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MODERN AND TIMELY INTENSIVE THERAPY FOR ACUTE HEART
FAILURE
S.Sh. Joniev
1,2
, S.Tukhsanboyev
2
, M. Dusmatov
1
, I.Togayev
1
1
Samarkand State Medical University,
2
Samarkand regional branch of the
Republican specialized scientific practical medical center of Cardiology, Samarkand,
Uzbekistan
Annotation.
Coronary artery disease (CAD) continues to be the primary cause of
mortality among elderly patients. In recent years, revascularization therapy centers
have been established across nearly all regions of our country. Specifically,
percutaneous coronary interventions (PCI) are employed to effectively treat patients
with acute coronary syndrome (ACS) and post-infarction cardiosclerosis (PICS),
aiming to enhance their quality of life. These endovascular procedures represent a
highly effective therapeutic approach, significantly improving patients' clinical status,
enhancing physical exercise tolerance, and facilitating their return to routine daily
activities.
In this article, a retrospective analysis was made of elderly and senile patients
who underwent percutaneous coronary intervention with various types of stenting. The
analysis revealed that the majority of patients were diagnosed with ACS.
Keywords:
percutaneous coronary intervention, stenting, acute coronary
syndrome, postinfarction cardiosclerosis
Relevance.
The problem of coronary heart disease (CHD) is in the focus of
scientific research, because. the consequences of atherosclerosis of the coronary
vessels lead to almost half of the deaths of the population [18, 19]. Recently,
indications for myocardial revascularization in this group of patients have been
expanding, which allows increasing exercise tolerance, significantly reducing the risk
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of recurrent myocardial infarction, and increasing long-term survival. The advanced
age of the patient is often associated with a large number of comorbidities, as well as
with high risks of cardiac surgery [11, 20]. In this regard, it became necessary to
classify the age groups of the population.
The World Health Organization (WHO) adopted a classification of age groups
approved by the Congress of Gerontologists and Geriatrics, the entire population over
50 years old is divided into four age categories: 1) mature age - 45-59 years; 2) old age
- 60-74 years; 3) senile age - 75-90 years; 4) centenarians - 90 years or more [12, 21].
In elderly patients with severe forms of chronic coronary heart disease (CIHD),
conservative methods of treatment can not always provide adequate control of anginal
symptoms of the disease and reduce the risk of coronary events. In such cases,
interventional interventions with coronary artery revascularization are the non-
alternative methods of choice. They are the "gold" standard in the treatment of patients
with severe forms of CIHD and not only relieve them of anginal symptoms, but also
increase survival. In this regard, there are data according to which the authors argue
that the operations of choice for patients of older age groups are endovascular methods,
which have minimal operational risk, and also reduce the risk of developing acute
myocardial infarction (MI) in the late postoperative period [5, 16, 19]. The detection
of coronary artery disease in the elderly is facilitated by the high incidence of stenosing
coronary atherosclerosis [9, 17]. Percutaneous coronary intervention does not reduce
mortality, but improves the quality of life, especially in severe angina [4, 10]. Modern
revascularization technology allows interventions even in patients aged 85 years and
older without compromising efficiency and with acceptable risk [2, 15]. In patients
aged 75 years and older, as well as in younger patients, radial access reduces the risk
of bleeding and complications at the vascular access site [6, 8]. Active discussions
regarding the benefits of stents of various modifications have not yet been completed.
According to the RESEARCH and T-SEARCH registries, implantation of drug-eluting
stents in patients over 80 years of age has reduced the risk of vascular events by 50%
compared with holometallic stents [1, 7, 11]. When choosing stents, one can take into
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account information about the greater safety of modern polymeric stents that secrete
everolimus (Xience) or zotarolimus (Rezolute) [3, 13].
Thus, the diagnosis and treatment of coronary artery disease in elderly and senile
patients requires knowledge of the characteristics of the aging organism, the
peculiarities of the manifestations of the disease in old age, the increased risk of
treatment complications, which can help practitioners more successfully control this
dangerous disease.
Objective:
To evaluate the possibilities of percutaneous coronary intervention as
one of the methods of managing patients with chronic coronary heart disease.
Materials and methods
: We conducted a retrospective analysis of elderly and
senile patients who underwent PCI from January 1 to November 1, 2021 according to
the data of the Samarkand Regional Regional Branch of the Republican Specialized
Scientific and Practical Medical Center for Cardiology. A total of 163 patients were
analyzed, who underwent interventional intervention (PCI) using the radial approach
96.32% (n=157) and other approaches 3.68% (n=6). Men accounted for 68.1%
(n=111), women 31.9% (n=52).
The mean age was 63.46. Of these, the average age (45-59) was 28.83% (n=47),
the elderly (60-74) - 63.8% (n=104) and the senile age (75-90) - 6.75% (n=11 ).
The majority of patients were diagnosed with coronary heart disease:
postinfarction cardiosclerosis (PICS) - 31.9% (n=52), diagnosed with acute coronary
syndrome (ACS) with ST segment elevation - 28.83% (n=47), diagnosed with acute
coronary syndrome without ST segment elevation - 13.49% (n=22), with myocardial
infarction 8.59% (n=14), with a diagnosis of coronary artery disease: angina pectoris
FC 3 17.79% (n=29).
During the study, the right type of blood circulation in 130 patients was 79.7%,
the balanced type in 22 - 13.6% and the left type of blood circulation in 11 - 6.7%. The
indication for endovascular intervention (EV) was the presence of acute coronary
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syndrome, as well as angiographic presence of coronary artery stenosis of more than
70%. A total of 337 PCIs were performed in 163 patients. Recanalization of coronary
artery occlusions was performed in 50 (30.67%) patients, balloon angioplasty - in 69
(42.33%) patients, circumflex branch stenting (OB) - 50 (30.67%), right coronary
artery (RCA) stenting - 66 ( 44.49%), stenting of the left coronary artery (LCA) - 4
(2.45%), stenting of the anterior interventricular branch (ALV) - 93 (57.05%), stenting
of the diagonal branch (DV) - 5 (3.07 %) of patients. Clinically, a good result was the
absence of angina and increased exercise tolerance.
In this cohort study, all patients underwent only coronary artery stenting; coronary
artery bypass grafting was not taken into account. There were no lethal cases and
serious complications during the intervention and after it during the stay in the hospital.
Results.
According to these indicators, it can be seen that the majority of patients
were diagnosed with acute coronary syndrome 69 patients (42.32%). It is necessary to
study the comparative long-term follow-up of patients with a diagnosis of acute
coronary syndrome with and without ST segment elevation, who underwent coronary
artery stenting, and patients with the same diagnosis, who were observed on basic
therapy. The second place in coronary artery stenting was occupied by patients with
postinfarction cardiosclerosis of elderly and senile age - 52 patients (31.9%). All
patients before and after PCI were prescribed statins, double or triple anticoagulant
therapy.
Conclusion
s. The importance of stenting patients with ACS for the prevention of
myocardial infarction and all the resulting severe complications in elderly and senile
people, in whom a high level of comorbidity is likely to be quite high, while the need
for stenting in patients who have had myocardial infarction with postinfarction
cardiosclerosis raises many questions. It is necessary to study the condition of patients
according to the data of a long-term 6-month follow-up who underwent stenting of the
elderly and senile age and are on constant therapy with statins, antiplatelet agents and
anticoagulants.
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