It is known that the interaction of diabetes and purulent infection with their simultaneous development leads to a complex and peculiar pathological process, causing a “syndrome of mutual burden" that requires a special comprehensive examination and treatment, deep understanding and adequate correction of changes occurring in the body. The mortality rate of patients with purulent diseases on the background of diabetes remains high and ranges from 6 to 44%, and it has been stable in recent years. Despite the successes achieved in the prevention and treatment of diabetic foot, 40-60% of all amputations of the lower extremities are still performed in patients with this pathology.