Rising pharmaceutical costs have driven many countries to adopt reference pricing as a tool for regulating medicine prices. However, the effectiveness of this approach depends heavily on access to timely and accurate data from international markets. This article explores the global experience in implementing digital platforms for calculating reference prices, compares key country-level platforms, and presents methodological approaches to selecting and analyzing reference data. Based on case studies and comparative analysis, the article identifies core success factors and outlines recommendations for developing countries seeking to implement or improve digital tools in this domain.