97
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
DISPERSIBLE TABLETS
—
PROSPECTS FOR THE DEVELOPMENT OF A NEW
DOSAGE FORM: CASE STUDY OF NYSTATIN DISPERSIBLE TABLET
FORMULATION
Almatov A.T.
1
Bulusov J.K.
2
Odilova D.M.
3
State «Center for Good Practices», Tashkent Region, Republic of
Uzbekistan
https://doi.org/10.5281/zenodo.17322238
Relevance:
Dispersible tablets are one of the most promising solid dosage forms, offering ease
of use, especially for patients with swallowing difficulties such as children, the elderly, and patients
with dysphagia. The ability to obtain a suspension from a tablet immediately before administration
makes this form attractive for expanding the range of oral drugs, including antifungal agents like
nystatin.
Objective of the Study:
To develop and optimize the formulation of nystatin dispersible tablets
suitable for use as a suspension in patients who have difficulty taking solid oral forms.
Materials and Methods:
Active substance:
Nystatin
Initial formulations:
10 variants with
different types of disintegrants and fillers, as well as other excipients, including flavoring agents and
sweeteners.
Excipients used:
Croscarmellose sodium, sodium starch glycolate, povidone, sorbitol,
mannitol, microcrystalline cellulose (MCC), starch, lactose, xanthan gum, and their combinations.
Parameters evaluated:
Appearance, weight, hardness, disintegration time.
Equipment:
ERWEKA ZT 320 Tablet and Capsule Disintegration Tester; ERWEKA TAR 220
Friability Tester; PTK PR-LM Tablet Press FRITSCH laboratory sieves with sizes: 0.4 mm; 0.6 mm;
0.8 mm
Results:
Initially, the impact of various disintegrants was studied; however, achieving the
regulatory disintegration time (within 3 minutes) was not successful. After shifting focus to the
selection and combination of fillers, satisfactory disintegration results were still not achieved. None
of the tested formulations provided stable disintegration within the required time frame. Variants with
croscarmellose sodium and sodium starch glycolate demonstrated acceptable disintegration times but
produced tablets that were too fragile. The addition of povidone improved mechanical strength but
negatively affected dispersibility. Formulations containing starch and sodium carboxymethyl starch
showed uneven disintegration and a tendency to form gels. Variants with microcrystalline cellulose
had satisfactory mechanical properties but poor dispersibility. In all cases, high sensitivity of the
composition to humidity was observed, which complicated the tableting process.
Conclusion:
The development of an effective dispersible dosage form of nystatin proved to be
more challenging than initially anticipated. The study showed that the choice of fillers and their
combinations significantly influences tablet disintegration, and none of the tested formulations met
the required standards. Further research is needed to identify suitable functional excipients, possibly
involving modern super-disintegrants and particle surface modification technologies.
