INTERNATIONAL JOURNAL OF ARTIFICIAL INTELLIGENCE
ISSN: 2692-5206, Impact Factor: 12,23
American Academic publishers, volume 05, issue 05,2025
Journal:
https://www.academicpublishers.org/journals/index.php/ijai
page 2635
RATE OF DEPRESSION IN SARS-CoV-2 PNEUMONIA AND HYPERTENSION CASE
IN THE MIDDLE ISCHEMIC DISEASE FOUNDATION
Togaeva Barchinoy Musogulovna
Samarkand State Medical University
Assistant of the Department of Internal Diseases № 2 and Cardiology
Bekkulova Mohigul Abdurasulovna
Ferghana Public Health Medical Institute
Assistant of the department of propaedeutics of internal medicine
Abstract:
COVID-19 diagnosis in the setting of ICU presents certain difficulties, as circulatory
failure often masks the clinical manifestations of the underlying disease and complicates its
timely diagnosis. It can be caused by typical manifestations of circulatory failure, including
shortness of breath (at rest, during exercise), fatigue, tachycardia, tachypnea, wheezing during
auscultation, and fluid accumulation in the pleural cavity. The course of ICU in the setting of
COVID-19 has its own characteristics. Coronary artery thrombosis in the setting of COVID-19
can develop according to two main mechanisms: first, it manifests itself as a coagulopathy
specific to the disease, and second, it manifests itself as a result of systemic inflammation and
destabilization of coronary artery atherosclerosis in response to viral infection. The cause of the
development of IHD in the context of COVID-19 is an imbalance between myocardial oxygen
demand and oxygen delivery against the background of severe respiratory and hemodynamic
disorders, as well as spontaneous dissection of the coronary arteries. According to data, IHD is
one of the main causes of death among patients hospitalized with COVID-19.
Keywords:
COVID-19, coronary heart disease, hypertension, cardiovascular system.
Introduction:
According to the World Health Organization (WHO), every year 17.7
million people die from coronary heart disease (CHD), which accounts for 31.1% of total
mortality. This figure has increased further during the SARS-CoV2 (COVID-19) pandemic.
This is because the main risk group for COVID-19 infection is people with cardiovascular
diseases, in particular, a population group with arterial hypertension (AH), CHD and diabetes
mellitus (DM), who are at high risk of contracting coronavirus infection, and the main risk
group is directly these patients. When studying the frequency of comorbidities against the
background of COVID-19, the following data were found: hypertension (HD) (53.8%), DM
(42.3%), CHD (19.2%), cerebral infarction (15.4%), chronic bronchitis (19.2%) and Parkinson's
disease (7.7%).
In addition, acute cardiac complications from SARS-CoV2 infection increase the
difficulty and complexity of treating patients. Thus, the development of cardiovascular
complications in patients with pre-existing heart disease or during COVID-19 disease is a very
important issue and may be a significant comorbid factor leading to death in COVID-19
INTERNATIONAL JOURNAL OF ARTIFICIAL INTELLIGENCE
ISSN: 2692-5206, Impact Factor: 12,23
American Academic publishers, volume 05, issue 05,2025
Journal:
https://www.academicpublishers.org/journals/index.php/ijai
page 2636
patients. COVID-19 is more severe in patients with cardiovascular disease, causing ACS
complications and in some cases, death.
Scientists are closely studying the pathophysiological mechanisms of the COVID-19
virus and its interaction with the human lung and heart. According to several sources, the AAF2
inhibitor located in alveolar epithelial cells serves as a carrier of SARS-CoV2 to human lung
cells. The first descriptions of patients with coronavirus infection, as well as previous
experience in treating patients with MERS-CoV, have led to a discussion about whether the
presence of comorbidities, including IBD, is associated with an increased risk of adverse
outcomes.
Research methods.
The studies were conducted from 2020 to 2023 in the Samarkand branch of the
Republican Scientific Center for Emergency Medical Care (RSCHEMC) and the Samarkand
regional branch of the Republican Specialized Scientific Medical Center for Cardiology. The
studies were conducted on 95 patients aged 35 to 75 years with HF and hypertension against the
background of COVID-19. 38 of the patients were women, which made up 40.0%, and 57 were
men, which made up 60.0%.
