93
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
PHARMACEUTICAL INTERPOLYMER COMPLEXES BASED ON SODIUM
CARBOXYMETHYLCELLULOSE POLYSACCHARIDE AND POLYACRYLAMIDE
Sabitjan Y. Inagamov
b
#
Ummatjon A. Asrorov
a
,
c
Olimjon
Т.Yomg’irov
b
a
National University of Uzbekistan named after Mirzo Ulugbek, Tashkent city, Uzbekistan
b
Tashkent Pharmaceutical Institute, Tashkent city, Uzbekistan
c
Tashkent State Pedagogical University named after Nizami, Tashkent city, Uzbekistan
https://doi.org/10.5281/zenodo.17322056
Relevance:
An analysis of international literature data shows that polyelectrolyte complexes
(PEC) are very promising, occupy an important place in materials technology, engineering, medicine,
and other areas of the national economy, as they reveal a number of unique and most valuable
properties. In addition, the ability of many polyelectrolytes to interact with other polymer compounds
opens up broad prospects in the field of modification and controlled synthesis of macromolecular
systems. Due to this, completely new materials can be obtained from most of the known substances.
Purpose of the study:
In this regard, this work is devoted to the study of new carriers of
medicinal particles based on sodium carboxymethyl cellulose (Na-CMC) and polyacrylamide (PAA).
Materials and methods:
Na-CMC, obtained on the basis of GOST 5.588-79, with a degree of
polymerization (SP) - 70 and a degree of substitution (SZ) - 450, was used as the main object of the
study. Polyacrylamide, a polyelectrolyte obtained by polymerization of acrylamide containing the
element nitrogen, which has a linearly branched structure, was used as the second component of the
PEC. IR spectra in the range of 400-4000 cm-1 were recorded on NIKOLET Magna-560 IR and
Specord–75 IR spectrophotometers (Karl Zeiss, GDR).
Results:
When mixing aqueous solutions of Na-CMC and PAA in various component ratios at
pH = 5-6, a water-soluble PEC is formed. It is formed mainly due to the weak ionic bond between
the Na-CMC carboxylate anion and the amino groups of PAA, which shows IR spectroscopic data.
A change in the intensity and a shift in the absorption band in the region of 1667 cm-1, 1609 cm-1
and in the region of 1407 cm-1, 1451 cm-1 indicates the formation of an ionic bond between the
carboxylate anions of Na-CMC and amino groups of polyacrylamide, which gives this PEC new
properties that differ from the initial components. The above experimental results are confirmed by
the physico-mechanical properties of PEK films. The film strength for Na-CMC is σp = 6.1 MPa; for
PAA, σp = 22 MPa, and for PEK films of an equimolar composition, it has a strength of σp = 38 MPa.
The elastic deformation for Na-CMC is ε =5.1%; for PAA, ε = 4.0%, and for PEK films with an
equimolar composition, it has ε = 0.5%. The elasticity of PEK films has E = 3.2 MPa for Na-CMC;
E = 8.1 MPa for PAA, and E = 73 MPa for PEK films with an equimolar composition. All these
changes in the properties of films of polyelectrolyte complexes are associated with the formation of
an ionic bond between the Na-CMC (CO-) carboxylate anions and the amine groups of
polyacrylamide, which are confirmed by IR spectroscopic data.
Conclusions:
Thus, a new PEC based on Na-CMC and PAA was obtained, which can be used
as carriers in medicinal products. The structure and properties of the polyelectrolyte complex have
been studied. It has been established that the structures and physico-mechanical properties of
polyelectrolyte complexes can be controlled based on changes in the quantitative ratios of the
constituent components of Na-CMC and PAA.
