453
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
STUDY OF THE ANTIPYRETIC ACTION OF DRY EXTRACT RHEUM
TATARICUM L.
Z. A. Khakimova
Z. T. Fayzieva
Tashkent Pharmaceutical Institute, Tashkent city, Republic of Uzbekistan
e-mail: fzt70@mail.ru tel. 97-7509512
https://doi.org/10.5281/zenodo.17342288
Relevance.
Herbal preparations are multicomponent, have different mechanisms of action and
do not have side effects on the div. Based on this, we studied the pharmacological activity of the
dry extract of Rheum Tataricum L. on experimental models .
Objective:
To study the antipyretic effect of dry extract of Rheum Tataricum L.
Materials and methods.
The antipyretic activity of the samples was assessed using the
generally accepted method on 15 white mice (both sexes) weighing 19-22 g, followed by division
into groups of 5 animals each. A 20% suspension of baker's yeast in physiological solution was used
as a pyrogen, at a dose of 4000 mg/kg, in a volume of 0.2 ml/10 g.
For this purpose, animals of all groups were preliminarily given daily oral administration of
samples at a dose of 250 mg/kg for 6 days. On the 7th day of the experiment, the animals' initial div
temperature was recorded, after which pyrogen was injected subcutaneously into the cervical fold.
Then, the animals' div temperature was recorded hourly for 4 hours. After achieving a pronounced
thermal reaction (in our case, at the 1st hour of observation), the animals were given a single oral
administration of the studied samples at a dose of 250 mg/kg (within 10 minutes of recording the
temperature). The animals were divided into the following groups: 1. control group (control) –
animals with test modeling, but without exposure to samples; 2. “Rheum Tataricum L” – animals
received dry extract at a dose of 250 mg/kg, in a volume of 0.2 ml/20 g; 3. "Biomol" - the animals
received "Biomol" capsules "Shrey Nutraceuticals & Herbals Pvt. Ltd.", India at a dose of 250 mg/kg
in a volume of 0.2 ml/20 g of div weight. Body temperature was recorded orally with an electronic
thermometer (with an accuracy of 0.1 0C).
Results of the study.
During the experiment, it was found that after the introduction of pyrogen,
a significant increase in the div temperature of animals was observed in the first hour of observation.
The studies showed that the dry extract of Rheum Tataricum L and capsules of Biomol (Shrey
Nutraceuticals & Herbals Pvt. Ltd., India) did not have a pronounced antipyretic effect in animals
with induced hyperthermia. The data obtained indicate that these samples did not reduce div
temperature under these experimental conditions and, accordingly, did not show reliable antipyretic
activity.
0
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Время (мин)
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Контроль
«Rheum Tataricum L» сухой экстракт
«Биомол» Shrey Nutraceuticals & Herbals Pvt
454
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
Figure 5. Results of the study of the antipyretic activity of the dry extract of “Rheum Tataricum
L”, (M SD; p=0.05; n=5)
Conclusion
. In the model of pyrogen-induced hyperthermia, the dry extract of Rheum
Tataricum L and capsules of Biomol did not cause a significant decrease in div temperature in
animals. Compared with the control group, no reliable antipyretic effect was found. Therefore, the
samples do not have pronounced antipyretic activity under the conditions studied.
