains high: every fourth
person in the world suffers from anemia, and women and children are especially affected. Anemia is
a common symptom of a wide range of diseases, including malignant tumors, and requires attention
due to its severe consequences for health and quality of life, especially in Africa and Southeast Asia.
Prevention and treatment of iron deficiency is one of the most important health problems in many
countries around the world. In the treatment of anemia, folic acid plays a key role, ensuring the
process of formation of blood cells (erythrocytes) when there is a lack of iron in the body. Stimulates
erythropoiesis, participates in the synthesis of nucleic and amino acids, purine and pyrimidine bases,
in the metabolism of choline and histidine.
484
36
6
DETERMINATION OF THE ACUTE TOXICITY OF WILD PEAR (PYRUS PYRASTER) DRY EXTRACT
As is known from the literature, the fruit of pear (Pyrus communis)
has been used as food since ancient times. There are more than 22 species of it, one of which is the
wild pear, which is the ancestor of the modern cultivated pear. Diabetes mellitus remains one of the
most urgent problems of clinical medicine. Diabetes mellitus is the third leading cause of death from
this disease (6%), after cardiovascular diseases (51%) and cancer (17%). Over the past 10 years, the
incidence of diabetes mellitus has increased in all countries of the world. Children under the age of
14 account for 6-8% of the population with diabetes. The annual increase in the number of children
with insulin-dependent diabetes is 6%. Up to 13% of children with diabetes are under the age of 5.
Due to the high content of beneficial substances in the composition of wild pear, it has been used: for
diuretics, inflammation, normalization of blood pressure, and boosting immunity. Scientific research
in recent years has shown that natural compounds consisting of polyphenols and polysaccharides in
their chemical composition are used to prevent the development of obesity and diabetes (by reducing
the amount of glucose in the blood).
has been used as food since ancient times. There are more than 22 species of it, one of which is the
wild pear, which is the ancestor of the modern cultivated pear. Diabetes mellitus remains one of the
most urgent problems of clinical medicine. Diabetes mellitus is the third leading cause of death from
this disease (6%), after cardiovascular diseases (51%) and cancer (17%). Over the past 10 years, the
incidence of diabetes mellitus has increased in all countries of the world. Children under the age of
14 account for 6-8% of the population with diabetes. The annual increase in the number of children
with insulin-dependent diabetes is 6%. Up to 13% of children with diabetes are under the age of 5.
Due to the high content of beneficial substances in the composition of wild pear, it has been used: for
diuretics, inflammation, normalization of blood pressure, and boosting immunity. Scientific research
in recent years has shown that natural compounds consisting of polyphenols and polysaccharides in
their chemical composition are used to prevent the development of obesity and diabetes (by reducing
the amount of glucose in the blood).
485
21
8
STUDY OF THE EFFECT OF THE SUBSTANCE “ALFAMANKOR” ON HEPG2 CELLS
Liver cancer, particularly hepatocellular carcinoma (HepG2), is one of the most
common cancers worldwide, with a high mortality rate. Current chemotherapeutic agents often have
significant side effects, and their effectiveness is limited. Therefore, the search for new, effective, and
less toxic compounds is considered a key area of research in oncology
common cancers worldwide, with a high mortality rate. Current chemotherapeutic agents often have
significant side effects, and their effectiveness is limited. Therefore, the search for new, effective, and
less toxic compounds is considered a key area of research in oncology
486-487
58
15
ИССЛЕДОВАНИЯ ПО ОСТРОЙ И ХРОНИЧЕСКОЙ ТОКСИЧНОСТИ БИОЛОГИЧЕСКОЙ АКТИВНОЙ ДОБАВКИ «АС-КУРКУМИН»
Разработка новых фармакологически эффективных лекарственных
средств (ЛС) или биологически активных добавок (БАД) включает совершенствование
технологий получения, а также подбор вспомогательных веществ и наполнителей,
способствующих улучшению биодоступности и стабильности активных компонентов. ЛС и
БАД растительного происхождения представлены в различных лекарственных формах и
включают стандартизованные экстракты, эфирные масла и выделенные биологически
активные соединения. Одним из направлений расширения ассортимента растительных
лекарственных средств является углублённое фармакологическое изучение уже известных
фармакопейных растений, традиционно применяемых при ограниченном числе показаний.
Многие из них обладают потенциалом для более широкого терапевтического использования.
Перспективным представляется также формирование рациональных многокомпонентных
фитокомпозиций, содержащих совокупность биологически активных веществ с
полифункциональным фармакологическим действием, направленным на регуляцию
физиологических процессов в функционально взаимосвязанных системах организма
средств (ЛС) или биологически активных добавок (БАД) включает совершенствование
технологий получения, а также подбор вспомогательных веществ и наполнителей,
способствующих улучшению биодоступности и стабильности активных компонентов. ЛС и
БАД растительного происхождения представлены в различных лекарственных формах и
включают стандартизованные экстракты, эфирные масла и выделенные биологически
активные соединения. Одним из направлений расширения ассортимента растительных
лекарственных средств является углублённое фармакологическое изучение уже известных
фармакопейных растений, традиционно применяемых при ограниченном числе показаний.
Многие из них обладают потенциалом для более широкого терапевтического использования.
Перспективным представляется также формирование рациональных многокомпонентных
фитокомпозиций, содержащих совокупность биологически активных веществ с
полифункциональным фармакологическим действием, направленным на регуляцию
физиологических процессов в функционально взаимосвязанных системах организма
488-489
30
6
HYGIENIC CHARACTERISTICS OF WORKING CONDITIONS IN THE PHYTOCHEMICAL SECTOR OF THE "SULTON MEDPHARM" LLC PRODUCTION
In the Republic of Uzbekistan, the task of creating its own industrial pharmaceutical
base, capable of solving many problems related to production conditions, is currently acute. To ensure
the creation of optimal working conditions in pharmaceutical enterprises operating under our natural
and climatic conditions, it is already necessary to have a comprehensive hygienic characterization of
pharmaceutical production.
base, capable of solving many problems related to production conditions, is currently acute. To ensure
the creation of optimal working conditions in pharmaceutical enterprises operating under our natural
and climatic conditions, it is already necessary to have a comprehensive hygienic characterization of
pharmaceutical production.
490
27
9
INFLUENCE OF DIHYDROQUERCITIN ON RESTORATION OF LACTATE CONTENT IN BLOOD IN HIGHLY SKILLED ROWERS
Today, the constant growth of sports results in canoeing requires intensification of
the athletes' training system. To improve the performance of high-class rowers, the use of biologically
active additives is in high demand. As such, dihydroquercetin, which has antioxidant, capillary
protective, anti-inflammatory properties, as well as positively affecting the functioning of the
cardiovascular, immune, nervous and respiratory systems, has not been studied
the athletes' training system. To improve the performance of high-class rowers, the use of biologically
active additives is in high demand. As such, dihydroquercetin, which has antioxidant, capillary
protective, anti-inflammatory properties, as well as positively affecting the functioning of the
cardiovascular, immune, nervous and respiratory systems, has not been studied
491
16
19
DETERMINATION OF ANTIOXIDANT AND ANTIRADICAL PROPERTIES OF GOSSITAN AND SAFFLOWER EXTRACTS
selective gossitan consists of studying the antioquism as well as
antiradicality nature of safflower extracts.
To achieve the purpose of the work, we used the following research tasks. Study of solubility
and properties of extracted gossitan, gallora extracts. Determination of the antioxidant and
antiradicality properties of selected gossitan, gallora extracts. The effect of Gossitan and safflower
extracts on LPO and oxygen balance in the body
antiradicality nature of safflower extracts.
