INTERNATIONAL JOURNAL OF ARTIFICIAL INTELLIGENCE
ISSN: 2692-5206, Impact Factor: 12,23
American Academic publishers, volume 05, issue 05,2025
Journal:
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page 273
UDC 541.49+538.113+547.447,484,574
COORDINATION COMPOUNDS OF ZN (II), NI (II), CO (II) AND CU (II) WITH
ETHYLENEDIAMINE-Β-PROPIONIC ACIDS
Kuchkorova Rano Rasulovna
Candidate of Chemical Sciences, Associate Professor
Tashkent State Pedagogical University named after Nizami, Tashkent, Uzbekistan, 100000
Tel.:
+998 99 527 50 09
Email:
rano.qochqorova@bk.ru
Abstract:
The article presents the biological significance of microelements nickel, copper,
cobalt and zinc found in the human div. An analysis of X-ray and IR spectra of synthesized
complexes of these microelements is also conducted.
Key words:
Coordination compounds, essential microelement
,
antidiuretic effect, B₁₂, lipid
metabolism, DNA, RNA.
Introduction
Among the various macro- and microelements contained in biological objects, cobalt,
nickel, zinc and copper play an important role. The biological role of microelements has not
yet been sufficiently studied [1], but the available data allow us to state that they are
necessary for the enzymatic systems of living organisms.
Experimental studies on living organisms have shown that nickel deficiency leads to a
sharp delay in growth and development, as well as to anemia due to a decrease in the level of
hemoglobin in the blood. Nickel enhances the antidiuretic effect of the pituitary gland and
actively promotes vitamin metabolism. Under its influence, ascorbic acid and vitamin B₁₂ are
absorbed [8]. This element regulates the absorption of calcium by the div, participates in
oxidation-reduction reactions and promotes the active supply of oxygen to cells. Without
nickel, tissue respiration and lipid metabolism processes in cells are impossible [2,6].
Copper is an important microelement involved in the regulation of oxidation-reduction
processes. It is a catalyst for a number of cellular reactions, in particular carbohydrate
metabolism, enhances water, gas and mineral metabolism, is part of copper-containing
enzymes, participates in hematopoiesis (erythropoiesis, heme synthesis), stimulates the
endocrine glands, has an insulin-like effect, affects neurophysiological processes and
increases vascular sensitivity. In addition, copper plays a role in the functioning of
mitochondrial membranes and regulates the processes of growth and development of the
div [3,9].
Zinc is the second most common element in the div after iron and is associated with
approximately 10% of proteins. It is involved in all types of metabolism, is part of 7,200
enzymes, plays an important role in the synthesis of proteins and nucleic acids, and is
necessary to stabilize the structure of DNA, RNA, and ribosomes. Zinc is also involved in the
processes of cellular transformation, growth, and division, affects the stability and
permeability of cell membranes, the processes of apoptosis, osteogenesis, hematopoiesis,
cellular respiration, as well as the formation of the brain and its neurotransmitter functions. In
INTERNATIONAL JOURNAL OF ARTIFICIAL INTELLIGENCE
ISSN: 2692-5206, Impact Factor: 12,23
American Academic publishers, volume 05, issue 05,2025
Journal:
https://www.academicpublishers.org/journals/index.php/ijai
page 274
addition, zinc is a neuromodulator and neurotransmitter, and is involved in the processes of
reproduction and fetal development [4,5,7].
Based on the above, we carried out a targeted synthesis of coordination compounds of
Zn(II), Ni(II), Co(II) and Cu(II) with ethylenediamine-β-propionic acids, which have low
toxicity and high biological activity.
Experimental part
Complex compounds Co(Eda-β-PK)₂·2H₂O, Ni(Eda-β-PK)₂·3,5H₂O, Zn(Eda-β-
PK)₂·3H₂O and Cu(Eda-β-PK)₂·3H₂O were synthesized as follows:
0.3 mol of ethylenediamine-β-propionic acid was dissolved in 75 ml of water, adding
0.6 mol of caustic soda. A solution of 0.3 mol of nitrates of the corresponding metals in 25 ml
of water was gradually added to the resulting transparent solution with stirring. The resulting
precipitate was washed with water, then with alcohol and ether [10].
Results and discussion
The purity and individuality of the obtained complexes were confirmed by X-ray
diffraction data. The X-ray diffraction pattern of the initial ligand sharply contrasts with the
X-ray diffraction pattern of the synthesized complex compounds, which confirms their purity
and individuality.
Figure 1
: X-ray image of a-(Eda - β-PK)
2
,
INTERNATIONAL JOURNAL OF ARTIFICIAL INTELLIGENCE
ISSN: 2692-5206, Impact Factor: 12,23
American Academic publishers, volume 05, issue 05,2025
Journal:
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page 275
The elemental composition of the isolated compounds and some of their
physicochemical properties were also studied. The main vibration frequencies in the IR
absorption spectra of the complexes are shown in Figure 2
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Figure 2: a-
free EDA-β-PK IR spectra. work IR spectrum of b-ZN(Eda-β-PK)
2
*
3H2O
Comparison of the IR spectra of free EDA-β-PK and the studied complex compounds
shows that the frequencies of the C–H bond stretching vibrations shift to higher frequencies,
while the predominant frequency of the C=O bond stretching vibrations decreases by 5–10
cm⁻¹ upon coordination. This shift ν(C=O) is associated with the formation of the M←O
bond
,
which in turn leads to a strengthening of the C–O bond and, accordingly, an increase
in the ν(C–O) frequency
.
INTERNATIONAL JOURNAL OF ARTIFICIAL INTELLIGENCE
ISSN: 2692-5206, Impact Factor: 12,23
American Academic publishers, volume 05, issue 05,2025
Journal:
https://www.academicpublishers.org/journals/index.php/ijai
page 276
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derivatives of fluorinated β-diketones: diss… Cand. chemistry sciences. Tashkent:
NUUz.–2007.–140 p.
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