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TREATMENT OF ARVI
Аrashova Gulnora Amirkulovna
Bukhara State Medical Institute named after Abu Ali ibn Sina,
Bukhara c., Uzbekistan.
https://orcid.org/0009-0009-0643-3775
Abstract: Every adult suffers from influenza or other acute respiratory
viral infections on average 2-4 times a year, a schoolchild - 4-5 times, a preschool
child - 6 times, a child of the first year of life has from 2 to 12 episodes of acute
respiratory viral infections. The polyetiology of ARVI pathogens and the variability
of viruses involved in the epidemic process, complications after an illness,
necessitate the search for new diagnostic methods and optimization of treatment and
preventive measures.
Key words: acute respiratory viral infections, influenza virus, prevention,
antiviral drugs
Introduction
Among acute respiratory viral infections, influenza is of particular
epidemiological and social significance, characterized by high morbidity and
mortality rates, as well as severe socio-economic consequences. A feature of the
epidemic situation in recent years is the simultaneous circulation in the human
population of several respiratory viruses: influenza A (H3N2 and H1N1) and B with
the periodic predominance of one of them, adenoviruses, parainfluenza viruses and
rhinoviruses, respiratory syncytial viruses, coronaviruses, etc. Influenza viruses
have unique variability of the genome, allowing it to evade the human immune
system, which, combined with aerogenic transmission of the pathogen in conditions
of close contact and high population migration, contributes to the rapid spread of
infection. Features of the biology of the virus and the epidemiology of influenza lead
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to its widespread distribution among the population. Over the past 10 years, there
has been a varying intensity of the influenza epidemic process - from seasonal
epidemic surges to epidemics and pandemics.
The nature and severity of clinical manifestations of influenza vary from
mild to extremely severe and depend on the type of pathogen and the reaction of the
patient's immune system (immune response). The frequency of hospitalization of
children with influenza depends on age: the younger the child, the higher the risk of
severe illness requiring treatment in a hospital setting.
Prevention of ARVI
As soon as a child begins to actively contact a large number of peers, the risk
of ARVI increases significantly. As a rule, in the first year of visiting a kindergarten,
the baby gets sick a lot, since his div encounters a large number of pathogens. It is
impossible to completely get rid of colds during this period [16-19]. General
preventive measures will help reduce the likelihood of infection. In addition, it is
very important to leave the child at home at the first signs of ARVI. This will not
only help avoid the spread of infection in the community, but will also help the
child’s div cope with the disease faster [20-23].
Flu vaccination
Vaccination is an effective way to protect both children (over 2 years old)
and adults from influenza. It is this disease that is most severe, accompanied by
severe intoxication and can cause life-threatening complications [24-27]. Vaccines
change each year to reflect the most common strains that season. Ideally, the vaccine
should be given 1-2 months before the start of the annual outbreak, as the immune
system needs time to produce antibodies. Before vaccination, you must contact your
pediatrician so that he can examine the child and make sure there are no
contraindications.
Preventing influenza and ARVI, especially during an epidemic, is not an
easy task. However, if you accustom yourself and your children to a daily routine,
proper microclimate in the premises, good and healthy nutrition, if you get
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vaccinations on time and do not forget about hygiene, the likelihood of illness will
be much lower [28-30].
Treatment
Influenza illness can present with a range of symptoms, ranging from a mild
upper respiratory tract infection to an acute, life-threatening illness. Knowledge of
the main symptoms of diseases caused by various respiratory viruses is essential for
a doctor. This is due to the fact that modern principles of treatment of ARVI, in
addition to symptomatic drugs, include a wide range of etiotropic drugs, many of
which have a selective effect against specific viruses, which must be taken into
account when prescribing them [38-41].
Modern approaches to the treatment of ARVI, including influenza, include
the use of both medicinal and non-medicinal methods (regime, hygiene, diet,
sanitation of the upper respiratory tract, physiotherapy). The main goals of therapy
for these infections are suppression of viral replication in the early stages of the
disease, relief of clinical manifestations of viral infection, prevention and treatment
of complications.
In recent years, in the treatment of ARVI and influenza, preference is given
to drugs that have several points of application and have a combined effect, which
combine direct antiviral, immunomodulatory and symptomatic effects. In situations
with an unspecified pathogen and the absence of a laboratory-confirmed mixed viral
infection, therapy with broad-spectrum antiviral drugs should be started.
The use of complex drugs that affect not only the proteins and key structures
of the virus, but also the cellular and humoral immune mechanisms of antiviral
defense, allows for effective therapy for a wide range of respiratory viral infections,
including influenza [42].
Conclusions
Influenza and other acute respiratory viral infections still remain one of the
pressing medical and socio-economic problems, the solution of which is possible
only at the state level.
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Vaccination against influenza for groups at increased risk of infection has
been introduced into the National Calendar of Preventive Vaccinations; work is
underway to prepare for the widespread use of a new generation influenza vaccine
that can mitigate the problem of variability of the influenza virus; A quadrivalent
vaccine has been created.
New etiotropic drugs are constantly being developed and introduced into
clinical practice that can quickly cure a patient from influenza and prevent the
development of complications, which are the main cause of mortality in the
unvaccinated population.
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