To achieve the purpose of the work, we used the following research tasks. Study of solubility
and properties of extracted gossitan, gallora extracts. Determination of the antioxidant and
antiradicality properties of selected gossitan, gallora extracts. The effect of Gossitan and safflower
extracts on LPO and oxygen balance in the body
492
15
8
ANTICOAGULANT PROPERTIES OF ENDOPHYTIC FUNGI FROM CERTAIN MEDICINAL PLANTS OF THE CHATKAL BIOSPHERE RESERVE
In the current era of modern technologies, the supply of medicines is an important
issue in the treatment of diseases caused by heredity, gene mutations, cell membrane disorders of
higher organisms, climate degradation, and other causes, including in the situation caused by the
coronavirus. One of the complications remaining after the COVID-19 disease, which has spread
throughout the world, is the state of platelet aggregation. This naturally increases the demand for the
production of blood thinners (for example, heparin, cleacsan, etc.). In the context of the current
pandemic, one of the urgent problems is the search for cost-effective substitutes for such drugs using
the anticoagulant properties of endophytic fungi, their screening and recommendation for
pharmaceuticals and medicine
issue in the treatment of diseases caused by heredity, gene mutations, cell membrane disorders of
higher organisms, climate degradation, and other causes, including in the situation caused by the
coronavirus. One of the complications remaining after the COVID-19 disease, which has spread
throughout the world, is the state of platelet aggregation. This naturally increases the demand for the
production of blood thinners (for example, heparin, cleacsan, etc.). In the context of the current
pandemic, one of the urgent problems is the search for cost-effective substitutes for such drugs using
the anticoagulant properties of endophytic fungi, their screening and recommendation for
pharmaceuticals and medicine
493
17
5
ANTIMICROBIAL PROPERTIES OF IONOGENIC INULIN DERIVATIVES
World medical practice faces the problem of increasing number of infectious
diseases that are difficult to treat with known antimicrobial agents. First of all, this is due to a sharp
increase in the number of resistant microorganisms to existing drugs and a decrease in their
therapeutic effectiveness due to uncontrolled administration. In such conditions, the need for the
development of new antimicrobial agents based on natural polymers increases. Of particular interest
are compounds that can combine antimicrobial activity with a minimal risk of side effects. It is known
that polysaccharides such as chitosan, pectin, alginic acid and their derivatives have a wide spectrum
of antimicrobial action. At the same time, antimicrobial polysaccharides do not exhibit toxic effects
and do not accumulate in the body. Based on this, research aimed at obtaining new polysaccharide
derivatives with antimicrobial action remains relevant.
diseases that are difficult to treat with known antimicrobial agents. First of all, this is due to a sharp
increase in the number of resistant microorganisms to existing drugs and a decrease in their
therapeutic effectiveness due to uncontrolled administration. In such conditions, the need for the
development of new antimicrobial agents based on natural polymers increases. Of particular interest
are compounds that can combine antimicrobial activity with a minimal risk of side effects. It is known
that polysaccharides such as chitosan, pectin, alginic acid and their derivatives have a wide spectrum
of antimicrobial action. At the same time, antimicrobial polysaccharides do not exhibit toxic effects
and do not accumulate in the body. Based on this, research aimed at obtaining new polysaccharide
derivatives with antimicrobial action remains relevant.
494-495
18
14
THE INFLUENCE OF THE ORGANIC NITROGEN SOURCE CONTENT ON THE ACTIVITY OF CHOLESTEROL OXIDASE PRODUCER
Cholesterol oxidase (CHO) is an enzyme from the oxidoreductase class that
catalyzes the conversion of cholesterol to cholest-4-en-3-one and hydrogen peroxide. It can be used
in test systems for determining blood cholesterol levels or as a catalyst in the synthesis of biologically
active derivatives of cholesterol. This enzyme is obtained only through microbial synthesis, during
which the selection of an optimal nutrient medium (NM) in general and the optimal content of the
organic nitrogen source, in particular, remains a very relevant issue.
catalyzes the conversion of cholesterol to cholest-4-en-3-one and hydrogen peroxide. It can be used
in test systems for determining blood cholesterol levels or as a catalyst in the synthesis of biologically
active derivatives of cholesterol. This enzyme is obtained only through microbial synthesis, during
which the selection of an optimal nutrient medium (NM) in general and the optimal content of the
organic nitrogen source, in particular, remains a very relevant issue.
496
34
8
EFFECTIVENESS AND SAFETY OF PHYTOTHERAPY OF THE MEDICINAL PLANT - PAPAVER SOMNIFERUM L .)
Opium poppy, an annual herbaceous plant, is widely cultivated in southern Central
Asia. Its petals contain 0.05% alkaloids and fatty acids. The greatest interest in studying this plant
lies in its effects on the nervous system, exhibiting a sedative effect, as well as less pronounced
hypnotic and analgesic properties. It is widely known for its hemostatic effect. An infusion made
from the petals of the opium poppy is highly valued for its cough suppressant effect. Given its well
known beneficial pharmacological effects, the potential for adverse effects of the opium poppy cannot
be ruled out.
Asia. Its petals contain 0.05% alkaloids and fatty acids. The greatest interest in studying this plant
lies in its effects on the nervous system, exhibiting a sedative effect, as well as less pronounced
hypnotic and analgesic properties. It is widely known for its hemostatic effect. An infusion made
from the petals of the opium poppy is highly valued for its cough suppressant effect. Given its well
known beneficial pharmacological effects, the potential for adverse effects of the opium poppy cannot
be ruled out.
497
22
11
FEATURES OF THERAPY WITH HERBAL PRODUCTS OF BELLADONNA (ATROPA BELLADONNA L.)
Belladonna , being perennial plant, It is considered widespread throughout Asia
Minor. The plant material is harvested primarily in plantations, the leaves during flowering, and the
herb during fruit ripening. Belladonna roots are of interest as the primary raw material for therapeutic
agents. All parts of the plant are poisonous and contain the alkaloids atropine, scopolamine, and
hyoscyamine: 0.14-1.20% in the leaves, 0.2-0.65% in the herb, 0.24-0.6% in the flowers, and 0.7%
in the ripe fruit.
Minor. The plant material is harvested primarily in plantations, the leaves during flowering, and the
herb during fruit ripening. Belladonna roots are of interest as the primary raw material for therapeutic
agents. All parts of the plant are poisonous and contain the alkaloids atropine, scopolamine, and
hyoscyamine: 0.14-1.20% in the leaves, 0.2-0.65% in the herb, 0.24-0.6% in the flowers, and 0.7%
in the ripe fruit.
498-499
36
23
USING THE DIURETIC PROPERTIES OF CUCUMBER ( CUCUMIS SATIVUS L. ) AS A PHYTOTHERAPY FOR KIDNEY DISORDERS
Cucumber ( Cucumis ) sativus L. ) contains a significant amount of moisture (90
95% ) , protein (0.8%), sugars (2-2.5%), fat (0.1%), hemicellulose (0.1%), all tissues (0.7%), pectin
(0.4%), as well as starch (0.1%) and organic acids. It is rich in vitamins B1, B2, B6, B15, C, PP, as
well as microelements K, Ca, Mg, Al, F, Zn, Fe, I.
95% ) , protein (0.8%), sugars (2-2.5%), fat (0.1%), hemicellulose (0.1%), all tissues (0.7%), pectin
(0.4%), as well as starch (0.1%) and organic acids. It is rich in vitamins B1, B2, B6, B15, C, PP, as
well as microelements K, Ca, Mg, Al, F, Zn, Fe, I.
500-501
13
9
POLYPHENOLS AS POTENTIAL INHIBITORS OF SARS-COV-2 CORONAVIRUS: AN IN SILICO STUDY
Currently, the search for antiviral substances is carried out in two ways: 1.
Repurposing existing and screening newly synthesized compounds. 2. Targeted search for natural
biologically active substances, in most cases, using computer modeling. The main disadvantage of
all currently used drugs is their fairly high toxicity and, as a consequence, the presence of side effects.
In the development of new drugs for the treatment of COVID-19, polyphenolic compounds are of
particular interest. Studies conducted by scientists from different countries have shown that plant
polyphenols are promising polyfunctional compounds with great potential as active ingredients for
the creation of new pharmaceutical substances with antiviral activity
Repurposing existing and screening newly synthesized compounds. 2. Targeted search for natural
biologically active substances, in most cases, using computer modeling. The main disadvantage of
all currently used drugs is their fairly high toxicity and, as a consequence, the presence of side effects.
In the development of new drugs for the treatment of COVID-19, polyphenolic compounds are of
particular interest. Studies conducted by scientists from different countries have shown that plant
polyphenols are promising polyfunctional compounds with great potential as active ingredients for
the creation of new pharmaceutical substances with antiviral activity
502
21
8
STUDY OF THE ANTI-INFLAMMATORY ACTIVITY OF THE SUPRAMOLECULAR COMPLEX OF GLYCYRRHIZIC ACID AND RUTIN
In leading pharmaceutical companies, the development of new herbal medicines and their
application in medical practice has significantly increased. Medicinal plants are of great importance
in the global healthcare system due to the effective therapeutic properties of their biologically active
components. Currently, phenolic compounds isolated from plants show antioxidant, antihypoxic,
antiviral, anti-inflammatory, and vasodilatory activities.
application in medical practice has significantly increased. Medicinal plants are of great importance
in the global healthcare system due to the effective therapeutic properties of their biologically active
components. Currently, phenolic compounds isolated from plants show antioxidant, antihypoxic,
antiviral, anti-inflammatory, and vasodilatory activities.
