98
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
PHARMACEUTICAL AND TECHNOLOGICAL FEATURES OF THE
DEVELOPMENT OF ADHESIVE FILMS WITH ASIAN MINT EXTRACT (
MENTHA
ASIATICA
BORISS.)
Altynkhan Sh.A.
1
Ustenova G.O.
2
NJSC “Kazakh National Medical University named after S.D. Asfendiyarov”, Almaty, Republic
of Kazakhstan
e-mail: shyrai.alimkhanovna02@mail.ru
https://doi.org/10.5281/zenodo.17322290
Relevance:
Modern dentistry requires dosage forms that provide prolonged and localized
release of active substances. Adhesive films are convenient to use, reduce systemic side effects, and
improve patient compliance. Asian mint extract (
Mentha asiatica
Boriss.) possesses anti-
inflammatory, antimicrobial, and analgesic properties, making it a promising component of dental
films.
Research objective:
To develop the composition and study the pharmaceutical-technological
properties of adhesive films with Asian mint extract.
Research methods:
Gelatin and collagen were used as the film-forming base, glycerin served
as the plasticizer, and liquid Asian mint extract was the active ingredient. The technology included
hydration of polymers, introduction of the extract, homogenization of the mass, and film formation
by layered drying. Pharmaceutical-technological parameters were evaluated by thickness, mechanical
strength, elasticity, adhesive properties, and disintegration time.
Results:
A technology was developed for obtaining films, which included swelling of gelatin
and collagen in water under controlled temperature, introduction of liquid Asian mint extract, addition
of glycerin, homogenization of the mass, casting onto substrates, and drying until stable samples were
formed.
The resulting films had a homogeneous structure, transparency, and smooth surface without
cracks, bubbles, or other defects. The thickness of the samples ranged between 0.20–0.25 mm, which
met the established requirements. Mechanical strength reached 2.5 N/cm², allowing the films to
withstand bending and tearing stresses. Elasticity tests showed that the samples did not break and
retained their integrity even after repeated folding.
The adhesive properties were pronounced: the films adhered to the mucous membrane within
3–5 seconds and remained fixed for more than 10 minutes, ensuring localized action. The
disintegration time was 12–15 minutes, confirming the potential for prolonged release of the active
substance.
Organoleptic testing revealed that the films had a pleasant fresh taste and aroma due to the
liquid mint extract, which significantly increased their acceptability for dental use. The inclusion of
collagen improved texture and enhanced mechanical strength compared to samples without it, while
its combination with gelatin ensured flexibility and uniform structure.
Thus, the developed films combined optimal physical and mechanical characteristics (strength,
elasticity, adhesion), prolonged release of the active substance, and high organoleptic appeal, making
them promising for use in dental practice.
Conclusion:
Adhesive films with Asian mint extract possess a balanced composition, optimal
physical and mechanical characteristics, pronounced adhesive properties, and prolonged release of
99
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
the active ingredient. The obtained results confirm the potential of this dosage form for
implementation in dental practice..
