Volume 03 Issue 06-2023
59
International Journal of Medical Sciences And Clinical Research
(ISSN
–
2771-2265)
VOLUME
03
ISSUE
06
P
AGES
:
59-61
SJIF
I
MPACT
FACTOR
(2021:
5.
694
)
(2022:
5.
893
)
(2023:
6.
184
)
OCLC
–
1121105677
Publisher:
Oscar Publishing Services
Servi
ABSTRACT
Since the time of Ivan Petrovich Pavlov's work, it is known that the juice collected from the pancreatic fistula, when it
is re-introduced into the duodenum, inhibits the secretion of the pancreas. Most recently, in the works of American,
French and Japanese physiologists, this inhibition was associated with the fact that trypsinogen secreted in the
pancreatic secretion and trypsin contained in the duodenal contents inhibit the release of the hormone
cholicystokininpancreosimin by duodenal endocrine cells - a powerful stimulator of enzyme secretion by the pancreas.
This explanation of the reverse reproduction of pancreatic secretion from the duodenum is recognized by most
experts. In connection with the above, the study of this problem seems to be an urgent task.
KEYWORDS
Pancreatic fistula , duodenal endocrine cell , secretion.
INTRODUCTION
Acute experiments were performed on 10 dogs in 2
series under hexanal anesthesia on controlled
breathing. The collection of pancreatic juice was
carried out from the main pancreatic duct of the
pancreas, the additional duct was ligated. The
duodenum was separated from the stomach by a
ligature applied at the site of the pyloric sphincter. In
one series of experiments, a catheter was
strengthened in the initial part of the duodenum, and
in another series, another catheter was strengthened
in the ileum. Pancreatic secretion was stimulated by
intraduodenally administered hydrolysin acidified to
Research Article
INHIBITORY EFFECT OF CARBOHYDRAZ ON SECRETORY ACTIVITY OF
THE PANCREAS
Submission Date:
June 09, 2023,
Accepted Date:
June 14, 2023,
Published Date:
June 19, 2023
Crossref doi:
https://doi.org/10.37547/ijmscr/Volume03Issue06-11
Baybekova G.D.
Andijan State Medical Institute, Uzbekistan
Journal
Website:
https://theusajournals.
com/index.php/ijmscr
Copyright:
Original
content from this work
may be used under the
terms of the creative
commons
attributes
4.0 licence.
Volume 03 Issue 06-2023
60
International Journal of Medical Sciences And Clinical Research
(ISSN
–
2771-2265)
VOLUME
03
ISSUE
06
P
AGES
:
59-61
SJIF
I
MPACT
FACTOR
(2021:
5.
694
)
(2022:
5.
893
)
(2023:
6.
184
)
OCLC
–
1121105677
Publisher:
Oscar Publishing Services
Servi
pH 2.0 (0.6 ml/kg every 15 min). A cannula was inserted
into the femoral veins to take blood, a cannula to take
blood, and ureters were cannulated to collect urine.
After a two-hour collection of juice, urine and blood (in
hourly portions), an amylase solution (0.15 mg / kg /
hour) was injected into the duodenum, in the next two
hours the collection of juice, urine, blood
(consequence) was continued, then the cycle was
repeated again. The second series of experiments was
carried out according to the same scheme, but amylase
was injected not into the duodenum, but into the
ileum. In the juice collected and accounted for by the
volume
of
hourly
periods,
bicorbanates
(titrometrically), amylase (according to Smith-Roy in
the modification of Ugolev), lipase (according to Titz),
total proteolytic activity (according to Kunitz), protein
(according to Lowry) were determined. Amylase was
determined in urine and blood by the same method as
in juice. The results obtained in the first B series of
experiments
showed
that
intraduadenal
administration of amylase causes a significant
inhibition of pancreatic secretion of amylase, the
secretion of other enzymes and bicarbonates did not
undergo changes. When amylase was injected into the
ileum at the hour of its administration, no inhibition of
pancreatic secretion was observed. Nonselectively
generalized inhibition of pancreatic secretion
developed after 1-2 hours, it was at this time that
hyperamylasuria was also noted. The results obtained
indicate the leading role of duodenal mechanisms in
the urgent selective, feedback-based inhibition of
pancreatic enzyme secretion. A more delayed non-
selective inhibition of pancreatic secretion may be due
to the action of enzymes absorbed from the distal
parts of the small intestine from the bloodstream.
Indirect evidence of the participation of duodenal
peptides in the implementation of inhibitory selective
effects of enzymes (amylase) from the duodenum on
the secretion of pancreatic hydrolases was also that
the
secretion
stimulated
by
inraduadenal
administration of hydrolysin (that is, endogenous
duodenins) is inhibited more pronounced than the
secretion stimulated by exogenous secretin with
cholicystokinin. The search for specific mechanisms
through which inhibition of pancreatic secretion by
intraduodenally injected amylase is realized continues.
But the experimental data already obtained indicates
that the adaptation of enzyme secretion by the
pancreas depends more on the enzymatic activity of
the duodenal contents.
R
EFERENCES
1.
Коротько Г.Ф Трубцина И.Е Амирова Н.Щ
Эксперементальная
клиническая
гастроэнтрология. Вып 11
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2013 стр 60
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Коротько Г.Ф Секреция поджелудочной железы
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Краснодар: Кубанский гос.мед.унверститет,
2005-
312 стр
Volume 03 Issue 06-2023
61
International Journal of Medical Sciences And Clinical Research
(ISSN
–
2771-2265)
VOLUME
03
ISSUE
06
P
AGES
:
59-61
SJIF
I
MPACT
FACTOR
(2021:
5.
694
)
(2022:
5.
893
)
(2023:
6.
184
)
OCLC
–
1121105677
Publisher:
Oscar Publishing Services
Servi
3.
Коротько
Г.Ф
Физиология
системы
пищеварения. Краснодар Изд 000 БК <Группа
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