503-504
27
10
BIOLOGICAL ACTIVITY OF RIBOSOME-INACTIVATING PROTEINS ISOLATED FROM NIGELLA SATIVA (BLACK SEED)
One of the most important directions in the development of new biotechnologies is the creation
of pharmacological preparations that have a highly specific effect on cells or molecules in the
organism. Currently, proteins or their conjugates are attracting particular interest from researchers in
the creation of highly selective drugs. In this context, plant toxins that completely stop protein
synthesis in the cell by switching ribosomes to an inactive state are being actively studied. These
toxins are collectively called Ribosome-Inactivating Proteins (RIPs).
of pharmacological preparations that have a highly specific effect on cells or molecules in the
organism. Currently, proteins or their conjugates are attracting particular interest from researchers in
the creation of highly selective drugs. In this context, plant toxins that completely stop protein
synthesis in the cell by switching ribosomes to an inactive state are being actively studied. These
toxins are collectively called Ribosome-Inactivating Proteins (RIPs).
505-506
22
11
EFFECTS OF HYALURONIC ACID AND GELATIN-BASED HYDROGELS LOADED WITH DOXORUBICIN ON 4T1 CANCER CELLS
Cancer is one of the most life-threatening diseases, and conventional therapies such as
chemotherapy, radiotherapy, and systemic treatments are widely used. However, these methods often
cause severe side effects, highlighting the need for alternative strategies. Hydrogels, especially those
based on hyaluronic acid (HA) and gelatin, are promising due to their biocompatibility,
biodegradability, and drug delivery potential. They can release therapeutic agents locally, in a
controlled and sustained manner. HA, a natural polysaccharide, combined with gelatin, a collagen
derivative, forms hydrogels that interact efficiently with cancer cells, while their water retention and
microenvironment support cell regulation. Doxorubicin (DOX), a common chemotherapeutic,
inhibits proliferation and induces apoptosis but is limited by systemic toxicity. Therefore, HA–gelatin
hydrogels provide an innovative carrier to enhance efficacy and reduce side effects. The 4T1 breast
cancer line, known for its aggressive and metastatic behavior, is a suitable model to evaluate these
systems. This study examines DOX-loaded HA–gelatin hydrogels on 4T1 cells to provide insights
for effective localized cancer therapy.
chemotherapy, radiotherapy, and systemic treatments are widely used. However, these methods often
cause severe side effects, highlighting the need for alternative strategies. Hydrogels, especially those
based on hyaluronic acid (HA) and gelatin, are promising due to their biocompatibility,
biodegradability, and drug delivery potential. They can release therapeutic agents locally, in a
controlled and sustained manner. HA, a natural polysaccharide, combined with gelatin, a collagen
derivative, forms hydrogels that interact efficiently with cancer cells, while their water retention and
microenvironment support cell regulation. Doxorubicin (DOX), a common chemotherapeutic,
inhibits proliferation and induces apoptosis but is limited by systemic toxicity. Therefore, HA–gelatin
hydrogels provide an innovative carrier to enhance efficacy and reduce side effects. The 4T1 breast
cancer line, known for its aggressive and metastatic behavior, is a suitable model to evaluate these
systems. This study examines DOX-loaded HA–gelatin hydrogels on 4T1 cells to provide insights
for effective localized cancer therapy.
507-508
18
3
ИССЛЕДОВАНИЕ СЕДАТИВНОГО ДЕЙСТВИЯ СУХОГО ЭКСТРАКТА НА ОСНОВЕ МЕСТНОГО ПИОНА ЛЕКАРСТВЕННОГО (PAEÓNIA OFFICINÁLIS L.)
С целью создания лекарственных препаратов на основе местного
растительного сырья и внедрения их в медицинскую практику необходимо исследование
специфической активности разработанных лекарственных препаратов. Методом
полиэкстракции получен сухой экстракт, успокаивающего действия, из местного сырья
корней и корневищ пиона лекарственного (Paeónia officinális L.).
растительного сырья и внедрения их в медицинскую практику необходимо исследование
специфической активности разработанных лекарственных препаратов. Методом
полиэкстракции получен сухой экстракт, успокаивающего действия, из местного сырья
корней и корневищ пиона лекарственного (Paeónia officinális L.).
509-510
26
3
STUDY OF THE PHYSICAL AND CHEMICAL PROPERTIES, ANTIOXIDANT AND BIOLOGICAL ACTIVITY OF HUMIC ACIDS OF COALFROM KAZAKHSTAN DEPOSITS OF THE REPUBLIC OF KAZAKHSTAN
Currently, Kazakhstan market of medicines is filled with quite expensive antioxidant drugs
mainly of foreign production. The country needs domestic medicines and medicinal preparations that
can compete with foreign analogues. In this regard, research on the development of innovative
import-substituting drugs based on humic substances of peloids are of particular relevance and
practical importance. One of the interesting and promising sources of biologically active substances
(BAS) in terms of economic and therapeutic efficacy are peloids, in particular, coal, which is a
complex of both inorganic and organic substances
mainly of foreign production. The country needs domestic medicines and medicinal preparations that
can compete with foreign analogues. In this regard, research on the development of innovative
import-substituting drugs based on humic substances of peloids are of particular relevance and
practical importance. One of the interesting and promising sources of biologically active substances
(BAS) in terms of economic and therapeutic efficacy are peloids, in particular, coal, which is a
complex of both inorganic and organic substances
511-512
25
20
ANALYSIS OF STATIONARY CULTIVATION OF THE PASTEUR STRAIN OF RABIES VIRUS
Modern production of immunobiological preparations and diagnostic test systems primarily
relies on economic efficiency. Traditionally, a stationary cultivation method is used to accumulate
virus-containing material, which has a number of advantages associated primarily with the lack of
need for expensive equipment , consumables , and greater opportunities for monitoring fungal and
bacterial contamination, with low personnel qualifications.
relies on economic efficiency. Traditionally, a stationary cultivation method is used to accumulate
virus-containing material, which has a number of advantages associated primarily with the lack of
need for expensive equipment , consumables , and greater opportunities for monitoring fungal and
bacterial contamination, with low personnel qualifications.
513
23
4
PROSPECTS FOR THE DEVELOPMENT OF PHYTOPREPARATIONS BASED ON STELLARIA MEDIA (L.) VILL
Chickweed (Stellaria media (L.) Vill.) is a widely distributed medicinal plant
containing flavonoids (apigenin and kaempferol glycosides), phenolic acids, and saponins, exhibiting
antioxidant, anti-inflammatory, and antimicrobial activity. The plant is used in traditional medicine
for inflammatory diseases and metabolic disorders, which confirms the prospects for the development
of phytopreparations.
containing flavonoids (apigenin and kaempferol glycosides), phenolic acids, and saponins, exhibiting
antioxidant, anti-inflammatory, and antimicrobial activity. The plant is used in traditional medicine
for inflammatory diseases and metabolic disorders, which confirms the prospects for the development
of phytopreparations.
514
21
9
REVIEW OF CURRENT DATA ON GOLDEN HARE’S EAR (BUPLEURUM AUREI FISCH.) AND PROSPECTS FOR ITS USE IN PHARMACEUTICAL PRACTICE
Medicinal plants are a valuable source of biologically active substances (BAS).
Among them, a promising object is golden hare’s ear (Bupleurum aurei Fisch.), traditionally used in
the treatment of liver and gastrointestinal diseases. Modern studies confirm its rich chemical
composition and pharmacological potential.
Among them, a promising object is golden hare’s ear (Bupleurum aurei Fisch.), traditionally used in
the treatment of liver and gastrointestinal diseases. Modern studies confirm its rich chemical
composition and pharmacological potential.
