ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ
https://scientific-jl.org/obr
Выпуск журнала №-71
Часть–2_ июня–2025
87
2181-
3187
COMPARATIVE CHARACTERISTICS OF MORPHOMETRIC
CHANGES IN THE KIDNEYS DURING CHEMICAL BURNS OF THE
DIGESTIVE ORGANS.
Mukhammadiyeva.F.R.
Bukhara State Medical Institute
,
(998) 65-223-00-50, bsmi.uz
Summary: Comparative characteristics of morphometric changes in the kidneys
during chemical burns is the main factor in their diagnosis and treatment and allows
in this case to cure the patient completely without complications. Therefore, if scientific
research is carried out in this direction, the life expectancy of most patients will
increase and their health will improve.
Key words: kidney, burn, morphometry, clinic, change.
The widespread use of chemicals and drugs that have a nephrotoxic effect, cause
hemodynamic disturbances and have a direct negative effect on the organs of the
urinary system can lead to different levels of the functional state of the kidneys. In
recent decades, in Russia and Western European countries, most of these cases are
observed among children; if you pay attention to this, 2-3 cases of poisoning are
recorded annually per 1000 children, and the number of deaths from chemical
poisoning in children ranks 4th in terms of number injuries, burns, drownings and
exceeds the general figure. About 3 percent of hospitalizations in children are
associated with poisoning from various chemicals and drugs. Often, in both children
and adult patients, toxic kidney damage is accompanied by the development of acute
renal failure (ARF). O`BI, including its nephrotoxic effect, plays a leading role in the
development of persistent renal dysfunction in children of different ages and often
determines the prognosis. In case of poisoning, the frequency of nephropathies reaches
30%, and many toxic substances are directly caused. Besides the fact that it has a
ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ
https://scientific-jl.org/obr
Выпуск журнала №-71
Часть–2_ июня–2025
88
2181-
3187
nephrotoxic effect, a small concentration may be sufficient for the development of
toxic nephropathy in a child.
Toxic nephropathy is a non-inflammatory disease caused by acute exogenous
intoxication, characterized by damage to the entire nephron system and impaired
filtration, secretion and reabsorption functions. Toxic kidney damage is characterized
by acute and chronic interstitial nephritis, glomerulonecrosis, tubular necrosis, as well
as acute kidney injury, including acute renal failure (ARF). It is known that the kidneys
are one of the main responsible organs in the div. The main function of the kidneys
is to remove decomposed toxins from the div.
As a result of accidental or suicidal use of the substance in chemical burns, burns
of the gastrointestinal tract and respiratory tract may occur. The circumstances of the
incident and the chemical nature of the substance determine the degree of injury and
toxicological risk. The initial period after a chemical burn is associated with the
possibility of laryngeal edema, perforation of the esophagus, stomach and intestines,
gastrointestinal bleeding, and pancreatitis.
Chemical burns of the digestive tube Acute poisoning with acetic acid occupies
one of the first places among poisonings in Russia; poisoning is characterized by high
mortality (6-17%) in hospitalized patients.
Active research confirms the complexity of this problem and its relevance. Many
aspects of acetic acid poisoning have been well studied. The severity of acetic acid
poisoning is determined by the degree of damage to internal organs, which is associated
with the specific effect of acetic acid (hemoglobinuric nephrosis against the
background of intravascular hemolysis of red blood cells) and exotoxic shock. The
most important morphofunctional changes are observed in parenchymal organs (lungs,
liver, spleen, kidneys), their damage mainly determines the clinical picture and severity
of the disease in the acute period of poisoning.
References:
ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ
https://scientific-jl.org/obr
Выпуск журнала №-71
Часть–2_ июня–2025
89
2181-
3187
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