The effect of vitamin E on rat liver cytochrome P-450 in experimental acute pancreatitis (ЛР) was studied. The animals were divided into 4 groups. The obtained data were compared with the indicators of the 1 -st group (intact). During the experiment, the development of AP showed a decrease in the content of cytochrome P450 in the microsomal fraction. The administration of vitamin E to animals of the 4th group led to an increase in the content of cytochrome P-450, strengthening the protection of the liver, the abolition of inhibition of the monooxygenase system of the liver.