Volume 02 Issue 11-2022
8
International Journal of Medical Sciences And Clinical Research
(ISSN
–
2771-2265)
VOLUME
02
I
SSUE
11
P
AGES
:
08-11
SJIF
I
MPACT
FACTOR
(2021:
5.
694
)
(2022:
5.
893
)
OCLC
–
1121105677
METADATA
IF
–
5.654
Publisher:
Oscar Publishing Services
Servi
ABSTRACT
This article presents information about the clinical and neurological features of COVID-19 in children. A new
coronavirus infection, COVID-19, caused by the SARS-CoV-2 virus, along with damage to the respiratory system, can
lead to involvement of the central and peripheral nervous system and the muscular system. There is a relationship
between the severity of COVID-19 and the severity and frequency of neurological disorders. The course of COVID-19 in
children depends on age, premorbid background, the development of neurological complications that negatively
affect the clinic of the disease.
KEYWORDS
COVID-19, polyneuropathy, myalgia, rhabdomyolysis, cellular reaction, central nervous system, blood-brain barrier.
INTRODUCTION
SARS-CoV-2 infections among children and adolescents
usually cause less severe diseases and are less likely to
lead to death compared to adults. Although less severe
infection is a positive aspect, milder symptoms may
have led to fewer tests, resulting in fewer cases of
SARS-CoV-2 in children and adolescents. If children and
Research Article
CLINICAL AND NEUROLOGICAL FEATURES OF COVID-19 IN CHILDREN
Submission Date:
October 25, 2022,
Accepted Date:
October 30, 2022,
Published Date:
November 07, 2022
Crossref doi:
https://doi.org/10.37547/ijmscr/Volume02Issue11-02
N.M. Azimova
Doctor Of Medical Sciences, Associate Professor Tashkent Pediatric Medical Institute. Uzbekistan
M.K. Temirova
Student Tashkent Pediatric Medical Institute. Uzbekistan
D.A. Khasanov
Student Tashkent Pediatric Medical Institute. Uzbekistan
Journal
Website:
https://theusajournals.
com/index.php/ijmscr
Copyright:
Original
content from this work
may be used under the
terms of the creative
commons
attributes
4.0 licence.
Volume 02 Issue 11-2022
9
International Journal of Medical Sciences And Clinical Research
(ISSN
–
2771-2265)
VOLUME
02
I
SSUE
11
P
AGES
:
08-11
SJIF
I
MPACT
FACTOR
(2021:
5.
694
)
(2022:
5.
893
)
OCLC
–
1121105677
METADATA
IF
–
5.654
Publisher:
Oscar Publishing Services
Servi
adolescents with mild or absent symptoms also
transmit the infection, they may contribute to
community-based transmission. However, starting in
March 2020, reports began to arrive from a number of
European countries and the United States about
children with a new disease with signs of Kawasaki
disease (CD) and toxic shock syndrome (TSS), which
received one of the names
—
children's multisystem
inflammatory syndrome (DMVS) associated with
COVID-19. Coronavirus in children is insidious in that its
signs are often less pronounced than in adults, and
more similar to SARS. Parents think that the baby has a
common cold, and do not consult a doctor. And on the
5-7 day, the child rapidly develops complications:
pneumonia, bronchitis, neuritis, myocarditis, etc. D.
Chronic diseases and damage to the nervous system
may also worsen.
The purpose of the study: To study the clinical and
neurological features of COVID-19 in children.
MATERIALS AND METHODS OF RESEARCH
We conducted the generally accepted clinical and
neurological, instrumental, laboratory methods of
studying children hospitalized with coronavirus
infection in the specialized hospital of Zangiota No. 1 in
the period from 2020-2022. To fulfill the tasks of
scientific research, a sample was created with the
allocation of two groups of clinical observation: 30
children with severe coronavirus infection with
neurological disorders.
Results
The study showed that boys in the study group
numerically prevailed over girls, and accounted for 58%
(29) of boys and 42% (21) of girls.