515
17
18
PROSPECTS FOR THE PHARMACEUTICAL APPLICATION OF TRIBULUS TERRESTRIS L
In the pharmaceutical industry, the demand for natural, low-toxicity, and effective
phytopreparations is increasing. This interest is associated with the fact that plant-derived substances,
compared to synthetic drugs, are generally safer and more accessible. For many centuries, the practice
of traditional medicine has demonstrated the positive effects of medicinal plants in the treatment and
prevention of various diseases
phytopreparations is increasing. This interest is associated with the fact that plant-derived substances,
compared to synthetic drugs, are generally safer and more accessible. For many centuries, the practice
of traditional medicine has demonstrated the positive effects of medicinal plants in the treatment and
prevention of various diseases
516-517
22
8
HYALURONAN/CHITOSAN HYDROGELS FOR LOCAL DELIVERY OF DOXORUBICIN
Cancer is a leading cause of death worldwide, and conventional treatments like
chemotherapy often cause significant systemic toxicity. Targeted drug delivery systems are therefore
essential. Hydrogels, with high fluid retention and balanced structure, provide an ideal platform for
local, controlled delivery. This study focuses on hyaluronan–chitosan hydrogels for localized
doxorubicin delivery. Hyaluronan, a natural polysaccharide, offers biocompatibility and
degradability, while chitosan enables high drug loading and promotes cell adhesion. Together, they
encapsulate doxorubicin for controlled release at the target site. The inclusion of sodium alginate and
polyvinyl alcohol optimizes hydrogel structure and properties, aiming to increase local drug
concentration, reduce side effects, and improve treatment outcomes. The study investigates hydrogel
preparation, characterization, and performance, highlighting their potential in enhancing cancer
therapy and advancing innovative drug delivery strategies
chemotherapy often cause significant systemic toxicity. Targeted drug delivery systems are therefore
essential. Hydrogels, with high fluid retention and balanced structure, provide an ideal platform for
local, controlled delivery. This study focuses on hyaluronan–chitosan hydrogels for localized
doxorubicin delivery. Hyaluronan, a natural polysaccharide, offers biocompatibility and
degradability, while chitosan enables high drug loading and promotes cell adhesion. Together, they
encapsulate doxorubicin for controlled release at the target site. The inclusion of sodium alginate and
polyvinyl alcohol optimizes hydrogel structure and properties, aiming to increase local drug
concentration, reduce side effects, and improve treatment outcomes. The study investigates hydrogel
preparation, characterization, and performance, highlighting their potential in enhancing cancer
therapy and advancing innovative drug delivery strategies
518
22
11
ANTIPROLIFERATIVE ACTIVITY OF AQUEOUS-ETHANOL EXTRACTS OF LENZITES BETULINUS AND TRAMETES VERSICOLOR AGAINST BREAST CARCINOMA CELLS
Malignant tumors remain one of the leading causes of mortality worldwide, with
breast carcinoma ranking first in incidence among women. Despite the development of modern
therapeutic approaches, drug resistance and pronounced side effects of cytostatic drugs necessitate
the search for new selective agents with antiproliferative activity. A promising direction is the study
of biologically active compounds from natural sources, among which polypore fungi are of particular
interest due to their richness in polysaccharides and triterpenoids with pronounced
immunostimulatory and cytotoxic properties. In particular, the relatively unexplored yet widely
distributed species Lenzites betulinus and Trametes versicolor are potential sources of new anticancer
agents.
breast carcinoma ranking first in incidence among women. Despite the development of modern
therapeutic approaches, drug resistance and pronounced side effects of cytostatic drugs necessitate
the search for new selective agents with antiproliferative activity. A promising direction is the study
of biologically active compounds from natural sources, among which polypore fungi are of particular
interest due to their richness in polysaccharides and triterpenoids with pronounced
immunostimulatory and cytotoxic properties. In particular, the relatively unexplored yet widely
distributed species Lenzites betulinus and Trametes versicolor are potential sources of new anticancer
agents.
519
20
8
INVESTIGATION OF THE CYTOTOXICITY OF NEW AMIODARONE DERIVATIVES IN NORMAL HEPATOCYTE CULTURE
Arrhythmias remain a pressing challenge in modern cardiology because of their high prevalence
and the serious threat they pose to patient survival. Current antiarrhythmic drugs, although effective,
are often associated with side effects involving the central nervous system, the gastrointestinal tract,
and other organ systems
and the serious threat they pose to patient survival. Current antiarrhythmic drugs, although effective,
are often associated with side effects involving the central nervous system, the gastrointestinal tract,
and other organ systems
520
22
9
STUDY OF THE COMBINED ACTIVITY OF POLYHEXAMETHYLENE GUANIDINE HYDROCHLORIDE AND TETRAMETHYLENEDIAMINETETRAMINE AGAINST CLINICAL ISOLATES
The widespread availability and use of antibacterial and antiseptic agents have
led to the emergence of antimicrobial resistance among many strains of pathogenic and conditionally
pathogenic microorganisms. Antibiotic resistance poses a particular challenge in the treatment of
nosocomial infections in hospital settings, especially in intensive care units (ICUs). Addressing the
pharmacotherapy of nosocomial infections in ICUs remains one of the most pressing issues in modern
medicine. To tackle this problem, novel antimicrobial agents as well as their combined activity are
being investigated. Synergistic interactions between antimicrobials can facilitate therapy and enhance
efficacy at lower doses, thereby reducing adverse and toxic effects on the human body
led to the emergence of antimicrobial resistance among many strains of pathogenic and conditionally
pathogenic microorganisms. Antibiotic resistance poses a particular challenge in the treatment of
nosocomial infections in hospital settings, especially in intensive care units (ICUs). Addressing the
pharmacotherapy of nosocomial infections in ICUs remains one of the most pressing issues in modern
medicine. To tackle this problem, novel antimicrobial agents as well as their combined activity are
being investigated. Synergistic interactions between antimicrobials can facilitate therapy and enhance
efficacy at lower doses, thereby reducing adverse and toxic effects on the human body
521
19
7
REPURPOSING 20-HYDROXYECDYSONE FOR CANCER THERAPY: COMPUTATIONAL EVIDENCE FOR AQUAPORIN-5 INHIBITION
Aquaporin-5 (AQP5) is a membrane channel protein whose abnormal
overexpression has been linked to tumor growth, migration, and metastasis in cancers such as breast,
lung, and gastric carcinoma. These oncogenic roles make AQP5 an attractive therapeutic target.
Natural compounds like 20-Hydroxyecdysone (ecdysterone), known for diverse biological activities,
warrant investigation as potential modulators of AQP5 in cancer.
overexpression has been linked to tumor growth, migration, and metastasis in cancers such as breast,
lung, and gastric carcinoma. These oncogenic roles make AQP5 an attractive therapeutic target.
Natural compounds like 20-Hydroxyecdysone (ecdysterone), known for diverse biological activities,
warrant investigation as potential modulators of AQP5 in cancer.
522
21
7
DETERMINATION OF THE ACTIVITY LEVEL OF THE GALACTOSIDASE ENZYME ISOLATED FROM CHICKPEAS
According to the Decree of the President of the Republic of Uzbekistan No. PF
4947 dated February 7, 2017 "On the Strategy of Actions for the Further Development of the Republic
of Uzbekistan", general goals are set, such as developing agriculture, ensuring food security, and
increasing export potential. Within the framework of this strategy, measures are being implemented
to expand and support the cultivation of legumes, including peas.
4947 dated February 7, 2017 "On the Strategy of Actions for the Further Development of the Republic
of Uzbekistan", general goals are set, such as developing agriculture, ensuring food security, and
increasing export potential. Within the framework of this strategy, measures are being implemented
to expand and support the cultivation of legumes, including peas.
523
16
5
19
STUDY OF ANTIMICROBIAL ACTIVITY OF COSMETIC EMULSION “EMULZARMAJ”
In modern cosmetology, interest in the use of herbal remedies with not only caring
but also therapeutic and prophylactic properties is growing. Juniperus seravschanica Kom. belongs
to the cypress family (Cupressaceae). This evergreen coniferous plant is endemic to the mountainous
regions of Central Asia, particularly Uzbekistan, Tajikistan, and Kyrgyzstan. It plays an important
role in the region's ecosystems and is valuable both in folk medicine and in modern pharmacology
and cosmetology. Juniperus seravschanica Kom. is an endemic species of Central Asia, known for its
high content of essential oils, flavonoids, terpenoids, and phenolic compounds. These biologically
active substances exhibit pronounced antibacterial, anti-inflammatory, and fungicidal properties.
but also therapeutic and prophylactic properties is growing. Juniperus seravschanica Kom. belongs
to the cypress family (Cupressaceae). This evergreen coniferous plant is endemic to the mountainous
regions of Central Asia, particularly Uzbekistan, Tajikistan, and Kyrgyzstan. It plays an important
role in the region's ecosystems and is valuable both in folk medicine and in modern pharmacology
and cosmetology. Juniperus seravschanica Kom. is an endemic species of Central Asia, known for its
high content of essential oils, flavonoids, terpenoids, and phenolic compounds. These biologically
active substances exhibit pronounced antibacterial, anti-inflammatory, and fungicidal properties.
