538
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
EFFECT OF HYPOGLYCEMIC PLANT COLLECTION EXTRACT ON SOME
INDICATORS OF CARBOHYDRATE METABOLISM IN CONDITIONS OF
ESPERIMENTAL DIABETES
Malikova G.Yu.
Tashkent Pharmaceutical Institute, Tashkent City., Øybek 45
gulchexramalikova.70@gmail.com
https://doi.org/10.5281/zenodo.17344064
Relevance:
Abu Ali Hussein ibn Abdallah ibn Sina (16 August 980 - 18 June 1037) created
works not only on medicine but also on the history of theology, philosophy, astronomy and religion.
A number of sources record more than 450 works by Ibn Sina, and only 242 Gypsies have reached
us. Ibn Sina's Works list more than 100 herbal products in the treatment of diabetes mellitus. One of
the most commonly used plants in diabetes is white mulberry (Morus alba) plant raw materials and
large zubturum (Plantago major) leaves. Ibn Sina cited that raw materials of these tumors are high in
effectiveness in diabetes mellitus not only when applied separately, but also in the form of folding.
Purpose:
Тhe extraction of sugar-lowering substances from medicinal plants consists in the
creation of effective antidiabetic drugs based on them by revealing mechanisms of action on
biochemical processes.
Methods and techniques:
Experiments for this were carried out on laboratory white rats with
a weight of 160-180 G bulgan. Rats were taken to the abdominal cavity with a div weight estimate
of 17 mg/ 100 g of the physiological solution of alloxangydrate, and alloxane diabetes was called.
For the experiment, the first intact, the second alloxan was administered to diabetes called rat, and
the third alloxan was administered orally to diabetic rats for 7 days with plant extracts of 50 mg / 100
g and oranil of 100 mg/kg. After 7 days of determining the level of glucose in the blood of rats, the
activity of lactate, pyruvate levels in liver and muscle tissues as well as the enzyme hexokinase were
anicized in one vaccine itself. Maxalli's raw materials have been cited as having a high effect in
diabetes mellitus not only when applied separately, but also in the form of folding
.
Results:
The hypoglycemic effect of the collection extract based on plant raw materials was
found in rats with experimental diabetes. The direction of the metabolic effect of the assembly was
assessed by quantitative shifts in the levels of metabolites of carbohydrate metabolism in intact and
diabetic conditions. A decrease in blood glucose levels has been found to occur with a simultaneous
increase in glycogen Reserve in the liver by stimulating hexokinase activity and providing energy
from free metabolites. Taking the inclusions to be studied in rats with alloxan diabetes has helped
increase glucose levels in skeletal muscle in vitro. Also from the results of the study led to the
activation of the enzyme hexokinase in the liver without a significant recommendation for enzyme
activity in the muscles of the collection. In the context of alloxan diabetes, a sharp decrease in enzyme
activity in the liver is observed, despite the fact that the amount of glucose in the mine is much higher,
indicating that it occurs as a result of a decrease in the synthesis of hexokinase. According to the
results of the experiment carried out, on the basis of plant extract, diabetes was called and reduced
blood sugar levels in rats by 40%.
Conclusion:
1. Alloxan significantly reduces blood sugar levels when hypoglycemic collection is
administered orally to diabetic rats.
2. In liver tissue, the enzyme stimulates hexokinase activity, significantly reducing lactate levels
in experimental diabetes.
539
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
3. demonstrated that it increases lactate levels in muscle tissue by having the property of
reducing sugar levels by oranil.