Patients with HF and hypertension against the background of COVID-19 had a large
number of and various neurotic complaints. While most of them were symptoms of the disease,
most were associated with dyscirculatory encephalopathy, a condition after cerebral circulation
disorders. Attention was paid to determining the degree of depression in the disease according
to the Beck scale. The scale has 21 category questions. Each question has 4 answers. Depending
on the manifestation of symptoms, the answers are assigned a score of 0 to 3. 0 points - no
symptoms. 3 points - maximum. The questionnaire is filled out by the patient. The sum of the
scores ranges from 0 to 63 points. In the assessment, 0-9 points are considered to be no
depression and nervous disorders, 10-15 points - mild depression (subdepression); 16-19 points
- moderate depression, 20-29 points - severe depression (moderately severe) and 30-63 points -
severe depression.
In our observations, the calculation of the points accumulated in 20 (21.0%) patients led
to the conclusion that “no depression and nervous disorders” were observed. 75 (79.0%)
patients had depression of varying degrees. Of all patients, 26 (27.4%) had mild (10-15 points)
depression (subdepression), 26 (27.4%) had moderate (16-19 points) depression, and 23 (24.2%)
had severe (20-29 points) depression.
When analyzing the level of depression by gender, mild and moderate depression was
more common among women, and severe depression was more common among men. In our
studies, there were no patients with severe depression (IV).
INTERNATIONAL JOURNAL OF ARTIFICIAL INTELLIGENCE
ISSN: 2692-5206, Impact Factor: 12,23
American Academic publishers, volume 05, issue 05,2025
Journal:
https://www.academicpublishers.org/journals/index.php/ijai
page 2637
Although the degree of depression did not have a clear relationship with the age of the
patients, the age of the patients with severe depression was the oldest, at 59.7 years. It was also
found that the duration of the disease was the longest in severe depression.
The dependence of the degree of depression on the stages of the disease on the
background of COVID-19 and the degree of IHD and arterial hypertension was analyzed, and
severe depression was detected in the third stage of the disease with the third degree of IHD and
arterial hypertension against the background of COVID-19
Table 1. Correlation of depression severity with clinical indicators of the disease
Description
Total
Degree of depression
0
I
II
III
Total
95
20
(21%)
26
(27,4%)
26
(27,4%)
23
(24,2%)
Women Table 1.
Relationship
of
depression level to
clinical indicators
of the disease
38
3
(15%)
14
(53,8%)
14
(53,8%)
7
(30,4%)
Men
57
17
(85%)
12
(46%)
12
(46%)
16
(69,5%)
Mean age
53,8
41,8
59,2
53,5
59,7
Duration
7,4
3,3
8,5
7,7
9,4
Stage
I
hypertension
3
3
(15%)
-
-
-
Stage
II 67
17
25
19
6
INTERNATIONAL JOURNAL OF ARTIFICIAL INTELLIGENCE
ISSN: 2692-5206, Impact Factor: 12,23
American Academic publishers, volume 05, issue 05,2025
Journal:
https://www.academicpublishers.org/journals/index.php/ijai
page 2638
hypertension
(85%)
(96,1%)
(73%)
(26%)
Stage
III
hypertension
25
-
1
(3,8%)
7
(26,9%)
17
(73,9%)
Stage
I
hypertension
3
-
3
(11,5%)
-
-
Stage
II
hypertension
51
8
(40%)
16
(61,5%)
19
(73%)
8
(34,7%)
Stage
III
hypertension
41
12
(60%)
7
(26,9%)
7
(26,9%)
15
(65,2%)
Angina
37
6
(30%)
9
(34,6%)
12
(60%)
10
(43,5%)
PICS
12
-
-
1
(3,8%)
11
(47,8%)
Heart failure
23
-
-
4
(15,3%)
18
(78,3%)
Arrhythmia
19
-
-
5
(19,2%)
14
(60,8%)
DVT
26
13
(65%)
7
(26,9%)
3
(11,5%)
3
(13%)
Stroke
5
-
-
1
(3,8%)
4
(17,4%)
The presence of comorbidities and complications of the disease led to an increase in the
level of depression and the number of patients with depression. In moderate and severe
depression, angina pectoris occurred in 60.0 and 43.5% of patients, respectively.
Conclusion
When determining the level of depression according to the Beck scale in patients with
coronary artery disease and hypertension against the background of COVID-19, 79.0% of
patients had depression of varying degrees, 27.4% had mild depression (subdepression), 27.4%
had moderate depression, and 24.2% had severe depression. Mild and moderate depression was
more common among women, and severe depression was more common among men.