524
20
4
UNDER X-RAY IRRADIATION
It has been shown that the effect of X-ray irradiation at 2 Gy and 4 Gy leads to
suppression of the activity of the studied enzymes in various brain structures. Moreover, it was found
that pre-administration of saffron extract in many cases prevents significant suppression of the studied
enzymes by irradiation, and on the contrary, this antioxidant promotes an increase in their activity in
brain structures. Objective: To study the effect of saffron (Crocus sativus L.) stigma extract on the
dynamics of changes in the content of different types of surface-exposed SH-groups, structurally
masked protein SH-groups, and glutathione under X-ray irradiation at doses of 2 and 4 Gy in different
brain regions.
suppression of the activity of the studied enzymes in various brain structures. Moreover, it was found
that pre-administration of saffron extract in many cases prevents significant suppression of the studied
enzymes by irradiation, and on the contrary, this antioxidant promotes an increase in their activity in
brain structures. Objective: To study the effect of saffron (Crocus sativus L.) stigma extract on the
dynamics of changes in the content of different types of surface-exposed SH-groups, structurally
masked protein SH-groups, and glutathione under X-ray irradiation at doses of 2 and 4 Gy in different
brain regions.
525
32
11
ASTAXANTHIN AS AN INNOVATIVE ANTIOXIDANT: CREATION AND STUDY OF SERUM WITH HAEMATOCOCCUS PLUVIALIS EXTRACT
Interest in natural antioxidants is growing in cosmetology. Astaxanthin from the
microalgae Haematococcus pluvialis is more active than many known antioxidants and can protect
the skin from photoaging and oxidative stress. Research into the development of stable and safe
formulas is needed to incorporate it into cosmetics
microalgae Haematococcus pluvialis is more active than many known antioxidants and can protect
the skin from photoaging and oxidative stress. Research into the development of stable and safe
formulas is needed to incorporate it into cosmetics
527
34
6
STUDY OF THE SEDATIVE EFFECT OF A DRY EXTRACT BASED ON LOCAL MEDICINAL PEONY (PAEÓNIA OFFICINÁLIS L.)
In order to create medicinal preparations based on local plant raw materials and
introduce them into medical practice, it is necessary to study the specific activity of the developed
medicinal preparations. A dry extract with a calming effect was obtained from local raw materials
using the polyextraction method. roots and rhizomes of the medicinal peony ( Paeonia officinalis L.).
introduce them into medical practice, it is necessary to study the specific activity of the developed
medicinal preparations. A dry extract with a calming effect was obtained from local raw materials
using the polyextraction method. roots and rhizomes of the medicinal peony ( Paeonia officinalis L.).
528-529
22
12
THE ROLE OF PHARMACEUTICALS IN THE PREVENTION AND TREATMENT OF DISEASES OF THE FEMALE REPRODUCTIVE SYSTEM
Modern pharmacological drugs play a key role in the prevention and treatment of
diseases of the female reproductive system, such as menstrual cycle disorders, endometriosis,
polycystic ovary syndrome (PCOS), infertility, and osteoporosis. The assessment of the effectiveness
and safety of drugs aimed at hormonal therapy, the use of drugs to improve fertility, as well as drugs
that regulate metabolism and immune reactions, is an important aspect of modern pharmacotherapy
in gynecology.
diseases of the female reproductive system, such as menstrual cycle disorders, endometriosis,
polycystic ovary syndrome (PCOS), infertility, and osteoporosis. The assessment of the effectiveness
and safety of drugs aimed at hormonal therapy, the use of drugs to improve fertility, as well as drugs
that regulate metabolism and immune reactions, is an important aspect of modern pharmacotherapy
in gynecology.
530-531
25
16
ФИТОХИМИЧЕСКИЙ АНАЛИЗ SCABIOSA OCHROLEUCA L
Скабиоза золотистая (Scabiosa ochroleuca L.) - перспективное
лекарственное растение, применяемое в народной медицине при заболеваниях ЖКТ, опорно
двигательной системы, инфекциях и как ранозаживляющее средство. В её надземной части
обнаружены флавоноиды (лютеолин, кверцетин), фенольные соединения, иридоиды,
дубильные вещества, сапонины и органические кислоты, обладающие различными
фармакологическими эффектами.
лекарственное растение, применяемое в народной медицине при заболеваниях ЖКТ, опорно
двигательной системы, инфекциях и как ранозаживляющее средство. В её надземной части
обнаружены флавоноиды (лютеолин, кверцетин), фенольные соединения, иридоиды,
дубильные вещества, сапонины и органические кислоты, обладающие различными
фармакологическими эффектами.
532-533
24
15
ВЛИЯНИЕ АНТИБИОТИКОВ НА МИКРОБИОЛОГИЧЕСКИЕ ПОКАЗАТЕЛИ ЙОГУРТА
Антибиотикорезистентность является одной из наиболее острых
проблем современной медицины и пищевой безопасности. Остаточные количества
антибиотиков могут попадать в молочную продукцию при применении препаратов для
лечения животных. Это не только способствует формированию устойчивых штаммов
микроорганизмов, но и изменяет микробиологический состав кисломолочных продуктов,
снижая их пищевую и пробиотическую ценность. Йогурт содержит живые молочнокислые
бактерии, которые выполняют важные функции: улучшают пищеварение, подавляют развитие
патогенной микрофлоры, стимулируют иммунитет. Однако антибиотики способны подавлять
не только патогенные, но и полезные микроорганизмы. В этой связи актуальным является
исследование действия различных антибиотиков на микрофлору йогурта.
проблем современной медицины и пищевой безопасности. Остаточные количества
антибиотиков могут попадать в молочную продукцию при применении препаратов для
лечения животных. Это не только способствует формированию устойчивых штаммов
микроорганизмов, но и изменяет микробиологический состав кисломолочных продуктов,
снижая их пищевую и пробиотическую ценность. Йогурт содержит живые молочнокислые
бактерии, которые выполняют важные функции: улучшают пищеварение, подавляют развитие
патогенной микрофлоры, стимулируют иммунитет. Однако антибиотики способны подавлять
не только патогенные, но и полезные микроорганизмы. В этой связи актуальным является
исследование действия различных антибиотиков на микрофлору йогурта.
