INTERNATIONAL JOURNAL OF ARTIFICIAL INTELLIGENCE
ISSN: 2692-5206, Impact Factor: 12,23
American Academic publishers, volume 05, issue 07,2025
Journal:
https://www.academicpublishers.org/journals/index.php/ijai
page 501
CORRECTION OF METABOLIC INDICATORS WITH THE USE OF CABBAGE
(BRASSICA OLERACEA) EXTRACT IN ANIMAL MODELS WITH DIABETES
Chorshanbiyev Shohzod
Master of Turon University
Kuziev Sherali
Associate Professor of the
National University of Uzbekistan, PhD
kuziev.sherali@gmail.com
Abstract.
In this study, the correction of key metabolic parameters such as blood glucose,
insulin levels, and water consumption was studied in diabetic (DM) model animals using an
extract prepared from cabbage leaves (Brassica oleracea). The results of the study showed that
cabbage extract has hypoglycemic and insulinotropic properties. Since this plant is widely
distributed in Uzbekistan, it has the potential to be used as a natural remedy for the treatment of
diabetes in local conditions.
Keywords:
Diabetes, cabbage extract, Brassica oleracea, glucose, insulin, animal model,
natural products.
Introduction.
Type 2 diabetes is a metabolic syndrome characterized by impaired glucose
metabolism in the div, accompanied by insulin deficiency or insulin resistance [1]. Current
drugs cause many side effects, so the search for safe, affordable and effective alternatives is an
urgent issue [2]. Cabbage (Brassica oleracea) is a widely cultivated plant in Uzbekistan, which
contains flavonoids, polyphenols, vitamin C, potassium and other antioxidant substances [3].
There is scientific data on the hypoglycemic and antioxidant effects of these bioactive
substances [4].
Materials and methods.
Animals: Healthy male Wistar rats (200–250 g) were used for the
experiment.
Model establishment:
Diabetes was induced using streptozocin (STZ) at a dose of 55 mg/kg
(intraperitoneal) [5].
Experimental groups:
• Group 1 – healthy control (n=6)
• Group 2 – diabetic control (STZ, no treatment)
• Group 3 – diabetic + cabbage extract (400 mg/kg, given orally for 14 days)
Extract preparation:
Fresh cabbage leaves were dried, powdered, and extracted using 70%
ethanol. The concentrated extract was mixed with water and administered to the animals.
Indicators assessed:
• Blood glucose level (via biochemical analyzer);
• Insulin level (ELISA method);
• Water consumption (based on daily monitoring).
Results.
According to the results of the experiment, cabbage (Brassica oleracea) extract had a
significant positive effect on the main metabolic parameters - blood glucose, insulin levels and
water consumption in animals with diabetes. The results are analyzed below for each parameter:
1. Blood glucose:
INTERNATIONAL JOURNAL OF ARTIFICIAL INTELLIGENCE
ISSN: 2692-5206, Impact Factor: 12,23
American Academic publishers, volume 05, issue 07,2025
Journal:
https://www.academicpublishers.org/journals/index.php/ijai
page 502
In rats induced with STZ (group 2), a significant increase in glucose levels was observed
(hyperglycemia). In group 3 animals given cabbage extract, when glucose levels were
monitored
for 14 days, an average decrease of 28% was observed compared to the initial hyperglycemic
state (p<0.05).
This glucose reduction may be due to the flavonoids (e.g. quercetin), antioxidants and other
phytochemicals in cabbage leaves increasing insulin sensitivity or reducing glucose absorption
[3,4]. This is also explained by the suppression of the activity of enzymes such as glucose-6-
phosphatase and phosphoenolpyruvate carboxykinase, which slows down the process of
gluconeogenesis [6].
2. Insulin levels:
In animals in the diabetic group (group 2), insulin secretion was reduced due to damage to β-
cells under the influence of STZ. In animals treated with cabbage extract, insulin levels
increased by 36% compared to the diabetic group (p<0.05).
This result may be due to the fact that bioflavonoids and polyphenols in cabbage protect β-cells
from oxidative stress and stimulate insulin secretion [2,5]. At the same time, microelements (e.g.
potassium, magnesium) present in cabbage can also improve the ability of insulin to bind to
receptors [3].
3. Water consumption (polydipsia):
In diabetic animals, elevated glucose levels caused polyuria (frequent urination) and consequent
polydipsia (frequent drinking). Water consumption was significantly normalized in the treated
group (~25% reduction compared to group 2).
Cabbage extract not only has a hypoglycemic effect, but also affects the main pathogenetic
links of diabetes mellitus by restoring the activity of β-cells, enhancing antioxidant defenses
and normalizing water-electrolyte balance. These results indicate that plant-based treatments
are promising as a pharmacological alternative.
Discussion.
The results of the study showed that cabbage extract has a positive effect on
glucose metabolism in diabetes. Its flavonoids and antioxidants can reduce glucose levels,
increase cell sensitivity, and activate insulin secretion [6]. These results are consistent with
previous scientific studies and confirm that Brassica oleracea extract can be used as a
hypoglycemic agent [7]. At the same time, cabbage is also notable for its availability and
affordability.
Conclusion:
Extract of the cabbage plant, which is widely grown in Uzbekistan, improves
metabolic status in a diabetic model by reducing blood glucose and water consumption, and
increasing insulin levels. This indicates the need for its further study and involvement in
clinical trials as a natural anti-diabetic agent.
References:
1.
American Diabetes Association. Diagnosis and classification of diabetes mellitus.
Diabetes Care. 2014;37(Supplement 1): S81-S90. https://doi.org/10.2337/dc14-S081
2.
Kooti W, et al. Medicinal plants in the treatment of diabetes mellitus. Biomed
Pharmacother. 2016; 84:124-135. https://doi.org/10.1016/j.biopha.2016.09.095
3.
Podsędek A. Natural antioxidants and antioxidant capacity of Brassica vegetables: A
review. LWT-Food Sci Technol. 2007;40(1):1–11. https://doi.org/10.1016/j.lwt.2005.07.023
INTERNATIONAL JOURNAL OF ARTIFICIAL INTELLIGENCE
ISSN: 2692-5206, Impact Factor: 12,23
American Academic publishers, volume 05, issue 07,2025
Journal:
https://www.academicpublishers.org/journals/index.php/ijai
page 503
4.
Ali M, et al. Role of flavonoids in the management of diabetes. Phytotherapy Research.
2018;32(10):1875–1885. https://doi.org/10.1002/ptr.6140
5.
Lenzen S. The mechanisms of alloxan- and streptozotocin-induced diabetes.
Diabetologia. 2008;51(2):216-226. https://doi.org/10.1007/s00125-007-0886-7
6.
Xu X, et al. Dietary flavonoids and the risk of type 2 diabetes: a meta-analysis. Br J Nutr.
2018;120(1):83-94. https://doi.org/10.1017/S0007114518000869
7.
Kim MJ, et al. Anti-diabetic activity of fermented cabbage in streptozotocin-induced
diabetic rats. Food Sci Biotechnol. 2011;20(2):441-445. https://doi.org/10.1007/s10068-011-
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