The article presents the results of studying the risk factors for urinary tract infection and its impact on the development of preterm labor. A To solve prospective analysis was carried out. the tasks set in the work, 128 women (Group I - 65 women with UTIs and the threat of PR and II 63 women with PR group without infections) and 25 women in the control group were conditionally healthy pregnant women who underwent enzyme-linked immunosorbent assay (ELISA), metalloproteinase level 12 (ADAM 12), cystatin C, RBP4 in blood serum. In the venous blood, the indicators of the hemostasis system were studied, the microbiocenoses of the vagina and the general analysis of urine in women with a threat were studied.