90
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
MODERN METHODS OF MICROENCAPSULATING ACTIVE PHARMACEUTICAL
SUBSTANCES
Baymuratova Zh. A.
South Kazakhstan Research University named after. M. Auezova, Shymkent, Republic of
Kazakhstan
e-mail: zhaina.baimuratova@mail.ru
https://doi.org/10.5281/zenodo.17321945
Relevance:
Microencapsulation is one of the most promising methods for improving the
stability, bioavailability, and controlled release of drugs. Development of this approach will enable
the development of new forms of drug delivery with fewer side effects.
Objective:
To study modern methods of microencapsulation of active pharmaceutical
ingredients and evaluate their effectiveness for the development of innovative dosage forms.
Research methods:
Analysis of literature on modern microencapsulation technologies.
Comparative study of coacervation, spray drying, and extrusion methods. Use of electron microscopy
to study microcapsule morphology. Physicochemical analysis to assess the stability and homogeneity
of active ingredient distribution. Use of mathematical modeling to predict drug separation kinetics.
Results: The coacervation method.
was found to produce microcapsules with a high degree
of encapsulation and controlled release of the active ingredient. Spray drying ensures process
scalability and is suitable for heat-stable compounds. Extrusion technology demonstrated good results
in the production of long-acting microgranules. Electron microscopy confirmed uniform distribution
of the active ingredient within the capsules. Physicochemical analysis revealed increased stability of
encapsulated compounds compared to unencapsulated forms. Mathematical modeling allowed us to
predict production kinetics and select optimal process parameters. Overall, it was found that modern
microencapsulation methods significantly expand the possibilities for creating innovative dosage
forms.
Diagram compares specified main microencapsulation methods main parameters: degree
encapsulation, stability, scalability And control reproduction. 1. Coacervation exhibits the highest
encapsulation efficiency and control, making it ideal for producing higher-capsule microcapsules.
However, its scalability is limited compared to other methods. 2. Spray drying is highly scalable,
making it suitable for industrial production. In this case, the encapsulation efficiency and yield control
are comparable to other methods. 3. Extrusion occupies an intermediate position: it provides good
stability and control of intake, but has a low level of encapsulation.
91
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
Conclusions:
Thus, the choice of microencapsulation method depends on the objectives:
coacervation is best for maximum control and efficiency, spray drying is suitable for industrial
production, and extrusion is optimal when it is necessary to create prolonged forms .
