Allergy

Sabjects of research: AR patients, 161 - DNA samples of patients, also from healthy donors, polymorphism in GSTT1 genes, GSTM1, TNF-a, RANTES and CTLA4.
Purpose of work: To study the clinical and genetic features of manifestation of allergic rhinitis in view of studying the influence of the polymorphic markers of key genes involved in its formation, the frequency of occurrence and risk factors for disease, new approaches and forecasting of complex treatment of this disease.
Methods of research: clinical-laboratory, immunoenzyme method and molecular genetic (PCR etc.), statistical.
The results obtained and their novelty: first described the clinical and molecular genetic parallels AR. A comparative analysis ofpathogcnctically important for the formation of atopy gene polymorphisms TNF-a, RANTES, CTLA4, GSTT1 and GSTM1, among apparently healthy donors and patients with RA of various origins. For the first time revealed significant association of polymorphisms 308G> A TNF-a gene with the development of seasonal forms of AR and RANTES gene polymorphism A403G with the development of year-round form of the form AR. Set associative connection is not enough pronounced polymorphism 49A / Ggcnc CTLA4, and GSTT1 null genotype and GSTM1 genes individually with the development of AR. For the first time set key intcrgenic interactions that determine the risk of developing RA with high probability.
Practical value: The obtained results complement the global database of molecular genetics of AR, as well as serve as a basis for the creation and implementation of special prevention programs.
Degree of embed and economic effectivity: developed results arc used in clinical practice of the Republican scientific center of the specialized allergy, ENT Department Clinic TMA-2 and in the laboratory of Medical Genetics, Research Institute of Hematology and Blood Transfusion, Ministry of Health Uzbekistan.
Field of application: medicine.

Subject of research: 117 patients, of them 28 were without allergy; 77 ones with allergic background and without allergy to basic plastic, 12 patients with allergy to acrylic plastic.
Purpose of work: To undertake a clinical and immunologic study and on its basis to develop approaches for predicting allergic effects of basic plastics on oral mucosa in patients with allergic background.
Methods of research: clinical, stomatoscopical, microbiological, immunologic and cytochemical.
The results obtained and their novelty: It is demonstrated that in patients with allergic background (AB) the frequency of development of allergic response (AR) to plastics of a dental prosthesis (PDP) has made 13.48%. AR to PDP in the oral mucosa (OM) manifests itself in the form of hyperemia, edema, presence of teeth prints, disturbance in epithelium transparence in the form of opacification with elements of keratosis, various coatings, catarrhal events, hyperemia of glands and decubital stomatites. On the background of development of AR to PDP, enhancement of local immunity of OM, augmentation of T-LP, IRI rise, aggravation B-lymphopenia, rising in IL-4, IgE and IgG, a high NP activity in NBT-test were noted. The rise in NBT-test rates by over 15% at in vitro monomer affect prior to prosthetic repair was associated with development of allergic response following prosthetic repair.
Practical value: Introduction of prediction of risk of development of the allergic response based on NBT-test rates into orthopedic stomatology will enable to optimize selection of basic materials for patients with allergic background, to lower economic and moral damage caused by it.
Degree of embed and economic effectivity: The results of the research are used in medical practice of an orthopedic stomatologic out-patient department of the Third Clinic of the Tashkent Medical Academy and in the educational process oat the faculty of orthopedic stomatology and orthodontology of the Tashkent Medical Academy.
Field of application: stomatology.

The article describes the clinical manifestation and course of pollen bronchial asthma in children. One of the most severe clinical manifestations of pollinosis is seasonal pollen asthma. Her attacks usually begin suddenly and acutely. In some cases, an asthma attack develops against the background of aggravated allergic rhinitis and conjunctivitis. It was determined that almost all patients had symptoms that began with the appearance of sneezing and itching in the nose and coughing, difficulty breathing, and attacks of suffocation. Pollen bronchial asthma in children is characterized by a cyclical course.

Allergy occupies a special place in medicine, and therefore, our work reflects aspects of the prevention of allergic diseases in children born to mothers with allergic diseases based on literary analysis.

The article includes data from a literature analysis on aspects offood allergy in young children, which are important for physicians, especially pediatricians, and the study of this problem remains an open question

The article includes data from a literature review on aspects of the study of the clinical manifestations of allergic diseases in children born to mothers suffering from allergic pathology, which are important for physicians, especially pediatricians, and the study of this problem remains an open question.

Nukus branch of the Tashkent Pediatric Medical Institute In recent decades, there has been a significant increase in the prevalence of allergies among children in most countries of the world. The observations of many scientists and clinicians have shown that the most common pathologies in children are bronchial asthma, atypical dermatitis and allergic pathologies. This paper reflects aspects of these pathological processes based on literary analysis.

Bugungi kunda global muamolardan biriga aylanib borayotgan allergik kassaliklar aholi orasida tez suratlarda rivojlanib bormoqda. Bu kassalik aholni har bir qatlamida uchraydi (qariyalar va yoshlarda h.k) Butun dunyoda allergiya bilan kasallanganlar soni oshishi kuzatilmoqda. «Allergy UK» ma’lumotlariga ko'ra, taxminan 30-40% odamlar hayotining muayyan bir qismida allergiyaga to'qnash keladi. Ushbu holatdan bolalar eng ko'p aziyat chekadi.

The article includes data from a literature analysis on aspects of allergopathology in children, which are important for physicians, especially pediatricians, and the study of this problem remains an open question.

 

A total of 50 patients who were diagnosed with allergic rhinitis were inclu-ded in the study. Patients were categorized into two groups: as having intermittent (34%) and perennial (66%) rhinitis. All patients were given conservative treatment to facilitate symptom impairment and prolonged remission.