To study the quantitative and qualitative composition of microflora, as well as indicators of local protective factors in the oral fluid in children with viral hepatitis C. Material and methods: Microbiological and immunological studies in 61 children with viral hepatitis C (HCV), which were divided into 3 groups: 1st (control) – 10 healthy children, 2nd – 30 children with viral hepatitis C (traditional treatment), 3rd – 21 children with HCV (traditional therapy+eubiotics). Results: When conducting microbiological studies in the oral fluid of children with viral hepatitis C, the most pronounced quantitative changes were found in the facultative flora. With HCV, microbes appeared in the oral cavity that was not sown in healthy children (Staph. aureus, Str. pyogenes and lactose-negative strains of Escherichia). Conclusions: It is necessary to take into account when providing medical care to such children.