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EVALUATION OF THE EFFECTIVENESS OF MIDIAN® IN ADJUVANT
THERAPY AFTER LAPAROSCOPIC REMOVAL OF OVARIAN FOLLICULAR
CYSTS
Sharipova Shakhnoza Ozod kizi
Email: sharipova.shaxnoza@bsmi.uz https://orcid.org/0009-0006-7764-9782
Bukhara State Medical Institute named after Abu Ali ibn Sina, Uzbekistan, Bukhara, st. A.
Navoi. 1 Tel: +998 (65) 223-00-50 e-mail:
Resume :
90 women were under observation. Of these, 60 patients (main group) operated on
with a diagnosis of follicular ovarian cysts, taking Midiana® as an adjuvant therapy in the
postoperative period, and 30 operated patients with the same diagnosis, but who refused
hormonal adjuvant therapy. The use of the combined estrogen-gestagenic drug Midiana as
part of adjuvant therapy confirmed its high efficiency in restoring fertility by 4.1 times (in
85% of patients) and preventing recurrence of follicular ovarian cysts, which allows it to be
recommended to women after laparoscopic surgery.
Keywords:
follicular cyst , laparoscopic cystectomy, median , Hysteroresectoscopy, Oral
contraceptives
Rezyume :
Nazoratga 90 ta ayol qamrab olingan. Ulardan 60 nafari (asosiy guruh)
tuxumdonlarning follikulyar kistalari tashxisi bilan operatsiya qilingan, operatsiyadan
keyingi davrda yordamchi terapiya sifatida Midiana® preparatini qabul qilgan va 30 nafari
bir xil tashxis qo'yilgan, ammo gormonal yordamchi terapiyadan bosh tortgan operatsiya
qilingan bemorlardir. Adjuvant terapiyaning bir qismi sifatida estrodiol estrogen-gestagen
preparati Midianani qo'llash tug'ilishni 4,1 baravar tiklashda (bemorlarning 85 foizida) va
tuxumdon follikulyar kistalarining takrorlanishining oldini olishda yuqori samaradorligini
tasdiqladi, bu esa Laparoskopik operatsiyadan keyin ayollarga tavsiya qilish imkonini beradi.
Резюме
: Под наблюдением находились 90 женщин. Из них 60 пациенток (основная
группа), оперированных с диагнозом фолликулярные кисты яичников, принимающих
в качестве адъювантной терапии в послеоперационном периоде препарат Мидиана®,
и 30 оперированных больных с таким же диагнозом, но отказавшихся от
гормональной адъювантной терапии. Применение комбинированного эстроген-
гестагенного препарата Мидиана, в составе адъювантной терапии подтвердил свою
высокую эффективность в восстановлении фертильности в 4,1 раза (у 85% пациенток)
и профилактики рецидивов фолликулярных кист яичников, что позволяет
рекомендовать его женщинам после лапароскопической операции
Relevance
. According to epidemiological studies, in recent years there has been an increase
in follicular cysts of the ovaries among women of reproductive age. Surgery is the primary
treatment for ovarian follicular cysts greater than 5 cm if conservative treatment does not
produce sufficient effects. However, despite the improvement of surgical techniques and
instruments in the treatment of follicular cysts the risk of relapse is still considered a
problem that has not found its solution until the end .
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Goal
. In Adyuvant therapy after laparoscopic removal of follicular cysts of the ovaries, the
combined estrogen-gestagen drug is an assessment of the effectiveness of midiana®.
Materials and methods
.
90 women were covered for the study. Of these, 60 (the main group) are operated patients
who have been diagnosed with follicular cysts of the ovaries, have taken the drug Midiana®
as an adjuvant therapy in the postoperative period, and 30 have been diagnosed the same,
but have refused hormonal adjuvant therapy. The age of those examined was 28.5±0.5 years.
Results .
Before and after the operation, a hormonal test was performed on all patients. Prior to
laparoscopic surgery, high FSG levels of 14.7±0.16 IU/L and low concentrations of LH
7.8±0.38 IU/L were identified.the E2 estradiol content in the core group is 122.4±8.7 PG/ml
higher than the comparison group indicators of 137.6±12.11 PG/ml(p<0.001). Progesterone
levels were also much lower than 1.4±0.09 ng/ml, respectively. 3 months after laparoscopic
removal of follicular cysts of the ovaries against the background of hormonal adjuvant
therapy with a drug containing 3mg Drospirenone and 0.03 mg ethinyl estradiol, the results
of hormonal studies in patients showed a decrease in FSG to 10.4±0.16 IU/L, and an
increase in l G to 10.0±0.46 IU/l (p<0.001), 108.8± 11.87 PG/ml (p> 0.05 in the group up to.
The use of the drug Midiana® as an auxiliary therapy for 3 months in women after the
laparoscopic removal of follicular cysts of the ovaries led to the normalization of the level of
sex steroid hormones and the restoration of fertility in 85% of women. As a rule, all women
tolerated taking a drug containing 3 mg of Drospirenone and 0.03 mg of ethinyl estradiol for
3 months. We did not observe adverse reactions in any of them when using the drug, no
woman stopped taking it early. None of the representatives of the main group (when
observing them for 1 year) recorded a recurrence of the disease. After 4-9 months during the
year, 52 (85%) of them became pregnant. 12 (40%) of patients in the comparison group who
refused to use Midi® reported recurrence of ovarian follicular cysts after 6 months, with
pregnancy occurring in 6 (20.0%). Thus, the conduct of adyuvant hormone therapy allowed
the onset of pregnancy in 85% of women.
Conclusion :
The drug estrodiol-gestagen, which contains 3 mg Drospirenone and 0.03 mg ethinyl
estradiol, as part of auxiliary therapy, confirmed 4.1 times higher efficacy in fertility
recovery (in 85% of patients) and Prevention of recurrence of follicular ovarian cysts, which
allows women to recommend after laparoscopic surgery.
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