All children underwent a generally accepted clinical
examination, including the collection of complaints
and anamnesis, clinical and neurological, instrumental
and laboratory methods of research, also confirming
the presence of caronovirus infection.
One of the objectives of our study was to study the
features of an unfavorable premorbid background in
young children of the examined groups of young
children. The most frequent clinical syndromes of
perinatal CNS damage in the group of children with
were vegetative-visceral disorders syndrome (53%),
hypertension-hydrocephalus
syndrome
(60%),
syndrome of increased neuro-reflex excitability (50%).
In all children of the main group, a combination of
syndromes of perinatal central nervous system
damage was noted, which leads to a decrease in
adaptation mechanisms in somatic pathology.
It should be noted that the children belonged to the
group of frequently ill children with low immunity.
Frequent acute respiratory infections were observed in
24 (80%) children, sepsis was observed in 4 children
(13%), lacunar angina - 7 children (23%), intestinal
infections - 16 children (53%).
Upon admission to the hospital, the main complaints
made by parents of children with coronavirus infection,
in addition to complaints about the underlying disease,
were anxiety (13; 43%), capriciousness (7; 23%), sleep
disturbance (16; 53%) or lethargy (12; 40%), decreased
activity (15; 50%), refusal to eat (18; 60%). All patients
were hospitalized due to deterioration of their
condition.
On examination, 18 children had predominant
symptoms of central nervous system arousal. The
children were conscious, there was strong motor
anxiety (12; 67%), hyperesthesia of the skin (10; 56%),
excited crying (17; 94%), a negative reaction to the
examination (16; 89%). During the examination, 10
children (33%) had symptoms of central nervous
Volume 02 Issue 11-2022
10
International Journal of Medical Sciences And Clinical Research
(ISSN
–
2771-2265)
VOLUME
02
I
SSUE
11
P
AGES
:
08-11
SJIF
I
MPACT
FACTOR
(2021:
5.
694
)
(2022:
5.
893
)
OCLC
–
1121105677
METADATA
IF
–
5.654
Publisher:
Oscar Publishing Services
Servi
system depression, all children were sluggish, drowsy,
reacted poorly to the examination, usually not
pronounced crying and painful grimace. In 2 children
(7%), depression of consciousness in the form of a
soporotic state was noted: all reactions were reduced.
8 children (27%) had febrile convulsions with
hyperthermia, were tonic-clonic in nature. In 14
children (47%) there were signs of cerebrospinal
vascular distension: swelling of the fontanel, restless
crying with throwing back of the head.
There were no meningeal symptoms in neurostatus.
Cranial nerve damage was noted in 6 children (20%): in
3 children (10%) - convergent strabismus, in 1 (3%) child
horizontal nystagmus, central paresis of the facial
nerve in 1 (3%) child, bulbar disorders in 1 (3%) child -
choking, dysarthric speech was noted in 3 children. In
the motor sphere, 12 children (40%) had hyperreflexia
and revival of tendon reflexes, 10 children (33%) with
central nervous system depression had a diffuse
decrease in tendon reflexes and hypotension.
Pathological reflexes and signs were not noted.
When examining children in somatic status, we
identified multisystem inflammation with the
development of multiple organ damage: toxic hepatitis
was noted in 6 (20%), carditis in 7 (23%), nephritis in 5
(17%).
CONCLUSION
Thus, the course of caronovirus infection in children is
accompanied by signs of infectious and toxic
encephalopathy with the development of multiple
organ damage.
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Volume 02 Issue 11-2022
11
International Journal of Medical Sciences And Clinical Research
(ISSN
–
2771-2265)
VOLUME
02
I
SSUE
11
P
AGES
:
08-11
SJIF
I
MPACT
FACTOR
(2021:
5.
694
)
(2022:
5.
893
)
OCLC
–
1121105677
METADATA
IF
–
5.654
Publisher:
Oscar Publishing Services
Servi
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