534-535
30
15
EFFECT OF POLYPHENOLS ISOLATED FROM EUPHORBIA FRANCHETII (B.FEDTSCH) ON LPO PROCESSES IN MITOCHONDRIA
The production of free radicals in various tissues and cells of the body through many
endogenous and exogenous pathways causes oxidative stress, which leads to the development of
various diseases in humans. Therefore, the study of the antioxidant properties of biologically active
substances isolated from plants is of great importance. It is known that epidemiologically, fruits and
vegetables rich in antioxidants in the diet prevent the development of many diseases associated with
oxidative stress. Recent studies have shown that mitochondria play an important role in apoptotic and
necrotic cell death. As a result of mitochondrial dysfunction, the number of mitochondria in tissues
decreases, deep ultrastructural anomalies of organelles develop, mitochondrial biogenesis is
disrupted, the activity of enzyme complexes of the respiratory chain changes, and ATP synthesis is
inhibited. At the same time, mitochondrial dysfunction can lead to calcium homeostasis disruption,
excessive production of reactive oxygen species, as well as the transition of the megapore to an open
conformation, a decrease in the expression of the antiapoptotic protein Bcl-2, the release of
cytochrome c, the activation of proapoptotic caspase-3 and the DNA repair enzyme poly (-ADP
ribose) polymerase. From the above, it can be seen that a specific mitochondrial dysfunction is
observed in the process of lipid peroxidation (LPO) that develops during oxidative stress
endogenous and exogenous pathways causes oxidative stress, which leads to the development of
various diseases in humans. Therefore, the study of the antioxidant properties of biologically active
substances isolated from plants is of great importance. It is known that epidemiologically, fruits and
vegetables rich in antioxidants in the diet prevent the development of many diseases associated with
oxidative stress. Recent studies have shown that mitochondria play an important role in apoptotic and
necrotic cell death. As a result of mitochondrial dysfunction, the number of mitochondria in tissues
decreases, deep ultrastructural anomalies of organelles develop, mitochondrial biogenesis is
disrupted, the activity of enzyme complexes of the respiratory chain changes, and ATP synthesis is
inhibited. At the same time, mitochondrial dysfunction can lead to calcium homeostasis disruption,
excessive production of reactive oxygen species, as well as the transition of the megapore to an open
conformation, a decrease in the expression of the antiapoptotic protein Bcl-2, the release of
cytochrome c, the activation of proapoptotic caspase-3 and the DNA repair enzyme poly (-ADP
ribose) polymerase. From the above, it can be seen that a specific mitochondrial dysfunction is
observed in the process of lipid peroxidation (LPO) that develops during oxidative stress
536-537
22
5
FDP PLYUS VA L-KARNITIN BIOLOGIK AKTIV QO‘SHIMCHASINI LABORATOR HAYVONLARNING JISMONIY MEXNAT FAOLLIGIGA TA’SIRINI O‘RGANISH
Jahon miqyosida sport yutuqlarining doimiy o'sishi sport sohasida ishlaydigan tadqiqotchilarni
sportchilar tanasini jismoniy faoliyatga moslashtirish chegaralarini kengaytiradigan samarali
vositalar va usullarni izlashga majbur qilmoqda. Ular orasida dori-darmonlar eng keng qo'llanilishini
o‘z o‘rnini topdi, ular asosli foydalanish bilan mashg'ulot yuklaridan keyin tiklanish jarayonlarini
sezilarli darajada tezlashtirishga, tananing o'quv jarayonini idrok etishni yaxshilashga va tananing
jismoniy faoliyatga moslashishining tarkibiy asoslarini rivojlantirishga yordam beradi. Shunday qilib,
sport farmakologiyasi sohasida yangi dori-darmonlarni ishlab chiqish, ilmiy yondashuv va ruxsat
etilgan farmakologik preparatlarni qo'llash algoritmidan foydalanish sportchilarning jismoniy
ko'rsatkichlarini tiklaydigan va oshiradigan moslashish va energiya ta'minotining asosiy
mexanizmlariga maqsadli ta'sir ko'rsatishga imkon beradi.
sportchilar tanasini jismoniy faoliyatga moslashtirish chegaralarini kengaytiradigan samarali
vositalar va usullarni izlashga majbur qilmoqda. Ular orasida dori-darmonlar eng keng qo'llanilishini
o‘z o‘rnini topdi, ular asosli foydalanish bilan mashg'ulot yuklaridan keyin tiklanish jarayonlarini
sezilarli darajada tezlashtirishga, tananing o'quv jarayonini idrok etishni yaxshilashga va tananing
jismoniy faoliyatga moslashishining tarkibiy asoslarini rivojlantirishga yordam beradi. Shunday qilib,
sport farmakologiyasi sohasida yangi dori-darmonlarni ishlab chiqish, ilmiy yondashuv va ruxsat
etilgan farmakologik preparatlarni qo'llash algoritmidan foydalanish sportchilarning jismoniy
ko'rsatkichlarini tiklaydigan va oshiradigan moslashish va energiya ta'minotining asosiy
mexanizmlariga maqsadli ta'sir ko'rsatishga imkon beradi.
538-539
26
16
EFFECT OF HYPOGLYCEMIC PLANT COLLECTION EXTRACT ON SOME INDICATORS OF CARBOHYDRATE METABOLISM IN CONDITIONS OF ESPERIMENTAL DIABETES
Abu Ali Hussein ibn Abdallah ibn Sina (16 August 980 - 18 June 1037) created
works not only on medicine but also on the history of theology, philosophy, astronomy and religion.
A number of sources record more than 450 works by Ibn Sina, and only 242 Gypsies have reached
us. Ibn Sina's Works list more than 100 herbal products in the treatment of diabetes mellitus. One of
the most commonly used plants in diabetes is white mulberry (Morus alba) plant raw materials and
large zubturum (Plantago major) leaves. Ibn Sina cited that raw materials of these tumors are high in
effectiveness in diabetes mellitus not only when applied separately, but also in the form of folding
works not only on medicine but also on the history of theology, philosophy, astronomy and religion.
A number of sources record more than 450 works by Ibn Sina, and only 242 Gypsies have reached
us. Ibn Sina's Works list more than 100 herbal products in the treatment of diabetes mellitus. One of
the most commonly used plants in diabetes is white mulberry (Morus alba) plant raw materials and
large zubturum (Plantago major) leaves. Ibn Sina cited that raw materials of these tumors are high in
effectiveness in diabetes mellitus not only when applied separately, but also in the form of folding
540
36
9
SCIENTIFIC JUSTIFICATION FOR THE USE OF BUCKWHEAT IN THE COMPOSITION OF PHYTOSUPPOSITORIES FOR THE TREATMENT OF HEMORRHOIDS
Hemorrhoids are among the most common diseases of the rectum and anal canal.
According to the World Health Organization, 10–15% of the adult population suffers from various
forms of hemorrhoids, and among patients over 50 years old, this figure reaches 50–70%. The disease
significantly reduces quality of life, being accompanied by pain, inflammation, itching, bleeding, and
impaired normal functioning. In my work, I aimed to find a safer and more effective remedy. I chose
phytosuppositories, since plant-based raw materials combine availability, low toxicity, and a complex
therapeutic effect. Buckwheat, due to its rutin and flavonoid content, strengthens blood vessels and
reduces inflammation. In combination with calendula, plantain, oak bark, and sea buckthorn oil, I
obtained a preparation with pronounced wound-healing and anti-inflammatory effects.
According to the World Health Organization, 10–15% of the adult population suffers from various
forms of hemorrhoids, and among patients over 50 years old, this figure reaches 50–70%. The disease
significantly reduces quality of life, being accompanied by pain, inflammation, itching, bleeding, and
impaired normal functioning. In my work, I aimed to find a safer and more effective remedy. I chose
phytosuppositories, since plant-based raw materials combine availability, low toxicity, and a complex
therapeutic effect. Buckwheat, due to its rutin and flavonoid content, strengthens blood vessels and
reduces inflammation. In combination with calendula, plantain, oak bark, and sea buckthorn oil, I
obtained a preparation with pronounced wound-healing and anti-inflammatory effects.
541
35
7
IMMUNOSUPPRESSANTS IN MODERN PHARMACOLOGY: MECHANISMS OF ACTION AND CLINICAL APPLICATION
The immune system is a complex network of cells and mediators designed to
protect the body from pathogens. However, in some cases (organ transplantation, autoimmune and
allergic diseases) this protective reaction becomes excessive or directed against one's own tissues,
which requires pharmacological correction. Immunosuppressants are a heterogeneous group of drugs
that specifically inhibit the immune response. Their introduction revolutionized transplantology and
significantly improved the prognosis for many autoimmune pathologies. However, their use is
associated with serious side effects, primarily with an increased risk of infections and cancer, which
dictates the need to search for new, more selective targets and drugs.
protect the body from pathogens. However, in some cases (organ transplantation, autoimmune and
allergic diseases) this protective reaction becomes excessive or directed against one's own tissues,
which requires pharmacological correction. Immunosuppressants are a heterogeneous group of drugs
that specifically inhibit the immune response. Their introduction revolutionized transplantology and
significantly improved the prognosis for many autoimmune pathologies. However, their use is
associated with serious side effects, primarily with an increased risk of infections and cancer, which
dictates the need to search for new, more selective targets and drugs.
542
24
14
THE STUDY OF THE EFFECT OF MEDICINAL PLANTS ON BLOOD PRESSURE
According to the literature, arterial hypertension is one of the most widespread
diseases today. Alongside pharmaceutical drugs, traditional remedies and medicinal plants are widely
used because they are natural, affordable, and have fewer side effects. Therefore, the use of medicinal
plants in treatment is of great importance.
diseases today. Alongside pharmaceutical drugs, traditional remedies and medicinal plants are widely
used because they are natural, affordable, and have fewer side effects. Therefore, the use of medicinal
plants in treatment is of great importance.
543-544
26
8
MODERN APPROACHES TO THE USE OF BETA-BLOCKERS IN CLINICAL PHARMACOLOGY
Cardiovascular diseases (CVDs) remain the leading cause of mortality
worldwide and in the Republic of Kazakhstan. According to the World Health Organization (WHO),
more than 17.9 million people die from CVDs every year (WHO, 2021). In Kazakhstan, the
prevalence of arterial hypertension among the adult population exceeds 25%, which makes its control
particularly relevant (Ministry of Health of the Republic of Kazakhstan, 2022).
worldwide and in the Republic of Kazakhstan. According to the World Health Organization (WHO),
more than 17.9 million people die from CVDs every year (WHO, 2021). In Kazakhstan, the
prevalence of arterial hypertension among the adult population exceeds 25%, which makes its control
particularly relevant (Ministry of Health of the Republic of Kazakhstan, 2022).
