383
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
SYNTHESIS, STRUCTURE, AND INVESTIGATION OF A COMPLEX COMPOUND
BASED ON THE BENZIMIDAZOLE DERIVATIVE OF Co (II)
Khujaeva F.A.
1,2
Allamurodova SH.G.
2
Daminova SH.SH.
2
1
Tashkent Pharmaceutical Institute, Tashkent, Republic of Uzbekistan
2
National University of Uzbekistan, Tashkent, Republic of Uzbekistan
xojayevafarangiz891@gmail.com. tel:(90) 939-63-16
https://doi.org/10.5281/zenodo.17339240
Relevance:
Currently, benzimidazole and its derivatives are the main raw materials for the
development of important therapeutic agents in medicine and pharmaceuticals. For example,
benzimidazole and its derivatives exhibit pharmacological activities such as antimicrobial, antiviral,
anticancer, anti-inflammatory, and neurotropic, psychoactive, and analgesic properties. The synthesis
of drugs with high pharmaceutical properties and the creation of new generations of drugs using new
benzimidazole derivatives is currently one of the most important areas of the modern pharmaceutical
industry.
Purpose of the study:
Synthesis of a new coordination compound involving cobalt (II) and
1H-benzimidazole-2-carboxylic acid (1H-BIZ).
Materials and methods:
Differential thermal analysis (DTA) was used to determine the
thermal stability and composition of the resulting complex compound.
Results:
To synthesize the complex compound, the masses of metal and ligand were taken in a
1:2 ratio. A 96 percent solution of ethanol was used as the solvent. The mixture was stirred regularly
for 3-4 hours and stored in a dark place to dry. After a week, blue crystals formed.
Analysis of the dynamic thermogravimetric analysis (DTGA) curve of the complex
[Co(C
8
H
5
N
2
O
2
)
2
(C
7
H
6
N
2
)
2
] shows that the DTGA curve mainly occurs between 3 intense
decomposition temperatures. The 1st decomposition step occurred in the temperature range of 125-
250°C, with a mass loss of 0.266 mg (4.46%). In this case, the decomposition of the water of
crystallization contained in the complex compound was observed. The main decomposition occurred
in the 2nd range at 250-330°C (strong exothermic peak in DSC), with the largest mass loss of 1.524
mg (25.75%). In addition, decomposition in small ranges corresponds to temperatures of 330-550°C,
with a mass loss of 13.2%. The third decomposition range includes 550-680°C, and the mass loss in
this range is 14.2%. Dervatographic studies show that the main mass loss occurs in the range of 125-
680 °C, with 99% of the main mass being lost. At the end of the analysis, the residual mass consists
of CoO and other inorganic decomposition products, accounting for 12.96% of the total mass.
384
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
Conclusions:
The thermal stability of the synthesized complex was determined by
thermogravimetry. Endo- and exo-effects were discovered and thermal destruction products were
identified, and it was shown that the thermal decomposition of complexes proceeds in several stages,
including combustion of the organic part of the molecule, decomposition of the salt, oxidation of the
decomposition products, and the formation of a metal oxide.
