SCIENCE AND INNOVATION IN THE
EDUCATION SYSTEM
International scientific-online conference
5
PATHOMORPHOLOGICAL CHANGES OF ENDO AND MYOMETRY IN
THE DEVELOPMENT OF ABNORMAL UTERINE BLEEDING IN
WOMEN.
Abdusamieva Nargiza Khudratovna
Assistant
Termiz Economics service University.
Department of Medical Clinical Sciences
https://doi.org/10.5281/zenodo.14986950
Aim:
Purpose of this study to determine the pathomorphological causes of
abnormal uterine bleeding in perimenopausal women.
Materials and methods :
To achieve our goal, we examined 55
perimenopausal women with abnormal uterine bleeding who underwent the
following examination methods: anamnesis and assessment of the nature of
bleeding, clinical blood test, gynecological examination ,color doppler mapping,
curettage of the uterine cavity with subsequent histology , hysteroscopy with
targeted biopsy and histology.
Results
of the study and their discussion: The age of women varied from 45
to 49 years. From the anamnesis of relapse, abnormal uterine bleeding was
observed in 15 (27%) women. In the remaining 40 (72%). In 6 (11%) women,
on bimanual examination, the size of the uterus was within the normal range,
the appendages were not palpable. In 36 (65%), the size of the uterus during
bimanual examination was increased in size, in 25 (69%) of them, pain was also
observed during the examination. In 13 (24%) women, an increase in the uterus
and appendages was observed. Laboratory evaluation included a clinical blood
count and a coagulogram. All examined women had anemia of various degrees,
of which severe anemia was observed in 15 (27%). Blood coagulation disorder
was in 5(9%), 4(80%) of them were towards hypercoagulation, and 1(20%) -
hypocoagulation. Curettage of the uterine cavity with subsequent histology was
performed in 35 (64%) of the examined patients in order to diagnose and stop
bleeding. Histological responses were as follows: glandular hyperplasia of the
endometrium in 11 (31.5%) patients, glandular cystic hyperplasia in 6 (17%)
patients, endometrial polyposis in 9 (25%), atypical hyperplasia in 1 (3%),
endometrial cancer in 1 (3%), in the remaining 7 (20%), an inflammatory
process of the endometrium was revealed.
Conclusion
: According to the results of pathomorphological studies, the
most common causes of abnormal uterine bleeding in perimenopause are
endometrial hyperplastic processes (36%), which are often combined with
SCIENCE AND INNOVATION IN THE
EDUCATION SYSTEM
International scientific-online conference
6
adenomyosis and uterine myoma (20.8%). The most informative methods of
examination were Doppler ultrasound, diagnostic curettage of the uterine cavity.
Literature:
1.
Ablakulova V.S. On the risk of recurrence of endometrial polyps. Second
medical journal. Uzbekistan. 1999; 1; 53-55s.
2.
Vikhlyaeva E. M., Zheleznov B. Yu., Zaporozhan V. N. Guide to endocrine
gynecology. Hyperplastic processes of the endometrium / Ed. E. M.
Vikhlyaeva.— M.: Med. inform. Agency, 2017.— P. 684–710.
3.
Dubossarskaya ZM Reproductive endocrinology: Educational method.
allowance. - Dnepropetrovsk: Lira LTD, 2018. - 416 p. 26. Panay N., Studd J.
Treatment of gestagen intolerance // Progress in the management of the
Menopause.— N. Y., 1998.— P. 151–167.
4.
Zaidieva Ya.Z. Abnormal uterine bleeding in perimenopause // Russian
Bulletin of the Obstetrician-Gynecologist 5, 2018 p. 92-99.