545
28
6
STUDY OF ACUTE TOXICITY OF "PHYTOBRONCHIS"
Inflammatory processes underlie the development of most diseases, be it
pathology of the respiratory tract, gastrointestinal tract, joints or skin. Modern medicine has a wide
range of anti-inflammatory drugs, but their prolonged use is often accompanied by side effects and
complications. In this regard, there is a growing interest in the use of natural remedies, in particular
herbal preparations with anti-inflammatory activity. Medicinal plants contain flavonoids, essential
oils, tannins and other biologically active components that have a mild but pronounced antiinflammatory
effect.
pathology of the respiratory tract, gastrointestinal tract, joints or skin. Modern medicine has a wide
range of anti-inflammatory drugs, but their prolonged use is often accompanied by side effects and
complications. In this regard, there is a growing interest in the use of natural remedies, in particular
herbal preparations with anti-inflammatory activity. Medicinal plants contain flavonoids, essential
oils, tannins and other biologically active components that have a mild but pronounced antiinflammatory
effect.
546
29
8
GARLIC WITHOUT ODOR: NEW OPPORTUNITIES FOR IMMUNE ENHANCEMENT
Garlic is one of the most extensively studied natural immunomodulators with
antibacterial, antiviral, and antioxidant activity. Its use is limited by the presence of a characteristic
unpleasant odor associated with sulfur-containing compounds. To reduce the odor, we used cherry,
as it is rich in polyphenols, organic acids, and antioxidants, which are able to neutralize volatile garlic
compounds while preserving its beneficial properties. This makes the topic relevant for both
pharmaceuticals and the food industry
antibacterial, antiviral, and antioxidant activity. Its use is limited by the presence of a characteristic
unpleasant odor associated with sulfur-containing compounds. To reduce the odor, we used cherry,
as it is rich in polyphenols, organic acids, and antioxidants, which are able to neutralize volatile garlic
compounds while preserving its beneficial properties. This makes the topic relevant for both
pharmaceuticals and the food industry
547
30
12
(1-(4-NITROFENIL)-1H-1,2,3-TRIAZOL-4-IL)METIL 2-GIDROKSIBENZOAT MODDASINING YALLIG‘LANISHGA QARSHI TA’SIRI
Bugungi kunda revmatoid artrit va unga o‘xshash surunkali yallig‘lanish
kasalliklari butun dunyoda sog‘liqni saqlash tizimi uchun jiddiy muammo bo‘lib qolmoqda. Statistik
ma’lumotlarga ko‘ra, revmatoid artrit aholining, ko‘pincha mehnatga layoqatli yoshdagi insonlarning
1–2 % ini qamrab oladi. Ushbu jarayonlar bemorlarning hayot sifatini keskin pasaytiradi,
nogironlikka olib kelishi mumkin. So‘nggi yillarda qo‘llanilayotgan nosteroid yallig‘lanishga qarshi
dorilar (NYaQD), gormonlar va biologik preparatlar yallig‘lanish jarayonini kamaytirishda samarali
bo‘lsa-da, ular ko‘plab nojo‘ya ta’sirlarga ega. Shu bois xavfsizroq va samaraliroq yangi dori
vositalarini izlash farmakologiya va tibbiyotda dolzarb masalalardan biri hisoblanadi
kasalliklari butun dunyoda sog‘liqni saqlash tizimi uchun jiddiy muammo bo‘lib qolmoqda. Statistik
ma’lumotlarga ko‘ra, revmatoid artrit aholining, ko‘pincha mehnatga layoqatli yoshdagi insonlarning
1–2 % ini qamrab oladi. Ushbu jarayonlar bemorlarning hayot sifatini keskin pasaytiradi,
nogironlikka olib kelishi mumkin. So‘nggi yillarda qo‘llanilayotgan nosteroid yallig‘lanishga qarshi
dorilar (NYaQD), gormonlar va biologik preparatlar yallig‘lanish jarayonini kamaytirishda samarali
bo‘lsa-da, ular ko‘plab nojo‘ya ta’sirlarga ega. Shu bois xavfsizroq va samaraliroq yangi dori
vositalarini izlash farmakologiya va tibbiyotda dolzarb masalalardan biri hisoblanadi
548-549
29
7
СОВРЕМЕННЫЕ ПОДХОДЫ К ИСПОЛЬЗОВАНИЮ БЕТА- АДРЕНОБЛОКАТОРОВ В ФАРМАКОТЕРАПИИ
Сердечно-сосудистые заболевания (ССЗ) продолжают оставаться основной
причиной смертности в мире и Республике Казахстан. По данным Всемирной организации
здравоохранения, ежегодно от ССЗ умирает более 17,9 млн человек (WHO, 2021). В
Казахстане распространенность артериальной гипертензии среди взрослого населения
составляет более 25%, что делает проблему её контроля особенно актуальной (Минздрав РК,
2022). Одним из ключевых классов лекарственных средств для лечения ССЗ являются бета-
адреноблокаторы (БАБ), которые применяются более 50 лет и занимают важное место в
терапии артериальной гипертензии, ишемической болезни сердца (ИБС), хронической
сердечной недостаточности (ХСН) и нарушений ритма.
причиной смертности в мире и Республике Казахстан. По данным Всемирной организации
здравоохранения, ежегодно от ССЗ умирает более 17,9 млн человек (WHO, 2021). В
Казахстане распространенность артериальной гипертензии среди взрослого населения
составляет более 25%, что делает проблему её контроля особенно актуальной (Минздрав РК,
2022). Одним из ключевых классов лекарственных средств для лечения ССЗ являются бета-
адреноблокаторы (БАБ), которые применяются более 50 лет и занимают важное место в
терапии артериальной гипертензии, ишемической болезни сердца (ИБС), хронической
сердечной недостаточности (ХСН) и нарушений ритма.
550-551
40
17
TRANSFORMING PHARMACEUTICAL EDUCATION FOR THE FUTURE: A GLOBAL ASSESSMENT OF SUCCESSES, CHALLENGES, AND EMERGING OPPORTUNITIES
Pharmaceutical education plays a crucial role in preparing the next generation of
professionals who will shape global healthcare delivery. As the industry faces challenges such as
emerging diseases, an aging population, and the integration of advanced technologies, it is essential
for educational systems to evolve. Future pharmacists must possess the knowledge, skills, and
adaptability to address these issues. This study evaluates current educational reforms and explores
how pharmaceutical education systems can better align with emerging healthcare trends,
technological advancements, and global health crises. The findings offer valuable insights for
educators, policymakers, and industry leaders aiming to modernize pharmaceutical education
globally
professionals who will shape global healthcare delivery. As the industry faces challenges such as
emerging diseases, an aging population, and the integration of advanced technologies, it is essential
for educational systems to evolve. Future pharmacists must possess the knowledge, skills, and
adaptability to address these issues. This study evaluates current educational reforms and explores
how pharmaceutical education systems can better align with emerging healthcare trends,
technological advancements, and global health crises. The findings offer valuable insights for
educators, policymakers, and industry leaders aiming to modernize pharmaceutical education
globally
552
29
5
DEVELOPMENT OF AN EFFERVESCENT TABLET FORM FOR BATHS WITH SOOTHING AND ANTI-INFLAMMATORY EFFECT BASED ON NATURAL RAW MATERIALS
In recent decades, there has been a steady increase in the incidence of skin
pathologies — allergic dermatitis, eczema, psoriasis, as well as various forms of skin irritation caused
by adverse environmental conditions, stress, and reduced immunity. According to dermatological
practice, up to 20–30% of the population of different age groups experience manifestations of skin
hypersensitivity, accompanied by itching, inflammation, and impaired barrier function. Existing
dosage forms (ointments, alcohol-based solutions, creams) have limitations: they may cause burning
and discomfort, make it difficult to apply evenly over large skin areas, and reduce treatment
adherence. In this regard, there is growing interest in remedies based on natural plant and mineral raw
materials, which are characterized by mild action, ecological safety, and ease of use
pathologies — allergic dermatitis, eczema, psoriasis, as well as various forms of skin irritation caused
by adverse environmental conditions, stress, and reduced immunity. According to dermatological
practice, up to 20–30% of the population of different age groups experience manifestations of skin
hypersensitivity, accompanied by itching, inflammation, and impaired barrier function. Existing
dosage forms (ointments, alcohol-based solutions, creams) have limitations: they may cause burning
and discomfort, make it difficult to apply evenly over large skin areas, and reduce treatment
adherence. In this regard, there is growing interest in remedies based on natural plant and mineral raw
materials, which are characterized by mild action, ecological safety, and ease of use
554-555
18
7
ANALYSIS OF TORASEMIDE BY CHROMATOSPECTROPHOTOMETRIC METHOD
Torasemide is a loop diuretic. When used in low doses, its diuresis rate is similar
to that of the thiazide group, and the maximum effect is achieved 2 hours after administration. The
drug is rapidly and almost completely absorbed into the blood. In patients with impaired liver
function, an increase in the concentration of torasemide in the blood plasma is observed. Therefore,
such patients should exercise caution. The toxic effect of torasemide can lead to serious complications
such as arterial hypotension, confusion, thrombosis, cardiac arrhythmias, angina pectoris and acute
myocardial infarction as a result of impaired water and electrolyte balance, increased metabolic
alkalosis and excessive diuresis. From the urinary system. In patients with impaired urinary excretion,
it can lead to rapid urine output, its retention and overdistension of the bladder. Sometimes the level
of uric acid, glucose, lipids in the blood increases.
