DUE TO THE MIXED-COMBINED USE OF PSYCHOACTIVE SUBSTANCES MODIFICATION SYNDROME OF ACQUIRED ADDICTION PRINCIPLES OF PREVENTION AND TREATMENT: COMPARATIVE ANALYSIS

Summary: This article presents current views on the classification, diagnosis, treatment, and prevention of drug dependence caused by the со-use of several psychoactive substances (PASs). It describes the fundamental regularities of the development and course of the disease, the patterns of consumption, and the issues of laboratory diagnosis. Particular attention is paid to the clinical diagnosis of the most common patterns of use of various PASs. In order to make and propose the reader the most complete basis for evidencebased strategies for the treatment of various variants of polydrug abuse, the authors studied the results of investigations that enrolled patients using more than one PAS at least 1 month before the start of treatment. The section on therapy is presented as clinical recommendations, taking into account the levels of evidence and the grades of recommendations.