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GEPATIT C DA JIGAR SIRROZINI BAHOLASH USULLARI
Shamsiyeva Muattar Axmatovna
Abu Ali ibn Sino nomidagi Buxoro davlat tibbiyot instituti
Mavzuning dolzarbligi.
Ko'pgina HCV bilan kasallangan bemorlarga tashxis
qo'yilmagan va bir tadqiqotda HCV bilan kasallangan bemorlarning 50 foizi o'zlarining
tashxisini bilishmagan [1-4]. Jigar fibrozini baholash uchun ishlatiladigan invaziv
bo'lmagan testlar orasida vaqtinchalik elastografiya sirozni aniqlash uchun eng aniq
usullardan biridir [5-8]. Magnit-rezonans elastografiya ham jigar fibrozini baholashda
juda aniq ekanligi isbotlangan, ammo bu test kamroq tarqalgan [9-13]. Sirozni
kompyuter tomografiyasi (KT), ultratovush yoki magnit-rezonans tomografiya (MRI)
kabi rentgenologik tekshiruvlar yoki jigarning igna biopsiyasi orqali aniqlash mumkin
[14-19]. Vaqtinchalik yoki magnit-rezonans elastografiyani (MRE) o'z ichiga olgan
muayyan ko'rish testlari tavsiya etilishi mumkin[20-26]. Ushbu invaziv bo'lmagan
ko'rish testlari jigarning qattiqlashishi yoki qotib qolishini ko'rib chiqadi[27-32].
Material va metodlar.
Jigar funksiyasi testlari odatda:RNK testi (ribonuklein
kislotasi) bo'lib, u qonda virusning genetik materiali mavjudligini tekshiradi.
alanin transaminaza (ALT),aspartat transaminaza (ACT)Gamma-glutamil
transpeptidaza (GGT) testi.
Tekshirish natijalari.
2022 yildan 2024 yilgacha hujjatlashtirilgan HCV bilan
kasallangan va antiviral terapiya uchun rejalashtirilgan 40 bemor ushbu istiqbolli,
kuzatuv tadqiqotiga kiritilgan. Bemorlar tibbiy sog'liqni saqlash markazining
ambulatori sifatida yaratilgan. Yuqoridagi davrda HCV bilan davolangan qariyb 50
nafar bemordan 20 nafari faqat ishtirok etishga qiziqish bildirgan.Ushbu tadqiqotda
ishtirok etgan barcha bemorlarni tanlash mezonlari HCV uchun ijobiy antikorlar va
kamida 6 oy davomida tekshirilishi mumkin bo'lgan virus miqdori surunkali faol
infeksiyaga dalil sifatida ko'rsatilgan. Bemorlar haqiqiy yoki ilgari antiviral HCV
terapiyasidan mustaqil ravishda kiritilgan. Barcha bemorlar uchun HCV genotiplari
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sinovdan o'tkazildi. Institutsional tekshiruv kengashi tadqiqotni ma'qulladi va
bemorlarga o'rganish tartibi haqida ma'lumot berildi.
Xulosa.
Jigar fibrozini baholash bemorlarni tabaqalashtirish va boshqaruv va
kuzatuvni rejalashtirish uchun muhim ahamiyatga ega. Jigar biopsiyasi va gistologik
baholash o'ziga xos cheklovlarga qaramay, fibrozni aniqlashda oltin standart bo'lib
qolmoqda. Siroz - bu jigar ichidagi shikastlanishga sezilarli darajada saqlanib qolgan
javobning patogen oqibati bo'lib, to'qimalarda progressiv fibrozning cho'kishi va
jigarning normal tuzilishining buzilishi bilan tavsiflanadi. Tasdiqlovchi test ko'pincha
RNK testi (ribonuklein kislotasi) bo'lib, u qonda virusning genetik materiali
mavjudligini tekshiradi.
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