191
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
RISK ANALYSIS IN THE PRODUCTION OF EFFERVESCENT TABLETS WITH
HERBAL EXTRACTS: A CASE STUDY OF
MORUS ALBA
L
Kozhakhmetova N.M.
Rakhymbayev N.A.
Akhelova A.L.
Kazakh national medical university named by S. D.Asfendiyarov, Almaty city, Republic of
Kazakhstan
e-mail: nuraimaratkyzy@mail.ru
https://doi.org/10.5281/zenodo.17332662
Relevance:
in modern conditions, there is a growing interest in drugs and biologically active
additives containing plant extracts. Special attention is paid to dosage forms with high bioavailability
and ease of use, which include effervescent tablets. However, the production of this dosage form
involves a number of technological risks: the sensitivity of active substances to moisture and
temperature, the need to comply with GMP requirements, as well as the instability of the quality of
plant raw materials. In this regard, the task of analyzing the risks of the production of effervescent
tablets with plant extracts is urgent.
Purpose of the study:
to analyze the technological risks at the production stages of effervescent
tablets with white mulberry extract (
Morus Alba
L.).
Materials and methods:
the following methods were used in the work: an analytical review of
scientific literature and the pharmaceutical market, methods of comparative analysis of technological
schemes, risk assessment based on criteria of frequency of occurrence and degree of impact on
product quality.
Results:
the study revealed that the main critical factors in the production of effervescent tablets
with herbal extracts are:
1. Moisture – hypersensitivity of
Morus Alba
L. extract. resistance to moisture leads to the
destruction of active substances and a decrease in effervescence. To minimize this risk, it is necessary
to use moisture-proof packaging (aluminum blisters, tubes with desiccants).
2. Temperature regime – high temperatures at the stage of drying and pressing can destroy
flavonoids and vitamins. Optimization of the granulation technology and the use of mild drying
modes make it possible to maintain the extract activity.
3. The quality of the raw materials – mulberry extract may have a different content of
biologically active substances depending on the growing conditions. Standardization of the extract
by marker substances (for example, by the content of rutin and quercetin) ensures quality stability.
4. Organoleptic properties – the extract has a specific taste, which may reduce the consumer
appeal of the drug. The solution is to introduce flavors (lemon, orange) and sweeteners (aspartame,
sucralose).
FMEA (Failure Mode and Effects Analysis) risk assessment showed that the highest level of
risk (RPN = 180) is associated with exposure to moisture, the average level of risk (RPN = 120) is
associated with fluctuations in extract quality, and the low level (RPN < 80) is associated with
organoleptic characteristics.
Conclusions:
thus, the production of effervescent tablets with
Morus Alba
L extract It requires
an integrated approach, including standardization of plant raw materials, optimization of
technological modes and protection of the product from moisture. The economic efficiency of the
192
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
project confirms the feasibility of introducing these products into industrial production, and risk
analysis minimizes possible technological and organizational problems.
