Том 3 № 12 Part 2 (2024)

A brief description of modern antianginal drugs presented in the latest revision of the European Society of Cardiology recommendations is given. Angina pectoris is the most common form of chronic coronary insufficiency, the treatment of which consists in reducing the number, duration and severity of attacks of anginal pain, as well as improving the prognosis: preventing the development of such cardiovascular complications as acute myocardial infarction, life-threatening rhythm disturbances and chronic heart failure.

Senil aorta stenozi (SAS)- aorta qopqog'ining torayishi bilan bog'liq bo'lgan yurak kasalligi bo'lib, odatda yoshga bog'liq va jiddiy yurak-qon tomir muammolarini keltirib chiqaradi . Senil aortal stenoz dunyo bo’ylab keng tarqalayotgan va yildan –yilga soni ortib borayotgan kasalliklardan biridir. Uning o’ziga xosligi, u ko’proq katta yoshdagi odamlarda uchraydi va uning asosiy simptomlari kam, ular yashirin ko’rinishda namoyon bo’ladi.  Bundan tashqari, SAS ning patogenetik rivojlanishida immune yallig’lanish jarayonlarining roli muhimligi ilmiy –tadqiqotlar bilan tasdiqlangan. Yallig'lanish jarayonlari fibroz va qopqoq to'qimalarining kalsifikatsiyasiga olib kelishi mumkin, bu esa qopqoqning torayishiga olib keladi. Ko'pgina tadqiqotlar shuni ko'rsatadiki, SAS bilan og'rigan bemorlarda immunitet tizimi faolligi, yallig'lanish o'choqlari va hujayralar migratsiyasi o'zgargan. Ushbu yallig'lanish jarayonlari tana tuzilishining o'zgarishiga va uning funktsiyasining pasayishiga olib keladi.