to that of the thiazide group, and the maximum effect is achieved 2 hours after administration. The
drug is rapidly and almost completely absorbed into the blood. In patients with impaired liver
function, an increase in the concentration of torasemide in the blood plasma is observed. Therefore,
such patients should exercise caution. The toxic effect of torasemide can lead to serious complications
such as arterial hypotension, confusion, thrombosis, cardiac arrhythmias, angina pectoris and acute
myocardial infarction as a result of impaired water and electrolyte balance, increased metabolic
alkalosis and excessive diuresis. From the urinary system. In patients with impaired urinary excretion,
it can lead to rapid urine output, its retention and overdistension of the bladder. Sometimes the level
of uric acid, glucose, lipids in the blood increases.
556-557
28
12
МЕТОДИКА СУДЕБНО-ХИМИЧЕСКОГО ИССЛЕДОВАНИЯ НЕИЗВЕСТНОЙ ТАБЛЕТКИ С ПОМОЩЬЮ МЕТОДА ИК-СПЕКТРОФОТОМЕТРИИ
Неизвестные фармацевтические препараты являются частыми
объектами исследования судебно-экспертных учреждений. Неизвестные препараты
поступают в виде таблеток, порошка и инъекционных растворов в ампулах, которые
обнаруживаются на месте преступления. При этом перед экспертами ставятся задачи по
установлению его названия, отнесению к тому-или иному списку наркотических средств и
психотропных веществ, подлежащих контролю.
объектами исследования судебно-экспертных учреждений. Неизвестные препараты
поступают в виде таблеток, порошка и инъекционных растворов в ампулах, которые
обнаруживаются на месте преступления. При этом перед экспертами ставятся задачи по
установлению его названия, отнесению к тому-или иному списку наркотических средств и
психотропных веществ, подлежащих контролю.
558
28
3
TOXICITY OF METALS IN VITAL ORGANS OF THE BODY AND THE STUDY OF STRATEGIES FOR ELIMINATING THEIR TOXINS FROM THE PERSPECTIVE OF RHAZES AND AVICENNA
In recent decades, due to the expansion of the consumption of
processed foods, the increase in environmental pollutants, and the decline in nutritional quality, the
possibility of poisoning with some metals found in foods, such as lead and mercury, has increased.
These metals can negatively affect vital organs of the body, such as the brain, heart, and liver,
disrupting their function. The present study aimed to investigate how metal toxicity occurs in vital
organs of the body and analyze the therapeutic strategies for eliminating their toxins from the
perspectives of Rhazes and Avicenna in two valuable books, Al-Hawi fi al-Tibb and Al-Qanun fi alTibb
processed foods, the increase in environmental pollutants, and the decline in nutritional quality, the
possibility of poisoning with some metals found in foods, such as lead and mercury, has increased.
These metals can negatively affect vital organs of the body, such as the brain, heart, and liver,
disrupting their function. The present study aimed to investigate how metal toxicity occurs in vital
organs of the body and analyze the therapeutic strategies for eliminating their toxins from the
perspectives of Rhazes and Avicenna in two valuable books, Al-Hawi fi al-Tibb and Al-Qanun fi alTibb
559
16
8
ANALYSIS OF TOXIC METALS IN DAIRY PRODUCTS USING THE VOLTAMMETRY METHOD
Dairy products are widely consumed by humans and represent an important
source of proteins, fats, and minerals for the body. Unfortunately, due to environmental pollution,
these products may also contain toxic metals along with other harmful substances. The accumulation
of toxic metals in dairy products at elevated levels poses a serious threat to food safety and human
health. Therefore, determining the amount of toxic metals in dairy products is of great importance. In
this study, the contents of toxic metals such as lead (Pb) and cadmium (Cd) in certain dairy products
were determined using voltammetry, and the results were compared with the permissible hygienic
limits
source of proteins, fats, and minerals for the body. Unfortunately, due to environmental pollution,
these products may also contain toxic metals along with other harmful substances. The accumulation
of toxic metals in dairy products at elevated levels poses a serious threat to food safety and human
health. Therefore, determining the amount of toxic metals in dairy products is of great importance. In
this study, the contents of toxic metals such as lead (Pb) and cadmium (Cd) in certain dairy products
were determined using voltammetry, and the results were compared with the permissible hygienic
limits
560-561
34
8
РАЗРАБОТКА МЕТОДИКИ ХИМИКО-ТОКСИКОЛОГИЧЕСКОГО ИССЛЕДОВАНИЯ МАЛЫХ КОЛИЧЕСТВ НЕКОТОРЫХ ПРЕКУРСОРОВ С ИСПОЛЬЗОВАНИЕМ ИК-СПЕКТРОФОТОМЕТРИИ
Прекурсоры – вещества(уксусный ангидрид, эфедрин, псевдоэфедрин,
кислоты, растворители), которые используются при производстве, изготовлении, переработке
наркотических средств и психотропных веществ с целью получения более
сильнодействующих наркотиков (ацетилированный опий, героин, метамфетамин, ЛСД).
Так, эфедрин, псевдоэфедрин могут применяться для приготовления в кустарных
условиях наркотического средства - психостимулятора метамфетамина (первитина).
кислоты, растворители), которые используются при производстве, изготовлении, переработке
наркотических средств и психотропных веществ с целью получения более
сильнодействующих наркотиков (ацетилированный опий, героин, метамфетамин, ЛСД).
Так, эфедрин, псевдоэфедрин могут применяться для приготовления в кустарных
условиях наркотического средства - психостимулятора метамфетамина (первитина).
562
56
23
COMPOSITION OF VARIOUS HEMATOGEN PREPARATIONS AND THE TOXIC EFFECTS OF THEIR COMPONENTS ON THE HUMAN BODY
One of the most common health issues observed among the population today is iron
deficiency. According to the World Health Organization (WHO), in 2023, anemia was diagnosed in
2.24 billion people worldwide, and this number continues to increase daily. In Uzbekistan, anemia
has been recorded in 17.5% of men and 31.2% of women. Iron deficiency raises the demand for ironcontaining preparations, which necessitates their production. Currently, the pharmaceutical market
offers various types of iron-containing medicines. These preparations are based on iron (Ferrum), but
they differ in their main and excipient components, as well as in their dosage forms—such as tablets,
syrups, injections, biologically active supplements, and food-like products such as bars known as
hematogen. Hematogen lat. Haematogenum in greek αἷμα (blood) and γένος (generation).
deficiency. According to the World Health Organization (WHO), in 2023, anemia was diagnosed in
2.24 billion people worldwide, and this number continues to increase daily. In Uzbekistan, anemia
has been recorded in 17.5% of men and 31.2% of women. Iron deficiency raises the demand for ironcontaining preparations, which necessitates their production. Currently, the pharmaceutical market
offers various types of iron-containing medicines. These preparations are based on iron (Ferrum), but
they differ in their main and excipient components, as well as in their dosage forms—such as tablets,
syrups, injections, biologically active supplements, and food-like products such as bars known as
hematogen. Hematogen lat. Haematogenum in greek αἷμα (blood) and γένος (generation).