The presence of comorbidities and complications of the disease led to an increase in the
level of depression and the number of patients with depression.
Also, heart failure, post-infarction cardiosclerosis, and arrhythmias were detected only
in moderate and severe depression.
LITERATURE:
1.
Тогаева Б. и др. COVID-19 YURAK QON TOMIR KASALLIKLARI BOR
BEMORLARDA KECHISHI //Журнал кардиореспираторных исследований. – 2021. –
Т. 2. – №. 2. – С. 47-50.
2.
Khasanjanova F. O., Khaydarova D. D., Togayeva B. M. To study the frequency of the risk
factors of smoking in pstients with acute coronary syndrome in young age //Science,
Research, Development. – Т. 33. – С. 29-30.
INTERNATIONAL JOURNAL OF ARTIFICIAL INTELLIGENCE
ISSN: 2692-5206, Impact Factor: 12,23
American Academic publishers, volume 05, issue 05,2025
Journal:
https://www.academicpublishers.org/journals/index.php/ijai
page 2639
3.
Togaeva B. et al. OCCURRENCE OF SARS–COV-2 DISEASE (COVID-19) AND IN
PATIENTS WITH CARDIOVASCULAR DISEASES //InterConf. – 2021.
4.
Ташкенбаева Э. Н. и др. Связь тяжести хронической сердечной недостаточности от
локализации острого инфаркта миокарда //Наука и современное общество:
взаимодействие и развитие. – 2018. – Т. 2. – №. 1. – С. 36-38.
5.
Мухиддинов А. И. и др. Клиникая характерестика прогрессирования артериальной
гипертонии с риском сердечно сосудистных осложнений при СOVID-19 //Polish
Sience Journal. – №. 1. – С. 34.
6.
ТАШКЕНБАЕВА Э. Н. и др. COVID-19 БИЛАН КАСАЛЛАНГАНДА ЮРАК ҚОН
ТОМИР АСОРАТЛАРИ РИВОЖЛАНИШИ ХАВФИ БИЛАН АРТЕРИАЛ
ГИПЕРТЕНЗИЯНИНГ РИВОЖЛАНИШИ ВА КЛИНИК КЕЧИШИНИНГ УЗИГА
ХОС ХУСУСИЯТЛАРИ //ЖУРНАЛ БИОМЕДИЦИНЫ И ПРАКТИКИ. – 2022. – Т. 7.
– №. 4.
7.
МУХИДДИНОВ А. И. и др. COVID-19 БИЛАН ОҒРИГАН БЕМОРЛАРДА
ГИПЕРТОНИЯ
КАСАЛЛИГИ
ЎПКАНИНГ
СУРУНКАЛИ
ОБСТРУКТИВ
КАСАЛЛИГИНИНГ КОМОРБИДЛИГИДА КЛИНИК КЕЧИШИНИНГ ЎЗИГА
ХОСЛИГИ ВА ЗАМОНАВИЙ ДИАГНОСТИКАСИ //ЖУРНАЛ БИОМЕДИЦИНЫ И
ПРАКТИКИ. – 2022. – Т. 7. – №. 4.
8.
Халилов Н. Х. и др. Особенности Течения Гипертонических Кризов И Их
Осложнений В Условиях Экстренной Медицинской Помощи //CENTRAL ASIAN
JOURNAL OF MEDICAL AND NATURAL SCIENCES. – 2022. – Т. 3. – №. 1. – С. 44-
46.
9.
Ташкенбаева Э. Н., Мухиддинов А. И., Тогаева Б. М. ОСОБЕННОСТИ
КЛИНИЧЕСКОГО ТЕЧЕНИЯ БРОНХИАЛЬНОЙ АСТМЫ У ЛИЦ МОЛОДОГО
ВОЗРАСТА //ТОМ–III. – 2019. – С. 359.
10.
Ташкенбаева Э. и
др. РАСПРОСТРАНЕННОСТЬ
МЕТАБОЛИЧЕСКОГО
СИНДРОМА У ПАЦИЕНТОВ С ИШЕМИЧЕСКОЙ БОЛЕЗНЬЮ СЕРДЦА //Журнал
кардиореспираторных исследований. – 2021. – Т. 2. – №. 1. – С. 85-88.
